A robust and refillable magnetic sponge capsule for remotely triggered drug release

Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.

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Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release

Advances in Materials Science and Engineering ◽

10.1155/2014/169210 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Ranran Zhang ◽

Risheng Yao ◽

Binbin Ding ◽

Yuxin Shen ◽

Shengwen Shui ◽

...

Keyword(s):

Drug Release ◽

Near Infrared ◽

Uv Light ◽

Nile Red ◽

Controlled Drug Release ◽

Hybrid Nanoparticles ◽

Infrared Light ◽

Nir Light ◽

Triggered Drug Release ◽

Model Drug

Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release. Two strategies may solve the problem: one is to improve the sensitivity of the nanocarriers to light to decrease the radiation time; the other one is using more friendly light as the trigger. In this work, we fabricated a core-shell hybrid nanoparticle with an upconverting nanoparticle (UCNP) as the core and thermo- and light-responsive block copolymers as the shell to combine the two strategies together. The results indicated that the sensitivity of the block copolymer to light could be enhanced by decreasing the photolabile moieties in the polymer, and the UCNP could transfer near-infrared (NIR) light, which is more friendly to tissue and cell, to UV light to trigger the phase conversion of the block polymersin situ. Using Nile Red (NR) as the model drug, the hybrid nanoparticles were further proved to be able to act as carriers with the character of NIR triggered drug release.

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Near-infrared light-controlled drug release and cancer therapy with polymer-caged upconversion nanoparticles

RSC Advances ◽

10.1039/c4ra12678e ◽

2015 ◽

Vol 5 (7) ◽

pp. 5269-5276 ◽

Cited By ~ 28

Author(s):

Qingjian Xing ◽

Najun Li ◽

Yang Jiao ◽

Dongyun Chen ◽

Jiaying Xu ◽

...

Keyword(s):

Cancer Therapy ◽

Drug Release ◽

Self Assembly ◽

Near Infrared ◽

Controlled Drug Release ◽

Infrared Light ◽

Upconversion Nanoparticles ◽

Assembly Process ◽

The Core ◽

Triggered Drug Release

The core–shell nanocarrier, based on spiropyran-containing copolymer coated upconversion nanocomposites, was successfully prepared via a facile self-assembly process for NIR-triggered drug release and cancer therapy.

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A Novel Fluoride Anion Modified Gelatin Nanogel System

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/j3988j ◽

2008 ◽

Vol 11 (4) ◽

pp. 32 ◽

Cited By ~ 14

Author(s):

Daocheng Wu ◽

Mingxi Wan

Keyword(s):

Drug Release ◽

High Performance ◽

Average Diameter ◽

Controlled Drug Release ◽

Correlation Spectroscopy ◽

Precipitation Method ◽

Fluoride Anion ◽

Size Change ◽

Triggered Drug Release ◽

Ultrasound Generator

Purpose. Controlled drug release, especially tumor-targeted drug release, remains a great challenge. Here, we prepare a novel fluoride anion-modified gelatin nanogel system and investigate its characteristics of ultrasound-triggered drug release. Methods. Adriamycin gelatin nanogel modified with fluoride anion (ADM-GNMF) was prepared by a modified co-precipitation method with fluoride anion and sodium sulfate. The loading and encapsulation efficiency of the anti-neoplastic agent adriamycin (ADM) were measured by high performance liquid chromatography (HPLC). The size and shape of ADM-GNMF were determined by electron microscopy and photo-correlation spectroscopy. The size distribution and drug release efficiency of ADM-GNMF, before and after sonication, were measured by two designed measuring devices that consisted of either a submicron particle size analyzer and an ultrasound generator as well as an ultrasound generator, automatic sampler, and HPLC. Results. The ADM-GNMF was stable in solution with an average diameter of 46±12 nm; the encapsulation and loading efficiency of adriamycin were 87.2% and 6.38%, respectively. The ultrasound-triggered drug release and size change were most efficient at a frequency of 20 kHz, power density of 0.4w/cm2, and a 1~2 min duration. Under this ultrasound-triggered condition, 51.5% of drug in ADM-GNMF was released within 1~2 min, while the size of ADM-GNMF changed from 46 ± 12 nm to 1212 ± 35 nm within 1~2 min of sonication and restored to its previous size in 2~3 min after the ultrasound stopped. In contrast, 8.2% of drug in ADM-GNMF was released within 2~3 min without sonication, and only negligible size changes were found. Conclusions. The ADM-GNMF system efficiently released the encompassed drug in response to ultrasound, offering a novel and promising controlled drug release system for targeted therapy for cancer or other diseases.

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Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications

Materials ◽

10.3390/ma12162521 ◽

2019 ◽

Vol 12 (16) ◽

pp. 2521 ◽

Cited By ~ 4

Author(s):

Valentina Grumezescu ◽

Oana Gherasim ◽

Irina Negut ◽

Stefan Banita ◽

Alina Maria Holban ◽

...

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Cellular Adhesion ◽

Bioactive Materials ◽

External Stimulation ◽

Composite Microspheres ◽

Nanostructured Composite ◽

Release Studies ◽

Microbial Strains ◽

Triggered Drug Release

We report on the synthesis and evaluation of biopolymeric spheres of poly(lactide-co-glycolide) containing different amounts of magnetite nanoparticles and Ibuprofen (PLGA-Fe3O4-IBUP), but also chitosan (PLGA-CS-Fe3O4-IBUP), to be considered as drug delivery systems. Besides morphological, structural, and compositional characterizations, the PLGA-Fe3O4-IBUP composite microspheres were subjected to drug release studies, performed both under biomimetically-simulated dynamic conditions and under external radiofrequency magnetic fields. The experimental data resulted by performing the drug release studies evidenced that PLGA-Fe3O4-IBUP microspheres with the lowest contents of Fe3O4 nanoparticles are optimal candidates for triggered drug release under external stimulation related to hyperthermia effect. The as-selected microspheres and their chitosan-containing counterparts were biologically assessed on macrophage cultures, being evaluated as biocompatible and bioactive materials that are able to promote cellular adhesion and proliferation. The composite biopolymeric spheres resulted in inhibited microbial growth and biofilm formation, as assessed against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans microbial strains. Significantly improved antimicrobial effects were reported in the case of chitosan-containing biomaterials, regardless of the microorganisms’ type. The nanostructured composite biopolymeric spheres evidenced proper characteristics as prolonged and controlled drug release platforms for multipurpose biomedical applications.

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Evaluation of Swelling Process of Various Natural Polymer Matrix Tablets by X-ray Computed Tomography and Their Controlled Drug Release

10.26226/morressier.57d6b2bbd462b8028d88d91d ◽

2016 ◽

Author(s):

Makoto Otsuka

Keyword(s):

Computed Tomography ◽

Drug Release ◽

Polymer Matrix ◽

Controlled Drug Release ◽

Matrix Tablets ◽

Natural Polymer ◽

X Ray ◽

X Ray Computed

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Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

Revista de Chimie ◽

10.37358/rc.17.12.6008 ◽

2018 ◽

Vol 68 (12) ◽

pp. 2925-2918

Author(s):

Gabriela Cioca ◽

Maricel Agop ◽

Marcel Popa ◽

Simona Bungau ◽

Irina Butuc

Keyword(s):

Drug Release ◽

Tannic Acid ◽

Release Rate ◽

Controlled Drug Release ◽

Toxicity Threshold ◽

Release System ◽

Liposomal Formulations ◽

Cross Linker ◽

Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

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Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

Current Nanoscience ◽

10.2174/1573413714666180222134742 ◽

2018 ◽

Vol 14 (5) ◽

pp. 432-439 ◽

Cited By ~ 1

Author(s):

Juliana M. Juarez ◽

Jorgelina Cussa ◽

Marcos B. Gomez Costa ◽

Oscar A. Anunziata

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Therapeutic Efficacy ◽

Drug Delivery Systems ◽

Controlled Drug Release ◽

Delivery Systems ◽

The Body ◽

Fickian Diffusion ◽

Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

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