Inhomogeneities in Globular Clusters

1991 ◽  
Vol 9 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Mun-Suk Chun
Keyword(s):  
Globular Clusters ◽  
Large Scale ◽  
Structural Variation ◽  
Main Sequence ◽  
Early Stage ◽  
Observational Evidence ◽  
Chemical Abundance ◽  
Colour Variation ◽  
Evolved Stars ◽  
Colour Gradient

AbstractInhomogeneities in globular clusters are reviewed with the observational evidence for chemical abundance variations from star to star in individual clusters and the large-scale structural variation of clusters. The reality of the radial colour gradient is tested in 47 Tuc (NGC 104). The result shows that the observed radial colour gradient comes from the integration of the calculated colours of individual stars. The cause of this radial colour variation is the result of the concentration of evolved stars and the reddening of the main sequence in the central region. We propose that the CNO abundance gradient in the early stage of a cluster’s formation is the interpretation of the observed radial colour gradient.

scholarly journals A Search for Main-Sequence Binaries in Globular Clusters

1980 ◽  
Vol 85 ◽  
pp. 357-359 ◽  
Author(s):  
Martha H. Liller
Keyword(s):  
Globular Clusters ◽  
Main Sequence ◽  
Eclipsing Binaries ◽  
Cluster Center ◽  
Distance Modulus ◽  
List Type ◽  
Galactic Latitude ◽  
Plate Material ◽  
Evolved Stars ◽  
Visual Distance

It is becoming increasingly clear that no (or only one or two) binaries occur among the evolved stars in globular clusters. Therefore, if binaries exist at all in these systems, they must be found on or near the main sequence. I have chosen 6 clusters to search for faint eclipsing binaries by the following criteria: (1)the apparent visual distance modulus (Harris 1976) (m-M)V ≤ 14.5 mag;(2)the Peterson and King (1975) concentration class c ≤ 1.5, so that the search can be conducted near or at the cluster center where binaries would most likely be found; and(3)the galactic latitude is sufficiently large to avoid problems of extreme contamination by field stars. The clusters thus chosen are NGC3201, 5139 (Omega Cen), 6121 (M4), 6218 (M12), 6254 (M10), and 6809 (M55). The plate material obtained on three nights with the 4-m telescope at CTIO in 1979, consists of seven to nine plates of each cluster on IIIa-F emulsion with an RG610 filter; the search is being conducted with a blink microscope.

scholarly journals Magnetic fields in Planetary Nebulae: paradigms and related MHD frontiers

2008 ◽  
Vol 4 (S259) ◽  
pp. 35-46 ◽  
Author(s):  
Eric G. Blackman
Keyword(s):  
Magnetic Fields ◽  
Planetary Nebula ◽  
Large Scale ◽  
Rotational Energy ◽  
Observational Evidence ◽  
Supply Rate ◽  
Evolved Stars ◽  
Research Opportunity ◽  
Low Mass ◽  
Lower Luminosity

AbstractMany, if not all, post AGB stellar systems swiftly transition from a spherical to a powerful aspherical pre-planetary nebula (pPNE) outflow phase before waning into a PNe. The pPNe outflows require engine rotational energy and a mechanism to extract this energy into collimated outflows. Just radiation and rotation are insufficient but a symbiosis between rotation, differential rotation and large scale magnetic fields remains promising. Present observational evidence for magnetic fields in evolved stars is suggestive of dynamically important magnetic fields, but both theory and observation are rife with research opportunity. I discuss how magnetohydrodynamic outflows might arise in pPNe and PNe and distinguish different between approaches that address shaping vs. those that address both launch and shaping. Scenarios involving dynamos in single stars, binary driven dynamos, or accretion engines cannot be ruled out. One appealing paradigm involves accretion onto the primary post-AGB white dwarf core from a low mass companion whose decaying accretion supply rate owers first the pPNe and then the lower luminosity PNe. Determining observational signatures of different MHD engines is a work in progress. Accretion disk theory and large scale dynamos pose many of their own fundamental challenges, some of which I discuss in a broader context.

scholarly journals The quite complex “Simple Stellar Populations” of globular clusters

2009 ◽  
Vol 5 (S268) ◽  
pp. 119-128
Author(s):  
Angela Bragaglia
Keyword(s):  
Globular Clusters ◽  
Main Sequence ◽  
Stellar Populations ◽  
Observational Evidence ◽  
Formation Mechanisms ◽  
Light Elements ◽  
Complex Objects ◽  
Growing Body ◽  
Iron Abundance ◽  
The Many

AbstractThere is compelling observational evidence that globular clusters (GCs) are quite complex objects. A growing body of photometric results indicate that the evolutionary sequences are not simply isochrones in the observational plane -as believed until a few years ago- from the main sequence, to the subgiant, giant, and horizontal branches. The strongest indication of complexity comes however from the chemistry, from internal dispersion in iron abundance in a few cases, and in light elements (C, N, O, Na, Mg, Al, etc.) in all GCs. This universality means that the complexity is intrinsic to the GCs and is most probably related to their formation mechanisms. The extent of the variations in light elements abundances is dependent on the GC mass, but mass is not the only modulating factor; metallicity, age, and possibly orbit can play a role. Finally, one of the many consequences of this new way of looking at GCs is that their stars may show different He contents.

scholarly journals Variability of ω Centauri Blue Stragglers: Clues to their Origin

1988 ◽  
Vol 126 ◽  
pp. 681-682
Author(s):  
G. S. Da Costa ◽  
John Norris
Keyword(s):  
Globular Clusters ◽  
Main Sequence ◽  
Galactic Disk ◽  
Close Binaries ◽  
Blue Stragglers ◽  
The Core ◽  
Evolved Stars ◽  
Internal Mixing ◽  
Residual Gas ◽  
Lifetime Extension

The four possible origins usually discussed for blue stragglers in stellar systems are (a) mass transfer in, or coalescence of, close binaries; (b) main sequence lifetime extension either through internal mixing or high non-thermal pressures; (c) complete mixing events in evolved stars at the core helium flash; and (d) ongoing star formation over long intervals. However, alternative (d) can be ruled out for the case of globular clusters because any residual gas in the cluster is very efficiently swept out as the cluster passes through the galactic disk, an event that occurs approximately every hundred million years. Hypotheses (a) and (b) both predict masses for the blue stragglers that exceed the turnoff mass but if alternative (c) is correct, then the blue stragglers should have masses less than or equal to the turnoff mass.

CONTRIBUTION OF DNA COPY-NUMBER VARIATION (CNV) TO CANCER SUSCEPTIBILITY AND LARGE-SCALE GENOME ALTERATIONS IN OSTEOSARCOMA (OS)

2008 ◽  
Vol 31 (4) ◽  
pp. 19
Author(s):  
I Pasic ◽  
A Shlien ◽  
A Novokmet ◽  
C Zhang ◽  
U Tabori ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Large Scale ◽  
Structural Variation ◽  
Age Of Onset ◽  
Cancer Susceptibility ◽  
Small Sample Size ◽  
Snp Array ◽  
Tumour Suppressor Gene ◽  
Small Sample ◽  
International Hapmap Project

Introduction: OS, a common Li-Fraumeni syndrome (LFS)-associated neoplasm, is a common bone malignancy of children and adolescents. Sporadic OS is also characterized by young age of onset and high genomic instability, suggesting a genetic contribution to disease. This study examined the contribution of novel DNA structural variation elements, CNVs, to OS susceptibility. Given our finding of excessive constitutional DNA CNV in LFS patients, which often coincide with cancer-related genes, we hypothesized that constitutional CNV may also provide clues about the aetiology of LFS-related sporadic neoplasms like OS. Methods: CNV in blood DNA of 26 patients with sporadic OS was compared to that of 263 normal control samples from the International HapMap project, as well as 62 local controls. Analysis was performed on DNA hybridized to Affymetrix genome-wide human SNP array 6.0 by Partek Genomic Suite. Results: There was no detectable difference in average number of CNVs, CNV length, and total structural variation (product of average CNV number and length) between individuals with OS and controls. While this data is preliminary (small sample size), it argues against the presence of constitutional genomic instability in individuals with sporadic OS. Conclusion: We found that the majority of tumours from patients with sporadic OS show CN loss at chr3q13.31, raising the possibility that chr3q13.31 may represent a “driver” region in OS aetiology. In at least one OS tumour, which displays CN loss at chr3q13.31, we demonstrate decreased expression of a known tumour suppressor gene located at chr3q13.31. We are investigating the role ofchr3q13.31 in development of OS.

Konkurrenz zwischen Stieleiche und Buche auf Lothar-Sturmflächen | Competition between pedunculate oak and European beech on Lothar windthrow areas

2009 ◽  
Vol 160 (5) ◽  
pp. 114-123 ◽  
Author(s):  
Daniel Otto ◽  
Sven Wagner ◽  
Peter Brang
Keyword(s):  
Large Scale ◽  
Early Stage ◽  
Tree Height ◽  
European Beech ◽  
Threshold Value ◽  
Test Methods ◽  
Permanent Plots ◽  
Pedunculate Oak ◽  
Competitive Pressure ◽  
Competition Index

The competitive pressure of naturally regenerated European beech (Fagus sylvatica) saplings on planted pedunculate oak (Quercus robur) was investigated on two 1.8 ha permanent plots near Habsburg and Murten (Switzerland). The plots were established with the aim to test methods of artificial oak regeneration after large-scale windthrow. On both plots, 80 oaks exposed to varying levels of competitive pressure from at most 10 neighbouring beech trees were selected. The height of each oak as well as stem and branch diameters were measured. The competitive pressure was assessed using Schütz's competition index, which is based on relative tree height, crown overlap and distance from competing neighbours. Oak trees growing without or with only slight competition from beech were equally tall, while oaks exposed to moderate to strong competition were smaller. A threshold value for the competition index was found above which oak height decreased strongly. The stem and branch diameters of the oaks started to decrease even if the competition from beech was slight, and decreased much further with more competition. The oak stems started to become more slender even with only slight competition from beech. On the moderately acid beech sites studied here, beech grow taller faster than oak. Thus where beech is competing with oak and the aim is to maintain the oak, competitive pressure on the oak must be reduced at an early stage. The degree of the intervention should, however, take the individual competitive interaction into account, with more intervention if the competition is strong.

scholarly journals Discovery of Infrared Stars in Globular Clusters in the Magellanic Clouds and Their Light Variations

1998 ◽  
Vol 11 (1) ◽  
pp. 395-395
Author(s):  
S. Nishida ◽  
T. Tanabé ◽  
S. Matsumoto ◽  
T. Onaka ◽  
Y. Nakada ◽  
...  
Keyword(s):  
Mass Loss ◽  
Globular Clusters ◽  
Main Sequence ◽  
Near Infrared ◽  
Magellanic Clouds ◽  
Infrared Light ◽  
Agb Stars ◽  
Dust Shells ◽  
Infrared Stars ◽  
Infrared Survey

A systematic near-infrared survey was made for globular clusters in the Magellanic Clouds. Two infrared stars were discovered in NGC419 (SMC) and NGC1783 (LMC). NGC419 and NGC1783 are well-studied rich globular clusters whose turn-off masses and ages are estimated MTO ~ 2.0 Mʘ and т ~1.2 Gyr for NGC419, and MT0 ~ 2.0 Mʘ and т ʘ 0.9 Gyr for NGC1783, respectively. The periods of the infrared light variations were determined to be 540 dfor NGC419IR1 and to be 480 d for NGC1783IR1, respectively. Comparison of the measurements with the period—if magnitude relation for carbon Miras in the LMC by Groenewegen and Whitelock(1996) revealed that the Kmagnitudes of the infrared stars were fainter by about 0.3 — 0.8 magnitude than those predicted by the P — K relation. This deviation can be explained if the infrared stars are surrounded by thick dust shells and are obscured even in the K band. The positions of NGC419IR1and NGC1783IR1 on the P — K diagram suggest that AGB stars with the main sequence masses of about 2 Mʘ start their heavy mass-loss when P ʘ 500 d.

scholarly journals Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine

2021 ◽  
Vol 22 (15) ◽  
pp. 7917
Author(s):  
Hideaki Kaneto ◽  
Tomohiko Kimura ◽  
Masashi Shimoda ◽  
Atsushi Obata ◽  
Junpei Sanada ◽  
...  
Keyword(s):  
Large Scale ◽  
Cell Function ◽  
Apoptotic Cell ◽  
Early Stage ◽  
Insulin Biosynthesis ◽  
Protective Effects ◽  
Pancreatic Β Cell ◽  
Β Cells ◽  
Β Cell ◽  
Glucose Toxicity

Fundamental pancreatic β-cell function is to produce and secrete insulin in response to blood glucose levels. However, when β-cells are chronically exposed to hyperglycemia in type 2 diabetes mellitus (T2DM), insulin biosynthesis and secretion are decreased together with reduced expression of insulin transcription factors. Glucagon-like peptide-1 (GLP-1) plays a crucial role in pancreatic β-cells; GLP-1 binds to the GLP-1 receptor (GLP-1R) in the β-cell membrane and thereby enhances insulin secretion, suppresses apoptotic cell death and increase proliferation of β-cells. However, GLP-1R expression in β-cells is reduced under diabetic conditions and thus the GLP-1R activator (GLP-1RA) shows more favorable effects on β-cells at an early stage of T2DM compared to an advanced stage. On the other hand, it has been drawing much attention to the idea that GLP-1 signaling is important in arterial cells; GLP-1 increases nitric oxide, which leads to facilitation of vascular relaxation and suppression of arteriosclerosis. However, GLP-1R expression in arterial cells is also reduced under diabetic conditions and thus GLP-1RA shows more protective effects on arteriosclerosis at an early stage of T2DM. Furthermore, it has been reported recently that administration of GLP-1RA leads to the reduction of cardiovascular events in various large-scale clinical trials. Therefore, we think that it would be better to start GLP-1RA at an early stage of T2DM for the prevention of arteriosclerosis and protection of β-cells against glucose toxicity in routine medical care.

scholarly journals Understanding the Processes Causing the Early Intensification of Hurricane Dorian through an Ensemble of the Hurricane Analysis and Forecast System (HAFS)

Atmosphere ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 93
Author(s):  
Andrew Hazelton ◽  
Ghassan J. Alaka ◽  
Levi Cowan ◽  
Michael Fischer ◽  
Sundararaman Gopalakrishnan
Keyword(s):  
Tropical Cyclone ◽  
Large Scale ◽  
Early Stage ◽  
Early Period ◽  
Storm Track ◽  
Key Factors ◽  
Complex Interplay ◽  
Forecast System ◽  
Model Initialization

The early stages of a tropical cyclone can be a challenge to forecast, as a storm consolidates and begins to grow based on the local and environmental conditions. A high-resolution ensemble of the Hurricane Analysis and Forecast System (HAFS) is used to study the early intensification of Hurricane Dorian, a catastrophic 2019 storm in which the early period proved challenging for forecasters. There was a clear connection in the ensemble between early storm track and intensity: stronger members moved more northeast initially, although this result did not have much impact on the long-term track. The ensemble results show several key factors determining the early evolution of Dorian. Large-scale divergence northeast of the tropical cyclone (TC) appeared to favor intensification, and this structure was present at model initialization. There was also greater moisture northeast of the TC for stronger members at initialization, favoring more intensification and downshear development of the circulation as these members evolved. This study highlights the complex interplay between synoptic and storm scale processes in the development and intensification of early-stage tropical cyclones.

scholarly journals Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

2019 ◽  
Vol 25 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Olivia W. Lee ◽  
Shelley Austin ◽  
Madison Gamma ◽  
Dorian M. Cheff ◽  
Tobie D. Lee ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
High Throughput ◽  
High Throughput Screening ◽  
Drug Targets ◽  
Large Scale ◽  
Early Stage ◽  
Cancer Cell Line ◽  
Hek 293 ◽  
Cytotoxic Compounds

Cell-based phenotypic screening is a commonly used approach to discover biological pathways, novel drug targets, chemical probes, and high-quality hit-to-lead molecules. Many hits identified from high-throughput screening campaigns are ruled out through a series of follow-up potency, selectivity/specificity, and cytotoxicity assays. Prioritization of molecules with little or no cytotoxicity for downstream evaluation can influence the future direction of projects, so cytotoxicity profiling of screening libraries at an early stage is essential for increasing the likelihood of candidate success. In this study, we assessed the cell-based cytotoxicity of nearly 10,000 compounds in the National Institutes of Health, National Center for Advancing Translational Sciences annotated libraries and more than 100,000 compounds in a diversity library against four normal cell lines (HEK 293, NIH 3T3, CRL-7250, and HaCat) and one cancer cell line (KB 3-1, a HeLa subline). This large-scale library profiling was analyzed for overall screening outcomes, hit rates, pan-activity, and selectivity. For the annotated library, we also examined the primary targets and mechanistic pathways regularly associated with cell death. To our knowledge, this is the first study to use high-throughput screening to profile a large screening collection (>100,000 compounds) for cytotoxicity in both normal and cancer cell lines. The results generated here constitute a valuable resource for the scientific community and provide insight into the extent of cytotoxic compounds in screening libraries, allowing for the identification and avoidance of compounds with cytotoxicity during high-throughput screening campaigns.

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