The Hidden Sufferers: Parental Reactions to Childhood Cancer during Treatment and at Survival

2017 ◽  
Vol 20 ◽  
Author(s):  
Carmina Castellano-Tejedor ◽  
Tomás Blasco-Blasco ◽  
Marta Pérez-Campdepadrós ◽  
Lluis Capdevila
Keyword(s):  
Social Support ◽  
Childhood Cancer ◽  
Help Seeking ◽  
Childhood Cancer Survivors ◽  
Negative Consequences ◽  
Cross Sectional ◽  
General Stress ◽  
Parental Reactions ◽  
End Of Treatment ◽  
High Social Support

AbstractThis study was twofold: 1) to assess parental reactions to childhood cancer throughout the oncological experience and 2) to explore associations between parents’ reactions during treatment and cancer-related distress at survival. A cross-sectional descriptive study collecting data (at survival) from retrospective (perceived social support, optimism, distress, coping in the worst situation) and current variables (general stress, distress regarding cancer, benefit finding) was carried out. Forty-one parents of childhood cancer survivors were assessed. High levels of distress (M = 9.5, SD = 1.32, range 4-10) and self-reported efforts to overcome difficulties occurring during the hospitalization (M = 7.48, SD = 3.01, range 0-10) were found. However, parents received high social support from very different sources. This could explain the satisfactory levels of optimism found (43.9% of the sample, M ≥ 16, range 9 – 24). Most parents reported to use engagement (M = 2.57, SD = 0.41, range 1-4) and help-seeking (M = 2.52, SD = 0.53, range 1-4) coping strategies to overcome difficulties. Some parents recognized to use psychological defenses when coping with the distress of cancer. However, this disengagement style was less preferred (M = 1.62, SD = 0.37, range 1-4). Finally, 22% of parents reported positive consequences and 60% reported positive and negative consequences too. When exploring how treatment experiences can influence cancer-related distress in survivorship, we observed that those who received less social support used more disengagement coping and referred higher efforts to overcome difficulties during treatment, displayed persistent distress at survival. These same parents showed higher scores on general stress. Besides, these results were not influenced by child’s sequelae at survival. These findings support the hypothesis that “the end of treatment is not the end”. Consequently, special attention should be placed in screening parents experiences throughout different milestones of cancer to design tailored interventions aimed at reducing persistent distress at survival.

scholarly journals Social support of adults and elderly with chronic kidney disease on dialysis

2016 ◽  
Vol 24 (0) ◽  
Author(s):  
Simone Márcia da Silva ◽  
Natalia Fernanda Braido ◽  
Ana Carolina Ottaviani ◽  
Gabriela Dutra Gesualdo ◽  
Marisa Silvana Zazzetta ◽  
...  
Keyword(s):  
Social Support ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Individual Interviews ◽  
Instrumental Social Support ◽  
High Social Support ◽  
Social Support Scale ◽  
Emotional Social Support

ABSTRACT Objective: to evaluate the instrumental and emotional social support of patients with chronic kidney disease on hemodialysis. Method: descriptive cross-sectional study. The sample was sized for convenience and included 103 participants under treatment in a Renal Replacement Therapy Unit. Data were collected through individual interviews, using the Social Support Scale. Results: the mean scores of the emotional and instrumental social support were 3.92 (± 0.78) and 3.81 (± 0.69) respectively, an indication of good support received. The most frequent sources of instrumental and emotional social support mentioned by participants were partners, spouse, companion or boyfriend and friends. Conclusion: patients with chronic kidney disease have high social support, both instrumental and emotional, and the main support comes from the family.

scholarly journals Functional capacity and social support to people affected by cerebrovascular accident

2019 ◽  
Vol 72 (4) ◽  
pp. 868-873 ◽  
Author(s):  
Raquel Janyne de Lima ◽  
Cláudia Jeane Lopes Pimenta ◽  
Maria Cristina Lins de Oliveira Frazão ◽  
Gerlania Rodrigues Salviano Ferreira ◽  
Tatiana Ferreira da Costa ◽  
...  
Keyword(s):  
Social Support ◽  
Functional Capacity ◽  
Health Professionals ◽  
Barthel Index ◽  
Cerebrovascular Accident ◽  
Quantitative Research ◽  
Cross Sectional ◽  
The Social ◽  
High Social Support ◽  
Social Support Scale

ABSTRACT Objective: To investigate the functional capacity and its relationship with the level of social support to people affected by cerebrovascular accident. Methods: Cross-sectional and quantitative research, conducted with 108 individuals with sequelae of cerebrovascular accident in João Pessoa/PB. Data were collected through interviews, using a sociodemographic instrument – the Barthel Index and the Social Support Scale. Results: We observed the prevalence of functional dependency in 93.5%, and the mild dependency stood out in 40.7%. Medium social support was the most found, with 48.2%. The predominant dimensions of social support were the material dimension, followed by the emotional. There was a significant association (p ≤ 0.05) between very serious dependency and high social support. Conclusion: The results found allow us to reflect on the need for involvement of health professionals in strengthening the social support of patients with disabling diseases, such as the cerebrovascular accident.

scholarly journals Interaction between demand-control and social support in the occurrence of common mental disorders

2017 ◽  
Vol 51 (0) ◽  
Author(s):  
Amália Ivine Santana Mattos ◽  
Tânia Maria de Araújo ◽  
Maura Maria Guimarães de Almeida
Keyword(s):  
Social Support ◽  
Mental Disorders ◽  
Health Workers ◽  
Common Mental Disorders ◽  
Cross Sectional Study ◽  
High Demand ◽  
Cross Sectional ◽  
High Social Support ◽  
The Common ◽  
Demand Control

ABSTRACT OBJECTIVE To analyze the interaction between the psychosocial aspects of work and the occurrence of common mental disorders among health workers. METHODS This is a cross-sectional study conducted with a representative sample of workers of the primary health care of five municipalities of the State of Bahia, Brazil, in 2012. The variable of outcome were the common mental disorders evaluated by the SRQ-20, and the variables of exposure were high demand (high psychological demand and low control over the work) and low social support in the workplace. Interaction was checked by the deviation of the additivity of the effects for the factors studied from the calculation of excess risk from interaction, proportion of cases attributed to interaction, and the synergy index. RESULTS The global prevalence of common mental disorders was 21%. The group of combined exposure has shown higher magnitude (high demand and low social support), reaching 28% when compared to the 17% in the situation of no exposure (low demand and high social support). CONCLUSIONS The results strengthen the hypothesis of interaction between the factors investigated, directing to the synergy of the effects.

Bleomycin-associated lung toxicity in childhood cancer survivors.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9591-9591
Author(s):  
Alexandra Patricia Zorzi ◽  
Connie L Yang ◽  
Sharon Dell ◽  
Paul C. Nathan
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Lung Metastases ◽  
Univariate Analysis ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Current Recommendation ◽  
Cross Sectional

9591 Background: Bleomycin has been established as a pulmonary toxin, but the risk for toxicity in survivors of childhood cancer is poorly characterized. Methods: We conducted a cross-sectional study of lung function in survivors of childhood Hodgkin lymphoma and germ cell tumor treated with bleomycin at our institution between 1997 and 2010. We assessed their most recent post-therapy pulmonary function test (PFT). Spirometry and lung volumes were categorized as normal, restrictive, obstructive or mixed. Diffusing capacity of carbon monoxide (DLCO) was categorized as normal or abnormal. Results: 195 patients were treated with bleomycin. Ten died of non-pulmonary causes. Of 185 survivors, 143 (77%) had complete data available for analysis. Median cumulative bleomycin dose was 60U/m2 (IQR 30-60). Three patients (2%) had a history of acute bleomycin toxicity. PFTs were performed a median of 2.3 years (IQR 1.4-4.9) from completion of therapy. Spirometry was abnormal in 58 patients (41%); of whom 5 (9%) had respiratory symptoms. 42 (70%) had obstructive, 11 (18%) restrictive and 5 (9%) mixed ventilatory defects. Abnormalities were mild in 53 (91%), moderate in 3 (5%) and severe in 2 (4%). DLCO was abnormal in 27 patients, 26 (96%) of whom had mildly reduced DLCO and were asymptomatic. Univariate analysis did not demonstrate a significant association between gender, smoking, lung metastases, lung radiation, chemotherapy regimen, or autologous transplant and abnormal lung function. Disease relapse was associated with abnormal lung function (p=0.01). Smoking (p=0.04) and relapse (p=0.03) were associated with abnormal DLCO. The odds ratio of developing abnormal spirometry for each 1unit/m2 increase in bleomycin was 1.01 (95% CI 1.00-1.02, p=0.07). Conclusions: Childhood cancer survivors treated with bleomycin frequently have evidence of asymptomatic abnormalities on PFT. The current recommendation for pulmonary function testing in childhood cancer survivors appears justified.

scholarly journals Cardiovascular health status and genetic risk in survivors of childhood neuroblastoma and nephroblastoma treated with doxorubicin: protocol of the pharmacogenetic part of the LESS-Anthra cross-sectional cohort study (Preprint)

2021 ◽  
Author(s):  
Oliver Zolk ◽  
Annika von dem Knesebeck ◽  
Norbert Graf ◽  
Thorsten Simon ◽  
Barbara Hero ◽  
...  
Keyword(s):  
Cohort Study ◽  
Health Status ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Genetic Risk ◽  
Cardiac Toxicity ◽  
Childhood Cancer Survivors ◽  
Cross Sectional ◽  
Study Participants

BACKGROUND Cardiac toxicity is the most common non-malignant cause of death in childhood cancer survivors attributed to treatment-related consequences. Identifying patients at risk of developing late cardiac toxicity is therefore crucial to improving treatment outcomes. Genetic markers have been proposed to be used together with clinical risk factors to predict the individual risk of cardiac toxicity from cancer therapies such as doxorubicin. OBJECTIVE The primary aim is to replicate the previously described associations of doxorubicin-induced cardiotoxicity with RARG rs2229774, SLC28A3 rs7853758 and UGT1A6 rs17863783 variants and to evaluate the predictive value of the multimarker genetic test. The secondary aim is to evaluate the prevalence of cardiovascular dysfunction in childhood cancer survivors and to replicate the association of doxorubicin-related cardiotoxicity with other candidate genes. METHODS This is the pharmacogenetic sub-study of the research project Structural Optimization for Children with Cancer after Anthracycline Therapy (LESS-Anthra). We invited 2158 survivors of childhood neuroblasoma or nephroblastoma who were treated with doxorubicin according to the trial protocols of SIOP 9/GPOH, SIOP 93-01/GPOH, SIOP 2001/GPOH, NB 90, NB 97, or NB 2004 to participate in this prospective cross-sectional cohort study. The study participants underwent a cardiological examination and were asked to provide a blood or saliva sample for genotyping. The health status and cardiovascular diagnoses of the study participants were recorded using a questionnaire completed by the cardiologist. Digital echocardographic data were centrally evaluated to determine the contractile function parameters. Medical data on tumor diagnosis and treatment protocol were taken from the study documentation. Survivors were screened for variants in several candidate genes by TaqMan genotyping. RESULTS This study included 657 survivors treated with doxorubicin for childhood cancer, resulting in the largest German cohort assembled for investigation of cardiovascular late effects to date. Data analyses are yet to be completed. CONCLUSIONS The study will define the genetic risk related to three marker genes proposed for risk assessment in a pharmacogenetic guideline. Moreover, the results of this study will show the prevalence of cardiovascular dysfunction in survivors of pediatric neuroblastoma or nephroblastoma treated with doxorubicin. The results will help to improve primary treatment and follow-up care to reduce cardiovascular late effects in the growing population of childhood cancer survivors. CLINICALTRIAL German clinical trials register ID: DRKS00015084

scholarly journals METABOLIC SYNDROME PARAMETERS, DETERMINANTS, AND BIOMARKERS IN ADULT SURVIVORS OF CHILDHOOD CANCER: PROTOCOL OF THE DUTCH CHILDHOOD CANCER SURVIVOR STUDY METABOLIC SYNDROME (DUTCH LATER METS STUDY) (Preprint)

2020 ◽  
Author(s):  
Vincent Pluimakers ◽  
Marta Fiocco ◽  
Jenneke van Atteveld ◽  
Monique Hobbelink ◽  
Dorine Bresters ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Previous Treatment ◽  
Adult Survivors ◽  
Childhood Cancer Survivors ◽  
Snp Analysis ◽  
Cross Sectional ◽  
Survivors Of Childhood Cancer

BACKGROUND Potential late effects of treatment for childhood cancer include adiposity, insulin resistance, dyslipidemia and hypertension. These risk factors cluster together as metabolic syndrome (MetS) and increase the risk for development of diabetes mellitus and cardio- and cerebrovascular disease. Knowledge on risk factors, timely diagnosis and preventive strategies is of importance to prevent cardio- and cerebrovascular complications and improve quality of life. Currently, no studies in national cohorts on prevalence and determinants of MetS in childhood cancer survivors including biomarkers and genetic predisposition are available. OBJECTIVE The objectives of the Dutch LATER METS study are to assess 1) the prevalence and risk factors of MetS and its separate components, and 2) the potential value of additional biomarkers, in the national cohort of adult long-term survivors of childhood cancer. METHODS This is a cross-sectional study, based on recruitment of all survivors treated in the Netherlands between 1963 and 2002. MetS will be classified according to the definitions of the National Cholesterol Education Program (NCEP-ATP III) as well as the Joint Interim Statement (JIS), and compared to reference data. Dual-energy X-ray absorptiometry (DXA) scans were performed to assess body composition in more detail. The effect of patient characteristics, previous treatment, and genetic variation on the risk of MetS will be assessed. The diagnostic and predictive value of novel biomarkers will be tested. RESULTS Patient accrual started in 2016 and lasted until April 2020. A total of 2380 survivors has participated, in seven pediatric oncology hospitals. From July 2020, biomarker testing, SNP analysis and data analysis will be performed. CONCLUSIONS The Dutch LATER METS study will provide knowledge on clinical and genetic determinants of MetS, and the diagnostic value of biomarkers, in childhood cancer survivors. The results of this study will be used to optimize surveillance guidelines for MetS in survivors, based on enhanced risk stratification and screening strategies. This will improve diagnosis of MetS, and prevent complications. CLINICALTRIAL Registered at toetsingonline.nl, NL32117.018.10

Premature ovarian failure after childhood cancer and risk of metabolic syndrome – a cross-sectional analysis

2021 ◽  
Author(s):  
Axel Netterlid ◽  
Helena Mörse ◽  
Aleksander Giwercman ◽  
Emir Henic ◽  
Kristina E Akesson ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Childhood Cancer ◽  
Fasting Glucose ◽  
Childhood Cancer Survivors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovarian Insufficiency ◽  
Cross Sectional ◽  
X Ray ◽  
Sectional Analysis

Objective: Female childhood cancer survivors (CCS) are at risk of several late effects, among them metabolic syndrome (MetS) and premature ovarian insufficiency (POI). The objective is to study if POI is associated with risk of MetS and increased cardiovascular risk in CSS. Design: A cross-sectional study with a median time since cancer diagnosis of 25 (12 – 41) years. Patients and controls were recruited from the South Medical Region of Sweden. Methods: The study included 167 female CCS, median age 34 (19 – 57) years, diagnosed with childhood cancer at median age 8.4 (0.1 – 17.9) years together with 164 controls, matched for age, sex, ethnicity, residence, and smoking habits. All subjects were examined with fasting glucose, insulin, HbA1c, and lipid profile. Fat mass was calculated with dual-energy X-ray absorptiometry (DXA), questionnaires for medication were obtained. Detailed information of cancer treatment was available. Results: POI was present in 13% (22/167) among CCS (hypothalamic/pituitary cause excluded) and in none among controls. MetS was present in 14% (24/167) among all CCS (p = 0.001), in 23% (5/22) of those with POI (p < 0.001), compared with 4% (6/164) among controls. OR for MetS in all CCS compared with controls was 4.4 (95% CI 1.8, 11.1) (p = 0.002) and among CCS with POI the OR was 7.7 (CI 2.1, 28.1) (p = 0.002). Conclusion: The prevalence of MetS was higher in females treated for childhood cancer compared with controls and the presence of POI significantly increased the risk of developing MetS.

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