scholarly journals A single baroreceptor unit consists of multiple sensors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jun Liu ◽  
Nana Song ◽  
Yufang Wang ◽  
Jerome Walker ◽  
Jerry Yu
Keyword(s):  
Unit Activity ◽  
Myelinated Axon ◽  
Vital Role ◽  
Activity Level ◽  
Physiological Data ◽  
Multiple Sensors ◽  
Bolus Intravenous Injection ◽  
Multiple Sensor ◽  
Sensory Structures ◽  
High Level

AbstractArterial baroreceptors (BRs) play a vital role in the regulation of the cardiopulmonary system. What is known about how these sensors operate at the subcellular level is limited, however. Until recently, one afferent axon was considered to be connected to a single baroreceptor (one-sensor theory). However, in the lung, a single airway mechanosensory unit is now known to house many sensors (multiple-sensor theory). Here we tested the hypothesis that multiple-sensor theory also operates in BR units, using both morphological and electrophysiological approaches in rabbit aortic arch (in whole mount) labeled with Na+/K+-ATPase, as well as myelin basic protein antibodies, and examined microscopically. Sensory structures presented in compact clusters, similar to bunches of grapes. Sensory terminals, like those in the airways, formed leaf-like or knob-like expansions. That is, a single myelinated axon connected with multiple sensors forming a network. We also recorded single-unit activities from aortic baroreceptors in the depressor nerve in anesthetized rabbits and examined the unit response to a bolus intravenous injection of phenylephrine. Unit activity increased progressively as blood pressure (BP) increased. Five of eleven units abruptly changed their discharge pattern to a lower activity level after BP attained a plateau for a minute or two (when BP was maintained at the high level). These findings clearly show that the high discharge baroreceptor deactivates after over-excitation and unit activity falls to a low discharge sensor. In conclusion, our morphological and physiological data support the hypothesis that multiple-sensory theory can be applied to BR units.

scholarly journals The risk of venous thromboembolism and physical activity level, especially high level: a systematic review

2021 ◽  
Author(s):  
H. Danin-Mankowitz ◽  
A. Ugarph-Morawski ◽  
F. Braunschweig ◽  
P. Wändell
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Venous Thromboembolism ◽  
Activity Level ◽  
Case Control Studies ◽  
The Third ◽  
Area Of Interest ◽  
High Level ◽  
The Relationship

AbstractVenous thromboembolism (VTE) is the third most common cause of cardiovascular disease. Connection between high level of physical activity (PA) and the onset of VTE is unknown. We searched the literature on the possible association between PA level, especially high levels, and the risk of VTE. A systematic review was carried out to identify relevant articles on the relation between PA level and VTE. The initial search was conducted together with the Karolinska Institutet University Library in February 2018, with follow-up searches after that. In total, 4383 records were found and then screened for exclusion of duplicates and articles outside the area of interest. In total, 16 articles with data on 3 or more levels of PA were included. Of these, 12 were cohort and 4 were case-control studies. Totally 13 studies aimed at investigating VTE cases primarily, while three studies had other primary outcomes. Of the 16 studies, five found a U-shaped association between PA level and VTE risk, although non-significant in three of them. Two articles described an association between a more intense physical activity and a higher risk of VTE, which was significant in one. Nine studies found associations between increasing PA levels and a decreasing VTE risk. Available literature provides diverging results as to the association between high levels of PA and the risk of venous thromboembolism, but with several studies showing an association. Further research is warranted to clarify the relationship between high level PA and VTE.

Clarifying Institutional and Organizational Conditions Promoting Principals' Quality Leadership and Reform Design for Japan

Impact ◽  
2021 ◽  
Vol 2021 (7) ◽  
pp. 15-17
Author(s):  
Hirofumi Hamada
Keyword(s):  
Education Reform ◽  
Developed Countries ◽  
Vital Role ◽  
Quality Of Education ◽  
Organizational Conditions ◽  
Problem Situations ◽  
Distributed Approach ◽  
Area Of Interest ◽  
High Level

Education reform helps ensure that the education in a given country is of the highest possible quality and is a key area of focus for many developed countries. Japan's education system rates highly and the evolution of education reform is key to ensuring this high level is sustained. School principals play a key role in delivering high-quality education and, indeed, a school principal's leadership correlates with the quality of education available. This is an area of interest for Professor Hirofumi Hamada, School Management Laboratory in the Faculty of Human Sciences, University of Tsukuba, Japan, who is currently exploring the institutional and organisational conditions that affect the leadership of principals. The goal of this research is to help shape education reform in Japan. Hamada believes it is necessary to create an environment of independent and collaborative learning and to value the individuality of children. In addition, problem situations among children are diverse and complex and how schools respond influences the quality of education. Given that the principal is in charge of how a school is run, they play a vital role in assuring the quality of education. Key to Hamada's work is the idea that principals can share their knowledge and leadership with teachers and this creates an environment of shared leadership. He believes that empowering teachers and encouraging them to take on leadership duties is essential. He is working to inform educators that schools require the leadership of principals and for principals to promote a distributed approach to leadership.

scholarly journals Geo-Knowledge for an Ever Changing Society – The New Swiss National Map 1:10‘000 and its strategic relevance

2018 ◽  
Vol 1 ◽  
pp. 1-7
Author(s):  
Olaf Forte
Keyword(s):  
Reference Data ◽  
Vital Role ◽  
Focal Points ◽  
Technical Developments ◽  
National Centre ◽  
Open Government Data ◽  
Technological Developments ◽  
Government Data ◽  
High Level

The Federal Office of Topography swisstopo plays a vital role as Switzerland’s Geoinformation centre. This paper shows how the New Swiss National Map 1&amp;thinsp;:&amp;thinsp;10’000 will take its place, within the strategic Geoinformation preparations for 2020 and swisstopo’ future technical developments.<br> This topic can be told in five key chapters, each with their own strategic focal points for swisstopo: The National Centre of Geoinformation – Up-to-date reference data – Improved, future-orientated usability – Filling the gaps in Switzerland’s geographical reference data and finally Open Government Data.<br> Implementing each of these strategic focal points will enable swisstopo to provide an even more effective, efficient and cost-conscious service. The data and products provided by swisstopo are built on the core objectives of ensuring that Switzerland’s official Geoinformation, firstly complies with current legislation, secondly insuring that the information covering various time periods will be readily available over the long term, and finally that the data is maintained as up to date as possible.<br> In order to ensure long-term success and to provide a service that responds to the people’s needs and benefits Switzerland as a whole, swisstopo must also take into account social, political and technological developments. Moreover, it will enable swisstopo to continue a sustainable high-level of cartography in future.

scholarly journals Etanercept therapy in rheumatoid arthritis: Efficacy and safety

2013 ◽  
Vol 141 (7-8) ◽  
pp. 495-502
Author(s):  
Tatjana Ilic ◽  
Biljana Milic ◽  
Dejan Celic ◽  
Biljana Vuckovic ◽  
Igor Mitic
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Destruction ◽  
Life Quality ◽  
Activity Level ◽  
Inadequate Response ◽  
Efficacy And Safety ◽  
Etanercept Therapy ◽  
Acr20 Response ◽  
Clinically Significant ◽  
High Level

Introduction. Etanercept, tumor necrosis factor (TNF?) antagonist, lowers the disease activity level in patients with rheumatoid arthritis (RA), reduces joint destruction saving physical functions and improving life quality. Objective. The aim of this study was to establish efficacy and safety of etanercept in combination with disease modifying antirheumatic drugs (DMARDs) in the treatment of RA. Methods. To patients with active RA, who were on therapy with DMARD, etanercept was introduced in weekly doses of 50 mg, with continuation of DMARD. Efficacy of this form of treatment was evaluated in the 12th week. Maintenance of the effect of treatment was also evaluated during 24, 48 and 96 weeks. Long term evaluation of etanercept safety was assessed by registering all unwanted events during a two year period. Results. After 12 weeks of treatment with etanercept, 80% of patients had ACR20 response, while 85% showed clinically significant decrease of DAS28 index. We achieved remission in five patients (12.5%) and low activity of RA in 17 patients (42.5%). During a 96week of followup period, achieved therapy effects were maintained. In four patients (10%) etanercept therapy was interrupted after 24 weeks because of inadequate response. In one of them (2.5%) we recorded a cardiovascular incident. Acute infections were registered in 47 cases. Four of those were severe infections. Neither cases of malignancy development were noted, nor were there any lethal disease outcomes. Conclusion. Etanercept in combination with DMARD shows a high level of efficacy in the treatment of RA. The safety profile of the drug is satisfactory.

Effect of COVID-19 Lockdown on the Physical Activity and Lifestyle of Medical Students of University of Lahore

2021 ◽  
Vol 15 (9) ◽  
pp. 2175-2177
Author(s):  
Khadija Ghafoor Quraishi ◽  
Mian Ali Raza ◽  
Sadaf Waris ◽  
Fahad Tanveer ◽  
Ashfaq Ahmad
Keyword(s):  
Physical Activity ◽  
Medical Students ◽  
Sampling Technique ◽  
Activity Level ◽  
Health Concern ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Low Level ◽  
High Level ◽  
The University

Background: COVID-19 pandemic has become a foremost health concern, many countries have ordered lockdown to stop the spread of COVID-19 due to which many Universities are closed and students are taking lectures online, Pakistan is also one of the countries in which lockdown was imposed, the aim of this study is to examine the level of physical activity and lifestyle of medical students from University of Lahore (UoL) during COVID-19. Aim: To determine the effect of COVID-19 lockdown on the physical activity and lifestyle of medical students of University of Lahore. Materials: Sample size included 151 medical students from the University of Lahore, study was pure cross-sectional and convenient sampling technique was used, data was collected through online questionnaire which contained question from IPAQ-SF to estimate the physical activity and lifestyle of observed University students. Data was analyzed using SPSS version 25. Results: The results showed that from the population of 151 medical students of University of Lahore 75 students (49.7%) reported Low level of physical activity, while 44 students (29.1%) students reported Moderate level of physical activity, and 32 students (21.2%) reported high level of physical activity. Conclusion: Majority of the medical students showed Low level of physical activity, 49.7% in the last 7 days during COVID-19 pandemic. Medical students of University of Lahore showed a decrease in their overall physical activity level. Keywords: COVID-19, lockdown, Medical students, Physical activity

scholarly journals PENINGKATAN KAPASITAS GUDANG DENGAN PERANCANGAN LAYOUT MENGGUNAKAN METODE CLASS-BASED STORAGE

2016 ◽  
Vol 11 (2) ◽  
pp. 113
Author(s):  
Heldy Juliana ◽  
Naniek Utami Handayani
Keyword(s):  
Storage Capacity ◽  
Raw Materials ◽  
Vital Role ◽  
Raw Material ◽  
Time And Space ◽  
Storage Method ◽  
Space Efficiency ◽  
Packaging Industry ◽  
High Level

Gudang adalah suatu tempat penyimpanan untuk semua barang-barang hasil produksi maupun penjualan. Fungsinya sebagai tempat penyimpanan memiliki peranan yang sangat vital. Oleh sebab itu diperlukan adanya pengaturan yang tepat dan cepat dalam penggunaan ruang gudang. CV.MDP-Semarang merupakan industri kemasan karton yang berlokasi di Semarang. Tingginya tingkat penggunaan gudang di perusahaan ini membuat effisiensi waktu dan ruang menjadi penting. Dari hasil pengamatan, CV. MDP-Semarang belum memiliki tata letak penyimpanan yang baik. Hal ini terlihat dari cara penyimpanan bahan baku di gudang yang belum mengikuti kaidah tata letak gudang. Pada gudang bahan baku, karton diletakkan secara acak sehingga menyulitkan pencarian, kapasitas gudang bahan baku saat ini dikeluhkan tidak mencukupi kebutuhan. Parameter tata letak gudang bahan baku yang baik adalah dipenuhinya ruang secara maksimal dan pemenuhan terhadap permintaan bahan baku yang lebih cepat. Pada penelitian ini, metode class-based storage dan penggunaan rak, memisahkan karton berdasarkan jenis karton di gudang bahan baku mampu memberikan peningkatan kapasitas gudang. Dengan rancangan tata letak gudang bahan baku usulan dapat meningkatkan kapasitas gudang, sehingga mampu memberikan ruang kosong untuk 64.000 pieces karton. AbstractWarehouse is a storage for all the goods of production and sales. Its function as a storage has a very vital role. Therefore it is necessary to have the proper regulations in the use of warehouse space. CV.MDP-Semarang is the carton packaging industry located in Semarang. The high level of the activity in the warehouse make time and space efficiency becomes important. From the observation, CV. MDP-Semarang do not yet have good storage layout. It is shown from raw material inventory in storage that are not following the principle of good storage layout. In the raw materials storage carton are placed randomly, so it makes the operator difficult to find the goods and the storage become out of capacity to fulfill demand. The good parameters for good storage are the optimal utility and the capapbility to fulfill raw material demands faster. In this paper, class-based storage method and shelf are used to separate carton based on type of carton in raw material storage in order to improve storage capacity. By proposes the design raw material storage layout, the company should be able to increase storage capacity, thus, it will be able to give space for 640.000 pieces of carton.

scholarly journals Inferring Emotion Tags from Object Images Using Convolutional Neural Network

2020 ◽  
Vol 10 (15) ◽  
pp. 5333
Author(s):  
Anam Manzoor ◽  
Waqar Ahmad ◽  
Muhammad Ehatisham-ul-Haq ◽  
Abdul Hannan ◽  
Muhammad Asif Khan ◽  
...  
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Human Behavior ◽  
Real Life ◽  
Vital Role ◽  
Object Categories ◽  
Different Types ◽  
Gender Based ◽  
High Level ◽  
Human Behavior Analysis

Emotions are a fundamental part of human behavior and can be stimulated in numerous ways. In real-life, we come across different types of objects such as cake, crab, television, trees, etc., in our routine life, which may excite certain emotions. Likewise, object images that we see and share on different platforms are also capable of expressing or inducing human emotions. Inferring emotion tags from these object images has great significance as it can play a vital role in recommendation systems, image retrieval, human behavior analysis and, advertisement applications. The existing schemes for emotion tag perception are based on the visual features, like color and texture of an image, which are poorly affected by lightning conditions. The main objective of our proposed study is to address this problem by introducing a novel idea of inferring emotion tags from the images based on object-related features. In this aspect, we first created an emotion-tagged dataset from the publicly available object detection dataset (i.e., “Caltech-256”) using subject evaluation from 212 users. Next, we used a convolutional neural network-based model to automatically extract the high-level features from object images for recognizing nine (09) emotion categories, such as amusement, awe, anger, boredom, contentment, disgust, excitement, fear, and sadness. Experimental results on our emotion-tagged dataset endorse the success of our proposed idea in terms of accuracy, precision, recall, specificity, and F1-score. Overall, the proposed scheme achieved an accuracy rate of approximately 85% and 79% using top-level and bottom-level emotion tagging, respectively. We also performed a gender-based analysis for inferring emotion tags and observed that male and female subjects have discernment in emotions perception concerning different object categories.

Design of a High-Level Diagnostic System

1984 ◽  
Vol 106 (1) ◽  
pp. 17-21 ◽  
Author(s):  
R. H. Lyon ◽  
R. G. DeJong
Keyword(s):  
Signal Processing ◽  
Diagnostic System ◽  
Multiple Sensors ◽  
Gear Mesh ◽  
Vibration Sensors ◽  
Internal Sources ◽  
High Level ◽  
Signal Processing Methods ◽  
Excitation Propagation ◽  
Preliminary Application

The use of vibration signals produced by the operation of a machine to control its operations and detect developing faults is appealing because of the ruggedness of vibration sensors and their ease of placement. A diagnostic system that employs a few sensors, remotely located from a number of vibration generating mechanisms, to analyze the performance of these mechanisms is termed a “high-level” diagnostic system. The goal of such a diagnostic system is to infer from the remote vibration sensors the characteristics of the internal sources (such as forces and pressures) which could not be easily measured directly. The use of multiple sensors and advanced signal processing methods is necessary for such a system to be viable. A series of studies on vibration excitation, propagation, sensing, and signal processing that demonstrate the basic feasibility of such a diagnostic system are described. The design of a high-level diagnostic system for detecting the combustion and gear mesh excitations in a diesel engine analysis is presented, along with the results of a preliminary application of the system.

scholarly journals Temporal Modulation of an Autoprotease Is Crucial for Replication and Pathogenicity of an RNA Virus

2004 ◽  
Vol 78 (19) ◽  
pp. 10765-10775 ◽  
Author(s):  
T. Lackner ◽  
A. Müller ◽  
A. Pankraz ◽  
P. Becher ◽  
H.-J. Thiel ◽  
...  
Keyword(s):  
Rna Virus ◽  
Nonstructural Protein ◽  
Rna Replication ◽  
Vital Role ◽  
Diarrhea Virus ◽  
Nonstructural Protein 2 ◽  
Replication Control ◽  
High Level ◽  
Ns3 Protease

ABSTRACT Pestiviruses belong to the family Flaviviridae, and their genome is a single-stranded RNA of positive polarity encoding one large polyprotein which is further processed into mature proteins. Noncytopathogenic (noncp) strains of the pestivirus bovine viral diarrhea virus (BVDV) can establish persistent infection. In persistently infected animals, noncp BVDVs occasionally acquire mutations in viral nonstructural protein 2 (NS2) that give rise to cytopathogenic (cp) BVDV variants, and, eventually, lead to the onset of lethal disease. A molecular marker of cp BVDV infection is a high-level expression of the replicative NS3 protease/helicase that together with NS2 is derived from NS2-3. Here, we present evidence for NS2-3 autoprocessing by a newly identified cysteine protease in NS2 that is distantly related to the NS2-3 autoprotease of hepatitis C and GB viruses. The vital role of this autoprotease in BVDV infection was established, implying an essential function for NS3 in pestiviral RNA replication which cannot be supplied by its NS2-3 precursor. Accordingly, and contrary to a current paradigm, we detected almost complete cleavage of NS2-3 in noncp BVDV at early hours of infection. At 6 to 9 h postinfection, NS2-3 autoprocessing diminished to barely detectable levels for noncp BVDV but decreased only moderately for cp BVDV. Viral RNA synthesis rates strictly correlated with different NS3 levels in noncp and cp BVDV-infected cells, implicating the NS2 autoprotease in RNA replication control. The biotype-specific modulation of NS2-3 autoprocessing indicates a crucial role of the NS2 autoprotease in the pathogenicity of BVDV.

Constitutive Lymphoid Expression of the Nuclear Form of RNase H1 Is Associated with Development of Immature B Cell Lymphomas.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 1613-1613
Author(s):  
Kiran B Sakhuja ◽  
Lina A Gugliotti ◽  
Yutaka Suzuki ◽  
Alexander L Kovalchuk ◽  
Hongsheng Wang ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Cycle Progression ◽  
Conflicts Of Interest ◽  
Expression Profiles ◽  
Cell Lineage ◽  
Immature Stage ◽  
Vital Role ◽  
Mammalian Development ◽  
High Level

Abstract Abstract 1613 Poster Board I-639 Ribonuclease H1, which cleaves the RNA of RNA/DNA hybrids, plays a vital role in the replication of mitochondrial DNA during mouse embryogenesis, but its contributions to later mammalian development and adult biology are not known. In higher eukaryotes two isoforms of RNase H1, a nuclear form and mitochondrial form, are produced from a single transcript. To investigate the effects of constitutive high level RNase H1 expression, we generated transgenic (TG) mice, strain M27F7, with lymphocyte-specific over-expression of nuclear RNase H1. Transcripts in B cells from TG mice were ∼100-fold higher than in wild type B cells. Although there was no obvious phenotype in young mice, some of the older mice, especially females, developed lymphadenopathy, splenomegaly and mediastinal masses and were diagnosed histologically as having lymphoblastic lymphomas. Cell lines established from the tumors were examined by FACS, gene expression profiling and SKY as well as by FISH for Igh and Myc. By FACS criteria, the tumors were B cell lineage and were arrested at the pre-B to immature stage of differentiation. Expression profiles showed the lines to have increased expression of anti-apoptotic genes and genes promoting cell cycle progression. Chromosomal studies revealed no signs of genomic instability or translocations, although there were trisomies of chromosomes 3 and 15. Myc was structurally intact in all lines. These results suggest that RNase H1 plays a previously unappreciated role in early B cell development and that constitutive overexpression contributes to lymphomagenesis. This work was supported by the Intramural Research Program of the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Institute of Allergy and Infectious Diseases. Disclosures No relevant conflicts of interest to declare.

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