Effects of Hydroxyurea Administration on the Body Weight, Body Composition and Exercise Performance of Patients with Sickle-Cell Anaemia

1997 ◽  
Vol 92 (5) ◽  
pp. 481-486 ◽  
Author(s):  
A. C. Hackney ◽  
W. Hezier ◽  
T. P. Gulledge ◽  
S. Jones ◽  
D. Strayhorn ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
The Body ◽  
Aerobic Performance ◽  
Composition Analysis ◽  
Anaerobic Performance ◽  
Significant Difference

1. As an ancillary study carried out during the recently completed Multicenter Study of Hydroxyurea, we examined the effect of hydroxyurea on the body weight, body composition and exercise capacity of adult patients with sickle-cell anaemia. 2. The subjects received either hydroxyurea (six males and four females) or placebo (eight males and six females). Data for each subject were generated during four separate 24 h admissions to the General Clinical Research Center. These admissions occurred at baseline and then at 6, 12 and 18 months after the start of study drug (hydroxyurea or placebo) administration. During each admission, body composition was measured by using a dual X-ray absorptiometer, and exercise testing was performed by cycle ergometry. Anaerobic performance was assessed according to a ‘Wingate’ protocol (20 s at maximal intensity against a cycling resistance of 7.5% body weight). Aerobic performance was examined using a steady state submaximal exercise protocol (10 min cycling time). 3. At baseline, no significant difference in any parameter was found between the hydroxyurea- and placebo-treated groups. At 18 months, the hydroxy-urea-treated subjects exhibited an average weight gain of 3.16 kg. The mean weight gain in the placebo-treated subjects was 1.82 kg. Body composition analysis showed that the additional weight in both groups involved both lean and fat body mass components. In anaerobic performance, the subjects given hydroxyurea showed an increase in peak muscle power of 104.9 W. The placebo group also showed an increase, but theirs was a more modest gain of 57.7 W. The most marked improvement in anaerobic performance was observed in the hydroxyurea-treated men (P < 0.05). In aerobic performance, the hydroxyurea-treated subjects exhibited a decrease in peak heart rate response to a standardized workload of 15.2 beats/min, as compared with a decrease of only 4.3 beats/min in the placebo-treated patients. 4. Taken together, the overall weight gain, combined with increases in both anaerobic muscular performance and aerobic cardiovascular efficiency, provides objective data to support the subjective impression that hydroxyurea administration produces an improvement in the physical capacity of patients with sickle-cell anaemia.

scholarly journals Penggunaan Hasil Fermentasi Bungkil Kedelai Dalam Ransum Terhadap Pertumbuhan Ayam Pedaging

2001 ◽  
Vol 2 (2) ◽  
pp. 26-31
Author(s):  
Al Qudri
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Soybean Oil ◽  
Energy Content ◽  
Body Weight Gain ◽  
The Body ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Fermented Soybean ◽  
Significant Difference

ABSTRACT. Tempe of soybean is fermented soybean with Rhizopus ologosporus fungus. From a result of researchers, it is the fact that tempe can increase valuable of nutrion and digest capacity and also produce antibiotic . Utilization of abtibiotic in chiken food as stimulus growth in not recommended because it can cause resistance a certain germ and it is presume there are antibiotic residu in egg and chiken meat. It is hope that the use of fermented soybean oil meal can increase nutrient value and digest capacity as well as produce antibiotic, so that it can get a better growth and over come a problem of using antibiotic in chiken food. The study was conducted to evaluate the effect of fermented soybean oil meal utilization in the ration on body weight gain, feed consumption, feed conversion and mortality. The study use 80 unsex day old chick broiler CP-707 and conducted at Poulty Laboratory Product Agriculture Faculty, Syiah Kuala University. Chiken were putting in 27 houses unit, each unit contain of four chiken. The design of experiment was Completely Randomized Design, four treatments and five replication. The treatments were ration contained 0%, 5%, 10% and 15% fermented soybean oil meal as replace the use of soybean oil meal. The protein and energy content of all dietary treatments were equally composed from six weeks investigation, were body weight gain, feed consumption, feed conversion and mortality. The result of the study indicated that up to 10% graded of fermented soybean oil meal in ration were significant difference influenced increase the body weight gain and decrease the feed conversion. The fermented soybeanoil meal) utilization more than 10% were significant difference decrease the body weight gain and increase the feed conversion. If the inclusion was increase the feed consumption would tendency decline. In this study there were no mortality in all treatment. In can be advised from this study that fermented soybean oil meal could be used in broiler ration or in all poulty ration.

White tea drink (Camellia sinensis) improves endurance and body weight maintenance of rats

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Mahmud Aditya Rifqi ◽  
Stefania Widya Setyaningtyas ◽  
Qonita Rachmah
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Beneficial Effect ◽  
Camellia Sinensis ◽  
Intervention Research ◽  
The Body ◽  
Human Intervention ◽  
Content Type ◽  
White Tea ◽  
Significant Difference

PurposeWhite tea is an unfermented tea made from young shoots of Camellia sinensis protected from sunlight to avoid polyphenol degradation. White tea contains a high level of polyphenolic compounds known as catechins. Several types of evidence have suggested that tea consumption has benefits in body weight and endurance maintenance. This study was designed to evaluate the effect of white tea on body weight and endurance of animal models.Design/methodology/approachThis research was an intervention design using 20 Wistar white rats (Rattus Norvegicus) in body weight between 150 and 200 g. The rats were randomized into four groups, three groups receiving white tea drink (WTD) with different doses and the other group receiving plain water in equal volume as a control group for four weeks. The forced swim test (FST) was done to measure their struggling capacity, and digital bodyweight to measure the weight.FindingsIntervention (WTD Groups and Control) caused weight gain among except G3 with the highest doses of white tea. The result showed that WTD intake in G3 had a significant difference (p < 0.05) on body weight gain compared to control. The authors found that WTD in a specific dose (G3: 0.22 mg) tends to maintain the body weight of animals (219.2 ± 41.96; 212.6 ± 46.90, respectively), while other doses caused weight gain. WTD also significantly increased the swimming and struggling capacity of rats that represented improvements the endurance along with the test. There was a statistically significant difference in endurance among all groups (p < 0.05).Research limitations/implicationsThe results of this study can be followed as human intervention research as an input for nutritionists and sports scientists to explore the beneficial effect of white tea.Practical implicationsThe results of this study can be followed as human intervention research as an input for nutritionists and sports scientists to explore the beneficial effect of white tea.Originality/valueThis study adds more evidence and information about the advantages of white tea as potential beverages in future healthy lifestyles.

Experimental inoculation of day-old ducks with Brachyspira pilosicoli and B. alvinipulli

2011 ◽  
Vol 59 (2) ◽  
pp. 165-174 ◽  
Author(s):  
Ákos Thuma ◽  
Ádám Dán ◽  
Éva Kaszanyitzky ◽  
Béla Fazekas ◽  
Ádám Tóth ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Mucous Membrane ◽  
Body Weight Gain ◽  
Clinical Signs ◽  
Experimental Period ◽  
The Body ◽  
Bursa Of Fabricius ◽  
Brachyspira Pilosicoli ◽  
Significant Difference

Two groups of one-day-old Peking ducklings (Groups I and II, 12 birds/group) were inoculated orally withBrachyspira pilosicoliand two groups withB. alvinipulli(Groups III and IV, 12 birds/group). T-2 toxin was added to the feed of Groups II and IV in a dose of 1 mg/kg of feed. Groups V and VI served as uninfected control groups (ducks of Group VI received T-2 toxin). The body weight gain of the ducks was measured and clinical signs were monitored continuously. The birds were sacrificed and necropsied on days 7, 14, 21, and 28 post infection (PI). The liver, spleen, kidney, thymus, bursa of Fabricius, ileum, caecum and colon were examined histologically. Culturing ofBrachyspiraspp. and immunohistochemistry were performed from the sampled parts of the intestines as well. No gross pathological or histological lesions that could be associated withB. pilosicoliorB. alvinipulliwere detectable in the intestinal mucous membrane including the colonised intestinal glands. Mortality did not occur during the experimental period. Decrease in body weight gain was significant in the T-2-toxin-treated groups, and it was slight (not significant) in theBrachyspira-infected groups. Crust on the beaks, necrosis, crusting and ulceration in the mucous membrane of the oral cavity and on the skin of the feet, atrophy of the thymus and bursa of Fabricius due to the effect of T-2 toxin, accompanied by lymphocyte depletion, were observed. These lesions were most prominent on days 14 and 21 PI but were seen on day 28 PI as well. Immunohistochemical detection and reisolation ofB. pilosicoliandB. alvinipulliwere successful on days 7, 14, 21 and 28 days from different segments of the intestine of certain birds, but no significant difference was observed in the colonisation rate between the T-2-toxin-treated and the untreated groups.

scholarly journals Body composition and Hashimoto disease

2021 ◽  
pp. 345-352
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Body Fat ◽  
Bioelectrical Impedance ◽  
Good Health ◽  
The Body ◽  
Composition Analysis ◽  
Tissue Water ◽  
Healthy Women ◽  
Hashimoto Disease

Background. Body weight or BMI do not provide any information about the content of muscle tissue, water content, body fat and its distribution in the body. Thyroid dysfunction is associated with a change in body weight, but also its composition regardless of physical activity. Objective. The aim of the study was to compare the body composition of female patients diagnosed with Hashimoto's disease (HD) and the body composition of healthy women who have never been treated before due to thyroid diseases. Materials and methods. The study involved 47 women diagnosed with Hashimoto disease (HD) and 65 women declaring good health. Body mass and height and body composition analysis using bioelectrical impedance analysis were performed using the TANITA multi-frequency segmental body composition analyzer. Variables having a distribution similar to the normal distribution were analyzed by the analysis of variance (ANOVA), otherwise the Kruskal-Wallis test was used. Results. Women with Hashimoto disease were characterized by significantly higher values of body weight, and thus BMI index, than healthy women (respectively 73.64 kg vs. 64.36 kg, p <0.0001; 27.65 kg/m2 vs. 23.95 kg/m2, p <0.001).The problem of excess body fat in the body statistically significantly more often affected women with Hashimoto disease than healthy women (44.7% vs. 13.8%, p <0.001). Conclusions. The results regarding the weight and composition of the patients treated for thyroid disease indicate the need for further in-depth analyses. Even small abnormalities of the thyroid function in the range of reference values may result in the development of many adverse changes in the body.

scholarly journals The role and place of bioimpedance analysis assessment of body composition of children and adolescents with different body mass

2018 ◽  
Vol 17 (2) ◽  
pp. 121-132 ◽  
Author(s):  
Ya. V. Girsh ◽  
O. A. Gerasimchik
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Children And Adolescents ◽  
Body Mass ◽  
Clinical Medicine ◽  
Cell Mass ◽  
Overweight And Obesity ◽  
The Body ◽  
Composition Analysis ◽  
Bioimpedance Analysis

The steady rise of obesity in children and adolescents emphasizes the need for new, integrated approaches to its diagnosis and therapy. When diagnosing obesity and choosing methods for its correction, it is fundamentally important to use reliable methods of estimating the amount of adipose tissue. Using the body mass index is not always sufficient, since it does not provide complete information on quantitative content in the body weight of the patient’s body. For these purposes in clinical medicine use of bioimpedance analysis to assess the indicators, which characterize the basal metabolism, active cell mass, fat and basirova mass and total water content in the body. However, the holding of bioimpedance body composition analysis is currently limited mainly to dietetics and sports medicine, and adult patients. Quite interesting is the use of the bioimpedance method in the pediatric age group for accurate evaluation of body composition of children of various ages and body weight that will allow for dynamic control of all types of metabolism to evaluate the effectiveness of the observation and treatment of patients with overweight and obesity.

scholarly journals Changes in weight and body composition after initiating insulin therapy and their relationship with metabolic control during the first year of type 1 diabetes in adults. InLipoDiab1 Study

2021 ◽  
pp. e531
Author(s):  
Maja Miętkiewska ◽  
Aleksandra Uruska
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Weight Gain ◽  
Insulin Therapy ◽  
The Body ◽  
First Year ◽  
Newly Diagnosed ◽  
Metabolic Management

Introduction. As in the general population, an increase in the incidence of overweight has been observed in individuals with type 1 diabetes (T1DM). Nevertheless, weight gain in this group may contribute to the deterioration of the metabolic management. The aim of this study was to evaluate changes in the body weight and body composition after initiating insulin therapy and to assess their relationship with the metabolic management during the first year of T1DM in adults.Material and Methods. The prospective analysis included 139 adults patients with newly diagnosed T1DM, treated with Intensive functional insulin therapy (IFI) from the onset of the disease (age 26.3 ± 5.9 years). Patients were assessed at the time of the diagnosis and after 12 months. Metabolic parameters, including the HbA1c and lipid profile were investigated. The group was divided according to weight gain during the follow-up period.Results. Weight gain was observed in 68.3% of participants (n = 95). In most cases an increase in body fat was found (41% vs 59% p = 0.01). Changes in the body weight corresponded to significant changes in body composition. Conversely, HbA1c decreased during the follow-up in all groups. The highest reduction was observed in a group with “excessive weight gain”. Additionally, a significant increase in high density lipoproteins was observed in each group. However, weight gain was not accompanied by a deterioration of the lipid profile.Conclusions. Weight gain is a considerable problem among adults with newly diagnosed T1DM and is connected mainly with an increase of adipose tissue above the normal range. Changes in the body weight, associated with body composition changes, did not result in the dysfunctions of the metabolic management.

scholarly journals Effects of growth promoter and multivitamin-mineral premix supplementation on body weight gain in broiler chickens

2013 ◽  
Vol 10 (2) ◽  
pp. 245-248 ◽  
Author(s):  
MA Rahman ◽  
MS Parvin ◽  
RR Sarker ◽  
MT Islam
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
The Body ◽  
Growth Promoter ◽  
Commercial Feed ◽  
Significant Difference ◽  
Group A ◽  
Group B

An experiment was conducted at the Khanpura Poultry Farm, near to the Babugonj campus of Patuakhali Science and Technology University, Patuakhali during the period from August to September, 2011 to evaluate the effect of growth promoter and multivitamin-mineral premix on the body weight gain in broiler chickens. A total of 90 ‘Cobb 500’ day-old broiler chickens were randomly divided into three equal groups (n = 30), namely Groups A, B and C. Broiler birds in groups A and B were supplemented with growth promoter and multivitamin-mineral premix, respectively in addition to commercial feed from day 4 till day 25. The dose of both the growth promoter and multivitamin-mineral premix was 2.5 g/kg of feed. Chickens of group C served as control and supplemented with commercial feed only. Body weight was recorded at three times as on day 11, 18 and 25, respectively. The mean body weight was insignificantly (p > 0.05) higher in birds of groups A (992.5±139.6g) and B (978.3±147.0g) than those of group C (926.7±133.2g). The percent increase in body weight gain compare to control was increased in both the supplemented groups (5.8% in group A and 8.8% in group B) though there was no significant difference. Based on the results, it is suggested that supplementation of growth promoter and multivitamin-mineral premix in broilers even after feeding of commercial feed has positive effect on the growth of broilers.DOI: http://dx.doi.org/10.3329/jbau.v10i2.14914 J. Bangladesh Agril. Univ. 10(2): 245-248, 2012

Personality and the body composition of athletes using the example of the Polish national youth female wrestling team

2017 ◽  
Vol 2 (8) ◽  
pp. 107-109
Author(s):  
Paweł Piepiora ◽  
Magdalena Superson ◽  
Kazimierz Witkowski
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Psychological Needs ◽  
The Body ◽  
Composition Analysis ◽  
Combat Sport ◽  
Number Of Factors ◽  
Affect Body Weight ◽  
Study Results ◽  
The Relationship

Introduction. A positive relationship is recognised in literature between strength and body weight. On that basis a division into weight categories has been introduced in many combat sports. Nutritional behaviours are influenced by a number of factors that indirectly affect body weight. The purpose of this study was to examine the relationship between personality and the body composition of athletes using the example of the Polish national youth female wrestling team. Material and methods. The study consisted in the performance of a personality evaluation using the NEO-FFI questionnaire and a body composition analysis using a TANITA BC-418 analyser. 15 athletes from the Polish national youth female wrestling team aged (20.26 ± 1.43 years) participated in the study. Results. The study showed a lack of relationship between personality and body composition in members of the national wrestling team. Conclusions. Research points to a relationship between nutritional behaviours and satisfying not only the physiological, but also psychological needs of the body. A thorough investigation of this mechanism and of the possibility of its application may be very helpful, especially for combat sport athletes. The ability to optimise body weight, without the necessity of ensuring its fast reduction during the pre-start period, may have a significant impact on a person’s results.

scholarly journals Effect of Time-of-Day-Exercise in Group Settings on Level of Mood and Depression of Former Elite Male Athletes

2019 ◽  
Vol 16 (19) ◽  
pp. 3541 ◽  
Author(s):  
Khadijah Irandoust ◽  
Morteza Taheri ◽  
Hamdi Chtourou ◽  
Pantelis Theo Nikolaidis ◽  
Thomas Rosemann ◽  
...  
Keyword(s):  
Body Composition ◽  
Severe Depression ◽  
Time Of Day ◽  
The Body ◽  
Psychological State ◽  
Composition Analysis ◽  
Male Athletes ◽  
Group Settings ◽  
Significant Difference ◽  
Age Range

Since the prevalence of depression is high among athletes at the end of their athletic career, the purpose of this study was to investigate the effect of time-of-day-exercise in group settings on the level of the mood and depression of former elite male athletes.Out of 187 volunteers referring to the sports counseling clinic, 71 retired male athletes who had a national championship record were randomly divided into two morning and evening exercise groups. The inclusion criteria were severe depression (high score in the Beck Depression Inventory-II), the age range of 50 to 60 years, the absence of metabolic syndrome, and the body mass index (BMI) between 28 and 35. All body composition variables were measured using body composition analysis (In Body 320; Korea). The second stage was the collection of data after three months (completion of the training protocol). After data collection, independent and dependent t-tests were used to analyze the data. The results indicated that both groups had a significant improvement in depression compared to the pre-test (p ≤ 0.05), while there was no significant difference between the two groups (p ≥ 0.05). The overall conclusion is that exercise at different times of the morning or evening can improve the psychological state and reduce depression.

scholarly journals The Relationship between Body Weight Change and Body Constitutions of Traditional Chinese Medicine in Patients with Schizophrenia

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Jui-Fen Cheng ◽  
Xuan-Yi Huang ◽  
Te-Le Liu ◽  
Ruey-Yun Wang ◽  
Han-Yi Ching
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Waist Circumference ◽  
Health Care Providers ◽  
Weight Change ◽  
The Body ◽  
Care Providers ◽  
Body Constitution ◽  
Significant Difference ◽  
The Relationship

Objective. To explore the relationship between body constitution (BC) types and weight change in patients with schizophrenia and who underwent second-generation antipsychotics (SGAs) treatment.Method. Body weight and waist circumference of eighty-five participants were measured for 6 consecutive weeks. Constitutions of Yin-Xu, Yang-Xu, and Stasis were assessed using the Body Constitution Questionnaire (BCQ).Results. Participants with body constitutions Yin-Xu (50.6%), Yang-Xu (49.4%), or Stasis (38.8%) exhibited worse physical condition and unhealthy daily habits, particularly in Stasis constitution. Moreover, Stasis constitution was significantly associated with several factors, including BMI, body weight, waist circumference, perception of stress, perception of health, staying up late, and less physical exercise. However, perception of stress showed significant difference in Yin-Xu, Yang-Xu, and Stasis. Generalized estimating equation (GEE) analysis revealed that significant time effects in body weight increase in the imbalanced BC types and gentleness BC type. SGAs induced weight gain in imbalanced BC type as well as gentleness BC type, especially treated with olanzapine.Conclusions. This is the first study to explore the longitudinal relationship between BC and weight gain in schizophrenia patients undergoing SGAs treatment. Health care providers should focus on weight gain problems in schizophrenia patients who underwent SGAs treatment.

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