scholarly journals The effect of the Dietary Approaches to Stop Hypertension (DASH) diet on body composition, complete blood count, prothrombin time, inflammation, and liver function in hemophilic adolescents

2021 ◽  
pp. 1-25
Author(s):  
Atena Mahdavi ◽  
Hamed Mohammadi ◽  
Mohammad Bagherniya ◽  
Sahar Foshati ◽  
Cain C. T. Clark ◽  
...  
Keyword(s):  
Body Composition ◽  
Liver Function ◽  
Vitamin C ◽  
Blood Count ◽  
Complete Blood Count ◽  
Liver Steatosis ◽  
Serum Vitamin ◽  
Fat Free Mass ◽  
Control Group ◽  
Dash Diet

Abstract There is no dietary strategy that has yet been specifically advocated for hemophilia. Therefore, we sought to assess the effect of the Dietary Approaches to Stop Hypertension (DASH) diet in adolescents with hemophilia. In this parallel trial, 40 male adolescents with hemophilia were dichotomized into the DASH group or control group for 10 weeks. The serum high sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), complete blood count (CBC), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), partial thromboplastin time (PTT), waist circumference (WC), percentage of body fat, fat-free mass (FFM), and liver steatosis were measured at the beginning and end of the study. Serum vitamin C was measured as a biomarker of compliance with the DASH diet. The DASH diet was designed to include high amounts of whole grains, fruits, vegetables, and low-fat dairy products, as well as low amounts of saturated fats, cholesterol, refined grains, sweets and red meat. Serum vitamin C in the DASH group was significantly increased compared to the control (P=0.001). There was a significant reduction in WC (P=0.005), fat mass (P=0.006), hepatic fibrosis (P=0.02), and PTT (P=0.008) in the DASH group, compared with the control. However, there were no significant differences regarding other selected outcomes between groups. Patients in the DASH group had significantly greater increase in the levels of red blood cell, hemoglobin, and hematocrit, as compared to control. Adherence to the DASH diet in children with hemophilia yielded significant beneficial effects on body composition, complete blood count, inflammation, and liver function.

Comparison of energy expenditure, body composition, metabolic disorders, and energy intake between obese children with a history of craniopharyngioma and children with multifactorial obesity

2015 ◽  
Vol 28 (11-12) ◽  
Author(s):  
Ilanit Bomer ◽  
Carola Saure ◽  
Carolina Caminiti ◽  
Javier Gonzales Ramos ◽  
Graciela Zuccaro ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Positive Association ◽  
Bioelectrical Impedance ◽  
Fat Free Mass ◽  
Control Group ◽  
Model Assessment ◽  
Obese Children ◽  
Mass Percentage

AbstractCraniopharyngioma is a histologically benign brain malformation with a fundamental role in satiety modulation, causing obesity in up to 52% of patients.To evaluate cardiovascular risk factors, body composition, resting energy expenditure (REE), and energy intake in craniopharyngioma patients and to compare the data with those from children with multifactorial obesity.All obese children and adolescents who underwent craniopharyngioma resection and a control group of children with multifactorial obesity in follow-up between May 2012 and April 2013.Anthropometric measurements, bioelectrical impedance, indirect calorimetry, energy intake, homeostatic model assessment insulin resistance (HOMA-IR), and dyslipidemia were evaluated.Twenty-three patients with craniopharyngioma and 43 controls were included. Children with craniopharyngioma-related obesity had a lower fat-free mass percentage (62.4 vs. 67.5; p=0.01) and a higher fat mass percentage (37.5 vs. 32.5; p=0.01) compared to those with multifactorial obesity. A positive association was found between %REE and %fat-free mass in subjects with multifactorial obesity (68±1% in normal REE vs. 62.6±1% in low REE; p=0.04), but not in craniopharyngioma patients (62±2.7 in normal REE vs. 61.2±1.8% in low REE; p=0.8). No differences were found in metabolic involvement or energy intake.REE was lower in craniopharyngioma patients compared to children with multifactorial obesity regardless of the amount of fat-free mass, suggesting that other factors may be responsible for the lower REE.

scholarly journals Potential effects on cardiometabolic risk factors and body composition by short message service (SMS)-guided training after recent minor stroke or transient ischaemic attack: post hoc analyses of the STROKEWALK randomised controlled trial

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e054851
Author(s):  
Birgit Maria Vahlberg ◽  
Erik Lundström ◽  
Staffan Eriksson ◽  
Ulf Holmback ◽  
Tommy Cederholm
Keyword(s):  
Risk Factors ◽  
Body Composition ◽  
Mobile Phone ◽  
Fat Mass ◽  
Text Messaging ◽  
Standard Care ◽  
Cardiometabolic Risk ◽  
Fat Free Mass ◽  
Control Group ◽  
Randomised Controlled

ObjectivesTo evaluate effects of mobile phone text-messaging exercise instructions on body composition, cardiometabolic risk markers and self-reported health at 3 months after stroke.DesignRandomised controlled intervention study with per-protocol analyses.SettingUniversity Hospital in Sweden.ParticipantsSeventy-nine patients (mean (SD) age 64 (10) years, 37% female) ≥18 years with good motor function (modified Rankin Scale ≤2) and capable to perform 6 min walking test at hospital discharge were randomised to either intervention (n=40) or control group (n=39). Key exclusion criteria: subarachnoid bleeding, uncontrolled hypertension, severe psychiatric problems or cognitive limitations.InterventionsThe intervention group received beyond standard care, daily mobile phone instructional text messages to perform regular outdoor walking and functional leg exercises. The control group received standard care.Main outcome measuresFat mass and fat-free mass were estimated by bioelectric impedance analysis. Cardiometabolic risk factors like blood lipids, glycated haemoglobin and blood glucose were analysed at baseline and after 3 months.ResultsBoth groups changed favourably in fat-free mass (1.83 kg, 95% CI 0.77 to 2.89; p=0.01, effect size (ES)=0.63 vs 1.22 kg, 95% CI 0.39 to 2.0; p=0.05, ES=0.54) and fat mass (−1.30 kg, 95% CI −2.45 to −0.14; p=0.029, ES=0.41 vs −0.76 kg, 95% CI −1.74 to 0.22; p=0.123, ES=0.28). Also, many cholesterol related biomarkers improved; for example, total cholesterol −0.65 mmol/L, 95% CI −1.10 to −0.2; p=0.06, ES: 0.5 vs −1.1 mmol/L, 95% CI −1.47 to −0.56; p>0.001, ES=0.8. However, there were no between-group differences. At 3 months, 94% and 86%, respectively, reported very good/fairly good health in the text messaging and control groups.ConclusionsNo clear effect of 3 months daily mobile phone delivered training instructions was detected on body composition, cardiovascular biochemical risk factors or self-perceived health. Further research is needed to evaluate secondary prevention efforts in larger populations after recent stroke.Trial registration numberNCT02902367.

scholarly journals Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

2021 ◽  
Author(s):  
Ümit Görkem ◽  
Özgür Kan ◽  
Mehmet Ömer Bostancı ◽  
Deniz Taşkıran ◽  
Hasan Ali İnal
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Pregnancy Outcomes ◽  
Significant Relationship ◽  
Blood Count ◽  
Complete Blood Count ◽  
First Trimester ◽  
Study Groups ◽  
Control Group ◽  
Gestational Stage

Objective: Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester. Method: In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels. Results: There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all) Conclusions: We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy

scholarly journals Hubungan Karakteristik Ibu, Asupan Zat Besi, Asam Folat Dan Vitamin C Dengan Status Anemia Ibu Hamil

2020 ◽  
Vol 4 (4) ◽  
pp. 183
Author(s):  
Rizki Nadiya Putri ◽  
Sefita Aryuti Nirmala ◽  
Irna Kurnia Aprillani ◽  
Tina Dewi Judistiani ◽  
Merry Wijaya
Keyword(s):  
Vitamin C ◽  
Blood Count ◽  
Complete Blood Count ◽  
Food Record

Latar Belakang : Anemia ibu hamil bergantung pada banyak faktor risiko, misalnya usia ibu, paritas, status sosial-ekonomi dan trimester kehamilan sebagai faktor risiko potensial anemia. Riset Kesehatan Dasar (Riskesdas) tahun 2013, prevalensi anemia pada ibu hamil adalah 37,1%. Hasil penelitian Susanti dkk tahun 2017 di Kecamatan Jatinangor, dari 105 ibu hamil dengan pemeriksaan Complete Blood Count (CBC) diperoleh 21,9% ibu mengalami anemia.Tujuan : Mengetahui gambaran status anemia, karakteristik ibu (usia, paritas, pendidikan dan status gizi), kecukupan asupan zat besi, asam folat dan vitamin C dan hubungan antara karakteristik ibu, asupan zat besi, asam folat dan vitamin C dengan status anemia ibu hamil di Kecamatan Jatinangor.Metode: Penelitian ini adalah analitik dengan pendekatan potong lintang. Populasi adalah ibu hamil di kecamatan Jatinangor yang berjumlah 210 orang. Teknik pengambilan sampel adalah accidental sampling dengan jumlah sampel yang didapatkan yaitu sebanyak 66 sampel. Pengukuran asupan zat gizi dengan metode food record dalam waktu tiga hariHasil : Terdapat 31,6,% ibu hamil mengalami anemia, tidak ada hubungan antara usia (p=0,91), paritas (p=0,42), pendidikan (p=0,96), status gizi (0,41), zat besi (0,76), asam folat (0,94) dan vitamin C (0,92) dengan status anemia.Kesimpulan : Sebanyak 31,6% ibu hamil mengalami anemia, tidak ada hubungan antara karakteristik ibu, asupan zat besi, asam folat dan vitamin C dengan status anemia ibu hamil

scholarly journals Comparison Between Celiac Patients and Healthy Control Group Regarding Vitamin-Mineral Levels and Complete Blood Count Parameters

2020 ◽  
Author(s):  
Şükrü Güngör ◽  
Can Acıpayam
Keyword(s):  
Vitamin D ◽  
Celiac Disease ◽  
Blood Count ◽  
Complete Blood Count ◽  
Healthy Control Group ◽  
Control Group ◽  
Healthy Children ◽  
Vitamin D Levels ◽  
Healthy Control ◽  
Mineral Levels

INTRODUCTION: We aimed to compare the mean platelet volume (MPV) and plateletcrit (PCT) and vitamin-mineral levels in pediatric celiac disease patients with the healthy control group and to compare the results with the literature. METHODS: In this study, clinical and laboratory data of 80 pediatric patients diagnosed with celiac disease (CD) between July 2017 and December 2018 and 42 healthy children in the same age group were retrospectively analyzed. RESULTS: There was no significant difference between the groups in terms of age and gender (p=0.383, and p=0.462, respectively). The frequency of anemia, folate, iron and vitamin D deficiencies was higher in celiac patients compared to the control group (p=0.001, p=0.027, p<0.001, and p<0.001, respectively). When the patients were evaluated according to their complete blood count and vitamin-mineral levels; hemoglobin (Hb), mean corpuscular volume (MCV), ferritin and vitamin D levels were found to be significantly lower in the CD group compared to the control group (p<0.001, p=0.026, p<0.00, and p=0.001, respectively). Platelet (PLT), PCT, MPV levels were found to be significantly higher in the CD group compared to the control group (p=0.010, p<0.001, and p<0.001, respectively). We found a weakly negative correlation between the vitamin D levels and the degree of the Marsh classification (r: -0.273, and p=0.023). DISCUSSION AND CONCLUSION: Our study have shown that MPV, PCT values are higher and Hb, folate, iron and vitamin D levels are lower in patients with CD compared to healthy controls. We recommend investigating other nutrient deficiencies besides iron deficiency, especially in treatment-resistant anemias. We think that the correlation between vitamin D levels and the degree of histological damage should be elucidated with larger-scale and more comprehensive studies.

scholarly journals RELATION BETWEEN SALIVARY AND SERUM VITAMIN C LEVELS AND DENTAL CARIES EXPERIENCE IN ADULTS - A BIOCHEMICAL STUDY

2013 ◽  
Vol 03 (04) ◽  
pp. 030-033
Author(s):  
Mithra N. Hegde ◽  
Suchetha Kumari ◽  
Nidarsh D. Hegde ◽  
Shilpa S. Shetty
Keyword(s):  
Vitamin C ◽  
Biochemical Study ◽  
Serum Vitamin ◽  
Antioxidant Property ◽  
Caries Experience ◽  
Control Group ◽  
Serum Samples ◽  
Group Iii ◽  
Group I ◽  
Dmft Index

AbstractThe aim of this study was to estimate the vitamin C levels in saliva and serum of caries free and caries active adults and to correlate the vitamin C level with DMFT index (D=decayed, m=missing, f=filled, t=teeth) index. The present study included eighty healthy adults who were divided into four groups; Control, Group- I, Group II and Group- III with a DMFT index 0, <3, <10 and > 10 respectively. Saliva and serum samples were collected from all the four groups. The vitamin C of saliva and serum was estimated by dinitro phenyl hydrazine (DNPH) method. One-way ANOVA was used to compare the vitamin C levels of saliva and serum. Only differences with 'p'value <0.05 were considered statistically significant. Saliva and serum vitamin C level decreases with increase in caries activity and is statistically significant suggesting the powerful antioxidant property of vitamin C.

scholarly journals Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces)

2018 ◽  
Vol 29 ◽  
Author(s):  
Saad Bakrim ◽  
Youssef Motiaa ◽  
Ali Ouarour ◽  
Azlarab Masrar
Keyword(s):  
Pregnant Women ◽  
Reference Values ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Healthy Population ◽  
Corpuscular Hemoglobin ◽  
Significant Difference

Introduction: numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature. Methods: blood samples were taken voluntarily from 3898 healthy pregnant women from 18 to 46 years old who presented themselves at the center of health Kalaa and at the service of gynecology obstetrics of the Provincial Hospital Center of M'diq (Morocco), for prenatal care. To establish the reference intervals of the CBC for non-pregnant women, a control group was constituted by 7035 healthy women from 18 to 50 years old selected according to the Moroccan law of blood donation. The CBC was measured on a Sysmex KX21N® analyzer. For each sample a systematic blood smear was done to determine the leukocyte differential. Results: a statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. So, the comparison of the averages established between the first, second and third trimester of pregnancy showed the existence of a significant variation with regard to all the parameters of the CBC test looked for (p < 0.001). Conclusion: the present study provides additional baseline data for basic hematological parameters in healthy pregnant Moroccan women and concluded that pregnancy in women has the tendency to alter some hematological indices. For these reasons, there is an interest to take these modifications into account for optimal maternal and fetal medical care.

Complete blood count, cholinesterase, and renal function of organophosphate sprayers in Kulonprogo

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Idha Arfianti Wiraagni
Keyword(s):  
Renal Function ◽  
Blood Count ◽  
Complete Blood Count ◽  
Exposed Group ◽  
Control Group ◽  
Case Group ◽  
Pesticide Use ◽  
Normal Limits ◽  
The Mean ◽  
And Control

Background: There are several risks to health associated with pesticide use. The use of Personal Protective Equipment (PPE) can minimize pesticide exposure to farmers. The aim of this study was to determine the basic characteristics of farmers, blood parameters (complete blood count, cholinesterase, and creatinine), patterns of pesticide use, and the use of PPE. Methods: This research was a cross-sectional study, with total sampling method. The data were taken from all farmers in Kulonprogo, Yogyakarta, Indonesia. Case group was organophosphate sprayers that have sprayed organophosphate for more than 1 year. Results: In case of group, there were 36 farmers (31 male and 5 female), while in control group, there were 11 persons (4 male and 7 female). The mean blood cholinesterase level in the exposed group was 7.8 ± 2.01Ku/L and in the control group 8.7± 1.56 Ku/L. The mean of exposed group blood urea nitrogen: 12.08±3.88 mmol/L and control Group: 11.4±3.11 mmol/L. The mean of blood creatinine was within normal limits (case group: 0.9 ± 0.17mg/dl and control group: 0.7 ± 0.19 mg/dl), but there were significant differences between them (p : 0.015). Conclusions: The results of a complete blood count, cholinesterase, and renal function in the organophosphate sprayers In Kulonprogro were within normal limits. There was an increase of creatinine levels on exposed group significantly, although still within normal limit. They have sufficient rest period for farmers (1 month) in every planting season. It is necessary to educate farmers about the importance of using PPE and management of acute pesticide poisoning.

scholarly journals The lower vitamin C plasma concentrations in elderly men compared with elderly women can partly be attributed to a volumetric dilution effect due to differences in fat-free mass

2015 ◽  
Vol 113 (5) ◽  
pp. 859-864 ◽  
Author(s):  
Alexandra Jungert ◽  
Monika Neuhäuser-Berthold
Keyword(s):  
Body Composition ◽  
Vitamin C ◽  
Multiple Regression ◽  
Plasma Concentrations ◽  
Activity Level ◽  
Fat Free Mass ◽  
Elderly Subjects ◽  
Photometric Detection ◽  
Dietary Record ◽  
Lower Vitamin

Women show higher vitamin C plasma concentrations than men, but the reasons for this observation still require elucidation. The objective of the present study was to investigate whether sex differences in vitamin C plasma concentrations are present in elderly subjects and whether these differences are due to sex-specific lifestyles, total antioxidant status (TAOS) and/or body composition. Fasting plasma concentrations of vitamin C were assessed by photometric detection in a cross-sectional study of 181 women and eighty-nine men aged 62–92 years. Body composition was determined by bioelectrical impedance analysis. Vitamin C intake was assessed with a 3 d estimated dietary record. Stepwise multiple regression analyses were performed to investigate whether sex is an independent predictor of vitamin C plasma concentrations by controlling for age, vitamin C intake, lifestyle factors, TAOS and body composition. Women showed higher vitamin C plasma concentrations than men (76 v. 62 μmol/l, P< 0·0001). In the multiple regression analysis, male sex was a negative predictor of vitamin C plasma concentrations (β = − 0·214), as long as absolute fat-free mass (FFM) was not considered as a confounder. When absolute FFM was included, sex was no longer a predictor of vitamin C plasma concentrations, whereas absolute FFM (β = − 0·216), physical activity level (β = 0·165), intake of vitamin C supplements (β = 0·164), age (β = 0·147) and smoking (β = − 0·125) affected vitamin C plasma concentrations. The results indicate that a higher absolute FFM, and thus a higher distribution volume of vitamin C, contributes to lower vitamin C plasma concentrations in men than women.

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