scholarly journals Dietary zinc intake is inversely related to subclinical atherosclerosis measured by carotid intima-media thickness

2010 ◽  
Vol 104 (8) ◽  
pp. 1202-1211 ◽  
Author(s):  
Yoon Jung Yang ◽  
Bo Youl Choi ◽  
Byung-Yeol Chun ◽  
Sun-Seog Kweon ◽  
Young-Hoon Lee ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Epidemiological Studies ◽  
Protective Role ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness ◽  
The Relationship

The relationship between dietary Zn intake and the risk of atherosclerosis remains unclear, and no epidemiological studies have been reported on the effects of dietary Zn intake on morphological changes in the vascular wall. We examined the relationship between dietary Zn intake and common carotid intima-media thickness (IMT) as a marker of subclinical atherosclerosis among the middle-aged and elderly populations. A cross-sectional analysis of a prospective cohort baseline study was performed with 4564 adults aged 40–89 years and free of clinical CVD. Dietary data were collected by trained interviewers using an FFQ. Common carotid IMT was measured using a B-mode ultrasound imaging technique. Subclinical atherosclerosis was determined using carotid IMT, and defined as >80th percentile of carotid IMT or ≥ 1 mm of carotid IMT. After adjustment for potential confounders, the mean carotid IMT in the low Zn intake group was higher than that in the high Zn intake group. When subclinical atherosclerosis was defined as >80th percentile value of IMT or ≥ 1 mm of carotid IMT, after adjustment for potential confounders, Zn intake was inversely related to subclinical atherosclerosis (5thv.1st quintile, OR 0·64, 95 % CI 0·45, 0·90,Pfor trend = 0·069; 5thv.1st quintile, OR 0·34, 95 % CI 0·16, 0·70,Pfor trend = 0·005, respectively). In persons free of clinical CVD, dietary Zn intake was inversely correlated with subclinical atherosclerosis. The present findings suggest a putative protective role of dietary Zn intake against the development of atherosclerosis.

Abstract P074: Restless Legs Syndrome and Carotid Intima-Media Thickness in Women

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Karen Jacobo ◽  
Adriana Monge ◽  
Eduardo Ortiz-Panozo ◽  
Elsa Yunes ◽  
Andres Catzin-Khulmann ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Mean Difference ◽  
Lower Limbs ◽  
Cross Sectional ◽  
Restless Legs ◽  
Media Thickness ◽  
Increased Risk

Introduction: Restless legs syndrome (RLS) is a common chronic disorder characterized by an irresistible need to move the lower limbs that is usually worse in the evening and is associated with sleep disturbances. RLS has been associated with hypertension and has been proposed as a marker for increased cardiovascular risk. Hypothesis: Individuals with RLS have an increased common carotid intima-media thickness (cIMT) relative to individuals without RLS. Methods: We evaluated cross-sectional relation of RLS and cIMT in 1,147 disease-free Mexican women of the Mexican Teachers’ Cohort. In 2011, participants responded to a follow-up questionnaire that included standardized questions addressing the four minimal diagnostic criteria of the International Restless Legs Study Group. Participants were asked: “Do you have unpleasant leg sensations (like crawling, loss of sensation or pain) combined with restlessness and an urge to move your legs?”, “Do these symptoms occur only at rest?”, “Does moving improve these symptoms?”, “Are these symptoms worse in the evening or at night compared with the morning?” Women who answered yes to all the four questions were defined as having RLS. Between 2012 and 2013, a subsample of participants were invited for a clinical visit where neurologists assessed cIMT with an ultrasound. cIMT measurements were found to be reproducible in a substudy in 52 participants (intra-class correlation=0.89). We defined subclinical atherosclerosis as a cIMT ≥0.8 mm or the presence of plaque. Results: Among women with a mean age of 48.2 (SD±4.3), the prevalence of RLS was 14.2% (cases, 163). The age-adjusted mean difference of cIMT comparing participants with RLS to those without RLS was 0.009mm (95%CI -0.004 to 0.023). After further adjustment for diabetes, hypercholesterolemia, migraine, oral contraceptive use, menopause, smoking, body mass index, physical activity and alcohol, the mean difference of cIMT comparing participants with and without RLS was not statistically different (0.007mm; 95%CI -0.007 to 0.021). The prevalence of subclinical atherosclerosis was 27% (n=44) in those with RLS and 21.9% (n=215) in those without RLS. The age-adjusted OR comparing women with RLS to those without RLS was 1.23 (95%CI 0.83-1.82). In the multivariable model the OR remained non-significant (1.16, 95%CI 0.77-1.74). Conclusions: In this cross-sectional study in middle-aged women, RLS was not associated to cIMT. Our results do not support the observation that individuals with RLS are at an increased risk for cardiovascular disease.

scholarly journals Carotid artery intima–media thickness, distensibility and elasticity: population epidemiology and concordance in Australian children aged 11–12 years old and their parents

BMJ Open ◽  
2019 ◽  
Vol 9 (Suppl 3) ◽  
pp. 23-33 ◽  
Author(s):  
Richard S Liu ◽  
Sophie Dunn ◽  
Anneke C Grobler ◽  
Katherine Lange ◽  
Denise Becker ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Correlation Coefficients ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Repeated Measurements ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness ◽  
Parent Child

ObjectivesTo describe a well-established marker of cardiovascular risk, carotid intima–media thickness (IMT) and related measures (artery distensibility and elasticity) in children aged 11–12 years old and mid-life adults, and examine associations within parent–child dyads.DesignCross-sectional study (Child Health CheckPoint), nested within a prospective cohort study, the Longitudinal Study of Australian Children (LSAC).SettingAssessment centres in seven Australian major cities and eight selected regional towns, February 2015 to March 2016.ParticipantsOf all participating CheckPoint families (n=1874), 1489 children (50.0% girls) and 1476 parents (86.8% mothers) with carotid IMT data were included. Survey weights and methods were applied to account for LSAC’s complex sample design and clustering within postcodes and strata.Outcome measuresUltrasound of the right carotid artery was performed using standardised protocols. Primary outcomes were mean and maximum far-wall carotid IMT, quantified using semiautomated edge detection software. Secondary outcomes were carotid artery distensibility and elasticity. Pearson’s correlation coefficients and multivariable linear regression models were used to assess parent–child concordance. Random effects modelling on a subset of ultrasounds (with repeated measurements) was used to assess reliability of the child carotid IMT measure.ResultsThe average mean and maximum child carotid IMT were 0.50 mm (SD 0.06) and 0.58 mm (SD 0.05), respectively. In adults, average mean and maximum carotid IMT were 0.57 mm (SD 0.07) and 0.66 mm (SD 0.10), respectively. Mother–child correlations for mean and maximum carotid IMT were 0.12 (95% CI 0.05 to 0.23) and 0.10 (95% CI 0.03 to 0.21), respectively. For carotid artery distensibility and elasticity, mother–child correlations were 0.19 (95% CI 0.10 to 0.25) and 0.11 (95% CI 0.02 to 0.18), respectively. There was no strong evidence of father–child correlation in any measure.ConclusionsWe provide Australian values for carotid vascular measures and report a modest mother–child concordance. Both genetic and environmental exposures are likely to contribute to carotid IMT.

scholarly journals Association between carotid intima media thickness and metabolic syndrome

2018 ◽  
Vol 5 (6) ◽  
pp. 1503
Author(s):  
Abhishek T. G. ◽  
Arathi Darshan ◽  
Jayaprakash S. Appajigol ◽  
Naveen Angadi ◽  
Vijayalakshmi Chikkamath
Keyword(s):  
Metabolic Syndrome ◽  
Total Cholesterol ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Research Centre ◽  
Cross Sectional ◽  
Media Thickness ◽  
The Mean

Background: Metabolic syndrome and its individual criteria pose a risk for atherosclerosis and cardiovascular disease (CVD). Carotid intima media thickness (CIMT) is a well-known marker of subclinical atherosclerosis. This study was aimed to assess CIMT in patients with metabolic syndrome.Methods: This one year cross-sectional study was conducted in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi from January 2016 to December 2016. A total of 100 patients diagnosed to have metabolic syndrome based on national cholesterol education program adult treatment panel III (NCEP ATP III) criteria were studied. All the patients were subjected to carotid B mode ultrasonography.Results: The most common age group was 51 to 60years (29%). Out of 100 individuals who were diagnosed to have metabolic syndrome, 60% had five criteria, 29% had four criteria and 3% had three criteria. Most of the of the individuals (61.00%) had normal (≤0.10cms) CIMT while high (>0.10cm) levels were noted in 39.00% of the individuals. The mean CIMT was noted as 0.13±0.16cms. The mean SBP (150.15±10.39 vs 142.98±20.09mmHg; p=0.042), DBP (94.51±6.53 vs 90.16±9.91 mmHg; p=0.017), total cholesterol levels (243.53±65.74 vs 195.95±29.8 mg/dL; p<0.001) and triglyceride levels (221.07±48.44 vs 180.85±24.74mg/dL; p <0.001) were noted in individuals with raised CIMT compared to individuals with normal CIMT. Majority of the individuals had abnormal HDL (93.00%) and 41.94% of the individuals with abnormal HDL had raised CIMT (p=0.027).Conclusions: Some individuals with metabolic syndrome are likely to have raised CIMT. The rise in CIMT among the patients with metabolic syndrome is associated with raised SBP, DBP, abnormal HDL (specifically in males), total cholesterol and triglycerides.

scholarly journals Carotid Intima-Media Thickness in Healthy Children and Adolescents: Normative Data and Systematic Literature Review

2020 ◽  
Vol 7 ◽  
Author(s):  
Ana Drole Torkar ◽  
Emil Plesnik ◽  
Urh Groselj ◽  
Tadej Battelino ◽  
Primoz Kotnik
Keyword(s):  
Imaging Techniques ◽  
Intima Media Thickness ◽  
Medical Personnel ◽  
Carotid Intima Media Thickness ◽  
Epidemiological Studies ◽  
Normative Values ◽  
Published Data ◽  
Healthy Children ◽  
Cross Sectional ◽  
Media Thickness

Objectives: Early identification of children at risk of atherosclerosis is of paramount importance for implementing primary preventive measures addressing vascular health. Carotid intima-media thickness (cIMT) is a non-invasive biomarker of atherosclerosis. Semiautomatic radiofrequency-based software-guided technique quality intima-media thickness (RF-QIMT) was used to determine cIMT normative values in a healthy cohort of Caucasian children aged 6 to 18 years.Study design: In a cross-sectional study, data on age, chronic illness, medication use, and pubertal status was acquired by a questioner. Anthropometric and blood pressure measurements were performed by standardized methods and trained medical personnel. cIMT of the right common carotid artery far wall (1 centimeter proximal to bifurcation) was determined using a multifrequency (3–13 MHz) electronic linear array transducer SL1543, a portable ultrasound device (MyLab Gamma Esaote, Genoa, Italy), and RF-QIMT software. A systematic review of the published normal cIMT in children was done using PRISMA methodology, and identified normative values were compared to those obtained in the presented study.Results: 1137 non-obese normotensive children (males: n = 512; mean age 12.04 ± 3.52 years, females: n = 625, mean age 12.98 ± 3.83 years) were included. Gender-, age-, and height-specific mean cIMT percentile tables, percentile charts, and LMS tables for the RF-QIMT method were provided. They were comparable to the previously published data on mean cIMT gained by other validated ultrasound imaging techniques. cIMT increased with age, height, hip circumference, and BMI and was higher in males.Conclusions: Gender-, age-, and height-specific normative cIMT values, using the semiautomatic software-guided RF-QIMT technique, in children aged 6 to 18 years were developed and validated in respect to the previously published pediatric normative cIMT data. It is suggested that the investigated method could be used for the estimation of atherosclerotic risk in children, especially in epidemiological studies.

scholarly journals Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Shun-Sheng Wu ◽  
Chew-Teng Kor ◽  
Ting-Yu Chen ◽  
Ko-Hung Liu ◽  
Kai-Lun Shih ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Markers ◽  
Oxidative Stress Biomarkers ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness

Oxidative stress is the major cause of atherosclerosis and cardiovascular diseases. This cross-sectional study is aimed at determining if parallel serum markers of oxidative stress are related to carotid intima-media thickness (IMT). We enrolled 134 participants with varied metabolic syndrome (Met-S) scores (zero, n=21; one, n=19; two, n=27; three, n=26; four, n=25; five, n=16). Biochemical profiles and potential oxidative stress biomarkers malondialdehyde (MDA) and uric acid were measured in fasting plasma. We found that carotid IMT positively correlated with both MDA and uric acid levels. Multivariate analysis revealed that both MDA (p<0.05) and uric acid (p<0.01) levels were significantly associated with carotid IMT in participants whose Met-S scores were ≥1 or ≥2. However, only uric acid (p<0.01) levels were positively associated with carotid IMT in patients with metabolic syndrome. Linear regression model analysis revealed that the prediction accuracies for carotid IMT from MDA combined with uric acid and from a combination of MDA, uric acid, and Met-S score were 0.176 and 0.237, respectively. These were better than the predication accuracies from MDA (r2=0.075) and uric acid (r2=0.148) individually. These results suggest that measuring uric acid levels along with MDA biomarkers and Met-S scores may be a promising step in the development of an effective model for monitoring the severity of carotid IMT and atherosclerosis in the patients with metabolic syndrome.

scholarly journals A Study of Intima Media Thickness and Their Cardiovascular Risk Factors in Patients with Psoriatic Arthritis

2009 ◽  
Vol 52 (3) ◽  
pp. 107-116 ◽  
Author(s):  
Sadhanah Aqashiah Mazlan ◽  
Mohd Shahrir bin Mohamed Said ◽  
Heselynn Hussein ◽  
Khadijah binti Shamsuddin ◽  
Shamsul Azhar Shah ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Psoriatic Arthritis ◽  
Disease Activity ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Community Research ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Media Thickness

Introduction: Psoriatic Arthritis (PsA) is an inflammatory arthritis associated with Psoriasis. Its recognition as an inflammatory disease distinct from Rheumatoid Arthritis has put forward for consideration several questions regarding its specific CVS mortality and morbidity (9, 11, 16, 26). Carotid intima media thickness is a useful surrogate and sensitive marker to determine atherosclerosis even in its subclinical stages (6, 14, 22, 27, 32). Objective: Prevalence of carotid intima media thickness in patients with Psoriatic arthritis is unknown in Asian population. We aim to identify the presence of subclinical atherosclerosis in patients with psoriatic arthritis and disease activity association and its predictors in a series of patients with PsA attended to the rheumatology clinic, tertiary hospitals. Methods: A total of 63 patients with PsA who fulfilled the CASPAR criteria were recruited from UKM Medical Centre and Hospital Putrajaya. Common carotid intima media thickness (IMT) was measured in both right and left carotid artery by using high resolution B-mode ultrasound. This was a cross sectional study first done in Malaysia for PsA patients. Results: The positive IMT (IMT >1.00 mm) among PsA was observed in 10 out of 63 patients (15.9 %) regardless of background cardiovascular risk. The mean±SD of IMT was 0.725 ±0.260 mm for this study. Variables significantly associated with positive IMT (p<0.05) included age at the time of study (p=0.005), waist circumference (p=0.001), Hypertension (p=0.007), Diabetes (p=0.002) and Metabolic syndrome (p=0.001) and not associated with gender, ethnicity, duration of PsA disease, pattern of PsA, disease activity and severity. Above all, only age had positive IMT independent predictor (p=0.032), with OR 1.116; 95 % CI (1.010–1.234). Conclusions: There was a significant association between CVS risk and positive Intima Media Thickness in Psoriatic Arthritis patients. Otherwise, there was no association in disease activity, disease severity and DMARDS therapy with positive Intima Media Thickness in Psoriatic Arthritis patients. The study was approved by Research and Ethics Committee of the faculty of medicine, Universiti Kebangsaan Malaysia with project code FF-114-2008 and by Community Research Center (CRC) of National Institutes of Health (NIH) for the case study in Hospital Putrajaya with the project code NMRR-08- 970-2125.

scholarly journals Ultrasonic assessment of carotid intima-media thickness in migraine: a meta-analysis

2019 ◽  
Vol 47 (7) ◽  
pp. 2848-2855 ◽  
Author(s):  
Qiao Wang ◽  
Zhen-Yu Liu ◽  
Jia Zhou
Keyword(s):  
Meta Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cerebrovascular Diseases ◽  
Cochrane Library ◽  
Carotid Imt ◽  
Media Thickness ◽  
The Cochrane Library ◽  
Ultrasonic Assessment ◽  
The Relationship

Objective Migraine is believed to be a risk factor for cerebrovascular diseases, and previous studies have indicated an association between migraine and cerebral atherosclerosis. Carotid artery intima-media thickness (IMT) is considered to be a biomarker of atherosclerosis pathology. This study aimed to investigate the relationship between carotid IMT and migraine by conducting a meta-analysis. Methods We searched Web of Science, PubMed, and the Cochrane Library for eligible studies assessing carotid IMT in patients with migraine and controls. Data were extracted independently by two reviewers and analyzed using Review Manager 5.3 software. Results The meta-analysis included seven articles with 555 subjects (279 migraine patients, 276 controls). Carotid IMT was significantly greater in patients with migraine compared with controls. However, there were no significant differences in IMT between patients with migraine with aura (MA) and controls, migraine without aura (MO) and controls, and patients with MA and MO. Conclusion Patients with migraine have greater carotid IMT than individuals without migraine, suggesting an association between atherosclerosis and migraine. However, further studies with more samples are needed to confirm this finding.

Abstract P322: Soda Consumption is Associated With Carotid Intima-Media Thickness Among Middle-Aged Mexican Women

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Mariel Arvizu ◽  
Adriana Monge ◽  
Martha Thamez ◽  
Eduardo Ortiz-Panozo ◽  
Elsa Yunes ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Subclinical Atherosclerosis ◽  
Menopausal Status ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Diet Change ◽  
Sugar Sweetened Beverages ◽  
Cross Sectional ◽  
Media Thickness ◽  
Sweetened Beverages

Introduction: Soda intake is associated with cardiovascular disease. Other sweetened drinks often considered healthy alternatives to sodas could have a similar impact on cardiovascular risk. Hypothesis: Sugar-sweetened beverages commonly consumed by Hispanics have a negative influence on cardiovascular risk. Methods: We evaluated the cross-sectional relationship of sweetened beverages and common carotid intima-media thickness (CIMT) in 1,054 disease-free women without diabetes, high cholesterol, history of stroke and/or myocardial infarction, from the Mexican Teachers’ Cohort. Beverage intake was estimated from a validated food-frequency questionnaire in 2008 and 4 years later, CIMT measurements were performed by neurologists. We defined subclinical atherosclerosis as CIMT ≥0.8mm or presence of plaque and beverage intake was categorized in quartiles of servings/day. Results: Mean (±SD) soda intake was 0.5 ± 0.7 servings/day among 45.2 ± 4.7 year old women and atherosclerosis prevalence was 8.7%. After adjusting for age, smoking, secondhand smoke, physical activity, oral contraception, menopausal status, SES, and diet, % change of CIMT per 1 serving/day of soda was 1.3 (95% CI 0.2-2.3). Comparing extreme quartiles of soda intake, we observed a 3.5% (95% CI 1.1-5.8; p-trend=0.003) increase in CIMT (Figure). Intake of artificially-sweetened soda, fruit infused water, and juice was not associated to CIMT. None of the beverages were associated to subclinical atherosclerosis. Conclusions: In this cross-sectional study, soda intake was associated to increased CIMT while artificially-sweetened soda, fruit water, or juice intakes were not. Our results support prior results on the adverse consequences of soda intake in cardiovascular health. Keywords: sugar-sweetened beverages, cardiovascular risk, intima media thickness, cross-sectional

scholarly journals Association of Ideal Cardiovascular Health with Carotid Intima-Media thickness (cIMT) in a Young Adult Population: Tehran Lipid and Glucose Study (TLGS)

2021 ◽  
Author(s):  
Vajihe Chavoshi ◽  
Maryam Barzin ◽  
Amir Ebadinejad ◽  
Pooneh Dehghan ◽  
Amin Momeni Moghaddam ◽  
...  
Keyword(s):  
Young Adults ◽  
Cardiovascular Health ◽  
Subclinical Atherosclerosis ◽  
Adult Population ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Inverse Association ◽  
Cross Sectional ◽  
Ideal Cardiovascular Health ◽  
Media Thickness

Abstract Ideal cardiovascular health (CVH) is associated with a lower risk of developing cardiovascular diseases. This study aims to investigate the association of CVH metrics with carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis in young adults. A cross-sectional study was performed on 1295 adults, average age of 29.7 ± 4.0 years, selected among the participants of the Tehran Lipid and Glucose Study (TLGS). The participants were divided into two CVH groups: Ideal CVH and poor/intermediate CVH. Multivariate-adjusted linear regression was used to determine the association of ideal CVH score with cIMT. Multivariate-adjusted odd ratios (ORs) were calculated for high cIMT (≥95%percentile). Also, the independent effects of each ideal CVH metric on cIMT were analyzed. The prevalence of ideal CVH was 9.3% in the studied population, and the mean of cIMT was 0.55±0.09 mm. A 1-point increase in CVH score was associated with a decrease of 0.128 mm (Beta [SE] = -0.128 [0. 002], p<0.001) in cIMT and rendered an odd ratio of 0.68 (OR = 0.68 [95% CI: 0.56-0.82], p<0.001) for having a high CIMT (≥95%percentile). Each ideal glucose, ideal blood pressure and ideal body mass index (BMI) had a significant inverse association with cIMT. There was a graded inverse association between ideal CVH score and cIMT among young adults, indicating that ideal CVH metrics are associated with better vascular health in this population. The low prevalence of ideal CVH highlighted the importance of implementing health promotion strategies.

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