scholarly journals Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments

2021 ◽  
Author(s):  
Magdalena E. Zasłona ◽  
A. Michael Downey ◽  
Peter H. Seeberger ◽  
Oren Moscovitz
Keyword(s):  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
High Efficiency ◽  
Low Cost ◽  
Cost Effective ◽  
Human Pathogenic Bacteria ◽  
Effective Manner ◽  
Recent Developments ◽  
Synthetic Carbohydrate ◽  
Carbohydrate Vaccines

The importance of vaccine-induced protection was repeatedly demonstrated over the last three decades and emphasized during the recent COVID-19 pandemic as the safest and most effective way of preventing infectious diseases. Vaccines have controlled, and in some cases, eradicated global viral and bacterial infections with high efficiency and at a relatively low cost. Carbohydrates form the capsular sugar coat that surrounds the outer surface of human pathogenic bacteria. Specific surface-exposed bacterial carbohydrates serve as potent vaccine targets that broadened our toolbox against bacterial infections. Since first approved for commercial use, antibacterial carbohydrate-based vaccines mostly rely on inherently complex and heterogenous naturally derived polysaccharides, challenging to obtain in a pure, safe, and cost-effective manner. The introduction of synthetic fragments identical with bacterial capsular polysaccharides provided well-defined and homogenous structures that resolved many challenges of purified polysaccharides. The success of semisynthetic glycoconjugate vaccines against bacterial infections, now in different phases of clinical trials, opened up new possibilities and encouraged further development towards fully synthetic antibacterial vaccine solutions. In this mini-review, we describe the recent achievements in semi- and fully synthetic carbohydrate vaccines against a range of human pathogenic bacteria, focusing on preclinical and clinical studies.

scholarly journals Novel biotechnological approaches for monitoring and immunization against resistant to antibiotics Escherichia coli and other pathogenic bacteria

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
José E. Belizário ◽  
Marcelo P. Sircili
Keyword(s):  
Escherichia Coli ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Low Cost ◽  
Methyl Esters ◽  
Cost Effective ◽  
Antibiotic Use ◽  
Immunological Methods ◽  
Bacterial Strains ◽  
Surveillance Programs

Abstract The application of next-generation molecular, biochemical and immunological methods for developing new vaccines, antimicrobial compounds, probiotics and prebiotics for zoonotic infection control has been fundamental to the understanding and preservation of the symbiotic relationship between animals and humans. With increasing rates of antibiotic use, resistant bacterial infections have become more difficult to diagnose, treat, and eradicate, thereby elevating the importance of surveillance and prevention programs. Effective surveillance relies on the availability of rapid, cost-effective methods to monitor pathogenic bacterial isolates. In this opinion article, we summarize the results of some research program initiatives for the improvement of live vaccines against avian enterotoxigenic Escherichia coli using virulence factor gene deletion and engineered vaccine vectors based on probiotics. We also describe methods for the detection of pathogenic bacterial strains in eco-environmental headspace and aerosols, as well as samples of animal and human breath, based on the composition of volatile organic compounds and fatty acid methyl esters. We explain how the introduction of these low-cost biotechnologies and protocols will provide the opportunity to enhance co-operation between networks of resistance surveillance programs and integrated routine workflows of veterinary and clinical public health microbiology laboratories.

scholarly journals Chemical Modification of Combusted Coal Gangue for U(VI) Adsorption: Towards a Waste Control by Waste Strategy

2021 ◽  
Vol 13 (15) ◽  
pp. 8421
Author(s):  
Yuan Gao ◽  
Jiandong Huang ◽  
Meng Li ◽  
Zhongran Dai ◽  
Rongli Jiang ◽  
...  
Keyword(s):  
Structural Analysis ◽  
High Efficiency ◽  
Low Cost ◽  
Chemical Activation ◽  
Cost Effective ◽  
Coal Gangue ◽  
Order Kinetic ◽  
Practical Applications ◽  
Detailed Structural Analysis ◽  
Alkaline Conditions

Uranium mining waste causes serious radiation-related health and environmental problems. This has encouraged efforts toward U(VI) removal with low cost and high efficiency. Typical uranium adsorbents, such as polymers, geopolymers, zeolites, and MOFs, and their associated high costs limit their practical applications. In this regard, this work found that the natural combusted coal gangue (CCG) could be a potential precursor of cheap sorbents to eliminate U(VI). The removal efficiency was modulated by chemical activation under acid and alkaline conditions, obtaining HCG (CCG activated with HCl) and KCG (CCG activated with KOH), respectively. The detailed structural analysis uncovered that those natural mineral substances, including quartz and kaolinite, were the main components in CCG and HCG. One of the key findings was that kalsilite formed in KCG under a mild synthetic condition can conspicuous enhance the affinity towards U(VI). The best equilibrium adsorption capacity with KCG was observed to be 140 mg/g under pH 6 within 120 min, following a pseudo-second-order kinetic model. To understand the improved adsorption performance, an adsorption mechanism was proposed by evaluating the pH of uranyl solutions, adsorbent dosage, as well as contact time. Combining with the structural analysis, this revealed that the uranyl adsorption process was mainly governed by chemisorption. This study gave rise to a utilization approach for CCG to obtain cost-effective adsorbents and paved a novel way towards eliminating uranium by a waste control by waste strategy.

scholarly journals 5G Wireless/Wired Convergence of UFMC Based Modulation for Intensity Modulation Direct Detection

2021 ◽  
Author(s):  
Keerthivasan K ◽  
Shibu S
Keyword(s):  
Network Architecture ◽  
Direct Detection ◽  
Low Cost ◽  
Cost Effective ◽  
Theoretical Work ◽  
Base Stations ◽  
Complex Nature ◽  
Implementation Model ◽  
Effective Manner ◽  
Media Applications

Faster data speeds, shorter end-to-end latencies, improved end-user service efficiency, and a wider range of multi-media applications are expected with the new 5G wireless services. The dramatic increase in the number of base stations required to meet these criteria, which undermines the low-cost constraints imposed by operators, demonstrates the need for a paradigm shift in modern network architecture. Alternative formats will be required for next-generation architectures, where simplicity is the primary goal. The number of connections is expected to increase rapidly, breaking the inherent complexity of traditional coherent solutions and lowering the resulting cost percentage. A novel implementation model is used to migrate complex-nature modulation structures in a highly efficient and cost-effective manner. Theoretical work to analyses modulations’ behavior over a wired/fiber setup and wireless mode is also provided. The state-of-the-art computational complexity, simplicity, and ease of execution while maintaining efficiency throughput and bit error rate.

Civil Marine Radar – A Review and a Way Ahead

1998 ◽  
Vol 51 (3) ◽  
pp. 394-403 ◽  
Author(s):  
P. D. L. Williams
Keyword(s):  
Collision Avoidance ◽  
Future Development ◽  
Cost Effective ◽  
Short History ◽  
Modus Operandi ◽  
Effective Manner ◽  
The Future ◽  
Recent Developments ◽  
Marine Radar

Civil Marine Radar (CMR) is now a mature instrument of some 50 years steady development. Following a short history, more to provide benchmarks of achievement than to satisfy historians, this paper examines what will drive the future development of CMR. The answer may not follow recent developments, but may well be the result of a fresh maritime modus operandi to fulfil the navigation, collision avoidance and safe passage needs of all types of craft operating in all types of water with different pressures and Operational Requirements (ORS). Having postulated fresh ORS, suggestions are made on how best to fulfil them in a logical and cost-effective manner.

scholarly journals Prospects for the development of fungal vaccines.

1997 ◽  
Vol 10 (4) ◽  
pp. 585-596 ◽  
Author(s):  
G S Deepe
Keyword(s):  
Vaccine Development ◽  
Fungal Infections ◽  
Low Cost ◽  
Mode Of Delivery ◽  
Cost Effective ◽  
Fungal Diseases ◽  
Haemophilus Influenzae Type ◽  
Medical Problems ◽  
Recent Developments ◽  
The Ideal

In an era that emphasizes the term "cost-effective," vaccines are the ideal solution to preventing disease at a relatively low cost to society. Much of the previous emphasis has been on childhood scourges such as measles, mumps, rubella, poliomyelitis, and Haemophilus influenzae type b. The concept of vaccines for fungal diseases has had less impact because of the perceived limited problem. However, fungal diseases have become increasingly appreciated as serious medical problems that require recognition and aggressive management. The escalation in the incidence and prevalence of infection has prompted a renewed interest in vaccine development. Herein, I discuss the most recent developments in the search for vaccines to combat fungal infections. Investigators have discovered several inert substances from various fungi that can mediate protection in animal models. The next challenge will be to find the suitable mode of delivery for these immunogens.

scholarly journals An Improved In Vitro Pyrogen Test To Detect The Presence of Endotoxin Containing Bacteria Using Limulus Amoebocyte Lysate Assay From Pharmaceutical Raw Product

1970 ◽  
Vol 1 (1) ◽  
pp. 76-79
Author(s):  
Tanvir Bashar ◽  
Khondokar Mahzebin Shurovi ◽  
Sanjida Dilshad
Keyword(s):  
Pathogenic Bacteria ◽  
Raw Materials ◽  
Cost Effective ◽  
Drug Preparation ◽  
Effective Manner ◽  
Key Word ◽  
Pseudomonas Species ◽  
Lal Assay

Most of the environmental organism possess endotoxin which presence indicates the organisms are much lethal and for the purposes bacteriological quality of pharmaceutical raw products is much important. In these current study, 2 raw materials out of 10 were found to containing pathogenic bacteria Escherichia coli and Pseudomonas species in the culture medium, that indicates the raw materials were contaminated with the deadly organism. These two raw materials checked for the presence of Endotoxin and both provided positive gel clot by Limulas amoebocyte lysate (LAL) assay. Quality maintenance and assurance is the essential need of Drug preparation in pharmaceutical sector. The result ensure that Pharmaceutical industry should need to follow GMP and HACCP to minimize the contamination for improving the biological safety of the product in a cost-effective manner. Key Word: Limulas amoebocyte lysate (LAL) assay, Gram negative bacteria, endotoxin. doi:10.3329/sjps.v1i1.1812    S. J. Pharm. Sci. 1(1&2): 76-79

scholarly journals Automatic Threshold on Current based Anti-pinch Mechanism for Power Windows

2018 ◽  
Vol 8 (4) ◽  
pp. 2172 ◽  
Author(s):  
Wahyu Kunto Wibowo ◽  
Seok-Kwon Jeong ◽  
Sam-Sang You ◽  
Lee Jaemin
Keyword(s):  
Low Cost ◽  
Experimental Tests ◽  
Cost Effective ◽  
Threshold Value ◽  
Contact Method ◽  
Threshold Method ◽  
Current Information ◽  
Safety Mechanism ◽  
Effective Manner ◽  
Optimal Calculation

<span>In this paper, the automotive power window has been integrated with an advanced safety mechanism called anti-pinch system for good protection. Based on a contact method, a new safety mechanism using a low-cost technology has been proposed to set a threshold value as a limit to decide the pinch condition, or automatic threshold method. The electric current information is easily detected by using current sensor installed on a motor driver without incorporating extra device. Then the pinch condition is quickly reflected and calculated by using current information in the system. Since the automatic threshold is decided by analyzing system behavior in advance, the optimal calculation can be guaranteed and then applied it on the safety mechanism in a cost-effective manner. Through extensive experimental tests, the squeezing forces of the proposed anti-pinch system have been verified to satisfy requirements of the FMVSS 118 regulations.</span>

scholarly journals Role of Fibrinolytic Enzymes in Anti-Thrombosis Therapy

2021 ◽  
Vol 8 ◽  
Author(s):  
Farwa Altaf ◽  
Shourong Wu ◽  
Vivi Kasim
Keyword(s):  
Plasminogen Activator ◽  
Thrombus Formation ◽  
Low Cost ◽  
Cost Effective ◽  
Tissue Type ◽  
High Yield ◽  
Efficacy Rate ◽  
Middle Income ◽  
Fibrinolytic Enzymes ◽  
Effective Manner

Thrombosis, a major cause of deaths in this modern era responsible for 31% of all global deaths reported by WHO in 2017, is due to the aggregation of fibrin in blood vessels which leads to myocardial infarction or other cardiovascular diseases (CVDs). Classical agents such as anti-platelet, anti-coagulant drugs or other enzymes used for thrombosis treatment at present could leads to unwanted side effects including bleeding complication, hemorrhage and allergy. Furthermore, their high cost is a burden for patients, especially for those from low and middle-income countries. Hence, there is an urgent need to develop novel and low-cost drugs for thrombosis treatment. Fibrinolytic enzymes, including plasmin like proteins such as proteases, nattokinase, and lumbrokinase, as well as plasminogen activators such as urokinase plasminogen activator, and tissue-type plasminogen activator, could eliminate thrombi with high efficacy rate and do not have significant drawbacks by directly degrading the fibrin. Furthermore, they could be produced with high-yield and in a cost-effective manner from microorganisms as well as other sources. Hence, they have been considered as potential compounds for thrombosis therapy. Herein, we will discuss about natural mechanism of fibrinolysis and thrombus formation, the production of fibrinolytic enzymes from different sources and their application as drugs for thrombosis therapy.

Challenge and Complexity of Virtual Team Management

2014 ◽  
pp. 109-120
Author(s):  
Edward T. Chen
Keyword(s):  
Competitive Advantage ◽  
Virtual Teams ◽  
Business Strategy ◽  
Global Economy ◽  
Business Processes ◽  
Low Cost ◽  
Cost Effective ◽  
Business Leaders ◽  
Talent Pool ◽  
Effective Manner

To thrive in our global economy, businesses must continually seek ways to maintain a competitive advantage by supplying the market with innovative and effective products and services. To do this, barriers of space and time must be overcome, conventional business processes must be enhanced, and customer demand must be promptly answered by high-quality, low-cost, or value-based products and services. One way for companies to meet these fast-paced market demands is by utilizing virtual teams. With virtual teams, companies can expand their talent pool beyond geographical barriers. Furthermore, they can incorporate a follow-the-sun process in their business strategy. Combined, this leveraged approach can better position companies to meet market demands in a more timely and cost-effective manner. However, to achieve this competitive advantage, business leaders must thoroughly understand the challenges associated with developing and managing virtual teams. This research chapter examines the reasons for utilizing virtual teams, challenges that stem from diversity, structural and behavioral characteristics, and managerial considerations for effective leadership, supporting technologies, best practices, and future implications.

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