Orientierung in der medizinischen Forschung

2020 ◽  
Vol 145 (01) ◽  
pp. 47-55
Author(s):  
Christian Jassoy
Keyword(s):  
Medical Research ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical Study ◽  
Study Case ◽  
Study Type ◽  
Control Study

AbstractEducation of medical students requires teaching students how to navigate in the broad field of medical research. The objective of this article is to provide an overview about medical research and to show how to denote a medical study in a concise fashion. Medical research can be classified into categories according to the object of investigation. Examples for medical research categories are therapeutic, diagnostic and prognostic studies, epidemiological studies, animal and in vitro studies etc. Each research category uses a specific set of study types with names such as cross-sectional study, case-control study etc. The article describes the principles of the study types. Together, research category and study type briefly describe the design of a medical study.

scholarly journals Research methodology topics: Cohort studies or prospective and retrospective cohort studies

2019 ◽  
Vol 29 (3) ◽  
pp. 433-436
Author(s):  
Luís Marcelo Aranha Camargo ◽  
Romeu Paulo Martins Silva ◽  
Dionatas Ulises De Oliveira Meneguetti
Keyword(s):  
Cohort Studies ◽  
Case Control Study ◽  
Experimental Studies ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Epidemiological Method ◽  
Retrospective Cohort Studies ◽  
Study Case ◽  
Control Study

In health sciences, the epidemiological method can be divided into descriptive and analytical epidemiology and the latter being divided into observational (cross-sectional study, case-control study and cohort study) and experimental studies. Cohort studies may be retrospective or prospective, and both assume that the researcher will follow a population over time to seek a possible association between exposure (s) and outcome(s). These types of studies have as advantages the possibility of measuring several exposure factors and outcomes, both primary and secondary, for both relatively frequent outcomes and rare exposure factors. However, they are often long and therefore expensive studies. They have as main biases those of selection, memory and information. These are studies that may point to statistical associations between exposure and outcome that need other models to prove the casualty of these associations.

scholarly journals Attachment Characteristics Among Women Victimized in No, One, and Multiple IPV Relationships: A Case–Control Study

2021 ◽  
pp. 107780122098115
Author(s):  
Elisabeth Christie Ørke ◽  
Stål Bjørkly ◽  
Mariana Dufort ◽  
Solveig Karin Bø Vatnar
Keyword(s):  
Partner Violence ◽  
Emotional Abuse ◽  
Case Control Study ◽  
Cross Sectional Study ◽  
Attachment Anxiety ◽  
Multiple Relationships ◽  
Attachment Avoidance ◽  
Cross Sectional ◽  
Violent Relationships ◽  
Control Study

This cross-sectional study compared attachment characteristics among women victimized by intimate partner violence (IPV) in no, one, and multiple relationships ( N = 154). Results indicated that compared with the nonvictimized, victimized women had increased likelihood of higher attachment avoidance. Compared with women victimized in one relationship, women victimized in multiple relationships had higher likelihood of higher attachment anxiety scores. Adjusting for childhood adversities, childhood sexual abuse was an independent risk factor for IPV. Childhood emotional abuse mediated the association between attachment anxiety and IPV victimization in multiple relationships in particular. Attachment theory appeared useful for better understanding women’s vulnerability for multiple violent relationships.

Maternal and perinatal outcomes after bariatric surgery: a case control study

2016 ◽  
Vol 44 (4) ◽  
Author(s):  
Laura Arrais Sydrião de Alencar Costa ◽  
Edward Araujo Júnior ◽  
Francisco Edson de Lucena Feitosa ◽  
Andréa Cavalcante Dos Santos ◽  
Luiz Gonzaga Moura Júnior ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Case Control Study ◽  
Demographic Data ◽  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Obese Women ◽  
Cross Sectional ◽  
Average Body Mass ◽  
Average Body ◽  
Control Study

AbstractTo compare the results of maternal and perinatal pregnancies of obese women after bariatric surgery.A retrospective cross-sectional study was carried out on 63 women who had undergone bariatric surgery and 73 obese women (control). Demographic data, the characteristics of the bariatric surgery, and the maternal and perinatal results were evaluated. The Student’sThe average body mass index (BMI) at the 1Those women who had been submitted to bariatric surgery presented better maternal and perinatal results when compared to obese women.

Awareness of the use of hyponatraemia-inducing medications in older adults with hyponatraemia: a study of their prevalent use and association with recurrent symptomatic or severe hyponatraemia

2020 ◽  
Author(s):  
Kwanghee Jun ◽  
Yujin Kim ◽  
Young-Mi Ah ◽  
Ju-Yeun Lee
Keyword(s):  
Older Patients ◽  
Case Control Study ◽  
Cross Sectional Study ◽  
Case Control ◽  
Thiazide Diuretics ◽  
Cross Sectional ◽  
Severe Hyponatraemia ◽  
Prescription Rates ◽  
The Impact ◽  
Control Study

Abstract Background Cautious use or avoidance of hyponatraemia-inducing medications (HIMs) is recommended in older patients with hyponatraemia. Objective To evaluate the use of HIMs after treatment for symptomatic or severe hyponatraemia and to investigate the impact of HIMs on the recurrence of symptomatic or severe hyponatraemia in older patients. Design and settings A cross-sectional and nested case–control study using data obtained from national insurance claims databases. Methods The rate of prescribing HIMs during the 3 months before and after the established index date was analysed in a cross-sectional analysis. Multivariable logistic regression was performed to investigate the association between HIM use and recurrence of symptomatic or severe hyponatraemia after adjusting for covariates in a case–control study. Results The cross-sectional study included 1,072 patients treated for symptomatic or severe hyponatraemia. The proportion of patients prescribed any HIMs after hyponatraemia treatment decreased from 76.9 to 70.1%. The prescription rates significantly decreased for thiazide diuretics (from 41.9 to 20.8%) and desmopressin (from 8.6 to 4.0%), but the proportion of patients prescribed antipsychotics increased from 9.2 to 17.1%. Of 32,717 patients diagnosed with hyponatraemia, 913 (2.8%) showed recurrent hyponatraemia. After adjusting for comorbid conditions, the use of any HIMs including proton pump inhibitors [adjusted odds ratio (aOR) 1.34, 95% confidence interval (CI) 1.15–1.57] and two or more HIMs (aOR 1.48, 95% CI 1.22–1.78) especially in combination with thiazide diuretics increased the likelihood of severe hyponatraemia recurrence. Conclusions Prevalent use of HIMs after treatment for symptomatic or severe hyponatraemia and multiple HIM use increase the risk of recurrent hyponatraemia in geriatric patients.

scholarly journals Syringol metabolites as new biomarkers for smoked meat intake

2019 ◽  
Vol 110 (6) ◽  
pp. 1424-1433 ◽  
Author(s):  
Roland Wedekind ◽  
Pekka Keski-Rahkonen ◽  
Nivonirina Robinot ◽  
Vivian Viallon ◽  
Pietro Ferrari ◽  
...  
Keyword(s):  
Dietary Intervention ◽  
Meat Products ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Processed Meat ◽  
Sectional Study ◽  
Cross Sectional ◽  
Meat Intake ◽  
Hot Dog

ABSTRACT Background Processed meat intake is associated with a higher risk of colorectal and stomach cancers, coronary artery disease, and type 2 diabetes and with higher mortality, but the estimation of intake of different processed meat products in this heterogeneous food group in epidemiological studies remains challenging. Objective This work aimed at identifying novel biomarkers for processed meat intake using metabolomics. Methods An untargeted, multi-tiered metabolomics approach based on LC-MS was applied to 33 meat products digested in vitro and secondly to urine and plasma samples from a randomized crossover dietary intervention in which 12 volunteers consumed successively 3 processed meat products (bacon, salami, and hot dog) and 2 other foods used as controls, over 3 consecutive days. The putative biomarkers were then measured in urine from 474 subjects from the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study for which detailed 24-h dietary recalls and FFQs were available. Results Syringol and 4 derivatives of syringol were found to be characteristic of in vitro digests of smoked meat products. The same compounds present as sulfate esters in urine increased at 2 and 12 h after consumption of smoked meat products (hot dog, bacon) in the intervention study. The same syringol sulfates were also positively associated with recent or habitual consumption of smoked meat products in urine samples from participants of the EPIC cross-sectional study. These compounds showed good discriminative ability for smoked meat intake with receiver operator characteristic areas under the curve ranging from 0.78 to 0.86 and 0.74 to 0.79 for short-term and habitual intake, respectively. Conclusions Four novel syringol sulfates were identified as potential biomarkers of smoked meat intake and may be used to improve assessment of smoked meat intake in epidemiological studies. This trial was registered at clinicaltrials.gov as NCT03354130.

scholarly journals Saliva microRNA Biomarkers of Cumulative Concussion

2020 ◽  
Vol 21 (20) ◽  
pp. 7758
Author(s):  
Steven D. Hicks ◽  
Robert P. Olympia ◽  
Cayce Onks ◽  
Raymond Y. Kim ◽  
Kevin J. Zhen ◽  
...  
Keyword(s):  
Case Control Study ◽  
Cross Sectional Study ◽  
Professional Athletes ◽  
Neurocognitive Deficits ◽  
Sectional Study ◽  
Neurocognitive Performance ◽  
Cross Sectional ◽  
Increase Risk ◽  
History Of ◽  
Control Study

Recurrent concussions increase risk for persistent post-concussion symptoms, and may lead to chronic neurocognitive deficits. Little is known about the molecular pathways that contribute to persistent concussion symptoms. We hypothesized that salivary measurement of microribonucleic acids (miRNAs), a class of epitranscriptional molecules implicated in concussion pathophysiology, would provide insights about the molecular cascade resulting from recurrent concussions. This hypothesis was tested in a case-control study involving 13 former professional football athletes with a history of recurrent concussion, and 18 age/sex-matched peers. Molecules of interest were further validated in a cross-sectional study of 310 younger individuals with a history of no concussion (n = 230), a single concussion (n = 56), or recurrent concussions (n = 24). There was no difference in neurocognitive performance between the former professional athletes and their peers, or among younger individuals with varying concussion exposures. However, younger individuals without prior concussion outperformed peers with prior concussion on three balance assessments. Twenty salivary miRNAs differed (adj. p < 0.05) between former professional athletes and their peers. Two of these (miR-28-3p and miR-339-3p) demonstrated relationships (p < 0.05) with the number of prior concussions reported by younger individuals. miR-28-3p and miR-339-5p may play a role in the pathophysiologic mechanism involved in cumulative concussion effects.

scholarly journals Leukoedema pada Perokok

e-GIGI ◽  
2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Priska T. Mambu ◽  
Pieter L. Suling ◽  
Aurelia S. R. Supit
Keyword(s):  
Case Control Study ◽  
Cross Sectional Study ◽  
Case Control ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cigarette Smokers ◽  
Review Study ◽  
Cross Sectional Studies ◽  
Almost All ◽  
Control Study

Abstract: Smokers can be found in almost all groups of people worldwide since cigarettes can be obtained easily anywhere and have been addicted by adult smokers. Leukoedema is one of the lesions in oral cavity that most often appears in smokers. This study was aimed to obtain the description of leukoedema cases among smokers. This was a literature review study. This study used previous studies or reports related to leukoedema in smokers. There were 13 literatures in this study consisting of 9 cross-sectional studies, 3 cohort studies, and 1 case control study. The results showed that leukoedema lesions were more common in smokers than in those who consumed tobacco. Leukoedema was closely related to the duration of smoking and the frequency of smoking in a day. Leukoedema was also more common in men than in women, and was often found bilaterally on the buccal mucosa. In conclusion, leucoedema was most common in cigarette smokers and was related to duration of smoking, frequency of smoking per day, and sex. It was often found bilaterally on the buccal mucosa.Keywords: smokers, leukoedema Abstrak: Perokok ditemukan pada hampir semua kelompok masyarakat di dunia. Leukoedema merupakan salah satu lesi dalam rongga mulut yang paling sering muncul pada perokok. Penelitian ini bertujuan untuk mengetahui gambaran leukoedema pada perokok. Jenis penelitian ialah studi pustaka. Penelitian ini menggunakan topik terkait leukoedema pada perokok dari penelitian-penelitian sebelumnya. Pustaka yang diulas dan dipelajari dalam penelitian ini sebanyak 13 pustaka, terdiri dari 9 cross-sectional study, 3 cohort study, dan 1 case control study. Hasil penelitian ini memperlihatkan bahwa lesi leukoedema lebih sering ditemukan pada perokok dibandingkan yang tidak merokok meskipun mengonsumsi tembakau. Leukoedema erat hubungannya dengan lama kebiasaan merokok dan frekuensi merokok yang dilakukan dalam sehari. Leukoedema juga lebih sering ditemukan pada laki-laki dibandingkan perempuan, dan sering ditemukan pada mukosa bukal secara bilateral. Simpulan penelitian ini ialah leukoedema sering didapatkan pada perokok dan berhubungan erat dengan kebiasaan merokok, frekuensi merokok, jenis kelamin, dengan lokasi mukosa bukal bilateral.Kata kunci: perokok, leukoedema

scholarly journals Faktor-Faktor Yang Mempengaruhi Tuberculosis Multidrug Resistance (TB MDR)

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Trivianto G. Bawonte ◽  
Christi D. Mambo ◽  
Angelina S. R. Masengi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Multidrug Resistance ◽  
Literature Review ◽  
Case Control Study ◽  
Cross Sectional Study ◽  
Case Control ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mdr Tb ◽  
Control Study

Abstract: Multidrug Resistance Tuberculosis (MDR TB) is Mycobacterium tuberculosis resistance to the first line of antituberculosis drugs are rifampicin and isoniazid. Globally, in 2017 there were around 558.000 new cases (range, 483.000-639.000) resistant TB rifampicin (TB RR), nearly half of which were in three counties, India (24%), China (13%), and Rusia (10%). WHO estimates that there are 23.000 cases of MDR/RR in Indonesia. In 2017, there were 442.000 TB cases recorded in the program, of which an estimated 8.600-15.000 MDR/RR TB cases. The research to determine the factors that influence Multidrug Resistance Tuberculosis (MDR TB).this type of research is in the form of literature review with design of case control study and cross sectional study. The results showed that the risk factors were proven to influence the occurrence (MDR TB). The conclusion from 15 articles reviewed, it shows that age, gender, treatment irregularity and medication adherence are the most influencing factors for TB MDR.Keywords: Factors, TB MDR, multidrug resistance tuberculosis  Abstrak: Tuberculosis Multidrug Resistance (TB MDR) merupakan resistensi Mycobacterium tuberculosis terhadap jenis Obat Anti Tuberkulosis (OAT) lini pertama yaitu rifampisin dan isoniazid. Di tingkat global, di tahun 2017 terdapat sekitar 558.000 kasus baru (rentang, 483.000 - 639.000) TB rifampisin (TB RR) resistan di mana hampir separuhnya ada di tiga negara yaitu India (24%), China (13%), dan Rusia (10%). WHO memperkirakan ada 23.000 kasus MDR/RR di Indonesia. Pada tahun 2017 kasus TB yang tercatat di program ada sejumlah 442.000 kasus yang mana dari kasus tersebut diperkirakan ada 8.600-15.000 MDR/RR TB. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi Tuberculosis Multidrug Resistance (TB MDR). Jenis penelitian ini berbentuk literature Review dengan rancangan case control study dan cross sectional study. Hasil penelitian ini menunjukkan bahwa faktor risiko terbukti mempengaruhi terjadinya (TB MDR). simpulan dari 15 artikel yang di review, menunjukkan bahwa usia, jenis kelamin, ketidakteraturan berobat, dan kepatuhan minum obat merupakan faktor yang paling mempengaruhi terjadinyaTB MDR.Kata Kunci : Faktor – faktor, TB MDR, factors, multidrug tuberculosis

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