Antibody modified gold nanoparticles for fast colorimetric screening of rheumatoid arthritis

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with RA continue to have inadequate response to therapies, or intolerable side effects, with resultant progression of their disease. In this review, we detail multiple biomolecular pathways involved in RA disease pathogenesis to elucidate and highlight pathways that have been therapeutic targets in managing this systemic autoimmune disease. Here we present an up-to-date accounting of both emerging and approved pharmacological treatments for RA, detailing their discovery, mechanisms of action, efficacy, and limitations. Finally, we turn to the emerging fields of bioengineering and cell therapy to illuminate possible future targeted therapeutic options that combine material and biological sciences for localized therapeutic action with the potential to greatly reduce side effects seen in systemically applied treatment modalities.

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Current Therapeutic Options in the Treatment of Rheumatoid Arthritis

Journal of Clinical Medicine ◽

10.3390/jcm8070938 ◽

2019 ◽

Vol 8 (7) ◽

pp. 938 ◽

Cited By ~ 17

Author(s):

Köhler ◽

Günther ◽

Kaudewitz ◽

Lorenz

Keyword(s):

Rheumatoid Arthritis ◽

Autoimmune Disease ◽

Disease Activity ◽

Physical Function ◽

Chronic Inflammation ◽

Early Treatment ◽

Joint Destruction ◽

Therapeutic Options ◽

Systemic Autoimmune Disease ◽

Control Disease

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints. Untreated RA leads to a destruction of joints through the erosion of cartilage and bone. The loss of physical function is the consequence. Early treatment is important to control disease activity and to prevent joint destruction. Nowadays, different classes of drugs with different modes of action are available to control the inflammation and to achieve remission. In this review, we want to discuss differences and similarities of these different drugs.

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Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells

International Journal of Molecular Sciences ◽

10.3390/ijms23020905 ◽

2022 ◽

Vol 23 (2) ◽

pp. 905

Author(s):

Sunhee Jang ◽

Eui-Jong Kwon ◽

Jennifer Jooha Lee

Keyword(s):

Rheumatoid Arthritis ◽

T Cells ◽

Autoimmune Disease ◽

Immune Cells ◽

Cartilage Destruction ◽

Systemic Autoimmune Disease ◽

Pannus Formation ◽

Systemic Complications ◽

Tissue Proliferation ◽

Novel Therapeutic

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets.

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Image Processing Techniques for ROI Identification in Rheumatoid Arthritis Patients from Thermal Images

Acta Mechanica et Automatica ◽

10.2478/ama-2018-0008 ◽

2018 ◽

Vol 12 (1) ◽

pp. 49-53 ◽

Cited By ~ 1

Author(s):

Agnieszka Wasilewska ◽

Jolanta Pauk ◽

Mikhail Ihnatouski

Keyword(s):

Rheumatoid Arthritis ◽

Soft Tissues ◽

Cold Water ◽

Water Immersion ◽

Joint Inflammation ◽

Cold Water Immersion ◽

Thermal Recovery ◽

Systemic Autoimmune Disease ◽

The Moment ◽

Processing Techniques

AbstractRheumatoid arthritis (RA) is a systemic autoimmune disease that manifests itself by joint inflammation, swelling, pain, tenderness and may involve extra-articular organs in severe cases. Joint inflammatory lesions are associated with higher temperature due to increased vascularity in the area of inflamed tissues. This papers aimed to identify heat patterns from ROIs to interpret the presence of inflammation in rheumatoid arthritis patients. The thermovisual image sequences were collected from 65 patients with Rheumatoid Arthritis (RA). Infrared images were generated by a thermal scanning camera (FLIR E60bx Systems Inc., USA). Separate recordings of left and right foot temperature changes were performed for 3 minute periods. The temperature measurement was performed at the moment right after cold water immersion (post-cooling temperature) and at the moment after thermal recovery (post-recovery temperature). The recording of 3-minute foot thermal recovery was used for analysis. Automatically identified ROI corresponds to the area of the soft tissues covering cuboid and navicular bone.

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Diagnosis of rheumatoid arthritis

Spravočnik vrača obŝej praktiki (Journal of Family Medicine) ◽

10.33920/med-10-2003-03 ◽

2020 ◽

pp. 29-36

Author(s):

Lev Shlopak

Keyword(s):

Rheumatoid Arthritis ◽

Autoimmune Disease ◽

Connective Tissue ◽

Early Diagnosis ◽

Inflammatory Diseases ◽

Primary Lesion ◽

Systemic Autoimmune Disease ◽

Chronic Inflammatory Diseases

Rheumatoid arthritis is a chronic systemic autoimmune disease of the connective tissue, accompanied by a primary lesion of peripheral joints with the development of erosive-destructive changes and ankylosis. It is one of the most common chronic inflammatory diseases in humans. Early diagnosis of this pathology contributes to the timely start of therapy, which allows to reduce the level of disability and improve the prognosis for this group of patients.

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Mast Cells in Early Rheumatoid Arthritis

International Journal of Molecular Sciences ◽

10.3390/ijms20082040 ◽

2019 ◽

Vol 20 (8) ◽

pp. 2040 ◽

Cited By ~ 7

Author(s):

Felice Rivellese ◽

Francesca Wanda Rossi ◽

Maria Rosaria Galdiero ◽

Costantino Pitzalis ◽

Amato de Paulis

Keyword(s):

Rheumatoid Arthritis ◽

Innate Immunity ◽

Mast Cells ◽

Autoimmune Disease ◽

Animal Models ◽

Immune Cells ◽

Systemic Autoimmune Disease ◽

Disease Development ◽

Early Ra ◽

Contradictory Data

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial membrane, with thickening of the synovial layer, cellular hyperplasia, and infiltration of immune cells. Mast cells (MCs) are cells of the innate immunity present in healthy synovia and part of the cellular hyperplasia characterizing RA synovitis. Although their presence in synovia has been well described, the exact functions and the correlation of MCs with disease development and progression have been debated, particularly because of contradictory data obtained in animal models and from patients with longstanding disease. Here, we present a revision of the literature on MCs in RA, including the most recent observations obtained from patients with early RA, indicating MCs as relevant markers of disease severity in early RA.

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Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

eLife ◽

10.7554/elife.01202 ◽

2013 ◽

Vol 2 ◽

Cited By ~ 849

Author(s):

Jose U Scher ◽

Andrew Sczesnak ◽

Randy S Longman ◽

Nicola Segata ◽

Carles Ubeda ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Intestinal Bacteria ◽

Joint Inflammation ◽

Systemic Autoimmune Disease ◽

Strongly Correlated ◽

16S Sequencing ◽

Chemically Induced ◽

Increased Sensitivity ◽

Stool Samples ◽

Genetic And Environmental Factors

Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inflammation. Here we performed 16S sequencing on 114 stool samples from rheumatoid arthritis patients and controls, and shotgun sequencing on a subset of 44 such samples. We identified the presence of Prevotella copri as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients. Increases in Prevotella abundance correlated with a reduction in Bacteroides and a loss of reportedly beneficial microbes in NORA subjects. We also identified unique Prevotella genes that correlated with disease. Further, colonization of mice revealed the ability of P. copri to dominate the intestinal microbiota and resulted in an increased sensitivity to chemically induced colitis. This work identifies a potential role for P. copri in the pathogenesis of RA.

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ROLE OF PANCHAKARMA IN MANAGEMENT OF RHEUMATOID ARTHRITIS

International Journal of Advanced Research ◽

10.21474/ijar01/12662 ◽

2021 ◽

Vol 9 (04) ◽

pp. 122-126

Author(s):

Panchola Priyanka ◽

◽

Joshi Neha ◽

Deepshikha a ◽

Garg G.P ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Autoimmune Disease ◽

Systemic Disease ◽

Modern Science ◽

Body Part ◽

The Body ◽

Systemic Autoimmune Disease ◽

Loss Of Function ◽

Abnormal Immune Response

Rheumatoid arthritis is a systemic autoimmune disease that causes chronic inflammation of the joints.It causes inflammation of the tissue around the joints. As the disease advancement, the inflamed synovium occupies and damages the cartilage and bone of the joint. An autoimmune disease is a condition characterized by an abnormal immune response to a normal body part. Because it can affect various organs of the body, rheumatoid arthritis is referred to as a systemic disease and ultimately called rheumatoid disease. In Ayurvedaamavata is correlated with rheumatoid arthritis. Vitiatedvata and ama plays major role in the manifestation of amavata. Improper digestion of Rasaadidhatu leads to the formation of ama. Vitiated ama leads swelling, pain, stiffness, in many joints along with loss of function. Modern science does not offer any cure of RA, the management aims are limited. This article reviews the line of treatment for the management of amavata described by Acharyachakradatta. It was concluded that rheumatoid arthritis can be completely cured or treated with Ayurveda medication and Panchakarma therapies without any side effects.

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Rheumatoid Arthritis and miRNAs: A Critical Review through a Functional View

Journal of Immunology Research ◽

10.1155/2018/2474529 ◽

2018 ◽

Vol 2018 ◽

pp. 1-16 ◽

Cited By ~ 31

Author(s):

Maria Cristina Moran-Moguel ◽

Stefania Petarra-del Rio ◽

Evangelina E. Mayorquin-Galvan ◽

Maria G. Zavala-Cerna

Keyword(s):

Rheumatoid Arthritis ◽

English Language ◽

Inflammatory Responses ◽

Joint Inflammation ◽

Response To Treatment ◽

Mirna Biogenesis ◽

Systemic Autoimmune Disease ◽

Future Research ◽

Translation Rate ◽

Micro Rnas

Rheumatoid arthritis (RA) is a systemic autoimmune disease with severe joint inflammation and destruction associated with an inflammatory environment. The etiology behind RA remains to be elucidated; most updated concepts include the participation of environmental, proteomic, epigenetic, and genetic factors. Epigenetic is considered the missing link to explain genetic diversification among RA patients. Within epigenetic factors participating in RA, miRNAs are defined as small noncoding molecules with a length of approximately 22 nucleotides, capable of gene expression modulation, either negatively through inhibition of translation and degradation of the mRNA or positively through increasing the translation rate. Over the last decade and due to the feasibility of the identification of miRNAs among different tissues and compartments, they have been proposed as biomarkers for diagnosis, prognosis, and response to treatment in different pathologies. Nevertheless, miRNAs seem to be important regulators of networks instead of single genes; their hypothetical use as biomarkers needs to rely on a functional integrative description of their effects in the biological process of autoimmune conditions which until now is missing. Therefore, we underwent a bibliographic search for review and original articles related to miRNAs and their possible implications in rheumatoid arthritis. We found 48 different studies using the key words “miRNAs” or “micro-RNAs” and “rheumatoid arthritis” with restriction of publication dates from 2011 to 2016, in humans, using the English language. After a critical reading, we provide in this paper a functional view with respect to miRNA biogenesis, interaction with targets that are expressed in specific cells and tissues, during different stages of inflammatory responses associated with RA, and recognized specific areas where miRNAs might also have a pathogenic role but remain undescribed. Our results will be useful in designing future research projects that can support miRNAs as biomarkers or therapeutic targets in RA.

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Systemic Manifestations and Complications in Patients with Rheumatoid Arthritis

Journal of Clinical Medicine ◽

10.3390/jcm9062008 ◽

2020 ◽

Vol 9 (6) ◽

pp. 2008

Author(s):

Ji-Won Kim ◽

Chang-Hee Suh

Keyword(s):

Rheumatoid Arthritis ◽

Autoimmune Disease ◽

Systemic Autoimmune Disease ◽

Systemic Manifestations

Rheumatoid arthritis (RA) is a systemic autoimmune disease with symmetrical peripheral polyarthritis, predominantly involving the small joints [...]

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