scholarly journals Reference values for serum levels of vitamin B12and folic acid in a population-based sample of adults between 35 and 80 years of age

2002 ◽  
Vol 5 (3) ◽  
pp. 505-511 ◽  
Author(s):  
Åke Wahlin ◽  
Lars Bäckman ◽  
Johan Hultdin ◽  
Rolf Adolfsson ◽  
Lars-Göran Nilsson
Keyword(s):  
Folic Acid ◽  
Sex Education ◽  
Reference Data ◽  
Serum Levels ◽  
Population Based ◽  
Vitamin B ◽  
Reference Ranges ◽  
Mean Cell Volume ◽  
Vitamin Status ◽  
Age Related

AbstractObjectives:To examine folic acid and vitamin B12status in a group of 1000 persons sampled from the community of Umeå, Sweden, and aged 35, 40, 45, 50, 55, 60, 65, 70, 75 or 80 years. Reference data for folate and age-stratified reference data for vitamin B12are presented, together with an examination of potential confounders.Measurements:All subjects participated in extensive health examinations and interviews, and laboratory blood testing was performed.Results:A series of exclusion criteria were applied, and data from 961 subjects were analysed. Vitamin B12levels were found to decrease with increasing age, whereas folate levels remained constant across the age span studied. None of the vitamins was found to vary with sex, education, smoking or alcohol consumption, body mass index, prescription-free vitamin supplements, level of haemoglobin, or mean cell volume of erythrocytes. Further, none of these factors was associated with the age-related decrease of vitamin B12level.Conclusions:The offered reference ranges should be used only in order to rule out deficiency. For B12levels, the age of the subject should be considered such that, for elderly people in particular, values above the medians should be considered as indicative of normal vitamin status.

Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Rima Obeid ◽  
Wolfgang Herrmann
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Plasma Homocysteine ◽  
Vitamin B ◽  
Total Plasma ◽  
Vitamin Status ◽  
B Vitamin ◽  
Early Abortion

AbstractStudies linking hyperhomocysteinemia (HHCY) and B-vitamin deficiency to some health aspects in children have been accumulating. Low B-vitamin status inearly life, even as early as the time of conception, may endanger the potential for new life and may negatively influence the health of the offspring. Early abortion, pregnancy complications and poor pregnancy outcomes have been linked to elevated concentrations of total plasma homocysteine (tHcy) and low folate or vitamin B

scholarly journals Anogenital Distance in Healthy Infants: Method-, Age- and Sex-related Reference Ranges

2020 ◽  
Vol 105 (9) ◽  
pp. 2996-3004 ◽  
Author(s):  
Margit Bistrup Fischer ◽  
Marie Lindhardt Ljubicic ◽  
Casper P Hagen ◽  
Ajay Thankamony ◽  
Ken Ong ◽  
...  
Keyword(s):  
Population Based ◽  
Specific Reference ◽  
First Year ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Anogenital Distance ◽  
Sex Development ◽  
Age Related ◽  
Healthy Infants ◽  
First Year Of Life

Abstract Context The use of anogenital distance (AGD) in clinical and epidemiological settings is increasing; however, sex-specific reference data on AGD and data on longitudinal changes in AGD in children is scarce. Objective To create age-, sex-, and method-related reference ranges of AGD in healthy boys and girls aged 0–24 months, to assess the age-related changes in AGD and to evaluate the 2 predominantly used methods of AGD measurement. Design The International AGD consortium comprising 4 centers compiled data from 1 cross-sectional and 3 longitudinal cohort studies (clinicaltrials.gov [NCT02497209]). Setting All data were collected from population-based studies, recruiting from 4 maternity or obstetric centers (United States, Cambridge [United Kingdom], Odense, and Copenhagen [Denmark]). Subjects This study included a total of 3705 healthy, mainly Caucasian children aged 0–24 months on whom 7295 measurements were recorded. Main Outcome Measures AGDAS (ano-scrotal), AGDAF (ano-fourchette), AGDAP (ano-penile), AGDAC (ano-clitoral), AGD body size indices (weight, body mass index [BMI], body surface area, and length), and intra- and interobserver biases. Results We created age-specific reference ranges by centers. We found that AGD increased from birth to 6 months of age and thereafter reached a plateau. Changes in AGD/BMI during the first year of life were minor (0–6% and 0–11% in boys and girls, respectively). Conclusions Reference ranges for AGD can be used in future epidemiological research and may be utilized clinically to evaluate prenatal androgen action in differences-in-sex-development patients. The increase in AGD during the first year of life was age-related, while AGD/BMI was fairly stable. The TIDES and Cambridge methods were equally reproducible.

scholarly journals Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults

2019 ◽  
Vol 75 (6) ◽  
pp. 1089-1094 ◽  
Author(s):  
Laura M Pérez ◽  
Babak Hooshmand ◽  
Francesca Mangialasche ◽  
Patrizia Mecocci ◽  
A David Smith ◽  
...  
Keyword(s):  
Sex Education ◽  
Chronic Conditions ◽  
Serum Levels ◽  
Population Based ◽  
Total Serum ◽  
Reactive Protein ◽  
Education Levels ◽  
Study Population ◽  
Baseline Levels

Abstract We aimed to investigate the association between baseline levels of total serum glutathione (tGSH) and rate of chronic disease accumulation over time. The study population (n = 2,596) was derived from a population-based longitudinal study on ≥60-year-olds living in Stockholm. Participants were clinically assessed at baseline, 3- and 6-year follow-ups. Multimorbidity was measured as the number of chronic conditions from a previously built list of 60 diseases. Linear mixed models were applied to analyze the association between baseline tGSH levels and the rate of multimorbidity development over 6 years. We found that at baseline, participants with ≥4 diseases had lower tGSH levels than participants with no chronic conditions (3.3 vs 3.6 µmol/L; p < .001). At follow-up, baseline levels of tGSH were inversely associated with the rate of multimorbidity development (β * time: −0.044, p < .001) after adjusting for age, sex, education, levels of serum creatinine, C-reactive protein, albumin, body mass index, smoking, and time of dropout or death. In conclusion, serum levels of tGSH are inversely associated with multimorbidity development; the association exists above and beyond the link between tGSH and specific chronic conditions. Our findings support the hypothesis that tGSH is a biomarker of multisystem dysregulation that eventually leads to multimorbidity.

scholarly journals Interactions between plasma concentrations of folate and markers of vitamin B12status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study

2013 ◽  
Vol 111 (6) ◽  
pp. 1085-1095 ◽  
Author(s):  
Esmée L. Doets ◽  
Per M. Ueland ◽  
Grethe S. Tell ◽  
Stein Emil Vollset ◽  
Ottar K. Nygård ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Folic Acid ◽  
Cognitive Performance ◽  
Sex Education ◽  
Plasma Concentrations ◽  
Health Study ◽  
Vitamin B ◽  
Plasma Vitamin ◽  
Folic Acid Fortification ◽  
Plasma Folate

A combination of high folate with low vitamin B12plasma status has been associated with cognitive impairment in a population exposed to mandatory folic acid fortification. The objective of the present study was to examine the interactions between plasma concentrations of folate and vitamin B12markers in relation to cognitive performance in Norwegian elderly who were unexposed to mandatory or voluntary folic acid fortification. Cognitive performance was assessed by six cognitive tests in 2203 individuals aged 72–74 years. A combined score was calculated using principal component analysis. The associations of folate concentrations, vitamin B12markers (total vitamin B12, holotranscobalamin (holoTC) and methylmalonic acid (MMA)) and their interactions in relation to cognitive performance were evaluated by quantile regression and least-squares regression, adjusted for sex, education, apo-ɛ4 genotype, history of CVD/hypertension and creatinine. Cross-sectional analyses revealed an interaction (P= 0·009) between plasma concentrations of folate and vitamin B12in relation to cognitive performance. Plasma vitamin B12concentrations in the lowest quartile ( < 274 pmol/l) combined with plasma folate concentrations in the highest quartile (>18·5 nmol/l) were associated with a reduced risk of cognitive impairment compared with plasma concentrations in the middle quartiles of both vitamins (OR 0·22, 95 % CI 0·05, 0·92). The interaction between folate and holoTC or MMA in relation to cognitive performance was not significant. In conclusion, this large study population unexposed to mandatory folic acid fortification showed that plasma folate, but not plasma vitamin B12, was associated with cognitive performance. Among the elderly participants with vitamin B12concentrations in the lower range, the association between plasma folate and cognitive performance was strongest.

scholarly journals A Comparison of the Cyclic Variation in Serum Levels of CA125 Across the Menstrual Cycle Using Two Commercial Assays

2011 ◽  
Vol 14 (3) ◽  
pp. 250-256 ◽  
Author(s):  
Monica R. McLemore ◽  
Bradley E. Aouizerat ◽  
Kathryn A. Lee ◽  
Lee-may Chen ◽  
Bruce Cooper ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Premenopausal Women ◽  
Serum Levels ◽  
Population Based ◽  
Reference Ranges ◽  
Healthy Women ◽  
Serum Ca125 ◽  
Caucasian Women ◽  
Clinically Significant ◽  
Good Concordance

Background: Clinicians use CA125, a tumor-associated antigen, primarily to monitor epithelial ovarian cancer. However, CA125 lacks the sensitivity and specificity necessary for population-based screening in healthy women. The purpose of this study was to determine if serum concentrations of CA125 differed across the three phases of the menstrual cycle in healthy, premenopausal women using two commercially available assays. Methods: Healthy, Caucasian women between the ages of 18 and 39 were enrolled using strict criteria to exclude factors known to contribute to CA125 fluctuations. Menstrual cycle regularity was determined using calendars maintained by participants for 3 months. After cycle regularity was established, blood was drawn at three time points for CA125 determination using two commercial assays (i.e., Siemens and Panomics). Results: Regardless of the assay used, CA125 values were highest during menses. The CA125 values decreased 0.2 U/ml per day from menses to the end of the same cycle, which resulted in a net decrease of 5.8 U/ml across the cycle. Conclusions: The two commercial assays for CA125 determination demonstrated good concordance in terms of reference ranges regardless of epitope differences. While CA125 levels changed over the course of the menstrual cycle, these changes may not be clinically significant in healthy women. This study is the first to control for factors known to contribute to CA125 elevations; to quantify a decrease in CA125 levels across the menstrual cycle; and to confirm concordance in the relative decreases in serum CA125 levels across the menstrual cycle between two frequently used commercial assays.

Catha Edulis (Khat) Chewing Decreases Serum Levels of Iron, Ferritin and Vitamin B12 and Increases Folic Acid

2014 ◽  
Vol 84 (5-6) ◽  
pp. 223-228
Author(s):  
Waled Al-Dubai ◽  
Jameel Al-Ghazaly ◽  
Molham Al-Habori ◽  
Riyadh Saif-Ali ◽  
Ahmed Mohammed
Keyword(s):  
Body Mass Index ◽  
Folic Acid ◽  
Body Mass ◽  
Serum Iron ◽  
Serum Levels ◽  
Control Group ◽  
Vitamin B ◽  
Catha Edulis ◽  
One Year

Abstract. Background: Catha edulis (Khat) is customarily chewed to attain a state of stimulation and reduce physical fatigue. In view of the reported common adverse effects of Khat, the aim of this study was to evaluate the levels of iron, ferritin, folic acid, vitamin B12 and body mass index (BMI) as nutritive indicators in Yemeni Khat chewers. Methods: This study was a prospective cohort study, carried out on 90 male workers aged 19 - 23 years old; 45 were healthy non-Khat chewers serving as control group and 45 were regular Khat chewers. Serum iron, ferritin, folic acid, vitamin B12 and body mass index were measured at baseline and after a year of follow up. Results: Serum iron and BMI were significantly (p < 0.01) lower at baseline in Khat chewers by 9 % and 6 %, respectively; whereas ferritin, folic acid and vitamin B12 were non-significantly different from non-Khat chewers. In the follow-up one year later, serum iron, ferritin, vitamin B12 and BMI were significantly (p < 0.001) lower in Khat chewers by 19.0, 31.4, 20.6 and 10.7 %; whereas folic acid was significantly (p = 0.007) higher by 26.7 %. Comparison within groups showed serum iron, ferritin, and BMI to be significantly (p < 0.01) decreased after one year in the Khat chewers with respect to its baseline; whereas folic acid significantly (p < 0.001) increased. Conclusion: This study shows Khat chewers to be more susceptible to malnutrition, which should be considered by the general population and the public health authorities.

scholarly journals Defining the plasma folate concentration associated with the red blood cell folate concentration threshold for optimal neural tube defects prevention: a population-based, randomized trial of folic acid supplementation

2019 ◽  
Vol 109 (5) ◽  
pp. 1452-1461 ◽  
Author(s):  
Meng-Yu Chen ◽  
Charles E Rose ◽  
Yan Ping Qi ◽  
Jennifer L Williams ◽  
Lorraine F Yeung ◽  
...  
Keyword(s):  
Folic Acid ◽  
Intervention Group ◽  
Population Based ◽  
Folic Acid Supplementation ◽  
Reproductive Age ◽  
Vitamin B ◽  
Acid Supplementation ◽  
Folate Concentration ◽  
Plasma Folate ◽  
Vitamin B 12

ABSTRACT Background For women of reproductive age, a population-level red blood cell (RBC) folate concentration below the threshold 906 nmol/L or 400 ng/mL indicates folate insufficiency and suboptimal neural tube defect (NTD) prevention. A corresponding population plasma/serum folate concentration threshold for optimal NTD prevention has not been established. Objective The aim of this study was to examine the association between plasma and RBC folate concentrations and estimated a population plasma folate insufficiency threshold (pf-IT) corresponding to the RBC folate insufficiency threshold (RBCf-IT) of 906 nmol/L. Methods We analyzed data on women of reproductive age (n = 1673) who participated in a population-based, randomized folic acid supplementation trial in northern China. Of these women, 565 women with anemia and/or vitamin B-12 deficiency were ineligible for folic acid intervention (nonintervention group); the other 1108 received folic acid supplementation for 6 mo (intervention group). We developed a Bayesian linear model to estimate the pf-IT corresponding to RBCf-IT by time from supplementation initiation, folic acid dosage, methyltetrahydrofolate reductase (MTHFR) genotype, body mass index (BMI), vitamin B-12 status, or anemia status. Results Using plasma and RBC folate concentrations of the intervention group, the estimated median pf-IT was 25.5 nmol/L (95% credible interval: 24.6, 26.4). The median pf-ITs were similar between the baseline and postsupplementation samples (25.7 compared with 25.2 nmol/L) but differed moderately (±3–4 nmol/L) by MTHFR genotype and BMI. Using the full population-based baseline sample (intervention and nonintervention), the median pf-IT was higher for women with vitamin B-12 deficiency (34.6 nmol/L) and marginal deficiency (29.8 nmol/L) compared with the sufficient group (25.6 nmol/L). Conclusions The relation between RBC and plasma folate concentrations was modified by BMI and genotype and substantially by low plasma vitamin B-12. This suggests that the threshold of 25.5 nmol/L for optimal NTD prevention may be appropriate in populations with similar characteristics, but it should not be used in vitamin B-12 insufficient populations. This trial was registered at clinicaltrials.gov as NCT00207558.

scholarly journals A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels

2003 ◽  
pp. 171-175 ◽  
Author(s):  
I Rietveld ◽  
JA Janssen ◽  
A Hofman ◽  
HA Pols ◽  
CM van Duijn ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Body Height ◽  
Serum Levels ◽  
The Elderly ◽  
Population Based ◽  
Total Group ◽  
Age Related ◽  
Igf I ◽  
The Relationship ◽  
I Gene

OBJECTIVE: Recent studies have demonstrated an association between a 192 bp polymorphism of the IGF-I gene and total IGF-I serum levels, birth weight, body height and the risk of developing diabetes and cardiovascular diseases later on in life. This IGF-I gene polymorphism in the promoter region of the IGF-I gene may directly influence the expression of IGF-I. In the present study we evaluated the role of this polymorphism in the age-related decline in serum IGF-I levels. SUBJECTS AND METHODS: All subjects were participants of the Rotterdam Study, a population-based cohort study of diseases in the elderly. We studied a total group of 346 subjects, who comprised two subgroups: a randomly selected population-based sample of 196 subjects, and a group of 150 subjects selected on IGF-I genotype. In the total group of 346 individuals the relationship between this 192 bp polymorphism and the age-related decline in circulating total IGF-I levels was studied. RESULTS: Homozygous carriers of the 192 bp allele demonstrated significant decline in serum IGF-I with age (r=-0.29, P=0.002). This decline is similar to that seen in the general population. An age-related decline in serum total IGF-I was not observed in heterozygotes (r=-0.06, P=0.48) and non-carriers (r = -0.12, P=0.32). Interestingly, the relationship between age and serum IGF-binding protein-3 levels showed the same pattern. CONCLUSION: We observed only in homozygous carriers of the 192 bp alleles of the IGF-I gene an age-related decline in circulating total IGF-I levels, but not in heterozygotes and non-carriers of the 192 bp allele. We hypothesize that this IGF-I gene polymorphism directly or indirectly influences GH-mediated regulation of IGF-I secretion.

Interactive effects of alcohol and chloroquine on hematologic profile of Wistar rats

2018 ◽  
Vol 29 (5) ◽  
pp. 537-543
Author(s):  
Dimkpa Uchechukwu ◽  
Kelechi Loveth Ezeudensi ◽  
Babatunde Ishola Adejumo ◽  
Chinwe Obianuju Ewenighi ◽  
Elizabeth Enohnyaket Besong ◽  
...  
Keyword(s):  
Folic Acid ◽  
Adverse Effects ◽  
Blood Cell ◽  
Cell Volume ◽  
Wistar Rats ◽  
Control Group ◽  
Vitamin B ◽  
Concurrent Administration ◽  
Mean Cell Volume ◽  
Group D

AbstractBackgroundThere is paucity of information on the adverse effects of alcohol – chloroquine interaction on hematological parameters. To investigate the effects of concurrent administration of chloroquine and ethanol on hematologic parameters of adult Wistar rats and the ameliorative role of vitamin B12and folic acid supplementation on any adverse effects.MethodsSome 30 adult Wistar rats weighing 120–200 g were assigned to six major groups of five rats each according to their weights. The control group A was fed with normal rat chow and water. The experimental groups B–F were administered with drugs for a period of 7 days as follows: B (chloroquine only); C (ethanol only); D (chloroquine+ethanol); E (chloroquine+ethanol+vitamin B12); and F (chloroquine+ethanol+vitamin B12+folic acid). Blood samples were collected from each animal by cardiac puncture to determine red blood cell (RBC) count, white blood cell (WBC) count, packed cell volume (PCV), hemoglobin (Hb), mean corpuscular hemoglobin concentration, mean cell volume (MCV), and mean cell hemoglobin (MCH). Liver enzymes, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were analyzed to test for liver function.ResultsGroup D indicated lower PCV, Hb, MCV, MCH, and greater WBC compared with control. Group E indicated greater (p<0.05) PCV, Hb, and RBC compared with Group D. Greater (p<0.05) MCV and MCH, and lower WBC and RBC were observed in Group F compared with Group D. Furthermore, Group D rats indicated greater (p<0.05) mean AST and ALT compared with Groups A, E, and F.ConclusionsConcurrent administration of chloroquine and alcohol indicated adverse effects on hematologic parameters of Wistar rats. The administration of vitamin B12and folic acid appeared to ameliorate these adverse effects.

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