scholarly journals ‘Bare’, a new hairless mutant in the mouse—genetics and histology

1961 ◽  
Vol 2 (2) ◽  
pp. 283-289 ◽  
Author(s):  
Homai P. Randelia ◽  
L. D. Sanghvi
Keyword(s):  
Hair Follicles ◽  
Mouse Genetics ◽  
The Body ◽  
The Other ◽  
Hair Cycle ◽  
Hair Coat ◽  
Recessive Character ◽  
Sensory Hairs ◽  
Hereditary Defect ◽  
Air Cells

1. A new hereditary defect affecting the hair coat of Swiss albino mice is described. The defect was found to be inherited as a recessive character and is designated as bare (ba).2. The gene affected the vibrissae as well as pelage hairs. The lack of vibrissae and other sensory hairs at birth, helped to differentiate them easily from the normal animals. The first hairs on the body appeared at 13–14 days of age. The hairs were thin and tiny and remained there till about the thirtieth day. The hairs in the second hair cycle appeared at about 45 days, and again disappeared within 10 days. The animals were entirely naked when they were 6 months old.3. Gross as well as microscopic examination of hairs in the first hair cycle did not show the four different normal types of hairs. The hairs were comparatively very small, thin, and the internal structure did not show any regularity in the arrangement of the air cells.4. No difference was found in the number of hair follicles in the bare and the normal Swiss mice.5. Histology revealed the presence of keratinized globular masses instead of straight hair. This abnormality persisted in all the hair cycles.6. The bare mice were compared with the other mutants and placed in the Alopecia-Naked group where the abnormality was in the keratinization of the hair.

Histology of Hair Follicles in Different Breeds of Rabbits

2021 ◽  
Author(s):  
K.M. Lucy ◽  
N. Ashok ◽  
S. Maya ◽  
V.R. Indu ◽  
A.R. Sreeranjini ◽  
...  
Keyword(s):  
Rural Areas ◽  
Physical Environment ◽  
Skin Penetration ◽  
Hair Follicles ◽  
The Body ◽  
Leather Industry ◽  
Hair Coat ◽  
Standard Procedures ◽  
Nasal Region ◽  
Animal Skin

Background: Rabbit farming provides a valuable additional source of income in the rural areas of the county. Skin is the largest organ in the body and the hair coat forms the first line of defense against the invading pathogenic organisms as well as the physical environment. So far, no detailed comparative study has been conducted on the skin of various breeds of rabbits. Hence, the present work was undertaken to compare the structure and distribution of hair follicles in different breeds of rabbits commonly reared in Kerala.Methods: The study was conducted on the skin of six breeds of rabbits namely, Soviet Chinchilla, New Zealand White, Grey Giant, White Giant, Angora and crossbred. In total, 36 animals were used for the study. From each animal, skin samples were collected from eight representative areas of the body viz., dorsal nasal region, pinna, dorsal neck, dorsal thorax, dorsal abdomen, ventral abdomen, perineal and carpal regions. Standard procedures were adopted for histological studies.Result: All the six breeds of rabbits showed compound hair follicles with primary and secondary follicles with associated sebaceous glands. Arrangement of hair follicles showed differences among the breeds. There was no difference in the histology of hair/hair follicle among the breeds. This work will form a basis for further breed specific research in the area of fur and leather industry and skin penetration studies.

scholarly journals ISTOLOGY STRUCTURE AND HISTOMORPHOMETRY KINTAMANI DOGS SKIN OF BALI ORIGIN

2020 ◽  
Vol 21 (4) ◽  
pp. 646-653
Author(s):  
Ni Made Ayu Kurniawati ◽  
Ni Luh Eka Setiasih ◽  
Putu Suastika
Keyword(s):  
Blood Vessels ◽  
Sweat Gland ◽  
Hair Follicles ◽  
The Body ◽  
The Other ◽  
Objective Lens ◽  
Histological Structure ◽  
And Gender ◽  
Different Thickness

Kintamani dog is the only Balinese breed has been recognized by Federarion of International Cynology (Fédération Cynologique Internationale). Kintamani dogs live around Sukawana Village, Kintamani District, Bangli Regency, of Bali. The purpose of this study was to determine the hystologycal structure and histomorphometry of kintamani dog skin. The kintamani dog used in this study were 1-2 years old. Histological structure observed by carlzeiss teaching microscope with objective lens magnification 5, 10, 20, 40, and 100x. In this study, the hystologycal structure of kintamani dog consists of the epidermis, dermis, and hypodermis, except on planum nasale. Planum nasale of kintamani dogs do not have hypodermis. The other components found in the hystologycal structure is sebaseous gland, sweat gland, hair follicles and blood vessels. While the histomorphometry of kintamani dog skin have a different thickness depending on location of the body and gender. In this study, Kintamani dog skin is the thickest in female planum nasale with thickness from epidermis to dermis at 6437.040 ?m and the thinnest in male stomach at 2047.378 ?m.

Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated

Development ◽  
1995 ◽  
Vol 121 (10) ◽  
pp. 3223-3232 ◽  
Author(s):  
S.E. Millar ◽  
M.W. Miller ◽  
M.E. Stevens ◽  
G.S. Barsh
Keyword(s):  
Coat Color ◽  
Dermal Papilla ◽  
Transgenic Animals ◽  
Branchial Arch ◽  
Hair Follicles ◽  
The Body ◽  
Basal Cells ◽  
Hair Cycle ◽  
Transplantation Experiments ◽  
Agouti Gene

Expression of the agouti gene from two different promoters, one active at the midpoint of the hair cycle and the other specific for the ventrum, is responsible for generating a range of mammalian pigmentation patterns. We demonstrate that in postnatal mice transcripts from both promoters are confined to the dermal papilla of hair follicles, as predicted by classical transplantation experiments. Transcripts from the hair cycle promoter are detected in the embryonic whisker plate but not in other regions of the body before birth, whereas ventral-specific transcripts are detected in the ventral trunk of the embryo as well as ventral whisker plate. To investigate further the embryonic origins of adult pigmentation patterns, we carried out a detailed analysis of agouti expression in the embryo. The ventral-specific agouti isoform is first expressed at E10.5 in neural crest-derived ventral cells of the second branchial arch, in anterior regions of the forelimb buds and in a narrow stripe of ventral mesenchyme. By E14.5 a continuous layer of expression is observed in the upper cells of the dermis, including cells of the developing dermal papillae, and covering the entire ventral surface of the head and trunk and dorsal surfaces of the distal forelimb and hindlimb. This expression pattern reflects the domain of yellow coloration evident in adult animals and suggests that the agouti gene is regulated in part by factors responsible for establishing differences between the dorsal and ventral surfaces of the body during embryogenesis. To test the hypothesis that agouti is a paracrine signaling molecule that can influence pigment production by hair follicle melanocytes when expressed by either dermis or epidermis, as suggested by recombination and transplantation experiments, we created transgenic animals in which agouti is expressed in basal cells of the epidermis. These animals display stripes of yellow hairs corresponding to regions of epidermal agouti expression, confirming that agouti signals melanocytes to synthesize yellow pigment and providing direct evidence that it functions in a paracrine manner with a restricted radius of action.

High Heels sebagai Agensi bagi Tubuh Wanita

2020 ◽  
Vol 5 (2) ◽  
pp. 196
Author(s):  
Sunandar Macpal ◽  
Fathianabilla Azhar
Keyword(s):  
Body Image ◽  
Literature Review ◽  
The Body ◽  
The Other ◽  
Body Image Disturbance ◽  
Other Hand ◽  
High Heels ◽  
Experience Pain ◽  
Woman's Body

The aims of this paper is to explain the use of high heels as an agency for a woman's body. Agency context refers to pain in the body but pain is perceived as something positive. In this paper, the method used is a literature review by reviewing writings related to the use of high heels. The findings in this paper that women experience body image disturbance or anxiety because they feel themselves are not beautiful or not attractive. The use of high heels, makes women more attractive and more confident, on the other hand the use of high heels actually makes women feel pain and discomfort. However, for the achievement of beauty standards, women voluntarily allow their bodies to experience pain. However, the agency's willingness to beauty standards here is meaningless without filtering and directly accepted. Instead women keep negotiating with themselves so as to make a decision why use high heels.

EXPRESSION OF SOME IMMUNOLOGIC MARKERS FOR THE DIAGNOSIS OF SUSPECTED LYMPHOID LESIONS OF LYMPHOMA

2018 ◽  
Vol 8 (4) ◽  
pp. 28-33
Author(s):  
Mao Nguyen Van ◽  
Thao Le Thi Thu
Keyword(s):  
Correct Diagnosis ◽  
Tumour Cells ◽  
The Body ◽  
The Other ◽  
Cervical Region ◽  
Cross Sectional ◽  
Immunologic Markers ◽  
Microscopic Features ◽  
Poor Differentiation ◽  
Benign Tumours

Background: In practice it was difficult or impossible to have a correct diagnosis for the lymphoid proliferation lesions based on only H.E standard histopathology. In addition to histopathology, the application of immunohistochemistry was indispensable for the definitive diagnosis of the malignant or benign tumours and the origin of the tumour cells as well. Objectives: 1. To describe the gross and microscopic features of the suspected lesions of lymphoma; 2. To asses the expression of some immunologic markers for the diagnosis and classification of the suspected lesions of lymphoma. Materials and Method: Cross-sectional research on 81 patients diagnosed by histopathology as lymphomas or suspected lesions of lymphoma, following with immunohistopathology staining of 6 main markers including LCA, CD3, CD20, Bcl2, CD30 and AE1/3. Results: The most site was lymph node 58.1% which appeared at cervical region 72.3%, then the stomach 14.9% and small intestine 12.4%. The other sites in the body were met with lower frequency. Histopathologically, the most type of the lesions was atypical hyperplasia of the lymphoid tissue suspecting the lymphomas 49.4%, lymphomas 34.5%, the other diagnoses were lower including inflammation, poor differentiation carcinoam not excluding the lymphomas, lymphomas differentiating with poor differentiation carcinomas. Immunohistochemistry showed that, LCA, CD3, CD20, Bcl2, CD30 and AE1/3 were all positive depending on such type of tumours. The real lymphomas were 48/81 cases (59.3%), benign ones 35.8% and poor differentiated carcinomas 4.9%. Conclusion: Immunohistochemistry with 6 markers could help to diagnose correctly as benign or malignant lesions, classify and determine the origin of the tumour cells as lymphocytes or epithelial cells diagnosed by histopathology as lymphomas or suspected lesions of lymphomas. Key words: histopathology, immunohistochemistry, lymphomas, poor differentiated carcinomas, hyperplasia, atypicality

Basic Concepts and Definitions of Allergology

2019 ◽  
Author(s):  
Zoran Vrucinic
Keyword(s):  
Immune Reaction ◽  
The Body ◽  
The Other ◽  
Specific Response ◽  
Other Hand ◽  
Medical Vocabulary ◽  
The Future ◽  
Basic Concepts ◽  
Basic Insight ◽  
Insight Into

The future of medicine belongs to immunology and alergology. I tried to not be too wide in description, but on the other hand to mention the most important concepts of alergology to make access to these diseases more understandable, logical and more useful for our patients, that without complex pathophysiology and mechanism of immune reaction,we gain some basic insight into immunological principles. The name allergy to medicine was introduced by Pirquet in 1906, and is of Greek origin (allos-other + ergon-act; different reaction), essentially representing the reaction of an organism to a substance that has already been in contact with it, and manifested as a specific response thatmanifests as either a heightened reaction, a hypersensitivity, or as a reduced reaction immunity. Synonyms for hypersensitivity are: altered reactivity, reaction, hypersensitivity. The word sensitization comes from the Latin (sensibilitas, atis, f.), which means sensibility,sensitivity, and has retained that meaning in medical vocabulary, while in immunology and allergology this term implies the creation of hypersensitivity to an antigen. Antigen comes from the Greek words, anti-anti + genos-genus, the opposite, anti-substance substance that causes the body to produce antibodies.

Body and Soul

2017 ◽  
Author(s):  
Isabella Image
Keyword(s):  
Human Person ◽  
Fourth Century ◽  
The Body ◽  
The Other ◽  
Spiritual Nature ◽  
Body And Soul ◽  
Century Thought

This chapter discusses Hilary’s dichotomous body–soul anthropology. Although past scholars have tried to categorize Hilary as ‘Platonic’ or ‘Stoic’, these categories do not fully summarize fourth-century thought, not least because two-way as well as three-way expressions of the human person are also found in Scripture. The influence of Origen is demonstrated with particular reference to the commentary on Ps. 118.73, informed by parallels in Ambrose and the Palestinian Catena. As a result, it is possible to ascribe differences between Hilary’s commentaries to the fact that one is more reliant on Origen than the other. Nevertheless, Hilary’s position always seems to be that the body and soul should be at harmony until the body takes on the spiritual nature of the soul.

scholarly journals The Respiration of some Planktonic copepods II. The Effect Of Temperature

1953 ◽  
Vol 31 (3) ◽  
pp. 447-460 ◽  
Author(s):  
D. T. Gauld ◽  
J. E. G. Raymont
Keyword(s):  
Respiratory Rate ◽  
The Body ◽  
The Other ◽  
Effect Of Temperature ◽  
Acartia Clausi ◽  
Temora Longicornis ◽  
Different Temperatures ◽  
Planktonic Copepods ◽  
The Difference ◽  
The Relationship

The respiratory rates of three species of planktonic copepods, Acartia clausi, Centropages hamatus and Temora longicornis, were measured at four different temperatures.The relationship between respiratory rate and temperature was found to be similar to that previously found for Calanus, although the slope of the curves differed in the different species.The observations on Centropages at 13 and 170 C. can be divided into two groups and it is suggested that the differences are due to the use of copepods from two different generations.The relationship between the respiratory rates and lengths of Acartia and Centropages agreed very well with that previously found for other species. That for Temora was rather different: the difference is probably due to the distinct difference in the shape of the body of Temora from those of the other species.The application of these measurements to estimates of the food requirements of the copepods is discussed.

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