Isomeric control of the mechanical properties of supramolecular filament hydrogels

2018 ◽  
Vol 6 (1) ◽  
pp. 216-224 ◽  
Author(s):  
Yi-An Lin ◽  
Myungshim Kang ◽  
Wei-Chiang Chen ◽  
Yu-Chuan Ou ◽  
Andrew G. Cheetham ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Fine Tuning ◽  
Great Promise ◽  
Network Structures ◽  
Peptide Design

Supramolecular filament hydrogels are an emerging class of biomaterials that hold great promise for regenerative medicine, tissue engineering, and drug delivery. The use of isomeric hydrocarbons in the peptide design enables fine-tuning of the mechanical properties of their supramolecular filament hydrogels without altering their network structures.

Hydrogels as Antibacterial Biomaterials

2018 ◽  
Vol 24 (8) ◽  
pp. 843-854 ◽  
Author(s):  
Weiguo Xu ◽  
Shujun Dong ◽  
Yuping Han ◽  
Shuqiang Li ◽  
Yang Liu
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Oxygen Permeability ◽  
Structural Diversity ◽  
High Water ◽  
Clinical Applications ◽  
High Water Content ◽  
Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

scholarly journals Stress relaxation in tunable gels

Soft Matter ◽  
2021 ◽  
Author(s):  
Chiara Raffaelli ◽  
Wouter G Ellenbroek
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Stress Relaxation

Hydrogels are a staple of biomaterials development. Optimizing their use in e.g. drug delivery or tissue engineering requires a solid understanding of how to adjust their mechanical properties. Here, we...

scholarly journals Surface Modification of Bacterial Cellulose for Biomedical Applications

2022 ◽  
Vol 23 (2) ◽  
pp. 610
Author(s):  
Teresa Aditya ◽  
Jean Paul Allain ◽  
Camilo Jaramillo ◽  
Andrea Mesa Restrepo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Surface Modification ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Human Tissues ◽  
Naturally Occurring ◽  
Microstructure And Mechanical Properties

Bacterial cellulose is a naturally occurring polysaccharide with numerous biomedical applications that range from drug delivery platforms to tissue engineering strategies. BC possesses remarkable biocompatibility, microstructure, and mechanical properties that resemble native human tissues, making it suitable for the replacement of damaged or injured tissues. In this review, we will discuss the structure and mechanical properties of the BC and summarize the techniques used to characterize these properties. We will also discuss the functionalization of BC to yield nanocomposites and the surface modification of BC by plasma and irradiation-based methods to fabricate materials with improved functionalities such as bactericidal capabilities.

Aerogels for Biomedical Applications

2021 ◽  
pp. 23-42
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Biomedical Applications ◽  
Implantable Devices ◽  
Strategic Development ◽  
The World ◽  
Biomedical Field ◽  
Materials Used

The researchers across the world are actively engaged in strategic development of new porous aerogel materials for possible application of these extraordinary materials in the biomedical field. Due to their excellent porosity and established biocompatibility, aerogels are now emerging as viable solutions for drug delivery and other biomedical applications. This chapter aims to cover the diverse aerogel materials used across the globe for different biomedical applications including drug delivery, implantable devices, regenerative medicine encompassing tissue engineering and bone regeneration, and biosensing.

scholarly journals Marine Algae Polysaccharides as Basis for Wound Dressings, Drug Delivery, and Tissue Engineering: A Review

2020 ◽  
Vol 8 (7) ◽  
pp. 481 ◽  
Author(s):  
Tatyana A. Kuznetsova ◽  
Boris G. Andryukov ◽  
Natalia N. Besednova ◽  
Tatyana S. Zaporozhets ◽  
Andrey V. Kalinin
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Wound Dressing ◽  
Biological Properties ◽  
Wound Dressings ◽  
Tissue Engineering Scaffolds ◽  
Treatment Of Wounds ◽  
New Generation ◽  
Dressing Materials

The present review considers the physicochemical and biological properties of polysaccharides (PS) from brown, red, and green algae (alginates, fucoidans, carrageenans, and ulvans) used in the latest technologies of regenerative medicine (tissue engineering, modulation of the drug delivery system, and the design of wound dressing materials). Information on various types of modern biodegradable and biocompatible PS-based wound dressings (membranes, foams, hydrogels, nanofibers, and sponges) is provided; the results of experimental and clinical trials of some dressing materials in the treatment of wounds of various origins are analyzed. Special attention is paid to the ability of PS to form hydrogels, as hydrogel dressings meet the basic requirements set out for a perfect wound dressing. The current trends in the development of new-generation PS-based materials for designing drug delivery systems and various tissue-engineering scaffolds, which makes it possible to create human-specific tissues and develop target-oriented and personalized regenerative medicine products, are also discussed.

scholarly journals Status of Plant Protein-Based Green Scaffolds for Regenerative Medicine Applications

Biomolecules ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 619 ◽  
Author(s):  
Jahangirian ◽  
Azizi ◽  
Rafiee-Moghaddam ◽  
Baratvand ◽  
Webster
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Review Paper ◽  
Wheat Gluten ◽  
Environmentally Friendly ◽  
Plant Proteins ◽  
Current Review ◽  
Biodegradable Scaffolds ◽  
New Strategy

In recent decades, regenerative medicine has merited substantial attention from scientific and research communities. One of the essential requirements for this new strategy in medicine is the production of biocompatible and biodegradable scaffolds with desirable geometric structures and mechanical properties. Despite such promise, it appears that regenerative medicine is the last field to embrace green, or environmentally-friendly, processes, as many traditional tissue engineering materials employ toxic solvents and polymers that are clearly not environmentally friendly. Scaffolds fabricated from plant proteins (for example, zein, soy protein, and wheat gluten), possess proper mechanical properties, remarkable biocompatibility and aqueous stability which make them appropriate green biomaterials for regenerative medicine applications. The use of plant-derived proteins in regenerative medicine has been especially inspired by green medicine, which is the use of environmentally friendly materials in medicine. In the current review paper, the literature is reviewed and summarized for the applicability of plant proteins as biopolymer materials for several green regenerative medicine and tissue engineering applications.

scholarly journals Recent advances on polydiacetylene-based smart materials for biomedical applications

2020 ◽  
Vol 4 (4) ◽  
pp. 1089-1104 ◽  
Author(s):  
Fang Fang ◽  
Fanling Meng ◽  
Liang Luo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Recent Advances ◽  
Smart Biomaterials

This review summarized most recent advances of designing strategies of polydiacetylene-based smart biomaterials with unique colorimetric and mechanical properties, as well as their applications in biosensing, drug delivery, and tissue engineering.

scholarly journals Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering

MRS Advances ◽  
2017 ◽  
Vol 2 (24) ◽  
pp. 1309-1314 ◽  
Author(s):  
Pengfei Duan ◽  
Nehir Kandemir ◽  
Jiajun Wang ◽  
Jinju Chen
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Rheological Characteristics ◽  
Scaffold Material ◽  
Rheological Characterization ◽  
Frequency Sweep ◽  
Strain Sweep

ABSTRACTHydrogels have been widely used in many applications from tissue engineering to drug delivery systems. For both tissue engineering and drug delivery, the mechanical properties are important because they would affect cell-materials interactions and injectability of drugs encapsulated in hydrogel carriers. Therefore, it is important to study the mechanical properties of these hydrogels, particularly at physiological temperature (37°C). This study adopted strain sweep and frequency sweep rotational rheological tests to investigate the rheological characteristics of various tissue engineering relevant hydrogels with different concentrations at 37°C. These hydrogels include alginate, RGD-alginate, and copolymerized collagen/alginate/fibrin. It has revealed that the addition of RGD has negligible effect on the elastic modulus and viscosity of alginate. Alginate gels have demonstrated shear thinning behavior which indicates that they are suitable candidates as carriers for cells or drug delivery. The addition of collagen and fibrin would reinforce the mechanical properties of alginate which makes it a strong scaffold material.

Biodegradable polymeric nanostructures in therapeutic applications: opportunities and challenges

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 94325-94351 ◽  
Author(s):  
S. K. Shukla ◽  
Sudheesh K. Shukla ◽  
Penny P. Govender ◽  
N. G. Giri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Great Promise ◽  
Therapeutic Applications

Biodegradable polymeric nanostructures (BPNs) have shown great promise in different therapeutic applications such as diagnosis, imaging, drug delivery, cosmetics, organ implants, and tissue engineering.

scholarly journals A Precised Surface Modification of Hydroxyapatite with Poly(methylmethacrylate) for Tissue Engineering & Regenerative Medicine

2019 ◽  
Vol 31 (3) ◽  
pp. 545-550
Author(s):  
Trinh Duy Nguyen ◽  
Phu Thuong Nhan Nguyen ◽  
Thien Hien Tran ◽  
Md. Rafiqul Islam ◽  
Kwon Taek Lim ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Radical Polymerization ◽  
Colloidal Stability ◽  
Hybrid Nanocomposites ◽  
Great Promise ◽  
Dsc Studies ◽  
One Step ◽  
Grafting From ◽  
Hydroxyapatite Nanocrystals

The poly(methylmethacrylate) (PMMA) grafted biocompatible hydroxyapatite nanocrystals (HAPs) hybrid nanocomposites (PMMA-g-HAPs) were synthesized by employing surface thiol-lactam initiated radical polymerization (TLIRP) through grafting from strategy. At first, the surface of HAPs was functionalized by 3-mercaptopropyl-trimethoxysilane in one-step process to prepare thiol immobilized HAPs (HAPs-SH). Subsequently, a controlled radical polymerization of MMA by using two component initiating system comprising of HAPs-SH and butyrolactam (BL) successfully afforded PMMA-g-HAPs nanocomposites. The resulting structure and morphological feature of nanocomposites was systematically characterized by FT-IR and XRD analyses. GPC studies of cleaved polymers from nanocomposites of different time revealed that the grafting polymerization from the surface of HAP was well controlled in nature. Moreover, the thermal property of the PMMA was found to be improved by incorporation of inorganic HAP nanoparticles in the polymer matrix as revealed by TGA and DSC studies. The colloidal stability of the synthesized nanocomposites was observed to be exceptionally good in organic solvents as suggested by the time dependent monitoring using UV-visible spectroscopy and captured digital photographs. The synthesized nanocomposites show a great promise for the safe application in tissue engineering and regenerative medicine.

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