scholarly journals Embolotherapy for Hepatic Oncology: Current Perspectives and Future Directions

2020 ◽  
Vol 04 (02) ◽  
pp. 134-147
Author(s):  
Raazi Bajwa ◽  
David C. Madoff ◽  
Sirish A. Kishore
Keyword(s):  
Artificial Intelligence ◽  
Liver Tumors ◽  
Transarterial Embolization ◽  
Supportive Evidence ◽  
Selective Internal Radiotherapy ◽  
Future Directions ◽  
Locoregional Treatment ◽  
Internal Radiotherapy ◽  
Liver Cancers ◽  
Bland Embolization

AbstractPrimary and secondary liver cancers are a major cause of mortality worldwide. Transarterial liver-directed therapy, or embolotherapy, represents an important locoregional treatment strategy for primary and secondary liver tumors. Embolotherapeutic modalities include bland embolization (transarterial embolization), chemoembolization (transarterial chemoembolization), and radioembolization or selective internal radiotherapy. A brief technical overview of embolotherapeutic modalities as well as supportive evidence for the treatment of most common primary and secondary liver tumors will be discussed in this review. Several potential future applications, including synergy with systemic therapy, interventional theranostics, and artificial intelligence will also be reviewed briefly.

scholarly journals Bland Embolization of Benign Liver Tumors: Review of the Literature and a Single Center Experience

2021 ◽  
Vol 10 (4) ◽  
pp. 658
Author(s):  
Daniel Crawford ◽  
Sailen Naidu ◽  
Indravadan Patel ◽  
Grace Knuttinen ◽  
Sadeer Alzubaidi ◽  
...  
Keyword(s):  
Tumor Volume ◽  
Liver Tumors ◽  
Transarterial Embolization ◽  
Single Center ◽  
Invasive Treatment ◽  
Benign Liver Tumors ◽  
Single Center Experience ◽  
Bland Embolization ◽  
Benign Liver ◽  
Median Change

Transarterial embolization has shown promise as a safe, effective, and less invasive treatment modality for benign liver lesions (hemangioma, focal nodular hyperplasia (FNH), and hepatic adenoma (HA)) with fewer complications compared to surgical intervention. There is no consensus regarding the most appropriate embolization material(s) for the treatment of benign liver tumors. The purpose of this study was to review the current literature regarding the transarterial embolization of benign liver tumors and to share our single center experience. This was a non-blinded, retrospective, single-institution review of the bland embolization of benign liver tumors. Clinical data and imaging before and after embolization were used to evaluate lesion response to transarterial embolization. Twelve patients were included in the study. Five patients with six hemangiomas were treated. Pain was a presenting complaint in all five of these patients. The median change in tumor volume was −12.4% and ranged from −30.1% to +42.3%. One patient with two FNH lesions was treated, and both lesion volumes decreased by more than 50%. Six patients with 10 adenomas were treated. Pain was a presenting complaint in three patients, and five patients had a lesion >5 cm. The median change in tumor volume was −67.0% and ranged from −92.9% to +65.8%. Bland transarterial embolization of liver hemangiomas, FNH, and HA can be an effective and minimally invasive treatment modality to control the size and/or symptoms of these lesions. There is a variable response depending on tumor type and the embolization materials used.

scholarly journals Embolotherapeutic Strategies for Hepatocellular Carcinoma: 2020 Update

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 791 ◽  
Author(s):  
Sirish A. Kishore ◽  
Raazi Bajwa ◽  
David C. Madoff
Keyword(s):  
Hepatocellular Carcinoma ◽  
Disease Control ◽  
Early Stage ◽  
Treatment Options ◽  
Developed Countries ◽  
Advanced Stage ◽  
Selective Internal Radiotherapy ◽  
Internal Radiotherapy ◽  
Similar Disease ◽  
Bland Embolization

Hepatocellular carcinoma (HCC) represents a significant contributor to cancer-related morbidity and mortality with increasing incidence in both developing and developed countries. Embolotherapy as a locoregional therapeutic strategy consists of trans-arterial or “bland” embolization (TAE), trans-arterial chemoembolization (TACE), and selective internal radiotherapy (SIRT). Trans-catheter arterial therapies can be applied along all stages of HCC, either as an alternative or neoadjuvant to surgical resection/transplantation in very early and early stage HCC or as a palliative option for local disease control in unresectable and advanced stage HCC. In advanced stage HCC, SIRT did not demonstrate superiority in comparison to systemic treatment options in several recent large prospective trials, though for carefully selected patients, may confer improved tolerability with similar disease control rates. The latest embolotherapeutic techniques and literature as they pertain to the management of HCC, as well as future directions, are reviewed in this article.

Locoregional Therapy for Hepatic Neuroendocrine Metastases

2017 ◽  
Vol 01 (03) ◽  
pp. 218-224
Author(s):  
Zachary Bercu ◽  
Jason Mitchell ◽  
Juan Camacho ◽  
Darren Kies ◽  
Eric Friedberg ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Transarterial Chemoembolization ◽  
Transarterial Embolization ◽  
Management Team ◽  
Locoregional Therapy ◽  
Multidisciplinary Management ◽  
Selective Internal Radiotherapy ◽  
Clinical Behavior ◽  
Internal Radiotherapy ◽  
Ablative Techniques

AbstractNeuroendocrine tumors are a heterogeneous group of malignancies with diverse biological and clinical behavior. Locoregional treatments available for the initial and temporal management of neuroendocrine tumors involving the liver include transarterial embolization, transarterial chemoembolization, selective internal radiotherapy, and ablative techniques. These therapies are best employed as part of a multidisciplinary management team focusing on appropriate histopathology, timing, and individuality of each intervention.

scholarly journals Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1102
Author(s):  
Alexander E. Kabakov ◽  
Anna O. Yakimova
Keyword(s):  
Heat Shock ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Liver Tumors ◽  
Oxygen Deficiency ◽  
Transarterial Embolization ◽  
Antiangiogenic Therapy ◽  
Adaptation To Hypoxia ◽  
Mesenchymal Transition

Within aggressive malignancies, there usually are the “hypoxic zones”—poorly vascularized regions where tumor cells undergo oxygen deficiency through inadequate blood supply. Besides, hypoxia may arise in tumors as a result of antiangiogenic therapy or transarterial embolization. Adapting to hypoxia, tumor cells acquire a hypoxia-resistant phenotype with the characteristic alterations in signaling, gene expression and metabolism. Both the lack of oxygen by itself and the hypoxia-responsive phenotypic modulations render tumor cells more radioresistant, so that hypoxic tumors are a serious challenge for radiotherapy. An understanding of causes of the radioresistance of hypoxic tumors would help to develop novel ways for overcoming this challenge. Molecular targets for and various approaches to radiosensitizing hypoxic tumors are considered in the present review. It is here analyzed how the hypoxia-induced cellular responses involving hypoxia-inducible factor-1, heat shock transcription factor 1, heat shock proteins, glucose-regulated proteins, epigenetic regulators, autophagy, energy metabolism reprogramming, epithelial–mesenchymal transition and exosome generation contribute to the radioresistance of hypoxic tumors or may be inhibited for attenuating this radioresistance. The pretreatments with a multitarget inhibition of the cancer cell adaptation to hypoxia seem to be a promising approach to sensitizing hypoxic carcinomas, gliomas, lymphomas, sarcomas to radiotherapy and, also, liver tumors to radioembolization.

scholarly journals Human-Centered Artificial Intelligence for Designing Accessible Cultural Heritage

2021 ◽  
Vol 11 (2) ◽  
pp. 870
Author(s):  
Galena Pisoni ◽  
Natalia Díaz-Rodríguez ◽  
Hannie Gijlers ◽  
Linda Tonolli
Keyword(s):  
Artificial Intelligence ◽  
Literature Review ◽  
Cultural Heritage ◽  
Conceptual Framework ◽  
Interaction Design ◽  
Participatory Design ◽  
Future Directions ◽  
Heritage Sites ◽  
Review Analysis

This paper reviews the literature concerning technology used for creating and delivering accessible museum and cultural heritage sites experiences. It highlights the importance of the delivery suited for everyone from different areas of expertise, namely interaction design, pedagogical and participatory design, and it presents how recent and future artificial intelligence (AI) developments can be used for this aim, i.e.,improving and widening online and in situ accessibility. From the literature review analysis, we articulate a conceptual framework that incorporates key elements that constitute museum and cultural heritage online experiences and how these elements are related to each other. Concrete opportunities for future directions empirical research for accessibility of cultural heritage contents are suggested and further discussed.

scholarly journals Hepatic Arterial Buffer Response in Liver Radioembolization and Potential Use for Improved Cancer Therapy

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1537
Author(s):  
Stephan Walrand ◽  
Michel Hesse ◽  
Philippe d’Abadie ◽  
François Jamar
Keyword(s):  
Animal Studies ◽  
Liver Tumors ◽  
Clinical Trial Design ◽  
Normal Liver ◽  
Dose Ratio ◽  
Liver Cancers ◽  
Tumoral Cell ◽  
Flow Enhancement ◽  
Curative Intention ◽  
Tumoral Cells

Liver radioembolization is a treatment option for unresectable liver cancers, performed by infusion of 90Y or 166Ho loaded spheres in the hepatic artery. As tumoral cells are mainly perfused via the liver artery unlike hepatic lobules, a twofold tumor to normal liver dose ratio is commonly obtained. To improve tumoral cell killing while preserving lobules, co-infusion of arterial vasoconstrictor has been proposed but with limited success: the hepatic arterial buffer response (HABR) and hepatic vascular escape mechanism hamper the arterioles vasoconstriction. The proposed project aims to take benefit from the HABR by co-infusing a mesenteric arterial vasodilator: the portal flow enhancement inducing the vasoconstriction of the intra sinusoids arterioles barely impacts liver tumors that are mainly fed by novel and anarchic external arterioles. Animal studies were reviewed and dopexamine was identified as a promising safe candidate, reducing by four the hepatic lobules arterial flow. A clinical trial design is proposed. A four to sixfold improvement of the tumoral to normal tissue dose ratio is expected, pushing the therapy towards a real curative intention, especially in HCC where ultra-selective spheres delivery is often not possible.

scholarly journals A Survey on Bias and Fairness in Machine Learning

2021 ◽  
Vol 54 (6) ◽  
pp. 1-35
Author(s):  
Ninareh Mehrabi ◽  
Fred Morstatter ◽  
Nripsuta Saxena ◽  
Kristina Lerman ◽  
Aram Galstyan
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Deep Learning ◽  
Real World ◽  
State Of The Art ◽  
Future Directions ◽  
Discriminatory Behavior ◽  
Real World Applications ◽  
Near Future ◽  
Different Sources

With the widespread use of artificial intelligence (AI) systems and applications in our everyday lives, accounting for fairness has gained significant importance in designing and engineering of such systems. AI systems can be used in many sensitive environments to make important and life-changing decisions; thus, it is crucial to ensure that these decisions do not reflect discriminatory behavior toward certain groups or populations. More recently some work has been developed in traditional machine learning and deep learning that address such challenges in different subdomains. With the commercialization of these systems, researchers are becoming more aware of the biases that these applications can contain and are attempting to address them. In this survey, we investigated different real-world applications that have shown biases in various ways, and we listed different sources of biases that can affect AI applications. We then created a taxonomy for fairness definitions that machine learning researchers have defined to avoid the existing bias in AI systems. In addition to that, we examined different domains and subdomains in AI showing what researchers have observed with regard to unfair outcomes in the state-of-the-art methods and ways they have tried to address them. There are still many future directions and solutions that can be taken to mitigate the problem of bias in AI systems. We are hoping that this survey will motivate researchers to tackle these issues in the near future by observing existing work in their respective fields.

scholarly journals Applications of Robotics, AI, and Digital Technologies During COVID-19: A Review

2021 ◽  
pp. 1-23
Author(s):  
Zhuo Zhao ◽  
Yangmyung Ma ◽  
Adeel Mushtaq ◽  
Abdul M. Azam Rajper ◽  
Mahmoud Shehab ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Technology Adoption ◽  
Digital Technology ◽  
Digital Technologies ◽  
Rapid Diagnosis ◽  
Quick Response ◽  
Virus Spread ◽  
Future Directions ◽  
Public Areas ◽  
Potential Impact

Abstract Many countries have enacted a quick response to the unexpected COVID-19 pandemic by utilizing existing technologies. For example, robotics, artificial intelligence, and digital technology have been deployed in hospitals and public areas for maintaining social distancing, reducing person-to-person contact, enabling rapid diagnosis, tracking virus spread, and providing sanitation. In this paper, 163 news articles and scientific reports on COVID-19-related technology adoption were screened, shortlisted, categorized by application scenario, and reviewed for functionality. Technologies related to robots, artificial intelligence, and digital technology were selected from the pool of candidates, yielding a total of 50 applications for review. Each case was analyzed for its engineering characteristics and potential impact on the COVID-19 pandemic. Finally, challenges and future directions regarding the response to this pandemic and future pandemics were summarized and discussed.

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