scholarly journals Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Gels ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 20 ◽  
Author(s):  
Sobhan Ghaeini-Hesaroeiye ◽  
Hossein Razmi Bagtash ◽  
Soheil Boddohi ◽  
Ebrahim Vasheghani-Farahani ◽  
Esmaiel Jabbari
Keyword(s):  
Tissue Regeneration ◽  
Targeted Delivery ◽  
Biomedical Engineering ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Chemical Structure ◽  
Salient Feature ◽  
Clinical Applications ◽  
Medical Applications ◽  
External Stimuli

Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release.

Responsive surfaces for biomedical applications

MRS Bulletin ◽  
2010 ◽  
Vol 35 (9) ◽  
pp. 673-681 ◽  
Author(s):  
K. G. Neoh ◽  
E. T. Kang
Keyword(s):  
Targeted Delivery ◽  
Biomedical Applications ◽  
Cell Sheet ◽  
Surface Characteristics ◽  
Therapeutic Agents ◽  
Clinical Applications ◽  
Cell Sheet Engineering ◽  
Responsive Surfaces ◽  
Surface Modified ◽  
External Stimuli

Much of the interaction of a material with its environment is governed by its surface, and modulation of the material's surface characteristics can vastly broaden its range of application. This review focuses on the tailoring of surfaces of materials to achieve specific changes in their responses to external stimuli to enhance their prospects for applications in the biomedical field. Combining the inherent properties of different classes of materials such as polymers, metals, mesoporous materials, and magnetic nanoparticles with a responsive surface presents unique opportunities. Applications include surface-modified filters for the effective adsorption and separation of biomolecules, materials for the promotion of cell adhesion or detachment for cell sheet engineering and regenerative medicine, actuators, or valves, and vehicles for the controlled and targeted delivery of therapeutic agents. The commonly used external stimuli are heat, pH, and light, and these, as well as electrical stimulation used in conjunction with conducting polymers, will be addressed in this review. Progress in the field of responsive surfaces has been rapid, and continuing research can be expected to result in more innovative and exciting developments. Nevertheless, much work remains to be done to meet the challenges in the translation of these systems from the laboratory to clinical applications.

scholarly journals Azo-polysiloxane micelles charged with nifedipine

2013 ◽  
Vol 11 (9) ◽  
pp. 1431-1438 ◽  
Author(s):  
Anca-Irina Prisacaru ◽  
Silvia Grama ◽  
Ana Durdureanu-Angheluta ◽  
Mariana Pinteala ◽  
Nicolae Hurduc
Keyword(s):  
Drug Delivery ◽  
Quaternary Ammonium ◽  
Drug Delivery Systems ◽  
Chemical Structure ◽  
Research Study ◽  
Critical Concentration ◽  
Embedding Capacity ◽  
Photosensitive Polymers ◽  
Optimum Range ◽  
External Stimuli

AbstractAbstract One recent aspect of the research study on polymers is their capability to respond to external stimuli. Of importance are photosensitive polymers due to their application in drug delivery systems, sensors, therapeutic devices or optoelectronic switches. The present paper focuses on the azo-polysiloxane micelles capacity charged with hydrophobic drugs, such as nifedipine. Azo-polysiloxanes modified with quaternary ammonium groups and which are capable to generate photo-sensitive micelles were synthesized and characterized by 1H-NMR, UV-VIS and fluorescence spectroscopy. The critical concentration of the micellar aggregation (CCA) was evaluated as was the nifedipine embedding capacity. The CCA values were influenced only by the hydrophobic/hydrophilic balance and not by the chemical structure of the quaternary ammonium groups. The disaggregation capacity of the micelles under UV irradiation was investigated as well, and the best results were obtained for the samples with higher azobenzene content. The DLS measurements evidenced micelles diameters situated in the optimum range domain (70–130 nm). The capacity to incorporate nifedipine inside the micelles was demonstrated. The micelles proved to be stable in time, 21 days after preparation with the diameter having constant values. Graphical abstract

Nanofibrous Substrate For Tissue Engineering Applications—A Review

2021 ◽  
Vol 8 (6) ◽  
pp. 13-21
Author(s):  
Odia Osemwegie ◽  
Lihua Lou ◽  
Ernest Smith ◽  
Seshadri Ramkumar
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Culture ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
High Volume ◽  
Clinical Applications ◽  
Critical Factors ◽  
Engineering Applications

Nanofiber substrates have been used for various biomedical applications, including tissue regeneration, drug delivery, and in-vitro cell culture. However, despite the high volume of studies in this field, current clinical applications remain minimal. Innovations for their applications continuously generate exciting prospects. In this review, we discuss some of these novel innovations and identify critical factors to consider before their adoption for biomedical applications.

Hydrogels as potential drug-delivery systems: network design and applications

2021 ◽  
Author(s):  
Hina Shoukat ◽  
Khuda Buksh ◽  
Sobia Noreen ◽  
Fahad Pervaiz ◽  
Irsah Maqbool
Keyword(s):  
Drug Delivery ◽  
Aqueous Solutions ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Specific Drug ◽  
Potential Drug ◽  
Physiological Conditions ◽  
Crosslinked Polymer ◽  
External Stimuli ◽  
Hydrophilic Network

Hydrogels are 3D crosslinked polymer matrices having a colossal tendency to imbibe water and exhibit swelling under physiological conditions without deformation in their hydrophilic network. Hydrogels being biodegradable and biocompatible, gained consideration due to some unique characteristics: responsiveness to external stimuli (pH, temperature) and swelling in aqueous solutions. Hydrogels offer a promising option for various pharmaceutical and biomedical applications, including tissue-specific drug delivery at a predetermined, controlled rate. This article presents a brief review of the recent and fundamental advances to design hydrogels, the swelling and deswelling mechanism, various crosslinking methods and their use as an intelligent carrier in the pharmaceutical field. Recent applications of hydrogels are also briefly discussed and exemplified.

Recent advances in Fe-MOF compositions for in biomedical applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Yuyu Zhong ◽  
Weicong Liu ◽  
Congying Rao ◽  
Baohong Li ◽  
Xiaoxiong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Materials ◽  
Antibacterial Agent ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Biomedical Application ◽  
Metal Organic Frameworks ◽  
Medical Applications ◽  
Future Perspectives ◽  
Metal Organic

Background: To date, a number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity, and weak ability of targeting have hampered most of the materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a typical subclass of metal-organic frameworks (MOFs), owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic conclusions and analyses of Fe-based MIL on medical applications are rare, even though the majority of documents have discussed one research branch of the porous materials MOFs. Discussion: In this review, we're going to focus mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly.. Further studies with the use of different therapies will be of great interest. Conclusion: This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.

Applications

2015 ◽  
Author(s):  
James E. Mark ◽  
Dale W. Schaefer ◽  
Gui Lin
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Tissue Cell ◽  
Medical Applications ◽  
Internal Diameter ◽  
Elastomeric Matrix ◽  
Zero Order Kinetics

Numerous medical applications have been developed for siloxane polymers. Prostheses, artificial organs, objects for facial reconstruction, vitreous substitutes in the eyes, tubing and catheters, for example, take advantage of the inertness, stability, and pliability of polysiloxanes. Artificial skin, contact lenses, and drug delivery systems utilize their high permeability as well. Such biomedical applications have led to extensive biocompatability studies, particularly on the interactions of polysiloxanes with proteins. There has been considerable interest in modifying these materials to improve their suitability for biomedical applications in general. Advances seem to be coming particularly rapidly in the area of high-tech drug-delivery systems. Figure 10.1 shows the range of diameters of Silastic medical-grade siloxane tubing available for medical applications. The smallest tubing has an internal diameter of only 0.012 inches (0.031 cm) and an outer diameter of only 0.025 inches (0.064 cm). Such materials must first be extensively tested (sensitization of skin, tissue cell culture compatibility, implant compatibility). There has been considerable controversy, for example, over the safety of using polysiloxanes in breast implants. The major concern was “bleeding” of low molecular polysiloxanes out of the gels into the chest cavity, followed by transport to other parts of the body. The extent to which “bleeding” occurred and its possible systemic effects on the body were argued vigorously in the media and in the courts, and led to restrictions on the use of polysiloxanes. In the case of controlled drug-delivery systems, the goal is to have the drug released at a relatively constant rate (zero-order kinetics) at a concentration within the therapeutic range. It is obviously important to minimize the amount of time the concentration is in the low, ineffective range, and to eliminate completely the time it is in the high, toxic range (figure 10.2). Figure 10.3 illustrates the use of polysiloxanes in such drug-delivery systems. The goal mentioned is approached by placing the drug inside a siloxane elastomeric capsule, which is then implanted in an appropriate location in the body. The drug within the capsule can be in the free state, in a fluid suspension, or mixed or dissolved into an elastomeric matrix.

scholarly journals Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Marta Barba ◽  
Claudia Cicione ◽  
Camilla Bernardini ◽  
Fabrizio Michetti ◽  
Wanda Lattanzi
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
State Of The Art ◽  
Biological Properties ◽  
Clinical Applications ◽  
Structure And Function ◽  
Tissue Reconstruction ◽  
And Function

Adipose tissue represents a hot topic in regenerative medicine because of the tissue source abundance, the relatively easy retrieval, and the inherent biological properties of mesenchymal stem cells residing in its stroma. Adipose-derived mesenchymal stem cells (ASCs) are indeed multipotent somatic stem cells exhibiting growth kinetics and plasticity, proved to induce efficient tissue regeneration in several biomedical applications. A defined consensus for their isolation, classification, and characterization has been very recently achieved. In particular, bone tissue reconstruction and regeneration based on ASCs has emerged as a promising approach to restore structure and function of bone compromised by injury or disease. ASCs have been used in combination with osteoinductive biomaterial and/or osteogenic molecules, in either static or dynamic culture systems, to improve bone regeneration in several animal models. To date, few clinical trials on ASC-based bone reconstruction have been concluded and proved effective. The aim of this review is to dissect the state of the art on ASC use in bone regenerative applications in the attempt to provide a comprehensive coverage of the topics, from the basic laboratory to recent clinical applications.

scholarly journals Influence of Soft Segment Molecular Structure on Physicochemical Properties of Cellulose Nanocrystals based Polyurethane

2021 ◽  
Vol 2076 (1) ◽  
pp. 012027
Author(s):  
Maolan Zhang ◽  
Jiale Wang ◽  
Yan Li ◽  
Xiujuan Lu ◽  
Xiaoling Liao ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Soft Segment ◽  
Cross Linking ◽  
Performance Requirements ◽  
Ring Structures ◽  
Good Biocompatibility ◽  
External Stimuli ◽  
Thermal Stability Of

Abstract SPUs are commonly used in clinic due to their good biocompatibility and can respond to different external stimuli. Among them, introducing CNCs into PUs to prepare water-driven PUs had attracted increasing attention. Herein, we report two new types of CNCs based PU nanocomposites by chemically cross-linking CNCs and PDLLA soft segment with flexible PEG chain or rigid piperazine ring structures. Specifically, the prepared nanocomposites were characterized by their morphology, chemical structure, thermal property, hydrophilicity as well as crystallinity, and the results showed that regardless of the molecular structure of the PDLLA, chemically cross-linking CNCs and PDLLA could significantly improve their compatibility. In addition, when the soft segment contains hydrophilic flexible sections, ie, PEG 200, the compatibility of CNCs with PU and crystallinity of obtained materials were better, and when the PDLLA contains a rigid cyclic structure, the thermal stability of obtained CNCs based PU would be more excellent. These results suggest that we can design the soft segment molecular structure of CNCs based PU to meet the performance requirements of different biomedical applications.

scholarly journals Nanotechnology-enabled biomedical engineering: Current trends, future scopes, and perspectives

2021 ◽  
Vol 10 (1) ◽  
pp. 728-743
Author(s):  
Shariqsrijon Sinha Ray ◽  
Jayita Bandyopadhyay
Keyword(s):  
Biomedical Engineering ◽  
Biomedical Applications ◽  
Metal Oxide Nanoparticles ◽  
Semiconductor Nanocrystals ◽  
Functional Materials ◽  
Medical Applications ◽  
Oxide Nanoparticles ◽  
Two Dimensional ◽  
Current Trends ◽  
Safety And Toxicity

Abstract Applications of nanotechnology in biomedical engineering are vast and span several interdisciplinary areas of nanomedicine, diagnostics, and nanotheranostics. Herein, we provide a brief perspective on nanotechnology as an enabling tool for the design of new functional materials and devices for medical applications. Semiconductor nanocrystals, also known as quantum dots, are commonly used in optical imaging to diagnose diseases such as cancer. Varieties of metal and metal oxide nanoparticles, and two-dimensional carbon-based nanostructures, are prospective therapeutics and may also be used in protective antiviral/antibacterial applications. Similarly, a number of nanomaterials have shown the potential to overcome the drawbacks of conventional antiviral drugs. However, assessing the adverse effects and toxicities of nanoparticles in medicine and therapeutics is becoming more critical. This article discusses the latest developments of nanomaterials in diagnosis, nanotheranostics, and nanomedicines, with particular emphasis on the importance of nanomaterials in fighting against coronavirus disease. Further, we considered the safety and toxicity of nanomaterials in the context of biomedical applications. Finally, we provided our perspective on the future of nanotechnology in emerging biomedical engineering fields.

scholarly journals Engineering bioactive synthetic polymers for biomedical applications: A review with emphasis on tissue engineering and controlled release

2021 ◽  
Author(s):  
Edna Johana Bolívar-Monsalve ◽  
Mario Moises Álvarez ◽  
Samira Hosseini ◽  
Michelle Alejandra Espinosa-Hernandez ◽  
Carlos Fernando Ceballos-González ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Controlled Release ◽  
Biomedical Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Synthetic Polymers

Synthetic polymers (SyPs) have found many relevant applications niches in biomedical engineering. Their mechanical properties, defined chemical structure, batch to batch consistency are attractive features that render them superior (at...

Sign in / Sign up

Export Citation Format

Share Document