scholarly journals Age-related features of the manifestation of non-contagious pathology and metabolic disorders of liver in broiler chickens

2020 ◽  
Vol 17 ◽  
pp. 00139
Author(s):  
Marina P. Semenenko ◽  
Elena V. Kuzminova ◽  
Denis V. Osepchuk ◽  
Vladimir A. Grin ◽  
Ksenia A. Semenenko ◽  
...  
Keyword(s):  
Blood Serum ◽  
Broiler Chickens ◽  
Metabolic Disorders ◽  
Total Population ◽  
Industrial Enterprise ◽  
Liver Pathology ◽  
Hepatic Parenchyma ◽  
Age Related ◽  
Causes Of Mortality

The article presents the data on the study of age-related features of non-contagious pathology in broiler chickens, as well as the level of metabolic processes in liver of healthy poultry and poultry with diseases. The results of the studies indicate that in the conditions of an industrial enterprise specializing in meat poultry rearing, poultry mortality in different age periods ranged from 3 to 5 % of the total population. In the structure of the causes of mortality of broiler chickens from the 8th to the 15th day, an increase in mortality from hepatopathies was registered, and by the 25th day of life hepatosis was recorded in the bulk of the dead poultry. Biochemical monitoring of blood serum in poultry with signs of liver pathology revealed an increase in the level of ALAT, β-globulins, and the “inflammation syndrome” of the hepatic parenchyma was confirmed by a positive thymol test. Long-term consumption of feed contaminated with mycotoxins by broilers led to the deterioration in the health of the poultry, an imbalance in liver and the development of general metabolic disorders of the poultry organism.

The integrated stress response: From mechanism to disease

Science ◽  
2020 ◽  
Vol 368 (6489) ◽  
pp. eaat5314 ◽  
Author(s):  
Mauro Costa-Mattioli ◽  
Peter Walter
Keyword(s):  
Stress Response ◽  
Metabolic Disorders ◽  
Protein Quality ◽  
Cognitive Disorders ◽  
Proper Function ◽  
Long Term Memory ◽  
Integrated Stress Response ◽  
Age Related ◽  
Wide Range

Protein quality control is essential for the proper function of cells and the organisms that they make up. The resulting loss of proteostasis, the processes by which the health of the cell’s proteins is monitored and maintained at homeostasis, is associated with a wide range of age-related human diseases. Here, we highlight how the integrated stress response (ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis rates, impedes the formation of long-term memory. In addition, we address how dysregulated ISR signaling contributes to the pathogenesis of complex diseases, including cognitive disorders, neurodegeneration, cancer, diabetes, and metabolic disorders. The development of tools through which the ISR can be modulated promises to uncover new avenues to diminish pathologies resulting from it for clinical benefit.

EVALUATION OF THE EFFECTIVENESS OF THE PREPARATION GEPRASAN IN PREVENTION OF MYCOTOXYCOSIS OF BROILER CHICKENS

2018 ◽  
Vol 1 (1) ◽  
pp. 95-98
Author(s):  
M. P. Semenenko ◽  
◽  
M. N. Sokolov ◽  
E. V. Kuzminova ◽  
P. V. Miroshnichenko ◽  
...  
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Dry Matter ◽  
Experimental Period ◽  
Liver Necrosis ◽  
Negative Effects ◽  
Complex Preparation ◽  
Positive Effect

The article presents materials on the use of a new complex preparation geprasan for the prevention of mycotoxicosis of broiler chickens and its influence on safety, results of biochemical parameters of the blood serum and data of necropsy of the poultry liver. According to the scheme of the experiment, three groups of chickens were formed with 50 goals in each. Bird of the 1st group (control) during the whole experimental period received only feed of the main diet, chickens of the 2nd and 3rd groups for 21 days in the feed were added geprasan in amount of 1 and 2%, respectively, of the dry matter of the feed. During the experiment the following parameters were taken into account: safety, biochemical parameters of blood serum and data of liver necrosis. We found out that a long-term introduction of geprasan to feed diets of broilers at various doses has a positive effect on the biochemical parameters of blood serum and the indicators, characterizing the functional activity of hepatocytes of liver and reduce the negative effects of mycotoxins on the poultry organism.

Clinical Efficacy of Dhatryadi Ghanavati in Shvitra (Vitiligo)

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Manjiri Walinjkar ◽  
P.D. Londhe ◽  
S. R. Makhare ◽  
Anil Avhad
Keyword(s):  
Clinical Efficacy ◽  
Skin Disorder ◽  
Total Population ◽  
Social Stigma ◽  
Term Treatment ◽  
Effective Therapy ◽  
Long Term Treatment ◽  
Percentage Area ◽  
Effective Remedy

Background: Shvitra (vitiligo) is a kind of skin disorder comprising of white coloured skin patches which is considered as a social stigma. Worldwide prevalence of Vitiligo is observed as 1% of the total population. Due to the chronic nature, long term treatment, lack of uniform effective therapy and unpredictable course the disease is usually very demoralizing for patients. Aim: To study the efficacy of ‘Dhatryadi Ghanavati’ in the management of Shvitra. Materials and Methods: Total 50 patients of Shvitra from OPD and IPD unit of Dr. M.N. Agashe Hospital, Satara were selected and provided with Dhatryadi Ghanavati 1gm B.D. for the duration of 3 months. Results: 100% relief was observed in Daha and Kandu followed by 83.33% relief was observed in Rukshata. 34.51% improvement was seen in number of patches, 34.82% in size of patches and 34.29% in percentage area involved. Color of the patches was improved by 69.01% whereas 44% improvement was seen in hair discoloration. Conclusion: The compound formulation ‘Dhatryadi Ghanavati’ was found as an effective remedy for ‘Shvitra’. The parameters like number of patches, size of patches, percentage area involved and colour of patches showed statistically highly significant results.

scholarly journals Crosstalk between Long-Term Sublethal Oxidative Stress and Detrimental Inflammation as Potential Drivers for Age-Related Retinal Degeneration

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 25
Author(s):  
Lara Macchioni ◽  
Davide Chiasserini ◽  
Letizia Mezzasoma ◽  
Magdalena Davidescu ◽  
Pier Luigi Orvietani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Molecular Mechanisms ◽  
Age Related Macular Degeneration ◽  
Inflammasome Activation ◽  
Related Factor ◽  
Nuclear Factor ◽  
Rpe Cells ◽  
Age Related ◽  
Oxidative Insult

Age-related retinal degenerations, including age-related macular degeneration (AMD), are caused by the loss of retinal pigmented epithelial (RPE) cells and photoreceptors. The pathogenesis of AMD, deeply linked to the aging process, also involves oxidative stress and inflammatory responses. However, the molecular mechanisms contributing to the shift from healthy aging to AMD are still poorly understood. Since RPE cells in the retina are chronically exposed to a pro-oxidant microenvironment throughout life, we simulated in vivo conditions by growing ARPE-19 cells in the presence of 10 μM H2O2 for several passages. This long-term oxidative insult induced senescence in ARPE-19 cells without affecting cell proliferation. Global proteomic analysis revealed a dysregulated expression in proteins involved in antioxidant response, mitochondrial homeostasis, and extracellular matrix organization. The analyses of mitochondrial functionality showed increased mitochondrial biogenesis and ATP generation and improved response to oxidative stress. The latter, however, was linked to nuclear factor-κB (NF-κB) rather than nuclear factor erythroid 2–related factor 2 (Nrf2) activation. NF-κB hyperactivation also resulted in increased pro-inflammatory cytokines expression and inflammasome activation. Moreover, in response to additional pro-inflammatory insults, senescent ARPE-19 cells underwent an exaggerated inflammatory reaction. Our results indicate senescence as an important link between chronic oxidative insult and detrimental chronic inflammation, with possible future repercussions for therapeutic interventions.

scholarly journals Magnesium and Hypertension in Old Age

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 139 ◽  
Author(s):  
Ligia J. Dominguez ◽  
Nicola Veronese ◽  
Mario Barbagallo
Keyword(s):  
Older Persons ◽  
Magnesium Deficiency ◽  
Favorable Effect ◽  
Processed Food ◽  
Negative Consequences ◽  
Magnesium Supplementation ◽  
Cerebrovascular Complications ◽  
Close Relationship ◽  
Causes Of Mortality

Hypertension is a complex condition in which various actors and mechanisms combine, resulting in cardiovascular and cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, and health expenses worldwide. In the last decades, there has been an exceptional amount of experimental, epidemiological, and clinical studies confirming a close relationship between magnesium deficit and high blood pressure. Multiple mechanisms may help to explain the bulk of evidence supporting a protective effect of magnesium against hypertension and its complications. Hypertension increases sharply with advancing age, hence older persons are those most affected by its negative consequences. They are also more frequently at risk of magnesium deficiency by multiple mechanisms, which may, at least in part, explain the higher frequency of hypertension and its long-term complications. The evidence for a favorable effect of magnesium on hypertension risk emphasizes the importance of broadly encouraging the intake of foods such as vegetables, nuts, whole cereals and legumes, optimal dietary sources of magnesium, avoiding processed food, which are very poor in magnesium and other fundamental nutrients, in order to prevent hypertension. In some cases, when diet is not enough to maintain an adequate magnesium status, magnesium supplementation may be of benefit and has been shown to be well tolerated.

scholarly journals Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

2021 ◽  
Author(s):  
Sujeong Yang ◽  
Sylvain Gigout ◽  
Angelo Molinaro ◽  
Yuko Naito-Matsui ◽  
Sam Hilton ◽  
...  
Keyword(s):  
Chondroitin Sulphate ◽  
Memory Loss ◽  
Memory Deficits ◽  
Long Term Potentiation ◽  
Aged Mice ◽  
Age Related ◽  
Term Potentiation ◽  
Early Memory

AbstractPerineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.

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