Hydrogel based cartilaginous tissue regeneration: recent insights and technologies

2017 ◽  
Vol 5 (4) ◽  
pp. 613-631 ◽  
Author(s):  
Yon Jin Chuah ◽  
Yvonne Peck ◽  
Jia En Josias Lau ◽  
Hwan Tak Hee ◽  
Dong-An Wang
Keyword(s):  
Articular Cartilage ◽  
Intervertebral Disc ◽  
Tissue Regeneration ◽  
Clinical Applications ◽  
Exploratory Research ◽  
Cartilaginous Tissue

Hydrogel based technologies has been extensively employed in both exploratory research and clinical applications to address numerous existing challenges in the regeneration of articular cartilage and intervertebral disc.

scholarly journals Therapeutic Effects of the Addition of Fibroblast Growth Factor-2 to Biodegradable Gelatin/Magnesium-Doped Calcium Silicate Hybrid 3D-Printed Scaffold with Enhanced Osteogenic Capabilities for Critical Bone Defect Restoration

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 712
Author(s):  
Wei-Yun Lai ◽  
Yen-Jen Chen ◽  
Alvin Kai-Xing Lee ◽  
Yen-Hong Lin ◽  
Yu-Wei Liu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Silicate ◽  
Clinical Applications ◽  
Fibroblast Growth Factor 2 ◽  
Therapeutic Effects ◽  
Fibroblast Growth ◽  
3D Printed

Worldwide, the number of bone fractures due to traumatic and accidental injuries is increasing exponentially. In fact, repairing critical large bone defects remains challenging due to a high risk of delayed union or even nonunion. Among the many bioceramics available for clinical use, calcium silicate-based (CS) bioceramics have gained popularity due to their good bioactivity and ability to stimulate cell behavior. In order to improve the shortcomings of 3D-printed ceramic scaffolds, which do not easily carry growth factors and do not provide good tissue regeneration effects, the aim of this study was to use a gelatin-coated 3D-printed magnesium-doped calcium silicate (MgCS) scaffold with genipin cross-linking for regulating degradation, improving mechanical properties, and enhancing osteogenesis behavior. In addition, we consider the effects of fibroblast growth factor-2 (FGF-2) loaded into an MgCS scaffold with and without gelatin coating. Furthermore, we cultured the human Wharton jelly-derived mesenchymal stem cells (WJMSC) on the scaffolds and observed the biocompatibility, alkaline phosphatase activity, and osteogenic-related markers. Finally, the in vivo performance was assessed using micro-CT and histological data that revealed that the hybrid bioscaffolds were able to further achieve more effective bone tissue regeneration than has been the case in the past. The above results demonstrated that this type of processing had great potential for future clinical applications and studies and can be used as a potential alternative for future bone tissue engineering research, as well as having good potential for clinical applications.

3D printed cell-laden collagen and hybrid scaffolds for in vivo articular cartilage tissue regeneration

2018 ◽  
Vol 66 ◽  
pp. 343-355 ◽  
Author(s):  
YoungWon Koo ◽  
Eun-Ji Choi ◽  
JaeYoon Lee ◽  
Han-Jun Kim ◽  
GeunHyung Kim ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Tissue Regeneration ◽  
Cartilage Tissue ◽  
3D Printed ◽  
Hybrid Scaffolds

BMP Signaling in Regenerative Medicine

2013 ◽  
pp. 1-30
Author(s):  
Julia Zimmer ◽  
Elisa Degenkolbe ◽  
Britt Wildemann ◽  
Petra Seemann
Keyword(s):  
Cardiovascular Disease ◽  
Bone Morphogenetic Proteins ◽  
Tissue Regeneration ◽  
Cancer Diagnosis ◽  
Bone Growth ◽  
Clinical Applications ◽  
Bmp Signaling ◽  
Non Union ◽  
Connective Tissue Regeneration ◽  
Growth Induction

More than 40 years after the discovery of Bone Morphogenetic Proteins (BMPs) as bone inducers, a whole protein family of growth factors connected to a wide variety of functions in embryonic development, homeostasis, and regeneration has been characterized. Today, BMP2 and BMP7 are already used in the clinic to promote vertebral fusions and restoration of non-union fractures. Besides describing present clinical applications, the authors review ongoing trials highlighting the future possibilities of BMPs in medicine. Apparently, the physiological roles of BMPs have expanded their range from bone growth induction and connective tissue regeneration to cancer diagnosis/treatment and cardiovascular disease prevention.

BMP Signaling in Regenerative Medicine

2013 ◽  
pp. 1252-1281
Author(s):  
Julia Zimmer ◽  
Elisa Degenkolbe ◽  
Britt Wildemann ◽  
Petra Seemann
Keyword(s):  
Cardiovascular Disease ◽  
Bone Morphogenetic Proteins ◽  
Tissue Regeneration ◽  
Cancer Diagnosis ◽  
Bone Growth ◽  
Clinical Applications ◽  
Bmp Signaling ◽  
Non Union ◽  
Connective Tissue Regeneration ◽  
Growth Induction

More than 40 years after the discovery of Bone Morphogenetic Proteins (BMPs) as bone inducers, a whole protein family of growth factors connected to a wide variety of functions in embryonic development, homeostasis, and regeneration has been characterized. Today, BMP2 and BMP7 are already used in the clinic to promote vertebral fusions and restoration of non-union fractures. Besides describing present clinical applications, the authors review ongoing trials highlighting the future possibilities of BMPs in medicine. Apparently, the physiological roles of BMPs have expanded their range from bone growth induction and connective tissue regeneration to cancer diagnosis/treatment and cardiovascular disease prevention.

scholarly journals Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Gels ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 20 ◽  
Author(s):  
Sobhan Ghaeini-Hesaroeiye ◽  
Hossein Razmi Bagtash ◽  
Soheil Boddohi ◽  
Ebrahim Vasheghani-Farahani ◽  
Esmaiel Jabbari
Keyword(s):  
Tissue Regeneration ◽  
Targeted Delivery ◽  
Biomedical Engineering ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Chemical Structure ◽  
Salient Feature ◽  
Clinical Applications ◽  
Medical Applications ◽  
External Stimuli

Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release.

scholarly journals Recent advances on gradient hydrogels in biomimetic cartilage tissue engineering

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2158 ◽  
Author(s):  
Ivana Gadjanski
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Blood Vessels ◽  
Cartilage Tissue Engineering ◽  
Structure And Function ◽  
Cartilage Tissue ◽  
Cartilaginous Tissue ◽  
Zonal Structure ◽  
Promising Target ◽  
And Function

Articular cartilage (AC) is a seemingly simple tissue that has only one type of constituting cell and no blood vessels and nerves. In the early days of tissue engineering, cartilage appeared to be an easy and promising target for reconstruction and this was especially motivating because of widespread AC pathologies such as osteoarthritis and frequent sports-induced injuries. However, AC has proven to be anything but simple. Recreating the varying properties of its zonal structure is a challenge that has not yet been fully answered. This caused the shift in tissue engineering strategies toward bioinspired or biomimetic approaches that attempt to mimic and simulate as much as possible the structure and function of the native tissues. Hydrogels, particularly gradient hydrogels, have shown great potential as components of the biomimetic engineering of the cartilaginous tissue.

scholarly journals Peptide-biofunctionalization of biomaterials for osteochondral tissue regeneration in early stage osteoarthritis: challenges and opportunities

2019 ◽  
Vol 7 (7) ◽  
pp. 1027-1044 ◽  
Author(s):  
D. Bicho ◽  
S. Ajami ◽  
C. Liu ◽  
R. L. Reis ◽  
J. M. Oliveira
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Tissue Regeneration ◽  
Early Stage ◽  
Degenerative Joint Disease ◽  
Synovial Inflammation ◽  
Joint Disease ◽  
Progressive Deterioration ◽  
Challenges And Opportunities ◽  
Osteochondral Tissue

Osteoarthritis is a degenerative joint disease characterized by the progressive deterioration of articular cartilage, synovial inflammation and changes in periarticular and subchondral bone, being a leading cause of disability.

Hybrid Chitosan Membranes Tested in Sheep for Guided Tissue Regeneration

2007 ◽  
Vol 361-363 ◽  
pp. 1265-1268 ◽  
Author(s):  
P.P. Cortez ◽  
Yuki Shirosaki ◽  
C.M. Botelho ◽  
M.J. Simões ◽  
F. Gartner ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Tissue Regeneration ◽  
Chitosan Solution ◽  
Clinical Applications ◽  
Histological Evaluation ◽  
Sheep Model ◽  
The Third ◽  
Chitosan Membranes

Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicate hybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivo histocompatibility of both membranes through subcutaneous implantations at different time periods, 1 week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberant inflammatory response and were consequently rejected. The hybrid chitosan membranes were not rejected and the degree of inflammatory response decreased gradually until the third month of implantation. Histological evaluation also showed that these membranes can be resorbed in vivo. This study demonstrates that the incorporation of silicate into the chitosan solution improves its histocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates to be used in clinical applications.

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