Comments on the updated recommendations of the American College of Rheumatology (ACR) for the treatment of gout. Lifestyle (part 2)

2021 ◽  
Vol 15 (2) ◽  
pp. 83-88
Author(s):  
M. S. Eliseev

Updated ACR recommendations for the treatment of gout concerning lifestyle are discussed. Factors related to a lifestyle, above all food habits, for many years were of leading importance in the treatment of patients with gout, even after application of effective drugs. The authors of the updated ACR recommendations for the first time offered to reconsider the role of environmental factors in the genesis of gout and objectively assess the possibility of its non-drug treatment. On the one hand, regardless of the activity of the disease, the need for restrictions of the alcohol, purine-rich products and fructose-containing beverages, as well as the decrease of body weight in obese patients and vitamin C usage unviability are confirmed. On the other hand, these recommendations are conditional. Their new version of ACR recommendations is significantly different from both its previous version and other international and national recommendations, including recommendations on the diagnosis and treatment of gout used in the Russian Federation.

Author(s):  
Kseniya V. Donik

The article considers the role of Prince A. Menshikov as a specific type of agent of supreme authority in the process of reforming the maritime administration. The problem context of reforms resulted from the involvement of the naval generals and officials in abuses, which was a consequence of nepotism and unrest in the navy. The involvement of sailors in the Decembrist revolt significantly affected the attitude of the tsar to the general situation in the naval environment. Distrustful of the existing naval administration, Nicholas I needed an intermediary who would implement his idea of the arrangement of the navy on the one hand, and provide him with an objective “impartial” account of maritime problems, on the other hand. As a result of that, Adjutant General Prince A. Menshikov, who had had nothing to do with the naval service earlier, joined the navy to become the monarch’s agent in charge of the naval issues in the bodies of autocratic authority. The objective of the article is to identify the functions of such an agent based on the example of the Maritime Department. The sources of the article include official records and personal documents, some of which are introduced into scientific circulation for the first time. The principal methodological approach to the problem under study is an attempt to bring the appointment of Menshikov beyond the scope of narrow departmental history which was based on the unmotivated decision of the emperor and to propose an interpretation of the events in the context of tsarist government via agents, which has already been described in historiography. The author makes a conclusion about the interconnection between the crisis in the naval department, the attitude of the supreme authority towards it, and the appearance of the monarch’s agent with a number of his own functional characteristics.


Der Islam ◽  
2019 ◽  
Vol 96 (1) ◽  
pp. 42-86
Author(s):  
Matthew Melvin-Koushki

Abstract This study presents and intellectual- and literary-historically contextualizes a remarkable but as yet unpublished treatise by Ibn Turka (d. 1432), foremost occult philosopher of Timurid Iran: the Munāẓara-yi bazm u razm. As its title indicates, this ornate Persian work, written in 1426 in Herat for the Timurid prince-calligrapher Bāysunghur (d. 1433), takes the form of a literary debate, a venerable Arabo-Persian genre that exploded in popularity in the post-Mongol period. Yet it triply transgresses the bounds of its genre, and doubly marries Arabic-Mamluk literary and imperial culture to Persian-Timurid. For here Ibn Turka recasts the munāẓara as philosophical romance and the philosophical romance as mirror for princes, imperializing the razm u bazm and sword vs. pen tropes within an expressly lettrist framework, making explicit the logic of the coincidentia oppositorum (majmaʿ al-aḍdād) long implicit in the genre in order to ideologically weaponize it. For the first time in the centuries-old Arabo-Persian munāẓara tradition, that is, wherein such debates were often rhetorically but never theoretically resolved, Ibn Turka marries multiple opposites in a manner clearly meant to be instructive to his Timurid royal patron: he is to perform the role of Emperor Love (sulṭān ʿishq), transcendent of all political-legal dualities, avatar of the divine names the Manifest (al-ẓāhir) and the Occult (al-bāṭin). This lettrist mirror for Timurid princes is thus not simply unprecedented in Persian or indeed Arabic literature, a typical expression of the ornate literary panache and genre-hybridizing proclivities of Mamluk-Timurid-Ottoman scientists of letters, and index of the burgeoning of Ibn ʿArabian-Būnian lettrism in late Mamluk Cairo; it also serves as key to Timurid universalist imperial ideology itself in its formative phase – and consciously epitomizes the principle of contradiction driving Islamicate civilization as a whole. To show the striking extent to which this munāẓara departs from precedent, I provide a brief overview of the sword vs. pen subset of that genre; I then examine our text’s specific political-philosophical and sociocultural contexts, with attention to Naṣīr al-Dīn Ṭūsī’s (d. 1274) Akhlāq-i Nāṣirī and Jalāl al-Dīn Davānī’s (d. 1502) Akhlāq-i Jalālī on the one hand – which seminal Persian mirrors for princes assert, crucially, the ontological-political primacy of love over justice – and the Ẓafarnāma of Sharaf al-Dīn Yazdī (d. 1454), Ibn Turka’s student and friend, on the other. In the latter, much-imitated history Amir Temür (r. 1370‒1405) was definitively transformed, on the basis of astrological and lettrist proofs, into the supreme Lord of Conjunction (ṣāḥib-qirān); most notably, there Yazdī theorizes the Muslim world conqueror as historical manifestation of the coincidentia oppositorum – precisely the project of Ibn Turka in his Debate of Feast and Fight. But these two ideologues of Timurid universal imperialism and leading members of the New Brethren of Purity network only became such in Mamluk Cairo, where lettrism (ʿilm al-ḥurūf) was first sanctified, de-esotericized and adabized; I accordingly invoke the overtly occultist-neopythagoreanizing ethos specific to the Mamluk capital by the late 14th century, especially that propagated at the court of Barqūq (r. 1382‒1399). For it is this Cairene ethos, I argue, that is epitomized by our persophone lettrist’s munāẓara, which it effectively timuridizes. To demonstrate the robustness of this Mamluk-Timurid ideological-literary continuity, I situate the Munāẓara-yi bazm u razm within Ibn Turka’s own oeuvre and imperial ideological program, successively developed for the Timurid rulers Iskandar Sulṭān (r. 1409‒1414), Shāhrukh (r. 1409‒1447) and Ulugh Beg (r. 1409‒1449); marshal three contemporary instances of the sword vs. pen munāẓara, one Timurid and two Mamluk, by the theologian Sayyid Sharīf Jurjānī (d. 1413), the secretary-encyclopedist Aḥmad al-Qalqashandī (d. 1418) and the historian Ibn Khaldūn (d. 1406), respectively; and provide an abridged translation of Ibn Turka’s offering as basis for comparative analysis.


2021 ◽  
pp. 11-19
Author(s):  
Irina Valentinovna Ivlieva

The study identifies features of potential modifications and lacuna-forming modifiers involved in word-formation synthesis in the process of generating new verbs. The scientific novelty of this study is in the differentiated representation of lexical-semantic and morphological means (verbal modifiers) that are capable, on the one hand, of synthesizing a desired meaning (verbal modification) and, on the other hand, of producing lexical gaps (lacunae). As a result of analyzing the specific modifiers and modifications with respect to the lexical-semantic group of verbs of sound, the new products of synthesis (potential modifications) have been identified. The conditions for the appearance of lacunae and the role of the lacunae-forming modifiers are demonstrated. Through a special project at the Missouri S&T (USA) using the data from the Russian National Corpus, for the first time in lexicographic practice, novel modifications, previously considered non-existent, are introduced.


Author(s):  
Iryna Rusnak

The author of the article analyses the problem of the female emancipation in the little-known feuilleton “Amazonia: A Very Inept Story” (1924) by Mykola Chirsky. The author determines the genre affiliation of the work and examines its compositional structure. Three parts are distinguished in the architectonics of associative feuilleton: associative conception; deployment of a “small” topic; conclusion. The author of the article clarifies the role of intertextual elements and the method of constantly switching the tone from serious to comic to reveal the thematic direction of the work. Mykola Chirsky’s interest in the problem of female emancipation is corresponded to the general mood of the era. The subject of ridicule in provocative feuilleton is the woman’s radical metamorphoses, since repulsive manifestations of emancipation becomes commonplace. At the same time, the writer shows respect for the woman, appreciates her femininity, internal and external beauty, personality. He associates the positive in women with the functions of a faithful wife, a caring mother, and a skilled housewife. In feuilleton, the writer does not bypass the problem of the modern man role in a family, but analyses the value and moral and ethical guidelines of his character. The husband’s bad habits receive a caricatured interpretation in the strange behaviour of relatives. On the one hand, the writer does not perceive the extremes brought by female emancipation, and on the other, he mercilessly criticises the male “virtues” of contemporaries far from the standard. The artistic heritage of Mykola Chirsky remains little studied. The urgent task of modern literary studies is the introduction of Mykola Chirsky’s unknown works into the scientific circulation and their thorough scientific understanding.


Author(s):  
Ксения Ивановна Голубцова

Статья посвящена рассмотрению проблем профилактики преступлений оперативными подразделениями исправительных учреждений (далее - ИУ). Автор, раскрывая роль оперативных отделов ИУ в общей профилактике правонарушений, указывает на ее двоякость, поскольку, с одной стороны, рассматриваемые подразделения обладают значительным преимуществом перед другими службами учреждения в выявлении негативных факторов (негласный метод получения оперативно значимой информации), с другой стороны - далеко не все условия, которые способствуют совершению преступлений в ИУ, можно устранить оперативным путем. Изучение специальной литературы позволило выявить в деятельности начальников ИУ определенные проблемы, связанные с оценкой состояния оперативной обстановки в ИУ, сложившейся ситуации; с отсутствием прогноза развития криминогенной ситуации в ИУ, а также с профессиональной некомпетентностью руководителей, неумением объективно оценивать результаты деятельности структурных подразделений. Автор особое внимание уделяет анализу статистических данных о совершенных и предотвращенных преступлениях лицами, находящимися в местах лишения свободы. The article is devoted to the consideration of problems of crime prevention by operational units of correctional institutions (hereinafter referred to as IA). The author, revealing the role of the operational departments of the IA in the general prevention of offences, points to its twofold. On the one hand, the units under consideration have significant advantages over other services of the institution in identifying negative factors (these are tacit methods of obtaining promptly meaningful information). On the other hand, not all conditions conducive to the commission of crimes in IA can be eliminated by operational means: For example, shortcomings in the activities of other departments and services (security department, duty shift, etc.). The study of special literature has made it possible to identify problems in the activities of heads of correctional institutions in the sphere of implementation of solutions in case of lack of objective and complete information on the state of the operational situation in IA, the current situation, the results of the activities of structural subdivisions; No forecast of the development of the crime situation in IE; Professional incompetence of managers, inability to objectively assess the results of activities of structural subdivisions. The author pays particular attention to the analysis of statistics on crimes committed and prevented by persons in detention.


1998 ◽  
Vol 25 (1) ◽  
pp. 57-72 ◽  
Author(s):  
David Oldroyd

This article examines the role that correspondence played in the accounting systems of Tudor merchants. Merchants relied heavily on letters as a means of controlling their businesses at a distance by making agents accountable. Written accountability, as well as information for business decisions, was encouraged by agency relationships in mercantile enterprises. The system could be undermined by the breakdown of communication through the negligence of a factor or the lack of involvement by the principal. The time delays between the sending and the receipt of letters, on the one hand, and the procurement and conveyance of goods, on the other, were additional problems.


Author(s):  
Zoltán Kövecses

The chapter reports on work concerned with the issue of how conceptual metaphor theory (CMT) functions as a link between culture and cognition. Three large areas are investigated to this effect. First, work on the interaction between conceptual metaphors, on the one hand, and folk and expert theories of emotion, on the other, is surveyed. Second, the issue of metaphorical universality and variation is addressed, together with that of the function of embodiment in metaphor. Third, a contextualist view of conceptual metaphors is proposed. The discussion of these issues leads to a new and integrated understanding of the role of metaphor and metonymy in creating cultural reality and that of metaphorical variation across and within cultures, as well as individuals.


Author(s):  
Steven French

What is a scientific theory? Is it a set of propositions? Or a family of models? Or is it some kind of abstract artefact? These options are examined in the context of a comparison between theories and artworks. On the one hand, theories are said to be like certain kinds of paintings, in that they play a representational role; on the other, they are compared to musical works, insofar as they can be multiply presented. I shall argue that such comparisons should be treated with care and that all of the above options face problems. Instead, I suggest, we should adopt a form of eliminativism towards theories, in the sense that a theory should not be regarded as any thing. Nevertheless, we can still talk about them and attribute certain qualities to them, where that talk is understood to be made true by certain practices. This shift to practices as truth-makers for theory talk then has certain implications for how we regard theories in the realism debate and in the context of the nature and role of representation in science.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Michele Bonus ◽  
Dieter Häussinger ◽  
Holger Gohlke

Abstract Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell function. It provides an early example for the interaction between a physical parameter (cell volume) on the one hand and metabolism, transport, and gene expression on the other. Such events involve mechanotransduction (osmosensing) which triggers signaling cascades towards liver function (osmosignaling). This article reviews our own work on this topic with emphasis on the role of β1 integrins as (osmo-)mechanosensors in the liver, but also on their role in bile acid signaling.


2021 ◽  
Vol 3 (4) ◽  
pp. 119-126
Author(s):  
Hadeel EJMAIL

Death is one of the most difficult topics a person can talk about. The human being is busy with how to continue his life and improve its conditions. This study aims is to explore the writing of Facebook pages of the dead. The research used the qualitative approach through a content analysis, where (50) publications were found on fifteen pages of a dead person with an intentional sample, and the results of the research showed that writing people in the pages of the dead included two directions, the first direction is a desire to immortalize the dead and a kind of preserving their roots Alive. As for the other direction, it was weeping over their ruins and showing the end of a person's death and his end life. Sometimes in the same post include both directions together, meaning "the use of the deceased’s account by his family by changing the profile picture of the dead, and at the same time inviting the deceased’s friends through his page to the memorial event. People write on the pages of the dead in order to weep over their ruins on the one hand, and to immortalize their memories on the other side. Facebook as a social platform and the interaction of people with the pages of the dead shows the great social interaction that takes place in this space, and research in this field is not consistent with one and only claim, as some posts are either temporary or permanent; Therefore, I have used screen capture technology to collect and retain information. The pages of the dead included referring to them, writing memorials and longing, etc. Facebook has become a social platform that allows those who lose a dear person to share their grief through it, and enables them to deal with death and relieve their pain


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