Association of dietary acid load and plant-based diet index with sleep, stress, anxiety and depression in diabetic women

AbstractDiabetes is a common chronic disease with various complications. The present study was conducted to determine the association of plant-based diet index (PDI) and dietary acid load (DAL) with sleep status as well as mental health in type 2 diabetic women. In this cross-sectional study, a validated FFQ was used to assess dietary intakes of 230 diabetic patients. We created a whole PDI, healthful PDI (hPDI) and unhealthful PDI (uPDI). DAL was calculated based on potential renal acid load and net endogenous acid production method. The Pittsburgh Sleep Quality Index and twenty-one-item Depression, Anxiety and Stress Scale were used to assess sleep and mental health disorders, respectively. Participants in the top group of uPDI had greater risk of poor sleep (OR 6·47, 95 % CI 2·75, 15·24). However, patients who were in the top group of hPDI had a lower risk of sleep problems (OR 0·28, 95 % CI 0·13, 0·62). Participants in the top group of uPDI had greater risk of depression, anxiety and stress (OR 9·35, 95 % CI 3·96, 22·07; OR 4·74, 95 % CI 2·28, 9·85; OR 4·24, 95 % CI 2·14, 8·38, respectively). In conclusion, participants with higher DAL scores and patients who adhered to animal-based diets rather than plant-based diets were more likely to be poor sleepers and have mental health disorders.

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No Interaction Effect between Interleukin-6 Polymorphisms and Acid Ash Diet with Bone Resorption Marker in Postmenopausal Women

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020827 ◽

2021 ◽

Vol 18 (2) ◽

pp. 827

Author(s):

Sook Yee Lim ◽

Yoke Mun Chan ◽

Vasudevan Ramachandran ◽

Zalilah Mohd Shariff ◽

Yit Siew Chin ◽

...

Keyword(s):

Bone Resorption ◽

Postmenopausal Women ◽

Interaction Effect ◽

Interleukin 6 ◽

Gene Polymorphisms ◽

Bone Resorption Marker ◽

Dietary Intakes ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Background: Evidence is growing that a high-acid diet might accelerate the rate of bone loss, and gene polymorphisms such as Interleukin 6 (IL6) -174G/C and -572G/C are related to bone deterioration. However, no study of the interaction between diet and IL6 polymorphisms has been conducted among Asians. Thus, the objective of this study was to determine whether IL6 gene polymorphisms modified the association between dietary acidity and the rate of bone resorption. Methods: This cross-sectional study recruited 203 postmenopausal women (age ranged from 51 to 85 years old) in community settings. The dietary intakes of the participants were assessed using a validated interviewer-administered semi-quantitative food frequency questionnaire (FFQ), while dietary acid load (DAL) was estimated using net endogenous acid production (NEAP). Agena® MassARRAY genotyping analysis and serum collagen type 1 cross-linked C-telopeptide (CTX1) were used to identify the IL6 genotype and as a bone resorption marker, respectively. The interactions between diet and single-nucleotide polymorphisms (SNPs) were assessed using linear regressions. Results: A total of 203 healthy postmenopausal women aged between 51 and 85 years participated in this study. The mean BMI of the participants was 24.3 kg/m2. In IL6 -174 G/C, all the participants carried the GG genotype, while the C allele was absent. Approximately 40% of the participants had a high dietary acid load. Dietary acid load (B = 0.15, p = 0.031) and the IL6 -572 CC genotype group (B = 0.14, p = 0.044) were positively associated with a higher bone resorption. However, there was no moderating effect of the IL6 genetic polymorphism on the relationship between and acid ash diet and bone resorption markers among the postmenopausal women (p = 0.79). Conclusion: High consumption of an acid ash diet and the IL6 -572 C allele seem to attribute to high bone resorption among postmenopausal women. However, our finding does not support the interaction effect of dietary acidity and IL6 (-174G/C and -572G/C) polymorphisms on the rate of bone resorption. Taken together, these results have given scientific research other candidate genes to focus on which may interact with DAL on bone resorption, to enhance planning for preventing or delaying the onset of osteoporosis among postmenopausal women.

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Cosleeping and Behavioral Sleep Problems in School-aged Children with Neurodevelopmental and Mental Health Disorders

Archives of Psychiatric Nursing ◽

10.1016/j.apnu.2018.02.002 ◽

2018 ◽

Vol 32 (3) ◽

pp. 483-487

Author(s):

María-Felisa Bastida-Pozuelo ◽

Lisa J. Meltzer ◽

María-Montserrat Sánchez-Ortuño

Keyword(s):

Mental Health ◽

Sleep Problems ◽

Mental Health Disorders ◽

School Aged Children ◽

Health Disorders

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Night-to-Night Variability of Sleep in Children With ADHD and Typically Developing Controls

Journal of Attention Disorders ◽

10.1177/1087054715575065 ◽

2015 ◽

Vol 22 (10) ◽

pp. 942-946 ◽

Cited By ~ 3

Author(s):

Abbey Poirier ◽

Penny Corkum

Keyword(s):

Mental Health ◽

Sleep Duration ◽

Sleep Problems ◽

Mental Health Disorders ◽

Typically Developing ◽

Children With Adhd ◽

Sleep Parameters ◽

Health Disorders ◽

Objective Research ◽

Age And Sex

Objective: Research results on the nature of sleep problems in children with ADHD are highly inconsistent. It is frequently reported that children with ADHD show more night-to-night variability in sleep than their typically developing (TD) peers, but this finding is also inconsistent. Lack of methodological control may account for these inconsistent findings. The current study examined the night-to-night variability of sleep between TD children and children with ADHD who were rigorously diagnosed, medication naïve, and free from comorbid mental health disorders. Method: Sleep parameters were analyzed for night-to-night variability across 4 weekday nights using actigraphy in 50 children with ADHD and 50 age- and sex-matched TD children. Results: There was a significant night-to-night variability for only sleep duration, but this was similar in both groups. Conclusion: These findings suggest that sleep problems in children with ADHD are not due to greater variability in sleep parameters relative to their TD peers.

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The Role of Sleep Quality and Mental Health in Cardiovascular Disease

10.53350/pjmhs211572082 ◽

2021 ◽

Vol 15 (7) ◽

pp. 2082-2086

Author(s):

Roya Vaziri- Harami ◽

Pegah Seif ◽

Ali Kheradmand ◽

Saharnaz Vaziri- Harami

Keyword(s):

Mental Health ◽

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Sleep Quality ◽

Mental Health Disorders ◽

Poor Sleep ◽

Sleep Wake Disorders ◽

Coronary Syndrome ◽

The Mean ◽

Health Disorders

Objectives: Cardiovascular diseases (CVDs) may accompany other diseases. Of which can name sleep disorders and also other psychiatric disorders. Aim: In current study we evaluate the concomitant mental health disorders and the sleep quality among the acute myocardial infarction (AMI) and acute coronary syndrome (ACS) patients. Method:180 cases were selected through random sampling. 90 of the cases were hospitalized because of acute myocardial AMI and 90 patients were admitted with the diagnosis of ACS. Demographic, GHQ 28 and PSQI questionnaire was applied to evaluate the demographic features, psychological wellbeing and sleep quality subsequently. Results: 57.8% of cases were women 42.2% were men. The age range was 27 75 years old and the mean age was 49.93+11.73years old. 87.8% of the patients were married and rest were single. The mean score for the GHQ 28 questionnaire was22.43+10.99in patients with angina and in AMI patients.38.8% of ACS patients and 50% of AMI patients didn’t feel well psychologically. The mean score for sleep quality in ACS patients was 3.08+3.6 and 4.06+3.8 in AMI patients. 32.3% of ACS cases and 24.4% of AMI cases had troubles in sleeping. Conclusion: The mental health disorders prevail in AMI and ACS patients. Furthermore, the poor sleep quality was correlated with mental health disorders. Keywords: Sleep Wake Disorders, Mental Health, Acute Coronary Syndrome, Myocardial Infarction

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Interaction Between Dietary Acid Load and IL6 -572 G/C Polymorphism on Blood Pressure Among Postmenopausal Women in Malaysia

Current Developments in Nutrition ◽

10.1093/cdn/nzaa058_022 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1264-1264

Author(s):

Sook Yee Lim ◽

Yoke Mun Chan ◽

Ramachandran Vasudevan ◽

Mohd Shariff Zalilah ◽

Yit Siew Chin

Keyword(s):

Blood Pressure ◽

Postmenopausal Women ◽

Positive Association ◽

Gene Interaction ◽

Community Dwelling ◽

Dietary Intakes ◽

Significant Positive Association ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Abstract Objectives We examined whether IL6 single nucleotide genetic polymorphism modified the association between dietary acid load (DAL) and blood pressure among postmenopausal women in Malaysia. Methods A total of 211 community-dwelling postmenopausal women were recruited. Dietary intakes of participants were assessed using a validated interview-administered semi-quantitative food frequency questionnaire while DAL was estimated using potential renal acid load (PRAL). Agena® MassARRAY genotyping analysis was used to identify the IL6 genotype and blood pressure was measured using a Digital Automatic BP monitor (OMRON HEM-907, Japan). Interaction between DAL and IL6 -572 G/C polymorphism was assessed using linear regression test. Results There was a significant interaction between DAL and IL6 -572 G/C polymorphism on systolic blood pressure (SBP) (Pinteraction = 0.041). A significant positive association between DAL and SBP with stronger relationship in CG and GG genotype carriers compare to CC carriers were observed. On the other hand, there was no significant diet-gene interaction effect on diastolic blood pressure. Conclusions Our findings suggest that the association between DAL and SBP might be influenced by IL6 -572 G/C polymorphism among postmenopausal women. Further work on how IL6 -572 G/C polymorphism influences the association with DAL on hypertension are warranted. Funding Sources Supported by Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education Malaysia, and Putra Grant UPM.

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Dietary acid load berhubungan dengan sindrom metabolik dan kesehatan mental pada mahasiswi obesitas

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.59033 ◽

2021 ◽

Vol 17 (3) ◽

pp. 113

Author(s):

Firdananda Fikri Jauharany ◽

Martha Irene Kartasurya ◽

Apoina Kartini ◽

Fillah Fithra Dieny ◽

Dian Ratna Sawitri ◽

...

Keyword(s):

Mental Health ◽

Metabolic Syndrome ◽

Health Status ◽

Linear Regression ◽

Risk Score ◽

Self Esteem ◽

Mental Health Status ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

The dietary acid load was associated with metabolic syndrome and mental health among obese college studentsBackground: The prevalence of metabolic syndrome has been increasing every year in the young population. The western diet is one of the causes that makes excess acid in the body called a dietary acid load. On the other hand, the high dietary acid load was associated with decreased mental health status.Objective: To examine the association between dietary acid load and the risk of metabolic syndrome and mental health.Methods: This was a cross-sectional study conducted with 115 female students in Semarang aged 18-22 years. The dietary acid load was evaluated through a potential renal acid load (PRAL), the risk score for metabolic syndrome was calculated by Metabolic syndrome risk score. Mental health status was assessed through levels of self-esteem and levels of anxiety. The level of self-esteem was measured by the Rosenberg Self-Esteem Scale questionnaire, while the level of anxiety was measured by the State Anxiety Inventory questionnaire. Multiple linear regression models with adjustment for a potential cofounding variable were used to evaluate the association between dietary acid load with metabolic syndrome scores, self-esteem scores, and anxiety scores.Results: The mean PRAL score was 6.11 ± 9.72 mEq/day indicated the intake of the subjects was the dietary acid load. 13% of subjects had metabolic syndrome, and 87% had a pre-metabolic syndrome. 36.5% of the subjects have low self-esteem scores. The anxiety level score calculation shows that 59.1% of the subjects are at high risk of anxiety. Pearson test showed that PRAL scores were correlated with anxiety scores (r=0,669; p<0,001). The linear regression test showed that PRAL scores were correlated with metabolic syndrome scores (β=0.899; p<0.001) and self-esteem scores (β =-0.069; p=0.047).Conclusions: High dietary acid load may be a risk factor related to the development of metabolic disorders and decreased mental health status in females with obesity.

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Dietary acid load and risk of cardiovascular disease: a prospective population-based study

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02243-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Parvin Mirmiran ◽

Zeinab Houshialsadat ◽

Zahra Bahadoran ◽

Sajjad Khalili‑Moghadam ◽

Mohammad Karim Shahrzad ◽

...

Keyword(s):

Cardiovascular Disease ◽

Asian Population ◽

Cardiovascular Effects ◽

The Body ◽

Dietary Intakes ◽

Food Frequency ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load ◽

The Impact

Abstract Background and aim Considering the inconsistencies in the cardiovascular effects of dietary acid load and the impact of dietary acidity on the acid–base homeostasis within the body, we aimed to assess the association of dietary acid load and the risk of cardiovascular disease (CVD) in a prospective community-based study. Materials and methods Participants (n = 2369) free of CVD at baseline (2006–2008) were included from the Tehran Lipid and Glucose Study (TLGS) and followed up for a mean of 6.7 ± 1.4 years. Dietary intakes of the participants were assessed using a semi-quantitative food frequency questionnaire (FFQ). The dietary acid load was evaluated by Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP) scores. Both scores have used the macronutrient and micronutrient data of the Food Frequency Questionnaires. Multivariate Cox proportional hazard regression models were used to estimate the 6-years incident risk of CVDs across tertiles of PRAL and NEAP scores. Results Mean age and body mass index of participants were 38.5 ± 13.3 years and 26.6 ± 4.8 kg/m2 at baseline. Within 6.7 ± 1.4 years of follow-up, 79 cases of cardiovascular events were reported. NEAP was significantly associated with the incidence of CVDs (HRs = 0.50, CI 0.32–0.96; P for trend = 0.032); however, after adjusting for potential confounders, no significant associations were observed between PRAL and NEAP scores and the risk of CVDs. Conclusions This study failed to obtain independent associations between dietary acid load and the incidence of CVDs among an Asian population.

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High dietary acid load score is not associated with the risk of metabolic syndrome in Iranian adults

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000626 ◽

2020 ◽

pp. 1-12

Author(s):

Noushin Mohammadifard ◽

Golgis Karimi ◽

Alireza Khosravi ◽

Nizal Sarrafzadegan ◽

Mahnaz Jozan ◽

...

Keyword(s):

Metabolic Syndrome ◽

Blood Sugar ◽

Cross Sectional Study ◽

Dietary Intakes ◽

Cross Sectional ◽

Dietary Acid Load ◽

Net Endogenous Acid Production ◽

Increased Risk ◽

Dietary Acid ◽

Acid Load

Abstract. Background and objective: The association between dietary acid load and metabolic syndrome (MetS) risk is not well-known. Therefore, we aimed to investigate the relationship between dietary acid load and the risk of MetS among Iranian adults. Methods: This cross-sectional study was carried out on 1430 Iranian adults. Dietary intakes were assessed using a validated food frequency questionnaire. Dietary acid load was estimated using potential renal acid load (PRAL) and net endogenous acid production (NEAP). MetS was defined according to the ATP-III criteria. The risk of MetS and its components was explored using logistic regression test. Results: Totally, 205 individuals were identified to have MetS. No significant association for MetS was found across the quartiles of PRAL and NEAP either in the crude model [Q4 PRAL: OR (95% CI): 0.94 (0.67–1.32), and NEAP: OR (95% CI): 0.88 (0.63–1.25)] or fully-adjusted model [Q4 PRAL: OR (95% CI): 0.90 (0.61–1.33), and NEAP: OR (95% CI): 1.05 (0.70–1.57)]. Amongst the components of MetS, higher scores of NEAP was associated with an increased risk of impaired blood sugar after adjustment for potential confounders [OR (95% CI): 1.35 (0.93–1.96)]. No significant association was found for other components either with PRAL or with NEAP. Conclusion: Our findings suggest no association between dietary acid load and MetS risk in Iranian adults. However, higher dietary acid load, measured by NEAP, but not PRAL, was associated with increased risk of impaired fasting blood sugar. Longitudinal studies are warranted to explore whether a diet low in potential acid load could reduce MetS risk.

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