scholarly journals Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

Author(s):  
Liubov S. Kalinichenko ◽  
Christiane Mühle ◽  
Tianye Jia ◽  
Felix Anderheiden ◽  
Maria Datz ◽  
...  

AbstractMental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis in 456,693 volunteers found associations of haplotypes of SMPD3 coding for NSM-2 (NSM) with alcohol consumption, but also with affective state, and bone mineralisation. Functional analysis in mice showed that NSM controls alcohol consumption, affective behaviour, and their interaction by regulating hippocampal volume, cortical connectivity, and monoaminergic responses. Furthermore, NSM controlled bone–brain communication by enhancing osteocalcin signalling, which can independently supress alcohol consumption and reduce depressive behaviour. Altogether, we identified a single gene source for multiple pathways originating in the brain and bone, which interlink disorders of a mental–physical co-morbidity trias of alcohol abuse—depression/anxiety—bone disorder. Targeting NSM and osteocalcin signalling may, thus, provide a new systems approach in the treatment of a mental–physical co-morbidity trias.

2020 ◽  
Author(s):  
Chiara Mazzarella ◽  
Annamaria Spina ◽  
Marcello Dallio ◽  
Antonietta Gerarda Gravina ◽  
Mario Romeo ◽  
...  

BACKGROUND Italy has been one of the first western countries seriously involved in the COVID-19 pandemic in the first months of 2020 and so that the national government was forced to impose a long lockdown period, stopping all the people aggregation outdoor and indoor activities. From a social point of view this period of domestic confinement resulted in deep changes of behaviours and lifestyles, promoting in many people the onset of psychological symptoms and signs (including anxiety, depression, insomnia, and irritability among others) already known as associated with drug and alcohol abuse OBJECTIVE this study aims to assess the variation of alcohol drinking habits in a sample of Italian citizens during the COVID-19 lockdown and to identify the psychosocial factors surrounding it, in order to assess the specific subset of the population that could need psychosocial support during these events METHODS An online anonymous questionnaire was created and submitted from 9th April 2020 to 28th April 2020 using social medias and e-mails. Questions were related to personal details such as age, work, instruction, and, moreover, to alcohol drinking habits during the lockdown, including Alcohol Use Disorders Identification Test (AUDIT C) test questions RESULTS A total of 1234 surveys were filled out by subjects with an age range from 18 to 80 years old. An increase in both anxiety and fear has been detected in most of the participants (63% and 61% respectively) with a direct (r=0.652; p<0.001) relationship between them. Participants older than 50 years showed the strongest correlation between alcohol consumption, fear, and anxiety, (r=0.830, P <0.001 and r=0.741, P<0.001, respectively). Subjects living alone experienced a stronger association between anxiety, fear, and higher level of alcohol consumption (r: 0.529; P<0.001; r: 0.628, P<0.001 respectively). Moreover, 18% of participants increased alcohol consumption drinking during the lockdown. These subjects showed a lower frequency of alcohol consumption before the lockdown in comparison to the rest of the study population (2.5±0.96 vs 3±1.03, P<0.0001 respectively). Moreover, comparing the abovementioned groups, the percentage of subjects who experienced higher alcohol assumption before the 11th of March was higher in those that didn't change their drinking behaviour during the lockdown in comparison to that portion of them that experienced a worsening of alcohol abuse (r: 30.422, P<0.0001) CONCLUSIONS according to these data, during the Italian lockdown due to COVID 19 pandemic, different kind of people experienced an increase in alcohol drinking. Several psychosocial factors are involved in determining the increase in harmful alcohol consumption during this extraordinary stressful event and they must be addressed by the healthcare support in order to avoid awful lockdown impact on human life


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Moreira de Sousa ◽  
L Lopes ◽  
P Costa ◽  
G Martins-Coelho ◽  
R Capucho

Abstract Background In 2017, the risk-weighted prevalence of alcohol consumption was the health indicator with a more negative impact on the Institute for Health Metrics and Evaluation Sustainable Development Goals Health Index Value in Portugal. According to data from 2012-14, the Alto Tâmega and Barroso (ATB) had the highest value of Years of potential life lost (YPLL) in North Portugal - 4570,1/10.000 people. Liver chronic disease was the specific cause of death that contributed to the value of YPLL - 465,4/10.000 people. Methods A cross-sectional study was conducted with data from the Northern Health Administration and the General Directorate for Intervention on Addictive Behaviours and Dependencies. We compared the number of patients with chronic alcohol consumption (CAC) in 2018, the leading causes of death between 2012-14, the main morbidity causes according to data from primary healthcare (PHC) physicians in 2018 and the number of patients in specialized treatment team (STT) for alcohol abuse treatment in 2018 in ATB. Results In 2018, 2643 patients of ATB had a diagnosis of CAC; only 178 were followed by an STT. Although CAC had a massive influence on YPLL, this was only the 11º cause of morbidity in ATB according to the data from PHC. The number of women with CAC was stable between 2012 (n = 284) and 2018 (n = 291). In the same period, there was an increase of 52,86% of CAC on men (n = 1523 to n = 2348). Even though 18,4% of YPLL due to chronic liver disease happen in women, only 11,2%of the patients with CAC in the PHC are women. Conclusions There is a need for the improvement of CAC diagnosis in PHC, and the improvement of referral of patients to STT and hospital care. Besides, to reach the SDG3, there is the need to work intensely on SDG 17 (partnership for the goals). The Public Health Unit of ATB is organizing Operation PROMETEU to improve communication, institutional collaboration, and monitoring of the existing health activities that are tackling CAC. Key messages The need to integrate data from different healthcare sources for a better analysis on health problems. The urgent need to tackle the alcohol abuse problem in ATB.


1996 ◽  
Vol 89 (7) ◽  
pp. 389-392 ◽  
Author(s):  
Gerond Lake-Bakaar ◽  
Roger Grimson

Our objective was to identify factors that might correlate with human immunodeficiency virus (HIV) disease stage in intravenous drug abusers (IVDA). Particular attention was given to alcohol abuse. We accordingly explored in a cross-sectional study the relation between stage of HIV disease and age, sex, needle sharing, ethnicity, self-reported history of alcohol consumption and CAGE scores. IVDA from a single municipal hospital were subdivided into three groups according to HIV disease status. Group 1 comprised 42 individuals with AIDS; group 2 comprised 114 who were HIV positive but without AIDS; and group 3 comprised 52 who were HIV negative. Information on alcohol consumption and CAGE responses were obtained by questionnaire and interview. Discriminant analysis indicated that alcohol abuse, assessed either by self-reported consumption or by CAGE scores, was significantly more common in the AIDS group than in either the HIV positive or the HIV negative groups, when controlled for age, sex, and needle sharing status. The relative risk of AIDS was 3.8 times higher in the heavy drinkers than in moderate drinkers. Needle sharing was also more common in the AIDS group than in the HIV positive or HIV negative groups when the other factors were controlled for. AIDS was more common in black than white IVDA, and this increased frequency did not appear related to alcohol consumption since the distribution of heavy drinkers within each category of HIV disease did not differ within the ethnic groups. These data indicate that a history of heavy alcohol consumption is more common in IVDA with AIDS than in IVDA at earlier stages of HIV disease.


Author(s):  
Mgbahurike AA ◽  
Oduogu SO ◽  
Bagbi BM

Background to study: Effective management of hypertension is influenced by several factors that center on social and economic status of the patient. Identification of these factors will enable informed intervention in the management of hypertensive patients. Objective: The study aimed to determine possible association between blood pressure control and socioeconomic status of patients who are managed in community pharmacies in Rivers State. Method: A descriptive cross-sectional survey of thirty-nine community pharmacies was conducted between July and December 2018.  A total of 195 respondents participated in the study. Every patient’s consent was obtained. Further information on patients’ demographics were extracted from pharmacists’ documentation files. Such include age, medication patient is on, duration of hypertension, co-morbidity, income/ social status, and habits like smoking, alcohol consumption, educational status, and mean blood pressure over the study period. The outcome measure taken as controlled blood pressure was mean BP ≤140/90 mm Hg for the general population and BP 130/80 mmHg for patients with diabetes as co-morbidity. BP >140/90 mm Hg was considered as uncontrolled blood pressure. Result: A total of 195 respondents participated in the study, of which 105(53.8%) were male and 90(46.2%) were female. Out of this number 75(38.5%) were below 40yrs of age, 105(53.8%) were between 41–50yrs of age and only 15(7.7%) were 60yrs and above. More female had BP control compared to the male (OR 1.89, 95% CI (1.16 - 3.0), P=0.009. Patients within ages 41 - 59yrs had more controlled BP compared to older age, 60yrs and above, OR 1.48, 95% CI (0.84 - 2.42) p 0.18. Uncontrolled BP was found more among employed patients and patients with highest monthly income, OR 1.05 95% CI (0.58 - 2.00); OR 1.16 95% CI (0.49 - 2.78) P, 0.36 respectively. Exercise activities have significant impact on BP control as alcohol consumption increased OR of BP control with no significant difference in OR on amount of monthly expenditure on medications. Conclusion: Male gender, employment, and high income earning have negative effect on BP control while exercise is associated with BP control.                    Peer Review History: Received: 4 September 2021; Revised: 10 October; Accepted: 21 October, Available online: 15 November 2021 Academic Editor:  Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, [email protected]  UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, [email protected] Dr. Vanina Doris Edo’o, University of Yaounde I, Yaounde, Cameroun, [email protected] Similar Articles: PRESCRIPTION PATTERN OF ANTI-HYPERTENSIVE DRUGS IN A TERTIARY CARE HOSPITAL IN KERALA AND ADHERENCE TO JNC-8 GUIDELINES


2016 ◽  
Vol 24 (4) ◽  
pp. 6-16
Author(s):  
A B Mulik ◽  
S V Bulatetsky ◽  
I V Ulesikova ◽  
I G Mulik ◽  
E V Nazarova ◽  
...  

The problem of alcohol consumption is one of the major causes of depopulation in the Russian Federation. The particular concern is the alcoholism of teenagers and young adults. Substantiates the relevance of complex factors influence the biological and social risks of substance use among youth. Objective: To develop an integrated system approach predicting human risk of alcohol abuse, combining the functional assessment, psychological and social factors in the formation of demand for psychoactive substances. As the object of the study 89 people of both sexes were involved, 18-23 years of age, students of Volgograd State University. The work was performed in accordance with Articles 5, 6 and 7 "on Bioethics and Human Rights, the Universal Declaration” with registration of informed consent. As a result of complex investigations undertaken identified a number of positions of principle capable of predicting the risk of alcohol abuse human. At the same time, it justified the increased susceptibility to alcohol consumption in individuals with a high level of general non-specific reactivity (UONRO). It revealed highly significant effect of negative feelings from the first samples of alcohol to block alcohol abuse human motivations. At the same time, positive feelings of alcohol during the first trial, significantly increase the risk of alcoholism. It was determined that the vast majority of respondents (95%) did not consume alcohol, brought up in the families of non-drinking parents. In contrast, respondents - consumers of alcohol, in 62% of cases vopityvalis in alcoholic families traditions. Thus, the facts revealed dependence on the combination of alcohol consumption UONRO indicators of psychosomatic condition of the person as a result of the first sample of alcohol and attitudes of members of the parental family to consume alcohol. Based on these data provided a method for predicting the risk of alcohol consumption, which provides a comprehensive account of the functional, psychological and social factors in the formation of demand for psychoactive substances, the possibility of a qualitative typology and differentiation degree of risk of alcohol abuse and algorithmization testing process.


REVISTA PLURI ◽  
2019 ◽  
Vol 1 (2) ◽  
pp. 241
Author(s):  
Veridiana Canezin Guimarães ◽  
Regiane Ribeiro ◽  
Tuanne Sousa ◽  
Audinéia Pereira

O presente estudo tem como objetivo pesquisar o consumo excessivo de álcool pelas gestantes e o comportamento dos bebês recém-nascidos, abordando consequências fisiológicas e psicológicas, visando também o tratamento e a prevenção. Trata-se de uma pesquisa de cunho bibliográfico, que investigou a relação entre o consumo de álcool pelas gestantes e a saúde física e psicológica dos bebês, tendo como referência teórica estudos psicanalíticos da relação mãe-bebê.Palavras-Chave: Abuso de álcool. Gravidez. PsicanáliseAbstractThe present study aims to investigate the excessive consumption of alcohol by pregnant women and the behavior of newborn babies, addressing physiological and psychological consequences, as well as treatment and prevention. This is a bibliographical research that will investigate the relationship between alcohol consumption by pregnant women and the physical and psychological health of the babies, having as theoretical reference psychoanalytic studies of the mother-baby relationship.Keywords: Alcohol abuse. Pregnancy. Psychoanalysis.


2020 ◽  
Vol 10 (19) ◽  
pp. 6690
Author(s):  
Marek Sawicki ◽  
Mariusz Szóstak

The value, care, and customs of workers are essential in terms of occupational health and safety. The abuse of alcohol is widely regarded as a serious threat to the lives, health, and safety of employees. The aim of the research was to identify the main problems that are associated with alcohol abuse and consumption at work among employees in the construction industry, with particular emphasis on workstations where work is carried out on construction scaffoldings. Data for the analysis were obtained from two different sources. The first one was post-accident documentation on occupational accidents. The second one was surveys collected during the research project. This study confirmed that excessive and disproportionate alcohol consumption can be the cause of an accident, and consequently death at workplaces with scaffolding. Of 219 accident reports, 17.4% indicated alcohol as a contributing factor. Analysis of accident documentations shows that in cases where alcohol was indicated as a contributing factor in an accident, the alcohol was consumed during the workday. The results obtained on the basis of the conducted research were able to constitute a justification for the directions of preventive actions carried out in order to reduce the number of occupational accidents in the construction industry caused by alcohol.


2016 ◽  
Vol 33 (S1) ◽  
pp. S300-S300
Author(s):  
M. Guerrero Jiménez ◽  
C.M. Carrillo de Albornoz Calahorro ◽  
A. Porras Segovia ◽  
J.A. Cervilla Ballesteros

IntroductionEpidemiological studies have reported associations between alcohol consumption or abuse and occurrence of delusional disorder (F.22) rather than in general population. Alcohol has not been described as the main cause of the delusional idea, but is an enhancer factor which would inhibit behavioral brake and executive function in prefrontal cortex facilitating the development of the existing delusional idea.HypothesisWe want to confirm this association in our influence area so this study aims to report compared frequency of alcoholism in DD versus a control group published in andalusian population.AimsTo review the literature on the potential links between alcohol abuse and delusional disorder and this relationship in general population.ResultsThis poster presents a brief but updated systematic literature review on the associations between DD and alcohol abuse. We will also present data from a relatively large case-mix of 2049 patients with the diagnosis of delusional disorder resulting from a thorough retrospective, medical-record based, assessment of patients attended in our clinical catchment area.In our sample, alcohol abuse and other drugs consumption was significantly less common in Delusional Disorder than in other psychoses.This result suggests that alcohol and other drugs consumption can be a greater importance parameter in other psychoses correlates than in delusional disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.


1979 ◽  
Vol 45 (3) ◽  
pp. 735-740 ◽  
Author(s):  
John W. Jones

This study examined 25 boys and 35 girls in an elementary school and found illicit alcohol use occurred in 1 out of 5. Moreover, the frequency of weekly alcohol consumption among both the students' families and friends, as observed by the student, reliably predicted alcohol consumption rates by male students but not females. The obtained pattern of results is discussed in terms of an observational learning model of youths' drinking behavior, and implications of the findings are given.


1992 ◽  
Vol 13 (12) ◽  
pp. 1315-1323 ◽  
Author(s):  
Reena Sommer ◽  
Gordon E. Barnes ◽  
Robert P. Murray

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