Soil and plant factors limiting the availability of copper to a beef suckler herd

1983 ◽  
Vol 101 (1) ◽  
pp. 39-46 ◽  
Author(s):  
S. C. Jarvis ◽  
A. R. Austin
Keyword(s):  
Serum Concentration ◽  
Severe Anaemia ◽  
High Concentration ◽  
Grazing Season ◽  
Cu Content ◽  
Cu Deficiency ◽  
Per Se ◽  
Beef Suckler

SUMMARYHypocuprosis has been diagnosed for 4 years in calves of a beef suckler herd at Warren Farm, Berkshire. The copper (Cu) contents and distribution in the soil at that site, as well as changes in herbage Cu throughout the 1979 grazing season, were examined. The herbage Cu concentration was always less than 7·5 μg/g and decreased markedly to 3·0 μg/g during July. Serum Cu contents of both untreated cows and untreated calves also decreased markedly, but at a much earlier stage than the decrease in herbage concentration. One untreated calf developed severe anaemia, but recovered when treated with Cu Ca EDTA. Although changes in the coefficient of absorption of dietary Cu were caused by changes in S and Mo contents, the calculated availability of Cu was dominated by the Cu content per se. Thus the calculated availability remained relatively high during the period when serum concentration decreased.The decrease in serum Cu may have occurred as the result of a differing availability of Cu in ensiled and grazed herbages. However, coincident with the decrease in serum Cu was a high concentration of Fe in the grazed herbage which was largely associated with the surfaces of the leaves. It is therefore possible that the development of Cu deficiency immediately after the animals started to graze was precipitated either through an interaction between Cu and Fe in the animal, or because of a reduced availability of Cu through an interaction with ingested soil.

scholarly journals 289 Effects of supranutritional levels of dietary zinc oxide on zinc, copper, and iron metabolism in post-weaned pigs

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 106-107
Author(s):  
Danyel Bueno Dalto ◽  
Frédéric Guay ◽  
Yan Martel-Kennes ◽  
Guylaine Talbot ◽  
Martin Lessard ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Serum Concentration ◽  
Treatment Effects ◽  
Experimental Period ◽  
Dietary Zinc ◽  
Weaned Pigs ◽  
Cu Content ◽  
Cu Deficiency ◽  
Fe Homeostasis ◽  
The Impact

Abstract This study evaluated the impact of supranutritional levels of dietary zinc oxide (ZnO) on zinc (Zn), copper (Cu), and iron (Fe) homeostasis in post-weaned pigs. One hundred twenty piglets were selected at d14 of age (5.65 ± 0.68 kg). At weaning (d21), they were fed a basal post-weaning diet (without antibiotics) supplemented (n = 40/treatment) with 100 mg/kg (low; LZn), 1000 mg/kg (medium; MZn) or 3000 mg/kg (high; HZn) of ZnO until d42. Dietary levels of Cu (130 mg/kg) and Fe (260 mg/kg) remained constant throughout the experimental period. Piglets were sacrificed at d21, d23, d35, and d42 of age (n = 10/treatment/d) for samples collection. Serum concentrations and total liver content of Zn and Cu were not different among treatments on d21 and d23 (P ≥ 0.10). For Zn, treatment effects were detected at d35 and d42 (P < 0.01) on both serum concentration and total Zn content in liver. For both parameters, values were greatest for HZn, intermediary for MZn, and lowest for LZn irrespective of ages in the two periods. For Cu, treatment effects were detected at d35 and d42 (P < 0.01) on both serum concentration and total Cu content in liver. For both parameters, values were greatest for LZn and MZn and lowest for HZn irrespective of ages. For Fe, no treatment effect was detected either on whole blood Fe concentrations (P = 0.81) or hemoglobin levels (P = 0.76). However, for total Fe content in liver, treatment effects were detected (P < 0.01). Values were greatest for LZn and lowest for HZn at d35 and d42 whereas for MZn they were intermediary at d35 and similar to LZn at d42 (P ≤ 0.01). In conclusion, supranutritional levels of dietary ZnO fed to piglets during 3 weeks post-weaning significantly impacted Zn, Cu, and Fe homeostasis. These results emphasise the potential risk of Cu deficiency as well as impairment in building body Fe reserves under long-term supranutritional supplementation of ZnO.

scholarly journals Role of acute phase proteins in diagnosis of uremic pancreatitis and destructive pancreatitis in patients receiving renal replacement therapy (programmed hemodialysis)

2021 ◽  
Vol 38 (5) ◽  
pp. 115-122
Author(s):  
Kazim G. Gasanov ◽  
Viktor A. Zurnadzhyants ◽  
Eldar A. Kchibekov ◽  
M. I. Shikhragimov
Keyword(s):  
Renal Replacement Therapy ◽  
Serum Concentration ◽  
Blood Serum ◽  
Replacement Therapy ◽  
Acute Phase Proteins ◽  
Control Group ◽  
Serum Concentrations ◽  
High Concentration ◽  
Surgical Unit

Objective. To determine the blood serum 2-microglobulin and 2-macroglobulin concentration in patients undergoing renal replacement therapy (programmed hemodialysis) for the diagnosis of uremic pancreatitis and / or destructive pancreatitis. Materials and methods. The study involved 52 patients admitted to the Surgical Unit of Astrakhan "RZhD-Medicine" Hospital and City Clinical Hospital № 3. The blood serum 2-microglobulin and 2-macroglobulin concentration was analyzed in patients admitted on an emergency basis with suspicion of uremic pancreatitis and destructive pancreatitis, who receive renal replacement therapy (programmed hemodialysis). The control group included 50 outpatients undergoing renal replacement therapy (programmed hemodialysis). The study did not include patients with suspected pancreatitis who were not receiving renal replacement therapy. The period of the study is 20192021. Results. The concentration of blood serum 2-microglobulin is statistically higher than normal in all patients, who had received renal replacement therapy (programmed hemodialysis) in anamnesis. The most statistically high concentration of 2-microglobulin was revealed while studying patients with uremic pancreatitis (n = 34), and was (30.0 2.75 mg/l) compared with the blood serum concentration in patients with destructive pancreatitis (8 0.51 mg / l). The concentration of 2-macroglobulin was statistically lower in destructive pancreatitis (n = 18) and was 615 161 mg/l compared with uremic pancreatitis (980 216 mg/l). In the control group of outpatients (n = 50) receiving renal replacement therapy (programmed hemodialysis), no statistically significant blood serum concentrations of 2-microglobulin and 2-macroglobulin were found. Conclusions. A clear dependence of the concentration of 2-microglobulin and 2-macroglobulin on the severity of uremic pancreatitis and destructive pancreatitis was established. Statistically high values of 2-microglobulin concentrations were obtained in patients with uremic pancreatitis, and the 2-macroglobulin level was statistically low in destructive pancreatitis.

Geographic determinants of copper and molybdenum concentrations in serum at the end of the grazing season and associations with reproductive performance in beef cows from western Canada

2011 ◽  
Vol 91 (3) ◽  
pp. 423-431 ◽  
Author(s):  
Leanne Van De Weyer ◽  
Cheryl Waldner
Keyword(s):  
Reproductive Performance ◽  
Important Determinant ◽  
Beef Cows ◽  
Western Canada ◽  
Serum Concentrations ◽  
Soil Color ◽  
Grazing Season ◽  
Cu Deficiency ◽  
The Mean ◽  
Feed Samples

Van De Weyer, L. M. and Waldner, C. L. 2011. Geographic determinants of copper and molybdenum concentrations in serum at the end of the grazing season and associations with reproductive performance in beef cows from western Canada. Can. J. Anim. Sci. 91: 423–431. Serum concentrations of Cu and Mo were measured at the end of the summer grazing season in an observational field study of 783 breeding females from 66 cow-calf herds located in western Canada. The mean Cu concentration was 0.82 ppm (S, 0.30 ppm) and the mean Mo concentration was 0.056 ppm (S, 0.055 ppm). Serum Cu concentration differed across ecoregions (P=0.013). Serum Mo concentrations varied by ecoregion (P =0.002), soil type (P =0.011), soil color (P=0.018), and total precipitation during the growing season (P =0.004). Copper and Mo serum concentrations at the end of the grazing season were not associated with reproductive outcomes. Herd location is an important determinant of the risk of primary and secondary Cu deficiency and can inform the need for trace mineral testing of feed samples as well as supplementation.

Influence of Soil-applied Micronutrients on Cassava (Manihot esculenta) in Malaysian Tropical Oligotrophic Peat

1978 ◽  
Vol 14 (2) ◽  
pp. 105-112 ◽  
Author(s):  
W. Y. Chew ◽  
K. T. Joseph ◽  
K. Ramli
Keyword(s):  
Copper Sulphate ◽  
Manihot Esculenta ◽  
Dry Matter ◽  
Peat Soil ◽  
Cu Content ◽  
Deficiency Symptoms ◽  
Cu Deficiency ◽  
Tuber Dry Matter ◽  
Cu Uptake

SUMMARYTwo experiments to investigate the micronutrient requirements of cassava (cv Black Twig) on Malaysian peat soil are described. Cu was found to be the only essential micronutrient and Mn, Zn, Fe, Mo and B were not needed. Fertilizing with 20 kg/ha of copper sulphate approximately tripled tuber dry matter, and starch and Cu uptake, but applying 10 kg/ha of copper sulphate gave the same results. Each crop of cassava absorbed only about 2% of the applied Cu, giving a leaf Cu content of about 14 ppm compared with about 7 ppm in Cu-deficient plants. Cu deficiency symptoms were invariably observed in Cu-deficient plots and these are also described.

Influence of plasma urea nitrogen on superovulatory response and embryo recovery in Merino ewes

2002 ◽  
Vol 2002 ◽  
pp. 129-129
Author(s):  
M. Omidi
Keyword(s):  
Serum Concentration ◽  
Crude Protein ◽  
Ovarian Response ◽  
High Serum ◽  
High Concentration ◽  
Urea Nitrogen ◽  
Plasma Urea ◽  
Embryo Recovery ◽  
High Serum Concentration ◽  
Fertilisation Rate

The plasma urea nitrogen (PUN) can be an indication of the quantity and degradability of the protein consumed. The high serum concentration of PUN may reduce fertility by local toxic effect on either the sperm, the ovum or the developing embryo (Jordan and Swanson, 1979). The objective of this study was to investigate the effect of high concentration of PUN following the increase of crude protein (CP) intake on ovarian response and fertilisation rate of superovulated ewes.

scholarly journals Role of Serum Fibrinogen Levels in Patients with Rotator Cuff Tears

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Umile Giuseppe Longo ◽  
Stefano Petrillo ◽  
Alessandra Berton ◽  
Filippo Spiezia ◽  
Mattia Loppini ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Serum Concentration ◽  
Vascular Supply ◽  
Rotator Cuff Tears ◽  
Control Group ◽  
High Concentration ◽  
Microvascular Damage ◽  
Cross Sectional ◽  
Arthroscopic Meniscectomy

Although rotator cuff (RC) tendinopathy is a frequent pathology of the shoulder, the real understanding of its aetiopathogenesis is still unclear. Several studies showed that RC tendinopathy is more frequent in patients with hyperglycemia, diabetes, obesity, or metabolic syndrome. This paper aims to evaluate the serum concentration of fibrinogen in patients with RC tears. Metabolic disorders have been related to high concentration of serum fibrinogen and the activity of fibrinogen has been proven to be crucial in the development of microvascular damage. Thus, it may produce progression of RC degeneration by reducing the vascular supply of tendons. We report the results of a cross-sectional frequency-matched case-control study comparing the serum concentration of fibrinogen of patients with RC tears with that of a control group of patients without history of RC tears who underwent arthroscopic meniscectomy. We choose to enrol in the control group patients with pathology of the lower limb with a likely mechanic, not metabolic, cause, different from tendon pathology. We found no statistically significant differences in serum concentration of fibrinogen when comparing patients with RC tears and patients who underwent arthroscopic meniscectomy (P= 0.5). Further studies are necessary to clarify the role of fibrinogen in RC disease.

Beneficial effect of medium with high concentration serum for direct sperm injection into mouse oocytes using a conventional pipette

Zygote ◽  
1997 ◽  
Vol 5 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Kazuo Suzuki ◽  
R. Yanagimachi
Keyword(s):  
Serum Concentration ◽  
Beneficial Effect ◽  
High Serum ◽  
High Concentration ◽  
Mouse Oocytes ◽  
High Serum Concentration

SummaryAlthough the piezo-electrically driven pipette is much more effective than a conventional pipette for direct sperm injection into mouse oocytes, the piezo-pipette driving unit is expensive and may not be readily accessible to most basic laboratories. We reprot here that the inefficiency of the conventional pipette can be improved by performing the operation in a medium with high serum concentration.

Investigation of the effect of copper status and therapy on fertility in beef suckler herds

1982 ◽  
Vol 99 (2) ◽  
pp. 359-364 ◽  
Author(s):  
M. Phillippo ◽  
W. R. Humphries ◽  
C. B. Lawrence ◽  
J. Price
Keyword(s):  
Copper Concentration ◽  
Serum Copper ◽  
Conception Rate ◽  
North East ◽  
The North ◽  
Copper Status ◽  
Per Se ◽  
Effect Of Copper ◽  
Beef Suckler

SUMMARYA survey on 17 beef suckler herds in the north-east of Scotland showed that there was no relationship between herd serum copper concentration (range 0·16–0·92 μg/ml) measured within 1 month of mating and the conception rate of the herd calculated from the pattern of calving to that mating. Cows treated with 100 mg copper before mating, in trials on four farms with low copper status and involving 221 animals, did not have an improved conception rate compared with control animals on the same farm. Copper per sewould therefore not appear to be a major factor in determining the fertility of beef suckler herds.

Vitamin D Metabolism in Patients Intoxicated with Ergocalciferol

1985 ◽  
Vol 68 (2) ◽  
pp. 135-141 ◽  
Author(s):  
E. Barbara Mawer ◽  
J. T. Hann ◽  
Jacqueline L. Berry ◽  
M. Davies
Keyword(s):  
Vitamin D ◽  
Serum Calcium ◽  
Calcium Concentration ◽  
Mass Action ◽  
Vitamin D Metabolites ◽  
Serum Concentrations ◽  
High Concentration ◽  
Vitamin D Metabolism ◽  
Serum Calcium Concentration ◽  
Per Se

1. Vitamin D metabolites were measured on admission in eight patients intoxicated with ergocalciferol (serum calcium 3.01-4.05 mmol/l) and also during the subsequent 2 months in six of the eight. 2. Serum concentrations of 25-hydroxyergocalciferol, on admission, were grossly elevated in all patients (range 583-1843 nmol/l). 3. Serum calcium concentration was related significantly only to the concentration of 25-hydroxyergocalciferol (P = 0.003). 4. Concentrations of 25-hydroxyergocalciferol in serum were significantly related to those of calciferol (P = 0.004). 5. Elevated initial concentrations of 1,25-dihydroxycalciferol, mainly as 1,25-dihydroxyergocalciferol, were found in seven of the eight patients (range 179-313 pmol/l). 6. It is suggested that the hypercalcaemia in these patients may be explained by the action of 25-hydroxyergocalciferol at high concentration in competing for 1,25-dihydroxycalciferol receptors, thus exerting a biological effect per se, and also by increasing the synthesis of 1,25-dihydroxycalciferol through a mass-action effect on the renal 1α-hydroxylase.

scholarly journals Biochemical and pathological changes in tissues of Friesian cattle during the experimental induction of copper deficiency

1976 ◽  
Vol 35 (3) ◽  
pp. 309-331 ◽  
Author(s):  
C. F. Mills ◽  
A. C. Dalgarno ◽  
G. Wenham
Keyword(s):  
Monoamine Oxidase ◽  
Cytochrome Oxidase ◽  
Copper Deficiency ◽  
Early Recognition ◽  
Clinical Signs ◽  
Clinical Appearance ◽  
Cu Content ◽  
Metabolic Defects ◽  
Cu Deficiency ◽  
Friesian Cattle

1. Copper deficiency was induced in five Friesian cattle offered a semi-synthetic diet containing < 1 mg Cu/kg. Changes in blood and liver Cu contents and in the Cu-containing enzymes, ferroxidase I (caeruloplasmin;EC1.16.3.1) and monoamine oxidase (EC1.4.3.4) of plasma and cytochrome oxidase (EC1.9.3.1) of liver and skeletal muscle were monitored during Cu depletion.2. Rapid decreases in blood and liver Cu and plasma ferroxidase I activity were found at least 80 d before the first appearance of overt clinical signs of deficiency. Plasma monoamine oxidase and liver cytochrome oxidase activities decreased less rapidly and thus may provide useful indices of chronic Cu depletion.3. Although results of these assays indicated that Cu depletion was occurring and metabolic defects supervening, none facilitated the early recognition of individuals that subsequently showed marked overt clinical signs of Cu deficiency compared with those less severely affected.4. Irrespective of their clinical appearance at slaughter, Cu-depleted cattle showed gross or microscopic lesions of the skeleton and cardiovascular system and, in some instances, lesions of the ligamentum nuchae and small intestine. The aetiology of these lesions is considered with particular respect to changes in the activities of the Cu-dependent enzymes studied and to the interpretation of field surveys based solely upon determination of blood or liver Cu content.5. A second group of five cattle was offered the same diet supplemented with Cu to provide 8 mg Cu/kg and, later, 15 mg Cu/kg. Although no pathological lesions attributable to Cu deficiency were detected at slaughter a marked reduction in liver Cu content, a decrease in plasma ferroxidase I activity and, in four animals, the development of a diarrhoea controlled by oral administration of Cu, suggested that 8 mg Cu/kg diet did not meet their requirement for Cu.

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