scholarly journals Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective

2018 ◽  
Vol 7 (3) ◽  
pp. 347-357 ◽  
Author(s):  
Toby J. Athersuch ◽  
Daniel J. Antoine ◽  
Alan R. Boobis ◽  
Muireann Coen ◽  
Ann K. Daly ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Therapeutic Use ◽  
Therapeutic Interventions ◽  
Considerable Research ◽  
The Subject ◽  
The Uk ◽  
Paracetamol Metabolism

After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen,N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity.

scholarly journals What’s in it for the animals? Symbiotically considering ‘therapeutic’ human-animal relations within spaces and practices of care farming

2019 ◽  
Vol 45 (3) ◽  
pp. 313-325 ◽  
Author(s):  
Richard Gorman
Keyword(s):  
Empirical Study ◽  
Human Health ◽  
Therapeutic Intervention ◽  
Therapeutic Use ◽  
Therapeutic Interventions ◽  
Farming Practices ◽  
Perspective Drawing ◽  
Human Animal ◽  
The Uk ◽  
Care Farming

Human-animal relations are increasingly imbricated, encountered and experienced in the production of medicine and health. Drawing on an empirical study of care farms in the UK, this article uses the language of symbiosis to develop a framework for critically considering the relationships enrolled within interspecies therapeutic practices. Care farming is an emerging paradigm that aims to deploy farming practices as a form of therapeutic intervention, with human-animal relations framed as providing important opportunities for human health. This article moves to attend to multispecies therapeutic interventions and relationships from a more-than-human perspective, drawing attention to the often-troubling anthropocentrism in which such practices are framed and performed. Attempting to perform and realise human imaginations of ‘therapeutic’ affects, spaces and relationships can rely on processes that reduce animals’ own opportunities for flourishing. Yet, the therapeutic use of other species does not have to be forever anthropocentric or utilitarian. The article explores whether relations between humans and animals might result in a level of mutual proliferation of affective capacities, reciprocally beneficial. These human-animal entanglements highlight opportunities to think more critically about how to practice interspecies relationships and practices in ways that are less parasitic, and instead framed more by attempts at producing opportunities for mutualistic flourishing.

Traditional knowledge and satellite tracking as complementary approaches to ecological understanding

2004 ◽  
Vol 31 (3) ◽  
pp. 177-180 ◽  
Author(s):  
HENRY P. HUNTINGTON ◽  
ROBERT S. SUYDAM ◽  
DANIEL H. ROSENBERG
Keyword(s):  
Environmental Management ◽  
Traditional Knowledge ◽  
Scientific Knowledge ◽  
Spatial Scales ◽  
Satellite Tracking ◽  
Migratory Species ◽  
Ecological Understanding ◽  
Considerable Research ◽  
The Subject ◽  
Management And Conservation

The integration or co-application of traditional knowledge and scientific knowledge has been the subject of considerable research and discussion (see Johannes 1981; Johnson 1992; Stevenson 1996; McDonald et al. 1997; Huntington et al. 1999, 2002), with emphasis on various specific topics including environmental management and conservation (see Freeman & Carbyn 1988; Ferguson & Messier 1997; Ford & Martinez 2000; Usher 2000; Albert 2001). In most cases, examples of successful integration compare traditional and scientific observations at similar spatial scales to increase confidence in understanding or to fill gaps that appear from either perspective. We present a different approach to integration, emphasizing complementarity rather than concordance in spatial perspective, using two migratory species as examples.

scholarly journals Classification and infection mechanism of entomopathogenic fungi

2018 ◽  
Vol 84 (0) ◽  
Author(s):  
Margy Alejandra Esparza Mora ◽  
Alzimiro Marcelo Conteiro Castilho ◽  
Marcelo Elias Fraga
Keyword(s):  
Biological Control ◽  
Entomopathogenic Fungi ◽  
Mode Of Action ◽  
Insect Cuticle ◽  
Biological Control Agents ◽  
Intensive Research ◽  
Infection Mechanism ◽  
The World ◽  
The Subject

ABSTRACT: Entomopathogenic fungi are important biological control agents throughout the world, have been the subject of intensive research for more than 100 years, and can occur at epizootic or enzootic levels in their host populations. Their mode of action against insects involves attaching a spore to the insect cuticle, followed by germination, penetration of the cuticle, and dissemination inside the insect. Strains of entomopathogenic fungi are concentrated in the following orders: Hypocreales (various genera), Onygenales (Ascosphaera genus), Entomophthorales, and Neozygitales (Entomophthoromycota).

The Lived Experience of Financialization at the UK Financial Fringe

2021 ◽  
pp. 1-22
Author(s):  
LINDSEY APPLEYARD ◽  
CARL PACKMAN ◽  
JORDON LAZELL ◽  
HUSSAN ASLAM
Keyword(s):  
Lived Experience ◽  
Financial Services ◽  
Global Financial Crisis ◽  
Credit Market ◽  
Short Term ◽  
Dramatic Decline ◽  
The Everyday ◽  
The Subject ◽  
The Uk ◽  
The Impact

Abstract The financialization of everyday life has received considerable attention since the 2008 global financial crisis. Financialization is thought to have created active financial subjects through the ability to participate in mainstream financial services. While the lived experience of these mainstream financial subjects has been the subject of close scrutiny, the experiences of financial subjects at the financial fringe have been rarely considered. In the UK, for example, the introduction of High-Cost, Short-Term Credit [HCSTC] or payday loan regulation was designed to protect vulnerable people from accessing unaffordable credit. Exploring the impact of HCSTC regulation is important due to the dramatic decline of the high-cost credit market which helped meet essential needs in an era of austerity. As such, the paper examines the impact of the HCSTC regulation on sixty-four financially marginalized individuals in the UK that are unable to access payday loans. First, we identify the range of socioeconomic strategies that individuals employ to manage their finances to create a typology of financial subjectivity at the financial fringe. Second, we demonstrate how the temporal and precarious nature of financial inclusion at the financial fringe adds nuance to existing debates of the everyday lived experience of financialization.

European Union Law

2021 ◽  
Author(s):  
Margot Horspool ◽  
Matthew Humphreys ◽  
Michael Wells-Greco
Keyword(s):  
European Union ◽  
Environmental Law ◽  
Research Topics ◽  
European Union Law ◽  
European Institutions ◽  
The Subject ◽  
Free Movement Of Goods ◽  
The Uk ◽  
Substantive Law ◽  
The Eu

Titles in the Core Text series take the reader straight to the heart of the subject, providing focused, concise and reliable guides for students at all levels. The eleventh edition of European Union Law provides a systematic overview of the European institutions and offers thorough, wide-ranging coverage of the key substantive law topics, including separate chapters on competition, discrimination, environmental law and services. It also features a new chapter on the EU and its relationship with third countries, including the UK. Incisive analysis of the governing themes and principles of EU law is consistently delivered, while chapter summaries, critical questions, further reading suggestions and the new ‘Brexit checklist’ feature help to guide the reader through the subject and support further research. Topics covered also include supremacy and direct effect, the European Courts, general principles, free movement of goods and persons and citizenship.

scholarly journals Macroeconomic Modelling at the Institute: Hopes, Challenges and a Lasting Contribution

2018 ◽  
Vol 246 ◽  
pp. R3-R14 ◽  
Author(s):  
Ray Barrell ◽  
Andy Blake ◽  
Garry Young
Keyword(s):  
Global Economy ◽  
Early Years ◽  
Macroeconomic Models ◽  
Macroeconomic Modelling ◽  
New Frontier ◽  
New Ideas ◽  
The Subject ◽  
The Uk ◽  
Economic Forecasts ◽  
Modelling And Forecasting

The Institute is a world leader in macroeconomic modelling and forecasting. It has produced quarterly economic forecasts for around sixty years, supported by macroeconomic models. The aim of the original builders of macroeconomic models was to transform understanding of how economies worked and use that knowledge to improve economic policy. In the early years, when computers were rare, macroeconomic modelling was a new frontier and Institute economists were among the first to produce a working model of the UK economy. It is remarkable how quickly models were being used to produce forecasts, assess policy and influence the international macroeconomic research agenda. The models built at the Institute were mainstream in the sense that they followed the contents of standard macroeconomic textbooks, developed with the subject, and fitted the facts as they were known at the time. There were continual improvements in understanding as the subject developed in response to new ideas and developments in the global economy. This article celebrates the development of macroeconomic modelling at the Institute and the contribution it has made to public life.

scholarly journals ICD, Mental Disorder and British Nosologists: An assessment of the uniquely British contribution to psychiatric classification

1994 ◽  
Vol 165 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Michael Shepherd
Keyword(s):  
North America ◽  
Mental Disorder ◽  
Historical Survey ◽  
Psychiatric Classification ◽  
The Subject ◽  
The Uk ◽  
National Systems ◽  
The Way

During several recent international meetings on classification, there have been frequent references to national systems of classification developed and used in Europe, North America and many other countries. The UK has been notably absent from this list. As Professor Kendell, in his brief historical survey of the subject, points out: “British psychiatry does not have, and indeed never has had, any important diagnostic concepts of its own in the way that French, American, and Scandinavian psychiatry still do” (Kendell, 1985).

The State of the Art in Management Education Applicable to Aerospace Activities

1967 ◽  
Vol 71 (677) ◽  
pp. 344-348
Author(s):  
J. V. Connolly
Keyword(s):  
Management Education ◽  
State Of The Art ◽  
Aerospace Industry ◽  
List Type ◽  
Industrial Training ◽  
The Past ◽  
The Subject ◽  
Economic Necessity ◽  
The Uk ◽  
The Impact

During the past two years, there has been a sharp acceleration to the interest which industry has displayed in the subject of management education. This can be attributed to these factors: —(a) A more widespread realisation of the gap developing between the UK and a number of foreign economies, as manifested by diverging rates of the major economic indicators.(b) The attainment of top-management responsibilities by a younger generation of managers, many of whom had been given some earlier training and who were more conscious of its value than the incumbents of the job from earlier generations.(c) The publication of the Franks, Robbins and (in the aerospace industry) the Plowden reports.(d) The impact of the Industrial Training Boards making it manifest, in terms of serious levies, that training was an economic necessity and therefore must be investigated thoroughly.Notwithstanding the widespread awakening of interest, it is very belated and sets numerous problems. The problems are in two areas—scale and quality.

scholarly journals Variability in Pavement Design

2015 ◽  
Vol 16 (2) ◽  
pp. 50-67 ◽  
Author(s):  
Paola Dalla Valle ◽  
Nick Thom
Keyword(s):  
Pavement Design ◽  
Pavement Performance ◽  
Design Parameters ◽  
Probability Density Distribution ◽  
Analysis And Design ◽  
The Subject ◽  
The Mean ◽  
Subgrade Modulus ◽  
Input Variables ◽  
The Uk

Abstract This paper presents the results of a review on variability of key pavement design input variables (asphalt modulus and thickness, subgrade modulus) and assesses effects on pavement performance (fatigue and deformation life). Variability is described by statistical terms such as mean and standard deviation and by its probability density distribution. The subject of reliability in pavement design has pushed many highway organisations around the world to review their design methodologies, mainly empirical, to move towards mechanistic-empirical analysis and design which provide the tools for the designer to evaluate the effect of variations in materials on pavement performance. This research has reinforced this need for understanding how the variability of design parameters affects the pavement performance. This study has only considered flexible pavements. The sites considered for the analysis, all in the UK (including Northern Ireland), were mainly motorways or major trunk roads. Pavement survey data analysed were for Lane 1, the most heavily trafficked lane. Sections 1km long were considered wherever possible. Statistical characterisation of the variation of layer thickness, asphalt stiffness and subgrade stiffness is addressed. A sensitivity analysis is then carried out to assess which parameter(s) have the greater influence on the pavement life. The research shows that, combining the effect of all the parameters considered, the maximum range of 15th and 85th percentiles (as percentages of the mean) was found to be 64% to 558% for the fatigue life and 94% to 808% for the deformation life.

scholarly journals RUDRA PARPATI: AN AYURVEDIC HERBO – MINERAL DRUG REVIEW

2021 ◽  
Vol 9 (8) ◽  
pp. 1819-1823
Author(s):  
Priyanka. B. Patil ◽  
Usha M ◽  
Ravi R Chavan
Keyword(s):  
Mode Of Action ◽  
Medical Literature ◽  
Review Article ◽  
The Internet ◽  
Pharmacological Properties ◽  
Review Articles ◽  
Therapeutic Uses ◽  
The Subject ◽  
Subject Material ◽  
Drug Review

The main objective of this review article is to discuss the therapeutic uses of Rudra Parpati and to discuss the different pharmacological properties and therapeutic uses of isolated constituent drugs of Rudra Parpati. The authentic subject material has been reviewed from Ayurveda and modern medical literature. Different research and review articles were searched in different journals. The subject material has also been searched on the internet. This review is mainly focused on different aspects of herbo mineral Ayurvedic formulation Rudra Parpati. Parpati rasayana is one among Chaturvidha Rasayana Kalpa which is very effective and can be prepared with less effort. In Ayurveda Rudra Parpati is mentioned in the management of Kasa/cough. Though it is popular as only Parpati used in Kharapaka form & having an indication other than Grahani but still an unexplored treasure with unique therapeutic utility. Hence an attempt has been made to address the therapeutic uses of Rudra Parpati and the probable mode of action of its constituent drugs. Keywords: Rudraparpati, Vataja Kasa.

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