scholarly journals The stability of short-term measures of energy regulation: associations with childhood adiposity

2008 ◽  
Vol 67 (OCE6) ◽  
Author(s):  
V. Mitchell ◽  
M. Hetherington
Keyword(s):  
Energy Regulation ◽  
Short Term ◽  
Childhood Adiposity ◽  
The Stability

Aggregation prone regions in antibody sequences raised against Vibrio cholerae: A bioinformatic approach

2020 ◽  
Vol 15 ◽  
Author(s):  
Zakia Akter ◽  
Anamul Haque ◽  
Md. Sabir Hossain ◽  
Firoz Ahmed ◽  
Md Asiful Islam
Keyword(s):  
Vibrio Cholerae ◽  
Binding Sites ◽  
Bioinformatic Analysis ◽  
Antigen Binding ◽  
Short Term ◽  
Protein Database ◽  
The Stability ◽  
Bioinformatic Approach ◽  
Self Aggregation ◽  
Complementarity Determining Region

Background: Cholera, a diarrheal illness causes millions of deaths worldwide due to large outbreaks. Monoclonal antibody used as therapeutic purposes of cholera are prone to be unstable due to various factors including self-aggregation. Objectives: In this bioinformatic analysis, we identified the aggregation prone regions (APRs) of different immunogens of antibody sequences (i.e., CTB, ZnM-CTB, ZnP-CTB, TcpA-CT-CTB, ZnM-TcpA-CT-CTB, ZnP-TcpA-CT-CTB, ZnM-TcpA, ZnP-TcpA, TcpA-CT-TcpA, ZnM-TcpA-CT-TcpA, ZnP-TcpA-CT-TcpA, Ogawa, Inaba and ZnM-Inaba) raised against Vibrio cholerae. Methods: To determine APRs in antibody sequences that were generated after immunizing Vibrio cholerae immunogens on Mus musculus, a total of 94 sequences were downloaded as FASTA format from a protein database and the algorithms such as Tango, Waltz, PASTA 2.0, and AGGRESCAN were followed to analyze probable APRs in all of the sequences. Results: A remarkably high number of regions in the monoclonal antibodies were identified to be APRs which could explain a cause of instability/short term protection of anticholera vaccine. Conclusion: To increase the stability, it would be interesting to eliminate the APR residues from the therapeutic antibodies in a such way that the antigen binding sites or the complementarity determining region loops involved in antigen recognition are not disrupted.

The stability and short-term fluctuation in serum oxytocinase activity in pregnancy

1989 ◽  
Vol 28 (4) ◽  
pp. 331-335
Author(s):  
A.A. Edebiri ◽  
D.S. Mack ◽  
D.J. McDonald ◽  
J. Philips
Keyword(s):  
Short Term ◽  
The Stability ◽  
Term Fluctuation ◽  
In Pregnancy

scholarly journals Review of Trimester-Specific Gestational Weight Gain and Childhood Adiposity

2014 ◽  
Vol 34 (1) ◽  
pp. 48-53
Author(s):  
K Thapa
Keyword(s):  
Weight Gain ◽  
Childhood Obesity ◽  
Gestational Weight Gain ◽  
Future Research ◽  
Institute Of Medicine ◽  
Short Term ◽  
Global Epidemic ◽  
Targeted Interventions ◽  
Gestational Weight ◽  
Childhood Adiposity

Childhood obesity is a global epidemic and a major public health challenge. There has been increasing evidence that intrauterine exposures, such as alcohol, smoking, and maternal nutritional status, may affect both the long and short term health consequences of the mother and offspring. Childhood adiposity may be affected by the mother’s pre-pregnancy weight and her weight gain during pregnancy. Consequently, interventions may need to start before conception of the child to prevent childhood obesity. In 2009, the Institute of Medicine updated its gestational weight gain recommendations by incorporating rates of gestational weight gain in the second and third trimesters based on the mother’s pre-pregnancy Body Mass Index. There is extensive research on the association between total gestational weight gain and short-term offspring adiposity. However, this review focuses on the association between trimester-specific gestational weight gain and childhood adiposity for singleton pregnancies with respect to the Institute of Medicine’s newly defined weight gain recommendations as very few studies have examined the association between the gestational weight gain during each trimester and childhood adiposity. Identifying the trimester that is most associated with childhood adiposity may help in the development of targeted interventions, guide physician’s nutritional and weight-gain recommendations for child-bearing mothers, and direct future research. DOI: http://dx.doi.org/10.3126/jnps.v34i1.8429   J Nepal Paediatr Soc 2014;34(1):48-53

Remaking Medicare: The Voucher Myth

1998 ◽  
Vol 28 (1) ◽  
pp. 29-46
Author(s):  
Jonathan Oberlander
Keyword(s):  
Consumer Choice ◽  
Baby Boom ◽  
Market Competition ◽  
The Elderly ◽  
Medicare Beneficiaries ◽  
Short Term ◽  
Medicare Program ◽  
The Stability ◽  
Voucher System

There is growing enthusiasm for transforming Medicare into a voucher system. Advocates claim vouchers would increase the health care choices available to Medicare beneficiaries, reduce the regulatory burden on the federal government, and promote the benefits of fair market competition. In addition, some analysts contend vouchers are the only feasible solution to Medicare's short-term financing problems and the long-term “crisis” of the retirement of the baby-boom generation. The author argues against these claims. Vouchers would not work as advertised by proponents because of the limitations of risk-adjustment methods and unrealistic assumptions about consumer choice. Moreover, the elderly and disabled Medicare population is ill-suited to cope in a competitive insurance system. Implementation of vouchers would therefore pose a threat to both the health of beneficiaries and the stability of the Medicare program. The implications of this analysis for Medicare reform are discussed.

scholarly journals A SLR Pre-Processing Algorithm Based on Satellite Signature Effect

2021 ◽  
Vol 11 (19) ◽  
pp. 8880
Author(s):  
Bowen Guan ◽  
Cunbo Fan ◽  
Ning An ◽  
Ricardo Cesar Podesta ◽  
Dra Ana Pacheco ◽  
...  
Keyword(s):  
Mean Value ◽  
Observation Data ◽  
Short Term ◽  
Error Sources ◽  
Effect Model ◽  
The Mean ◽  
The Stability ◽  
First Time ◽  
Satellite Signature Effect

As one of the major error sources, satellite signature effect should be reduced or even erased from the distribution of the post-fit residuals to improve the ranging precision. A simulation of satellite signature effect removal process for normal point algorithm is conducted based on a revised model of satellite response, which fully considers the structural and distribution characteristics of retroreflectors. In order to eliminate both long-term and short-term satellite signature effect, a clipping method for SLR data processing is proposed by defining the clipping location as 5.6 mm away from the mean value of the long-term fit residuals to select effective returns for normal points. The results indicate that, compared to normal points algorithm, the RMS per NP of LAGEOS-1 observation data processed by the clipping method is reduced from 62.90 ± 9.9 mm to 56.07 ± 4.69 mm, and the stability of RMS is improved 53%. This study improves the satellite signature effect model and simulates the fluctuation of normal points caused by satellite signature effect for the first time. The new method based on the simulation of satellite signature effect has stronger robustness and applicability, which can further minimize the influence of satellite signature effect on the SLR production and significantly improve the data property.

scholarly journals Analisa Rasio Keuangan Likuiditas, Profitabilitas dan Solvabilitas Terhadap Kebijakan Pembayaran Dividen Penyertaan

2013 ◽  
Vol 1 (2) ◽  
pp. 125-136
Author(s):  
Anna Setiana ◽  
Indah Melania
Keyword(s):  
Cost Efficiency ◽  
Selling Price ◽  
Operational Cost ◽  
Short Term ◽  
Current Ratio ◽  
Financial Ratio ◽  
Net Profit ◽  
The Stability ◽  
Solvency Ratio ◽  
Improve Cost

The purpose of this study is to find out the effect of the company’s performance to the welfare of shareholders by way of measuring the level of the company’s financial ratio expected having influence toward  the dividend level yielded. Based on the result of the study, the liquidity of PT Estika Yasakelola can be said has not satisfied yet because, observed from current ratio and quick ratio, PT Estika Yasakelola has found it difficult to pay short term debt that has been due date. Viewed in general, the profitability percentage has not been  satisfactory as well. It’s due to  the percentage of net profit margin  is too low, with the result that income left to cover the operational cost is too small. To improve the performance of of the company, PT Estika Yasakelola has to work more efficiently. The company must seek to improve cost efficiency by lowering cost items or increasing product selling price without reducing the competitiveness of the company. The description of solvency ratio fluctuation above reflects that the stability increase of the company in managing its dect is due to outstanding credit decrease caused by on time credit payment and because of the company keep continue to expand with its own fund. The result of this research shows that the company should improve its performance more,  work more efficiently, reduce cost items or increase product selling price so that the company will be able to reduce operational costs. PT Estika yasakelola must be able to manage the fund, so that the company’s profit increases more and more and the company will be able to survive unwaveringly. The management must be able to maintain the sharekolders’ trust. Therefore, the  level of shareholders’ welfare can be guaranteed.   Keywords: analysis of financial liquidity ratio; profitability, and solvency

Periodic breathing in the mouse

2002 ◽  
Vol 92 (3) ◽  
pp. 1133-1140 ◽  
Author(s):  
Fang Han ◽  
Shyam Subramanian ◽  
Edwin R. Price ◽  
Joseph Nadeau ◽  
Kingman P. Strohl
Keyword(s):  
Recombinant Inbred ◽  
Periodic Breathing ◽  
Inbred Strains ◽  
Genetic Influences ◽  
Short Term ◽  
Cycle Number ◽  
Term Potentiation ◽  
Genetic Mechanisms ◽  
The Stability ◽  
Recombinant Mice

The hypothesis was that unstable breathing might be triggered by a brief hypoxia challenge in C57BL/6J (B6) mice, which in contrast to A/J mice are known not to exhibit short-term potentiation; as a consequence, instability of ventilatory behavior could be inherited through genetic mechanisms. Recordings of ventilatory behavior by the plethsmography method were made when unanesthetized B6 or A/J animals were reoxygenated with 100% O2 or air after exposure to 8% O2 or 3% CO2-10% O2 gas mixtures. Second, we examined the ventilatory behavior after termination of poikilocapnic hypoxia stimuli in recombinant inbred strains derived from B6 and A/J animals. Periodic breathing (PB) was defined as clustered breathing with either waxing and waning of ventilation or recurrent end-expiratory pauses (apnea) of ≥2 average breath durations, each pattern being repeated with a cycle number ≥3. With the abrupt return to room air from 8% O2, 100% of the 10 B6 mice exhibited PB. Among them, five showed breathing oscillations with apnea, but none of the 10 A/J mice exhibited cyclic oscillations of breathing. When the animals were reoxygenated after 3% CO2-10% O2 challenge, no PB was observed in A/J mice, whereas conditions still induced PB in B6 mice. (During 100% O2 reoxygenation, all 10 B6 mice had PB with apnea.) Expression of PB occurred in some but not all recombinant mice and was not associated with the pattern of breathing at rest. We conclude that differences in expression of PB between these strains indicate that genetic influences strongly affect the stability of ventilation in the mouse.

Evolutionary Stable Strategies for Supply Chains: Selfishness, Fairness, and Altruism

2018 ◽  
Vol 6 (6) ◽  
pp. 532-551 ◽  
Author(s):  
Caichun Chai ◽  
Hailong Zhu ◽  
Zhangwei Feng
Keyword(s):  
Supply Chains ◽  
Evolutionary Dynamics ◽  
Replicator Dynamics ◽  
Management Strategies ◽  
Individual Preference ◽  
Short Term ◽  
Evolutionary Stable Strategies ◽  
Pure Strategies ◽  
The Stability

Abstract The management strategies of a firm are inevitable affected by individual behavior preferences. The effect of individual preference on the evolutionary dynamics for supply chains is studied by employing replicator dynamics. Each firm has three behavior preferences: selfishness, fairness, and altruism. Firstly, the case that the strategy set of manufacturers and retailers including two pure strategies is considered and the effect of preference parameter on the equilibrium outcome in the short-term interaction is discussed. Secondly, the equilibrium state in the short-term is always disturbed because the change of the environment, firm’s structure, and so forth. Using the replicator dynamics, the evolutionary stable strategies of manufacturers and retailers in the long-term interaction are analyzed. Finally, the extend case that the strategy set of manufacturers and retailers include three pure strategies is investigated. These results are found that the strategy profile in which both manufacturer and retailer choose fairness or altruism, or one player chooses fair or altruistic strategy and the other player chooses selfish strategy may be evolutionary stable, the stability of these equilibria depends on the the preference parameters.

Fabrication of Boron Compensated Hydrogenated Amorphous Silicon Films with Significantly Improved Stability Using Plasma Enhanced Chemical Vapor Deposition Technique

1995 ◽  
Vol 377 ◽  
Author(s):  
Mohan K. Bhan
Keyword(s):  
Chemical Vapor ◽  
Short Term ◽  
Term Stability ◽  
Long Term Stability ◽  
Vapor Deposition Technique ◽  
Improved Stability ◽  
Donor Acceptor ◽  
B Doping ◽  
The Stability

ABSTRACTWe have systematically investigated the effects of addition of sub-ppm levels of boron on the stability of a-Si:H films and p-i-n devices, deposited by PE-CVD technique. The films thus produced with appropriate amounts of boron, show a significant improvement in stability, when soaked under both AM 1.5 (short-term) as well as 10×sun (long-term) illumination conditions. The opto-electronic properties of the films are quite respectable It is concluded that boron compensates the native impurities by forming donor-acceptor pairs, which reduces the “fast” defects and hence the initial degradation of the films. It is also speculated that boron may also be improving the short-term stability, by reducing the recombination of light generated electrons and holes, by converting D° into D+ states. The long-term stability appears to get affected by hydrogen dilution which seems to reduce the amount of “slow” defects. As a result of B doping of i-layer, the initial conversion efficiency of the devices decreases. It is presumed that our devices may contain an enhanced level of boron impurity, than expected, making them as worse material and to degrade less.

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