Relationship between clinical signs and hormonal analytical findings in bitches with lactatio sine graviditate

2021 ◽  
Vol 49 (03) ◽  
pp. 174-182
Author(s):  
Sebastian Ganz ◽  
Carla Olschewski ◽  
Klaus Failing ◽  
Hartwig Bostedt
Keyword(s):  
Peripheral Blood ◽  
Prolactin Level ◽  
Clinical Relevance ◽  
Reference Range ◽  
Clinical Signs ◽  
Hormone Profile ◽  
The Individual ◽  
Almost All ◽  
Estradiol 17Β

Abstract Objective Lactatio sine graviditate of the bitch can become clinically relevant in particularly severe manifestations. The aim of the study was to relate the hormone pattern consisting of progesterone (P4), estradiol 17β (E2) and prolactin to the time of occurrence of lactatio sine graviditate in the course of metoestrus and anoestrus as well as to its symptomatology. Material and methods Sixty-eight bitches with apparent lactatio sine graviditate were divided into 3 groups according to their cycle status. All bitches were examined for gynaecological findings. Furhtermore, their blood progesterone, oestrogen, and prolactin concentrations were determined and compared with the 133-day hormone profile of 7 control animals. Results Lactatio sine graviditate occurring in early metoestrus was characterised more by a shifted P4:E2 ratio than by hyperprolactinaemia. Overall, the prolactin concentration in the peripheral blood was significantly increased. Analysis of the individual cases revealed that hyperprolactinaemia was present to varying degrees. It could be detected in almost all bitches that showed full symptomatology at the end of metoestrus or at the beginning of anoestrus. Only then clinical signs correlated with an increased prolactin concentration in the peripheral blood. In most cases, the estradiol-17β concentration was within the reference range. Conclusion and clinical relevance The study indicates that the administration of prolactin inhibitors alone is not indicated in all cases of lactatio sine graviditate and that the timepoint of onset of the clinically relevant symptoms and the current prolactin level should be taken into account in the treatment of affected bitches.

STUDYING SOME CLINICAL AND PARACLINICAL CHARACTERISTICS OF POSMATURE BABIES CARED IN NICU AT HUE UNIVERSITY HOSPITAL

2012 ◽  
pp. 74-84
Author(s):  
Thi Kieu Nhi Nguyen
Keyword(s):  
Respiratory Rate ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
University Hospital ◽  
Maternal Characteristics ◽  
Exact Test ◽  
Menstrual Cycles ◽  
Term Newborns ◽  
Student’S T ◽  
The Individual

Objectives: 1. Estimating the ratios of clinical and paraclinical signs of post-term newborns hospitalized at Pediatric Department of Hue University Hospital. 2. Identifying the relation between clinical signs and paraclinical signs. Materials and Method: 72 post- term babies < 7 days of life hospitalized at NICU from 2010/5 to 2011/4. Classification of post - term newborn was based on WHO 2003: gestational age ≥ 42 weeks with clinical manifestations: desquamation on press with fingers or natural desquamation, withered or meconial umbilicus, meconial long finger nails (*) or geatational age still < 42 weeks with theses clinical manifestations (*). Data were recorded on a clinical record form. Per-protocol analysis of clinical outcomes was performed by using Medcalc 11.5 and Excell 2007. Analyses used the χ2 test or Fisher's exact test for categorical data; Student's t test was used for continuous data and the Mann-Whitney U test for nonparametric data. Data were presented as means or proportions with 95% CIs. Results: Clinical characteristics: Tachypnea and grasp were main reasons of hospitalisation (48.61%). Poor feeding, vomitting (16.67%). Asphyxia (8.34%). Jawndice (6.94%). Hypothermia < 36.50C (13.89%), fever (13.89%). Tachypnea (59.72%). Bradycardia (1.39%). Poor feeding (11.11%). Hypertonia (9.72%). Paraclinical characteristics: Erythrocytes < 4.5.1012/l (51.39%), Leucocytes 5 – 25.103/mm3 (81.94%), Thrombocytes 100- 400.103/mm3 (94.44%). Hemoglobinemia < 10mg/l (67.61%). Maternal characteristics: Menstrual cycles regular (75%). Primiparity (75%). Amniotic volume average (70.42%), little (29.58%). Aminiotic liquid clair (62.5%), aminiotic liquid yellow (4.17%), aminiotic meconial liquid (33.33%). Maternal manifestation of one of many risk factors consist of genital infection; urinary infection; fever before, during, after 3 days of birth; prolonged delivery; medical diseases influence the foetus (75%). The relation between clinical signs and paraclinical signs: There was significantly statistical difference: between gestationnal age based on obstetrical criteria and amniotic volume on ultrasound (p < 0.05); between birth weight and glucosemia p < 0.02). There was conversional correlation of average level between erythroctes number and respiratory rate (r = - 0.5158; p < 0,0001), concordance correlation of weak level betwwen leucocytes number and respiratory rate r = 0.3045; p = 0.0093). Conclusion: It should made diagnosis of postterm baby based on degree of desquamation. The mother who has menstrual cycles regular is still delivered of a postterm baby. A postterm baby has the individual clinical and paraclinical signs.

scholarly journals Challenge of Naïve and Vaccinated Pigs with a Vaccine-Derived Recombinant Porcine Reproductive and Respiratory Syndrome Virus 1 Strain (Horsens Strain)

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 417
Author(s):  
Lise K. Kvisgaard ◽  
Lars E. Larsen ◽  
Charlotte S. Kristensen ◽  
Frédéric Paboeuf ◽  
Patricia Renson ◽  
...  
Keyword(s):  
Viral Load ◽  
Experimental Model ◽  
Recombinant Strain ◽  
Clinical Signs ◽  
Growing Pigs ◽  
Respiratory Syndrome Virus ◽  
Almost All ◽  
Highly Virulent

In July 2019, a vaccine-derived recombinant Porcine reproductive and respiratory syndrome virus 1 strain (PRRSV-1) (Horsens strain) infected more than 40 Danish sow herds, resulting in severe losses. In the present study, the pathogenicity of the recombinant Horsens strain was assessed and compared to a reference PRRSV-1 strain using a well-characterized experimental model in young SPF pigs. Furthermore, the efficacies of three different PRRSV-1 MLV vaccines to protect pigs against challenge with the recombinant strain were assessed. Following challenge, the unvaccinated pigs challenged with the Horsens strain had significant increased viral load in serum compared to all other groups. No macroscopic changes were observed at necropsy, but tissue from the lungs and tonsils from almost all pigs were PRRSV-positive. The viral load in serum was lower in all vaccinated groups compared to the unvaccinated group challenged with the Horsens strain, and only small differences were seen among the vaccinated groups. The findings in the present study, combined with two other recent reports, indicate that this recombinant “Horsens” strain indeed is capable of inducing infection in growing pigs as well as in pregnant sows that is comparable to or even exceeding those induced by typical PRRSV-1, subtype 1 strains. However, absence of notable clinical signs and lack of significant macroscopic changes indicate that this strain is less virulent than previously characterized highly virulent PRRSV-1 strains.

Adolescent Musicians' Perceptions of Conductors Within Musical Context

2009 ◽  
Vol 57 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Clifford K. Madsen ◽  
John M. Geringer ◽  
Katia Madsen
Keyword(s):  
College Students ◽  
Summer Camp ◽  
The Individual ◽  
Almost All ◽  
Audio Video ◽  
Musical Context

Attention to subtle changes in music, whether inadvertent or purposeful, occupies a great deal of practice and rehearsal time for the performer. Regardless of the extremely subtle acoustic changes that have been found to be perceptible within almost all studies, it is the total overall effect that most occupies the individual listener. This study investigated perception of digitally edited performances of Johann Strauss's Blue Danube Waltz, all performed by the Vienna Philharmonic Orchestra with various conductors across an 18-year period. Two groups of string musicians in grades 7 through 12 participated ( N = 104). One group was an intact class; the second was a group of summer camp students. All participants listened to two conditions: (a) audio only and (b) audio-video combination. Results indicated that there were no significant differences between groups and that no one was able to identify correctly that there were five different conductors in the audio-only condition. Results were much the same as earlier research with college students. In addition, many students indicated that there were differences in the audio portions of the two conditions when in fact there were not.

Justice as Fairness: For Groups?

1975 ◽  
Vol 69 (2) ◽  
pp. 607-614 ◽  
Author(s):  
Vernon Van Dyke
Keyword(s):  
John Rawls ◽  
Homogeneous State ◽  
Dominant Form ◽  
Justice As Fairness ◽  
Theory Of Justice ◽  
Indigenous Groups ◽  
The Social ◽  
Principles Of Justice ◽  
The Individual ◽  
Almost All

In A Theory of Justice, John Rawls assumes that the principles of justice are for individuals in a society, and in general he assumes that the society is an ethnically homogeneous state. He thus follows the tradition associated with the dominant form of the social contract theory, which focuses on the individual and the state. His assumptions neglect the fact that almost all states are ethnically plural or heterogeneous, and that many of them confer special status and rights on ethnic groups as collective entities; for example, many of them confer special status and rights on indigenous groups, on groups disadvantaged by prior discrimination, and on minorities and other groups conceded a right to survive as distinct cultural entities. Status and rights for groups necessarily mean differentiation among individuals depending on their membership; and this in turn means that a theory of justice that focuses on the individual and neglects the group both fails to account for existing practices and fails to give guidance where the practices are at issue.

scholarly journals Extraintestinal isosporoid coccidian causing atoxoplasmosis in captive green-winged saltators: clinical and hematological features

2017 ◽  
Vol 37 (11) ◽  
pp. 1327-1330
Author(s):  
Sabrina D.E. Campos ◽  
Camila S.C. Machado ◽  
Tatiana V.T. de Souza ◽  
Renan C. Cevarolli ◽  
Nádia R.P. Almosny
Keyword(s):  
Infectious Diseases ◽  
Clinical Improvement ◽  
Peripheral Blood ◽  
Inflammatory Process ◽  
Blood Smear ◽  
Preventive Measures ◽  
Clinical Signs ◽  
Acute Disease ◽  
Illegal Trade ◽  
Hygienic Conditions

ABSTRACT: Populations of green-winged saltators, Saltator similis, are decreasing especially because of illegal trade and infectious diseases. We describe natural cases of an extraintestinal isosporoid coccidian in caged S. similis, and suggest the need of preventive measures in handling these birds. Nonspecific clinical signs were seen in all of them, however, intracytoplasmic Atoxoplasma sp. was found in peripheral blood, reinforcing the idea of systemic isosporosis. Leukocytosis with high number of heterophils and monocytes suggested that atoxoplasmosis in green-winged saltators can progress as an acute disease. The birds showed clinical improvement after treatment. Handling recommendations were proposed to upgrade hygienic conditions of the facilities. We concluded that nonspecific symptoms and an acute inflammatory process can be associated with atoxoplasmosis in young S. similis. We emphasize the importance of blood smear to detect merozoites.

ABNORMALITY OF ESTROGEN METABOLISM IN HUMAN SUBJECTS WITH MYOCARDIAL INFARCTION

1957 ◽  
Vol 35 (1) ◽  
pp. 1277-1288
Author(s):  
William S. Bauld ◽  
Morris L. Givner ◽  
Ian G. Milne
Keyword(s):  
Myocardial Infarction ◽  
Intramuscular Injection ◽  
Human Subjects ◽  
Bed Rest ◽  
Estrogen Metabolism ◽  
Previous Myocardial Infarction ◽  
Daily Excretion ◽  
The Individual ◽  
Male Subjects ◽  
Estradiol 17Β

Estrogen metabolism has been investigated in male subjects with and without previous myocardial infarction. The urinary excretion of estriol, estrone, and estradiol-17β has been measured 1 day before and 4 days after intramuscular injection of estradiol-17β. The excretion of the individual estrogens resulting from the administration of estradiol was determined by subtracting preinjection values from the daily excretion following injection. The resultant values of estriol (T), estrone (O), and estradiol-l7β (D) were expressed as the following ratios:[Formula: see text]These urinary estrogen ratios were found to be significantly higher in subjects with previous myocardial infarction than in control subjects. The ratios in the infarction group were not influenced by bed rest nor by the duration of time following infarction which varied from 1 week to 2 years.

scholarly journals Blood antioxidant nutrients in riparian villagers of the Brazilian Amazon: its associations with wet/dry seasons and modulation by sociodemographic determinants

2016 ◽  
Vol 24 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Juliana Valentini ◽  
Carlos José Sousa Passos ◽  
Solange Cristina Garcia ◽  
Robert Davidson ◽  
Marc Lucotte ◽  
...  
Keyword(s):  
Vitamin E ◽  
Reference Range ◽  
Brazilian Amazon ◽  
Individual State ◽  
River Region ◽  
Baseline Information ◽  
Sociodemographic Determinants ◽  
Dry Seasons ◽  
The Individual ◽  
Β Carotene

Abstract This study associates blood antioxidants like copper (Cu), manganese (Mn), selenium (Se), zinc (Zn), β-carotene, lycopene and vitamins (A and E) to sociodemographic features and seasonality in communities from the Tapajós River region, Brazilian Amazon. We observed increased Mn, Se and Zn levels compared to the average Brazilian population, whereas this is only the case for β-carotene in the rainy season. Lycopene levels fall within the reference range, although lower than those found in other Brazilian regions. Cu, Se, Zn, β-carotene, lycopene and vitamin E levels vary among seasons. β-carotene, Mn and Se vary among communities. Se and Zn vary with smoking habits and sex, respectively. In addition, β-carotene and vitamins (A and E) are altered by alcohol consumption. Villagers who both farmed and fished present higher Cu and lower β-carotene levels than participants with a single occupation. Vitamin E levels depend upon the individual state of origin. These data provide important baseline information for antioxidant status in this Amazonian riparian population.

Urinary 5-HIAA Excretion is not Increased in Patients with Head and Neck Paragangliomas

2012 ◽  
Vol 27 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Leonie T. Van Hulsteijn ◽  
Nicolette Van Duinen ◽  
Johannes A. Romijn ◽  
Johannes W.A. Smit ◽  
Eleonora P.M. Corssmit
Keyword(s):  
Urinary Excretion ◽  
Head And Neck ◽  
Reference Range ◽  
Excretion Rate ◽  
Case Reports ◽  
Catecholamine Excess ◽  
Hydroxyindoleacetic Acid ◽  
Excretion Rates ◽  
Almost All ◽  
Head And Neck Paragangliomas

Background Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, in addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized to 5-hydroxyindoleacetic acid (5-HIAA). Aim To assess the urinary excretion rates of 5-HIAA and catecholamines in HNPGL patients. Methods In 114 consecutive HNPGL patients, normetanephrine, metanephrine, norepinephrine, epinephrine, VMA, dopamine, 3-methoxytyramine and 5-HIAA excretion rates were measured in two 24-hour urinary samples. Increased excretion rates were defined as an increase of the average hormone excretion rate of 2 urine samples above the reference range. In all patients with catecholamine excess, intrathoracic and abdominal paragangliomas were excluded by 123I-MIBG scintigraphy, MRI and/or CT. Genetic screening for mutations in genes of the succinate dehydrogenase (SDH) family was performed. Results Mean urinary 5-HIAA excretion rate was 14±9 μmol/24 hours (reference range 10–44 μmol/24 hours). Urinary 5-HIAA excretion was slightly increased in only 1 patient (48 μmol/24 hours). None of the 50 patients (44%) with increased urinary excretion rates of catecholamines and/or their metabolites had elevated 5-HIAA excretion. Conclusion Urinary 5-HIAA excretion is within the normal reference range in almost all HNPGL patients. Therefore, this parameter has no clinical relevance in the routine clinical assessment of HNPGL patients.

scholarly journals The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology

2021 ◽  
Vol 9 ◽  
Author(s):  
Martha Habibi ◽  
Panagiotis K. Karyofyllis ◽  
Aggeliki Nikolakopoulou ◽  
Panagiotis Papagiannis ◽  
Pantelis Karaiskos ◽  
...  
Keyword(s):  
Risk Estimation ◽  
Biological Effects ◽  
Interventional Cardiology ◽  
Mean Values ◽  
Individual Level ◽  
Cardiac Procedures ◽  
Before And After ◽  
Radiation Induced ◽  
The Individual ◽  
Almost All

The effect of the reportedly low ionizing radiation doses, such as those very often delivered to patients in interventional cardiology, remains ambiguous. As interventional cardiac procedures may have a significant impact on total collective effective dose, there are radiation protection concerns for patients and physicians regarding potential late health effects. Given that very low doses (&lt;100 mSv) are expected to be delivered during these procedures, the purpose of this study was to assess the potency and suitability of current genotoxicity biomarkers to detect and quantitate biological effects essential for risk estimation in interventional cardiology. Specifically, the biomarkers γ-H2AX foci, dicentric chromosomes, and micronuclei, which underpin radiation-induced DNA damage, were studied in blood lymphocytes of 25 adult patients before and after interventional cardiac procedures. Even though the mean values of all patients as a group for all three endpoints tested show increased yields relative to baseline following medical exposure, our results demonstrate that only the γ-H2AX biomarker enables detection of statistically significant differences at the individual level (p &lt; 0.001) for almost all patients (91%). Furthermore, 24 h after exposure, residual γ-H2AX foci were still detectable in irradiated lymphocytes. Their decline was found to vary significantly among the individuals and the repair kinetics of γ-H2AX foci was found to range from 25 to 95.6% of their maximum values obtained.

scholarly journals Seasonal changes of biological condition and reproductive cycle of hampback shrimp Pandalus hypsinotus (Caridea, Pandalidae) in the Tatar Strait

2021 ◽  
Vol 201 (3) ◽  
pp. 547-560
Author(s):  
D. N. Yuriev ◽  
G. V. Zhukovskaya
Keyword(s):  
Reproductive Cycle ◽  
Japan Sea ◽  
Biological Condition ◽  
Tatar Strait ◽  
Stage Of Development ◽  
Long Time ◽  
Pass Through ◽  
The Individual ◽  
Almost All ◽  
Trawl Catches

Research and commercial trawl catches of humpback shrimp Pandalus hypsinotus from the Tatar Strait (Japan Sea) in 2004–2020 were investigated, with bioanalysis of about 45 thousand specimens. Average timing of group molting, spawning, and eggs laying are determined, terms of gonads and eggs development are estimated. Prespawning and molting of the females occur between January-April, with the peaks in early February and middle February, respectively. All oviparous females have 30–40 days to lay eggs, and molt during 50–55 days; the peak of the eggs laying occurs in late June. The males molt in July-August, afterwards the largest individuals change gender and new intersexes are formed. The males have the second molting in October-December, with the peak in late November. In January, after finish of the males molting, a new annual reproduction cycle starts from the prespawning molting of females. Both vitellogenesis and embryogenesis are observed through the year, though females with developing gonads prevail from August to January (because of a long time span between winter and summer moltings while the egg carrying continued 15 months) but oviparous females — from February to July. The individual reproductive cycle of Pandalus hypsinotus in the Tatar Strait lasts 24 months, with 9 months of vitellogenesis (quick growth of gonads) and 15 months of embryogenesis. During the 2-year reproductive cycle, most of females pass through the following stages: i) gonads development (just after eggs laying) when almost all oviparous females (up to 95 % in May) have green gonads under carapace that corresponds to the stage of development «eggs laid — gonads weakly developed»; ii) summer molting from August when females lose hairs on pleopods and the gonads growth accelerates; iii) respawning in January-March (together with the firstly spawning intersexes, with slight delay of the latter); iv) initial developing of eggs during summer; v) stage of «eyed eggs» from December to March; and vi) eggs laying and molting from late March to late May; then the 2-year reproductive cycle repeats.

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