scholarly journals Rapid stimulation of human dentate gyrus function with acute mild exercise

2018 ◽  
Vol 115 (41) ◽  
pp. 10487-10492 ◽  
Author(s):  
Kazuya Suwabe ◽  
Kyeongho Byun ◽  
Kazuki Hyodo ◽  
Zachariah M. Reagh ◽  
Jared M. Roberts ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Dentate Gyrus ◽  
Acute Exercise ◽  
Memory Performance ◽  
Memory Function ◽  
Pattern Separation ◽  
Treadmill Running ◽  
Intensity Level ◽  
Individual Subject ◽  
The Impact

Physical exercise has beneficial effects on neurocognitive function, including hippocampus-dependent episodic memory. Exercise intensity level can be assessed according to whether it induces a stress response; the most effective exercise for improving hippocampal function remains unclear. Our prior work using a special treadmill running model in animals has shown that stress-free mild exercise increases hippocampal neuronal activity and promotes adult neurogenesis in the dentate gyrus (DG) of the hippocampus, improving spatial memory performance. However, the rapid modification, from mild exercise, on hippocampal memory function and the exact mechanisms for these changes, in particular the impact on pattern separation acting in the DG and CA3 regions, are yet to be elucidated. To this end, we adopted an acute-exercise design in humans, coupled with high-resolution functional MRI techniques, capable of resolving hippocampal subfields. A single 10-min bout of very light-intensity exercise (30%V˙O2peak) results in rapid enhancement in pattern separation and an increase in functional connectivity between hippocampal DG/CA3 and cortical regions (i.e., parahippocampal, angular, and fusiform gyri). Importantly, the magnitude of the enhanced functional connectivity predicted the extent of memory improvement at an individual subject level. These results suggest that brief, very light exercise rapidly enhances hippocampal memory function, possibly by increasing DG/CA3−neocortical functional connectivity.

scholarly journals Acute physical exercise improves memory consolidation in humans via BDNF and endocannabinoid signaling

2017 ◽  
Author(s):  
Blanca Marin Bosch ◽  
Aurélien Bringard ◽  
Maria Grazia Logrieco ◽  
Estelle Lauer ◽  
Nathalie Imobersteg ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Acute Exercise ◽  
Memory Performance ◽  
Long Term Memory ◽  
Hippocampal Activity ◽  
High Exercise Intensity ◽  
Acute Physical Exercise ◽  
Term Performance ◽  
The Impact

AbstractRegular physical exercise enhances memory functions and neurogenesis in the hippocampus, an effect partially mediated by BDNF (Brain Derived Neurotrophic Factor). Acute exercise promotes the release of endocannabinoids (especially anandamide, AEA), which enhance BDNF release and improve hippocampal plasticity in rodents. How acute exercise affects BDNF and AEA levels and influences memory performance in humans remains to date unknown. Here we combined blood biomarkers, behavioral and fMRI measurements to assess the impact of acute physical exercise on associative memory and underlying neurophysiological mechanisms. For each participant, memory was tested after three conditions: rest, moderate or high exercise intensity. A long-term memory retest took place 3 months later. At both test and retest, memory performance increased after moderate but not high intensity exercise or rest. We also show that memory benefited from exercise-related increases in both AEA and BNDF levels: AEA boosted hippocampal activity during memory recall, while BDNF enhanced hippocampal memory representations and long-term performance.

scholarly journals Experimental Manipulation of Psychological Control Scenarios: Implications for Exercise and Memory Research

Psych ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. 279-289 ◽  
Author(s):  
Jeremiah Blough ◽  
Paul D. Loprinzi
Keyword(s):  
Psychological Control ◽  
Acute Exercise ◽  
Memory Performance ◽  
Memory Function ◽  
Cognitive Engagement ◽  
Outcome Expectations ◽  
Experimental Manipulation ◽  
Exercise Session ◽  
Memory Research ◽  
Future Studies

The purpose of this experiment was to evaluate the extent to which variations in control activities influence memory function, as well as to investigate the participants’ memory expectations for the various conditions. A within-subject, counterbalanced experimental design was employed. Across four visits, participants engaged in four tasks, including an acute exercise session, and three cognitive-engagement control tasks of varying degrees of cognitive engagement and valence, namely reading neutral text, looking at a video, and puzzle completion. Participants’ perceived expectations for how each condition would improve their memory performance was also assessed. We observed no differences in objective cognitive performance or outcome expectations across the three evaluated control tasks, and thus, future studies may wish to employ either of these control tasks, which should not compromise making comparisons across studies.

scholarly journals Habitual physical activity mediates the acute exercise-induced modulation of anxiety-related amygdala functional connectivity

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yu-Chun Chen ◽  
Chenyi Chen ◽  
Róger Marcelo Martínez ◽  
Jennifer L. Etnier ◽  
Yawei Cheng
Keyword(s):  
Physical Activity ◽  
Functional Connectivity ◽  
Acute Exercise ◽  
Neural Mechanism ◽  
Habitual Physical Activity ◽  
Treadmill Running ◽  
Beneficial Effects ◽  
Fmri Study ◽  
Exercise Induced ◽  
Amygdala Reactivity

AbstractAerobic exercise, in relation to physical activity, has been shown to have beneficial effects on anxiety. However, the underlyig neural mechanism remains elusive. Using a within-subject crossover design, this fMRI study examined how exercise (12-min treadmill running versus walking) mediated amygdala reactivity to explicit and implicit (backward masked) perception of emotional faces in young adults (N = 40). Results showed that acute exercise-induced differences of state anxiety (STAI-S) varied as a function of individual’s habitual physical activity (IPAQ). Subjects with high IPAQ levels showed significant STAI-S reduction (P < 0.05). Path analyses indicated that IPAQ explained 14.67% of the variance in acute exercise-induced STAI-S differences. Running elicited stronger amygdala reactivity to implicit happiness than fear, whereas walking did the opposite. The exercise-induced amygdala reactivity to explicit fear was associated with the IPAQ scores and STAI-S differences. Moreover, after running, the amygdala exhibited a positive functional connectivity with the orbitofrontal cortex and insula to implicit happiness, but a negative connectivity with the parahippocampus and subgenual cingulate to implicit fear. The findings suggest that habitual physical activity could mediate acute exercise-induced anxiolytic effects in regards to amygdala reactivity, and help establish exercise training as a form of anxiolytic therapy towards clinical applications.

Fractionation of Verbal Memory Impairment in Schizophrenia and Schizophreniform Psychosis

2007 ◽  
Vol 41 (9) ◽  
pp. 732-739 ◽  
Author(s):  
Stephen J. Wood ◽  
Aleks U. Tarnawski ◽  
Tina M. Proffitt ◽  
Warrick J. Brewer ◽  
Greg R. Savage ◽  
...  
Keyword(s):  
Working Memory ◽  
Associative Learning ◽  
Verbal Memory ◽  
Memory Performance ◽  
Memory Function ◽  
Verbal Working Memory ◽  
First Episode ◽  
Story Recall ◽  
Associate Learning ◽  
The Impact

Objectives: The characterization, aetiology, and course of verbal memory deficits in schizophrenia remain ill defined. The impact of antipsychotic medications is also unclear. The purpose of the present paper was to investigate verbal memory performance in established schizophrenia (SZ) and first-episode schizophreniform psychosis (FE). Method: Performances of 32 SZ and 33 FE patients were compared to those of 47 healthy volunteers on measures of verbal working memory, verbal associative learning and story recall. Results: Story recall deficits, but not deficits in working memory or paired associate learning, were demonstrated by both patient groups. Patients treated with typical neuroleptics had more impairment in associative learning with arbitrary word pairings than those treated with atypicals, regardless of patient group. Conclusions: The results are consistent with the notion that some neuropsychological impairment is present at the time of psychosis onset and that this impairment is non-progressive. However, deficits may be specific to subclasses of memory function.

Effects of acute exercise on lipid content and dietary lipid uptake in liver and skeletal muscle of lean and diabetic rats

2015 ◽  
Vol 309 (10) ◽  
pp. E874-E883 ◽  
Author(s):  
Sharon Janssens ◽  
Richard A. M. Jonkers ◽  
Albert K. Groen ◽  
Klaas Nicolay ◽  
Luc J. C. van Loon ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lipid Content ◽  
Acute Exercise ◽  
Dietary Lipid ◽  
Diabetic Rats ◽  
Dietary Lipids ◽  
Treadmill Running ◽  
Resonance Spectroscopy ◽  
Lipid Uptake ◽  
The Impact

Insulin resistance is associated with ectopic lipid accumulation. Physical activity improves insulin sensitivity, but the impact of exercise on lipid handling in insulin-resistant tissues remains to be elucidated. The present study characterizes the effects of acute exercise on lipid content and dietary lipid partitioning in liver and skeletal muscle of lean and diabetic rats by use of magnetic resonance spectroscopy (MRS). After baseline measurements, rats were randomized to exercise or no-exercise groups. A subset of animals was subjected to MRS directly after 1 h of treadmill running for measurement of total intrahepatocellular lipid (IHCL) and intramyocellular lipid (IMCL) content ( n = 7 lean and diabetic rats). The other animals were administered 13C-labeled lipids orally after treadmill visit (with or without exercise) followed by MRS measurements after 4 and 24 h to determine the 13C enrichment of IHCL and IMCL ( n = 8 per group). Total IHCL and IMCL content were fivefold higher in diabetic vs. lean rats ( P < 0.001). Exercise did not significantly affect IHCL content but reduced IMCL by 25 ± 7 and 33 ± 4% in lean and diabetic rats ( P < 0.05), respectively. Uptake of dietary lipids in liver and muscle was 2.3-fold greater in diabetic vs. lean rats ( P < 0.05). Prior exercise did not significantly modulate dietary lipid uptake into muscle, but in liver of both lean and diabetic rats, lipid uptake was 44% reduced after acute exercise ( P < 0.05). In conclusion, IMCL but not IHCL represents a viable substrate source during exercise in both lean and diabetic rats, and exercise differentially affects dietary lipid uptake in muscle and liver.

scholarly journals Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Geoffroy Gagliardi ◽  
Madeline Kuppe ◽  
Cristina Lois ◽  
Bernard Hanseeuw ◽  
Patrizia Vannini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Performance ◽  
Memory Function ◽  
Common Symptom ◽  
Self Awareness ◽  
Delayed Recall ◽  
Clinically Normal ◽  
Positron Emission ◽  
The Impact

Abstract Introduction Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer’s disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memory self-awareness. Methods Two hundred thirty-six clinically normal (N) and 102 impaired (I) participants from the ADNI cohort were included. Amyloid (global) and tau burden (in entorhinal and inferior temporal cortices) were assessed using positron emission tomography (PET). Self-awareness of memory was assessed using discrepancy indexes of subjective participant-informant ratings, as well as participant-objective scores of memory performance. Subjective and objective values were derived from the Everyday Cognition memory questionnaire and Logical Memory (delayed recall). Results Lower awareness (both methods) of memory function was associated with higher levels of pathology in the I group as compared to N. There was a significant effect of tauopathy, but not amyloidosis, on individual complaint, such that higher levels of tau associated with lower awareness. Discussion Impaired self-awareness appears progressively in the evolution of the disease related to AD biomarkers. Discordant subjective and objective measures may be important for clinical consideration.

Effects of acute aerobic and resistance exercise on episodic memory function

2021 ◽  
pp. 174702182199457
Author(s):  
Paul D Loprinzi ◽  
Jeremy P Loenneke ◽  
Benjamin C Storm
Keyword(s):  
Young Adults ◽  
Episodic Memory ◽  
Resistance Exercise ◽  
Acute Exercise ◽  
Memory Performance ◽  
Memory Function ◽  
Experimental Studies ◽  
Post Exercise ◽  
List Learning ◽  
Research Questions

Accumulating research provides suggestive evidence that acute aerobic exercise may, potentially, enhance episodic memory function post-exercise. Limited research has evaluated whether acute resistance exercise may also enhance episodic memory post-exercise. Furthermore, whether these two exercise modalities have a differential effect on post-exercise episodic memory is relatively unknown. To address these research questions, three experimental studies were conducted ( N = 104) among young adults (18–25 years). The experiments implemented acute bouts of aerobic or resistance exercise for 15 min. Episodic memory was comprehensively evaluated post-exercise with a list-learning paradigm and a computerised assessment of what-where-when aspects of episodic memory. Various manipulations (e.g., between vs. within-group) of the study design were implemented across the experiments. Across these three experiments, we failed to find consistent evidence of either type of acute exercise affecting episodic memory performance post-exercise.

scholarly journals Gender Differences in the Association between Childhood Socioeconomic Status and Cognitive Function in Later Life

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Jiyoung Lyu
Keyword(s):  
Gender Differences ◽  
Socioeconomic Status ◽  
Cognitive Function ◽  
Memory Performance ◽  
Memory Function ◽  
Later Life ◽  
Long Term Effects ◽  
Growth Curve Models ◽  
Childhood Socioeconomic Status ◽  
The Impact

Objectives. This study was aimed to explore the gender differences in the association between childhood socioeconomic status (SES) and cognitive function in later life. Methods. Using a nationally representative sample from the Health and Retirement Study, 5,544 females and 3,863 males were analyzed separately. Growth curve models were used to examine memory status and change in memory from 1998 to 2010. Results. The results showed that SES disadvantage in childhood was associated with lower memory at baseline controlling for adult SES and other covariates. In addition, cumulated disadvantage in SES was associated with poor memory in both genders. Statistically, the impact of cumulative SES on memory function at baseline was significantly different by gender. Discussion. These findings suggest that childhood SES has long-term effects on cognitive function among both men and women, and cumulative SES from childhood to adulthood may be more important for men than women with respect to their memory performance.

scholarly journals Smoking Impairs Womens Verbal Learning and Memory Performance More than Mens: An International Web-Cohort Study of 70,000 Participants

2020 ◽  
Author(s):  
Candace Lewis ◽  
Joshua Siegfried Talboom ◽  
Matt D De Both ◽  
Annie M Schmidt ◽  
Marcus A Naymik ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cognitive Impairment ◽  
Learning And Memory ◽  
Verbal Memory ◽  
Memory Performance ◽  
Memory Function ◽  
Verbal Learning ◽  
Learning Performance ◽  
Permutation Testing ◽  
The Impact

Background: Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by exacerbating the risks associated with underlying vascular disease. Sex disparities in VCID have been reported, however, few studies have assessed the sex-specific impact of smoking on cognitive function and with contradictory results. This is an important topic since smoking and cardiovascular disease negatively impact health and possibly women have the greater lifetime risk of stroke and dementia than men. In this study, we sought to investigate the effect-modification of sex on the relationship between smoking, cardiovascular disease and verbal learning and memory function. Methods: Using MindCrowd, a web-based cohort of over 70,000 people aged 18 - 85, we investigated whether sex modifies the impact of smoking and cardiovascular disease on verbal memory performance on a paired-associate learning task using both multiple regression and propensity matching approaches. Artificial error introduction and permutation testing underscored the stability of our results. To demonstrate the necessity of large sample sizes to detect an interaction of sex and smoking, we performed down sampling analyses. Findings: We found significant interactions in that smoking impacts verbal learning performance more in women and cardiovascular disease more in men across a wide age range. Interpretation: These results suggest that smoking and cardiovascular disease impact verbal learning and memory throughout adulthood. Smoking particularly affects learning and memory in women and cardiovascular disease has a larger effect in men. Although the reasons for these sex-modification effects are not entirely understood, our findings highlight the importance of considering biological sex in VCID.

scholarly journals History of Alcohol Consumption and HIV Status Related to Functional Connectivity Differences in the Brain During Working Memory Performance

2020 ◽  
Vol 18 (3) ◽  
pp. 181-193 ◽  
Author(s):  
Vaughn E. Bryant ◽  
Joseph M. Gullett ◽  
Eric C. Porges ◽  
Robert L. Cook ◽  
Kendall J. Bryant ◽  
...  
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Alcohol Consumption ◽  
Memory Performance ◽  
Memory Function ◽  
Brain Networks ◽  
Memory Task ◽  
Hiv Positive ◽  
Hiv Status ◽  
Using Data

Background: Poorer working memory function has previously been associated with alcohol misuse, Human Immunodeficiency Virus (HIV) positive status, and risky behavior. Poorer working memory performance relates to alterations in specific brain networks. Objective: The current study examined if there was a relationship between brain networks involved in working memory and reported level of alcohol consumption during an individual’s period of heaviest use. Furthermore, we examined whether HIV status and the interaction between HIV and alcohol consumption was associated with differences in these brain networks. Methods: Fifty adults, 26 of whom were HIV positive, engaged in an n-back working memory task (0-back and 2-back trials) administered in a magnetic resonance imaging (MRI) scanner. The Kreek- McHugh-Schluger-Kellogg (KMSK) scale of alcohol consumption was used to characterize an individual’s period of heaviest use and correlates well with their risk for alcohol dependence. Connectivity analyses were conducted using data collected during n-back task. Results: Functional connectivity differences associated with greater alcohol consumption included negative connectivity, primarily from parietal attention networks to frontal networks. Greater alcohol consumption was also associated with positive connectivity from working memory nodes to the precuneus and paracingulate. HIV positive status was associated with more nodes of negative functional connectivity relative to alcohol consumption history alone, particularly in the frontoparietal networks. The HIV positive individuals with heavier drinking history related to negative fronto-parietal connectivity, along with positive connectivity from working memory nodes to mesolimbic regions. Conclusion: Findings allow for a better understanding of brain networks affected by HIV and alcohol and may provide avenues for interventions.

Sign in / Sign up

Export Citation Format

Share Document