On the Origin of Plasma Plasminogen Activator in Man

1979 ◽  
Author(s):  
N.A. Marsh ◽  
P. J. Gaffney

In the past, plasma plasminogen activators have been considered a wide group of dlssimiliar substances originating in plasma (the so-called “intrinsic” activators) and outside the vascular compartment (“extrinsic” activators). The “intrinsic” group appear to share the common property of being sensitive to complement Ci-lnactivator A series of simple experiments performed in our laboratories indicate however that these substances may not be quite so diaparate. We have measured “Intrinsic” and “extrinsic” plasminogen activators before and after exercise, a procedure known to elevate systemic levels. Activators were precipitated in the euglobulin fraction by diluting plasma L in 10 and acidifying to pH 5.9. The resuspended precipitate was tested on conventional and rapid fibrin plates using sodium flufenamate (an inhibitor of complement lnactivator) Co distinguish between the two “kinds” of activatorThe results showed a marked increase In “extrinsic” activator liberated by the vascular endothelium in response to exercise, the level of which quickly declined. By contrast theIntrinsic” activator fell immediately after exercise and then rose over the next 90 minutes. We suggest from these results that the two kinds of activator are more intimately related than was previously thought and that the disappearance of post-exercise “extrinsic” activator (formerly ascribed to inactivación by the liver) is due to conversion to the “intrinsic” form commonly assayed in “resting” plasma

2021 ◽  
Vol 38 (1) ◽  
pp. 22-27
Author(s):  
VM Alfaro Magallanes ◽  
L Barba Moreno ◽  
AB Peinado

Serum ferritin has been proposed as a predictor of hepcidin concentrations in response to exercise. However, this fact has not been studied in physically-active women. Therefore, the main objective of this study was to analyse the hepcidin response at different ferritin status before and after running exercise in physically active females. Fifteen eumenorrheic women performed a 40-min running protocol at 75% of VO2peak speed in different menstrual cycle phases (early-follicular phase, mid-follicular phase and luteal phase). Blood samples were collected pre-exercise, 0h post-exercise and 3h post-exercise. For statistics, participants were divided into two groups according to their pre-exercise ferritin levels (<20 and ≥20 μg/L). Through menstrual cycle, hepcidin was lower in both early follicular phase (p=0.024; 64.81±22.48 ng/ml) and mid-follicular phase (p=0.007; 64.68±23.91 ng/ml) for <20 μg/L ferritin group, in comparison with ≥20 μg/L group (81.17±27.89 and 79.54±22.72 ng/ml, respectively). Hepcidin showed no differences between both ferritin groups in either pre-exercise, 0h post-exercise and 3h post-exercise. Additionally, no association between pre-exercise ferritin and hepcidin levels 3h post-exercise (r=-0.091; p=0.554) was found. Menstrual cycle phase appears to influence hepcidin levels depending on ferritin reserves. In particular, physically-active females with depleted ferritin reserves seems to present lower hepcidin levels during the early-follicular phase and mid-follicular phase. However, no association between ferritin and hepcidin levels was found in this study. Hence, ferritin levels alone may not be a good predictor of hepcidin response to exercise in this population. Multiple factors such as sexual hormones, training loads and menstrual bleeding must be taken into account.


Author(s):  
Luís Filipe Cunha

This paper deals with the main similarities and differences that arise between past and future tenses. In particular, we argue that, while the propositions associated with past tenses are completely settled and their truth-value can be evaluated at the speech time, the propositions described by future tenses cannot be seen as true or false at the utterance time since these linguistic forms are ramifying, in that they typically point to a variety of inertia histories or inertia worlds. Nevertheless, if we consider more closely some particular tenses in European Portuguese – namely the Pretérito Imperfeito (Imperfect) and the Pretérito Perfeito do Indicativo (simple past), as representatives of the past tenses, and the Futuro Simples (simple future) and the structure ir (‘go’) + Infinitive, as representatives of the future ones, we conclude that there are also some important parallels across the two temporal domains. We claim that both the Imperfeito and the Futuro Simples merely locate the situations in a past or future interval, respectively, and that the final interpretation of the sentences in which they occur is the result of the interaction of their temporal characteristics with aspectual and modal features. The Pretérito Perfeito and the structure ir (‘go’) + Infinitive, on the other hand, share the common property of imposing an additional temporal boundary beyond which the eventualities cannot take place; as a result, aspectual effects and modal readings are much more conditioned and pure temporal interpretations – both in the past and in the future – become greatly predominant.


1958 ◽  
Vol 15 ◽  
pp. 1-8 ◽  
Author(s):  
Raymond H. Thompson

It seems to have become the custom for the author of a paper on archaeological methodology to provide his readers with a review of the theoretical trends of the discipline. The general outline of these trends must by now be the common property of all literate anthropologists. do not consider it improper, therefore, to refrain from repeating a summary of them here. Much more important to this study of the nature of archaeological inference is a statement of the present aims of the discipline and the role which inference is expected to play in achieving these aims.Phillips and Willey (1953: 616) succinctly describe the proper ends of archaeological research:The ultimate objective of archeology is the creation of an image of life within the limits of the residue that is available from the past. The procedural objectives toward such a goal may be dichotomized into reconstructions of space-time relationships, on the one hand, and contextual relationships on the other.


Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 393
Author(s):  
Phureephat Larsuphrom ◽  
Gladys Oluyemisi Latunde-Dada

Background: Prevalence of iron deficiency is commonly reported among athletic population groups. It impairs physical performance due to insufficient oxygen delivery to target organs and low energy production. This is due to the high demand of exercise on oxygen delivery for systemic metabolism by the erythrocytes in the blood. Hepcidin, the key regulator of iron homeostasis, decreases to facilitate iron efflux into the circulation during enhanced erythropoiesis. However, acute anaemia of exercise is caused by increased hepcidin expression that is induced by stress and inflammatory signal. The study aimed to systematically review changes in serum hepcidin levels during resistance and aerobic exercise programmes. Methods: A systemic literature search from 2010 to April 2020 across seven databases comprised of Cochrane library, PubMed, Web of Science, Scopus, Embase, MEDLINE, and OpenGrey. The primary outcome was increased or decreased serum hepcidin from baseline after the exercise activity. Risks of bias were evaluated by using the National Institutes of Health (NIH) for quality assessment of before and after different exercise programmes. Results: Overall, twenty-three studies met the inclusion criteria. Out of the 23 studies, 16 studies reported significantly exercise-induced serum hepcidin elevation. Of the 17 studies that evaluated serum interleukin (IL)-6 levels, 14 studies showed significant exercise-induced serum IL-6 elevation. Changes in exercise-induced serum hepcidin and IL-6 levels were similar in both resistance and endurance exercise. Significant correlations were observed between post-exercise hepcidin and baseline ferritin levels (r = 0.69, p < 0.05) and between post-exercise hepcidin and post-exercise IL-6 (r = 0.625, p < 0.05). Conclusion: Resistance and endurance training showed significant increase in serum hepcidin and IL-6 levels in response to exercise. Baseline ferritin and post-exercise IL-6 elevation are key determining factors in the augmentation of hepcidin response to exercise.


Author(s):  
Mukarom Mukarom ◽  
Rochsun Rochsun

Villagers of Waringinsari, Sukoharjo sub-district, Pringsewu district, Lampung province grows and develops from voluntary migrants from Java. They are a group of marginalized people economically, politically, socially and culturally, so they expected so much when migrating to get a better life for his family. Residents who occupy Waringinsari village as the voluntary migrants are from different regions. They were farmers who had come from the felds of Java (Central, East and West) to gain ground as a new livelihood. The question is why with all kinds of differences in the Javanese sub-culture they could then dissolve together, and then they feel just as Javanese (in the sense of not distinguishing which Javanese origin). The research was carried out to get an answer whether janengan contributing music as media of entertainment, communication and propagation for villagers of voluntary migrants in the Waringinsari village, Suhoharjo Sub-district, Pringsewu district, Lampung province. This research is qualitative. The data obtained show that janengan music does really as alternative music that is able to show the identity of the people of Java. Janengan identifes the Javanese sub-culture from Kebumen which later became the common property of the voluntary migrants. They feel a sense of musical art is proven fact that until now is still a viable alternative entertainment. Janengan also contribute to the cohesiveness, and was able to eliminate the bulkhead sub-culture of their respective regions of origin. Music janengan is able to be an alternative as a cheap entertainment media, as a means of gathering spontaneous migrants thus establish communication in the period since the beginning of the village to the present, the past 60 years. In addition, the content ofthe janengan music lyric also provide a moral message that as human beings they are not arrogant, and ableto follow prophets. Janengan is able to instill the values to the younger generation so that they can becomegood human in morality as told in the poem of janengan.


Philosophy ◽  
1958 ◽  
Vol 33 (125) ◽  
pp. 147-157
Author(s):  
J. Kemp

If we ask what are the problems which have to be dealt with when the subject of art is being discussed in a philosophical manner, we shall no doubt receive a variety of answers: but there will be in one respect a considerable measure of agreement, viz. that the main problem consists in discovering (a) what is the common property in all works of art which distinguishes them from things that are not works of art, and (b) what is the common property in all good works of art which distinguishes them from bad or mediocre ones. Certainly an immense amount of labour has in the past been devoted to this purpose. Recent philosophical practice, however, has implied some dissatisfaction with this type of approach, and the purpose of this article is to try to show that the dissatisfaction is justified.


Author(s):  
Ezzatollah Keyhani

Acetylcholinesterase (EC 3.1.1.7) (ACHE) has been localized at cholinergic junctions both in the central nervous system and at the periphery and it functions in neurotransmission. ACHE was also found in other tissues without involvement in neurotransmission, but exhibiting the common property of transporting water and ions. This communication describes intracellular ACHE in mammalian bone marrow and its secretion into the extracellular medium.


2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Pardan Syafrudin

The Common properties (community property) is an asset that the husband and wife acquired during the household lifes, which both of them is agree that after united through marriage bonds, that the property produced by one or both of them will be common property. It shows, that if there's an agreement between husband and wife before marriage (did not to unify their property), then the property produced both will not become a joint treasure. Thus, if a husband or wife dies, or divorces, then the property owned by both of them can be distributed in accordance with their respective shares, another case when the two couples are not making an agreement, then the property gained during marriage bonds can be divided into types of communal property. In Islamic law, this kind of treasure is not contained in the Qur'an or Sunnah. Nor in Islamic jurisprudence. However, Islamic law legalizes the existence of common property as long as it is applicable in a society and the benefit in the distribution of such property. In contrast to the positive law, this property types have been regulated and described in the Marriage Law, as well as the Islamic Law Compilations, which became the legal restriction in the affairs of marriage in force in Indonesia. In this study, the author tries to compile the existence of common property according to the Islamic law reviews and positive law.


2017 ◽  
Vol 1 (1) ◽  
pp. 1-6
Author(s):  
Jennifer M. Bernstein

Vickers Hot Springs is located near the rural Southern California town of Ojai, and local residents have long enjoyed soaking in the sulfuric pools. But as knowledge of the springs spread, the area saw increases in fights, traffic, burglaries, and drug use. In response, two residents purchased the land and committed to restore the property while allowing limited public access, subsequently generating a great deal of controversy within the community. Privatizing Vickers Hot Springs follows the archetypical lesson of Garrett Hardin's 1968 essay, “The Tragedy of the Commons.” Hardin stated that the problem for common-pool resources was that a finite amount of services are demanded by a potentially infinite number of users, who have little to gain by sacrificing for the common good. But Hardin's theory does not always apply. Many communities have come together to manage resources, often without government oversight. Thus, the question is not whether or not Hardin's theory is accurate, but rather “under what conditions it is correct and when it makes the wrong predictions.” Case studies provide nuance to the broad brushstrokes of a theory, and whether Hardin's parable is applicable depends on the particularities of the common property resource conflict. Employing the frameworks established by Hardin, Dietz et al., and Ostrom, this paper examines the management of Vickers Hot Springs within its broader social, ecological, and political context, asking whether the particular circumstances of this resource use conflict made privatization the most predictable outcome.


Author(s):  
Joseph Mazur

While all of us regularly use basic mathematical symbols such as those for plus, minus, and equals, few of us know that many of these symbols weren't available before the sixteenth century. What did mathematicians rely on for their work before then? And how did mathematical notations evolve into what we know today? This book explains the fascinating history behind the development of our mathematical notation system. It shows how symbols were used initially, how one symbol replaced another over time, and how written math was conveyed before and after symbols became widely adopted. Traversing mathematical history and the foundations of numerals in different cultures, the book looks at how historians have disagreed over the origins of the number system for the past two centuries. It follows the transfigurations of algebra from a rhetorical style to a symbolic one, demonstrating that most algebra before the sixteenth century was written in prose or in verse employing the written names of numerals. It also investigates the subconscious and psychological effects that mathematical symbols have had on mathematical thought, moods, meaning, communication, and comprehension. It considers how these symbols influence us (through similarity, association, identity, resemblance, and repeated imagery), how they lead to new ideas by subconscious associations, how they make connections between experience and the unknown, and how they contribute to the communication of basic mathematics. From words to abbreviations to symbols, this book shows how math evolved to the familiar forms we use today.


Sign in / Sign up

Export Citation Format

Share Document