The Biomechanics of Cycling with a Transtibial Amputation: Recommendations for Prosthetic Design and Direction for Future Research

2009 ◽  
Vol 33 (3) ◽  
pp. 256-271 ◽  
Author(s):  
W. Lee Childers ◽  
Robert S. Kistenberg ◽  
Robert J. Gregor
Keyword(s):  
Motor Control ◽  
Cycling Performance ◽  
The Body ◽  
Future Research ◽  
Confounding Variable ◽  
Prosthetic Design ◽  
Ongoing Research ◽  
Experience Levels ◽  
Cyclic Movement ◽  
Viable Model

People with amputations may find cycling advantageous for exercise, transportation and rehabilitation. The reciprocal nature of stationary cycling also makes it a viable model for research in motor control because the body is supported by the saddle allowing the researcher to focus on the cyclic movement of the legs without the confounding variable of balance. The purpose of this article is to provide an overview of the cycling task in intact cyclists and relate this information to understanding the challenges faced by cyclists with transtibial amputations (CTA). Ongoing research into the biomechanics of CTAs will be summarized to expose the differences between intact and CTA cycling mechanics, asymmetries between limbs of CTAs as well as neuromuscular adaptation following amputation. The article will include recommendations for prosthetic design and modification of the bicycle to improve cycling performance for CTA at all experience levels.

The Gut Microbiome in Hypertension

2021 ◽  
Vol 128 (7) ◽  
pp. 934-950
Author(s):  
Ellen G. Avery ◽  
Hendrik Bartolomaeus ◽  
Andras Maifeld ◽  
Lajos Marko ◽  
Helge Wiig ◽  
...  
Keyword(s):  
Immune Cells ◽  
Gut Microbiome ◽  
Short Chain Fatty Acids ◽  
The Body ◽  
Model Systems ◽  
Future Research ◽  
Hypertensive Disease ◽  
Preclinical Research ◽  
Ongoing Research ◽  
Diverse Range

The pathogenesis of hypertension is known to involve a diverse range of contributing factors including genetic, environmental, hormonal, hemodynamic and inflammatory forces, to name a few. There is mounting evidence to suggest that the gut microbiome plays an important role in the development and pathogenesis of hypertension. The gastrointestinal tract, which houses the largest compartment of immune cells in the body, represents the intersection of the environment and the host. Accordingly, lifestyle factors shape and are modulated by the microbiome, modifying the risk for hypertensive disease. One well-studied example is the consumption of dietary fibers, which leads to the production of short-chain fatty acids and can contribute to the expansion of anti-inflammatory immune cells, consequently protecting against the progression of hypertension. Dietary interventions such as fasting have also been shown to impact hypertension via the microbiome. Studying the microbiome in hypertensive disease presents a variety of unique challenges to the use of traditional model systems. Integrating microbiome considerations into preclinical research is crucial, and novel strategies to account for reciprocal host-microbiome interactions, such as the wildling mouse model, may provide new opportunities for translation. The intricacies of the role of the microbiome in hypertensive disease is a matter of ongoing research, and there are several technical considerations which should be accounted for moving forward. In this review we provide insights into the host-microbiome interaction and summarize the evidence of its importance in the regulation of blood pressure. Additionally, we provide recommendations for ongoing and future research, such that important insights from the microbiome field at large can be readily integrated in the context of hypertension.

TOWARD A HOLISTIC SIX-PERIOD RADICAL INNOVATION LIFE CYCLE MODEL

2012 ◽  
Vol 09 (01) ◽  
pp. 1250001 ◽  
Author(s):  
JOHN P. DISMUKES ◽  
JOHN A. BERS ◽  
JAI A. SEKHAR
Keyword(s):  
Life Cycle ◽  
Radical Innovation ◽  
Incremental Innovation ◽  
Future Research ◽  
Life Cycle Model ◽  
Cycle Model ◽  
Late 20Th Century ◽  
Ongoing Research ◽  
The Past ◽  
Viable Model

In-depth historical assessment of innovation over the past several hundred years shows that the incremental innovation and cost reduction emphasized in the late 20th century will prove inadequate and even counterproductive in the 21st century for achieving sustained, global competitive advantage requiring radical innovation. Accordingly, a comprehensive, holistic innovation life cycle model is needed. Ongoing research since the PICMET'07 Conference has confirmed this need for a viable model, and developed an Accelerated Radical Innovation (ARI) methodology as part of the life cycle framework for a viable model. A significant contribution of the ARI methodology has been to develop improved techniques for measuring and guiding innovation progress, based on focused assessment of 10 innovation attributes at each of the 10 ARI steps in the first two phases of a six-phase life cycle envisioned to describe any radical innovation life cycle. This paper first summarizes systematically the most prominent radical innovation approaches, including quantitative assessment of the dynamics of four major radical innovations over the past 100 years by retrospective application of the ARI theory and its associated four types of challenges and hurdles inherent in commercializing breakthrough innovations. It then proposes future research on a six-period innovation life cycle model as the basis for analysis of breakthrough innovations of all types.

A Case Study: Analysis of Patents of Coronaviruses and Covid-19 for Technology Assesment and Future Research

2020 ◽  
Vol 26 ◽  
Author(s):  
Pankaj Musyuni ◽  
Geeta Aggarwal ◽  
Manju Nagpal ◽  
Ramesh K. Goyal
Keyword(s):  
Disease Management ◽  
Research And Development ◽  
Technological Development ◽  
Research Work ◽  
Large Family ◽  
Future Research ◽  
Biological Drugs ◽  
Ongoing Research ◽  
Patent Literature ◽  
Patent Documents

Background: Protecting intellectual property rights are important and particularly pertinent for inventions which are an outcome of rigorous research and development. While the grant of patents is subject to establishing novelty and inventive step, it further indicates the technological development and helpful for researchers working in the same technical domain. The aim of the present research work is to map the existing work through analysis of patent literature, in the field of Coronaviruses (CoV), particularly COVID-19 (2019-nCoV). CoV is a large family of viruses known to cause illness in human and animals, particularly known for causing respiratory infections as evidenced in earlier times such as in MERS i.e. Middle East Respiratory Syndrome; SRS i.e. Severe Acute Respiratory Syndrome. A recently identified novel-coronavirus has known as COVID-19 which has currently caused pandemic situation across the globe. Objective: To expand analysis of patents related to CoV and 2019-nCoV. Evaluation has been conducted by patenting trends of particular strains of identified CoV diseases by present legal status, main concerned countries via earliest priority years and its assignee types and inventors of identified relevant patents. We analyzed the global patent documents to check the scope of claims along with focuses and trends of the published patent documents for the entire CoV family including 2019- nCoV through the present landscape. Methods: To extract the results, Derwent Innovation database is used by a combination of different key-strings. Approximately 3800 patents were obtained and further scrutinized and analyzed. The present write-up also discusses the recent progress of patent applications in a period of the year 2010 to 2020 (present) along with the recent developments in India for the treatment options for CoV and 2019-nCoV. Results: Present analysis showed that key areas of the inventions have been focused on vaccines and diagnostic kits apart from the composition for treatment of CoV. We also observed that no specific vaccine treatments is available for treatment of 2019-nCov, however, developing novel chemical or biological drugs and kits for early diagnosis, prevention and disease management is the primarily governing topic among the patented inventions. The present study also indicates potential research opportunities for the future, particularly to combat 2019-nCoV. Conclusion: The present paper analyzes the existing patents in the field of Coronaviruses and 2019-nCoV and suggests a way forward for the effective contribution in this upcoming research area. From the trend analysis, it was observed an increase in filing of the overall trend of patent families for a period of 2010 to the current year. This multifaceted analysis of identified patent literature provides an understanding of the focuses on present ongoing research and grey area in terms of the trends of technological innovations in disease management in patients with CoV and 2019-nCoV. Further, the findings and outcome of the present study offer insights for the proposed research and innovation opportunities and provide actionable information in order to facilitate policymakers, academia, research driven institutes and also investors to make better decisions regarding programmed steps for research and development for the diagnosis, treatment and taking preventive measures for CoV and 2019-nCoV. The present article also emphasizes on the need for future development and the role of academia and collaboration with industry for speedy research with a rationale.

Conclusion

2020 ◽  
pp. 698-719
Author(s):  
Ronald E. Rice ◽  
Simeon J. Yates ◽  
Jordana Blejmar
Keyword(s):  
Digital Technology ◽  
Digital Literacy ◽  
Theory Development ◽  
Policy Implications ◽  
Digital Culture ◽  
Future Research ◽  
Technology And Society ◽  
Ongoing Research ◽  
Positive Effects ◽  
Research Areas

We conclude the Handbook of Digital Technology and Society by identifying topics that appear in multiple chapters, are more unique to some chapters, and that represent general themes across the material. Each of these is considered separately for the ESRC theme chapters and the non-ESRC chapters. In the ESRC theme chapters, cross-cutting research topics include digital divides and inequalities; data and digital literacy; governance, regulation, and legislation; and the roles and impacts of major platforms. Cross-cutting challenges include methods; theory development, testing, and evaluation; ethics; big data; and multi-platform/holistic studies. Gaps include policy implications, and digital culture. In the non-ESRC chapters, more cross-cutting themes include future research and methods; technology venues; relationships; content and creation; culture and everyday life; theory; and societal effects. More unique, these were digitization of self; managing digital experience; names for the digital/social era; ethics; user groups; civic issues; health, and positive effects. The chapter also shows how the non-ESRC chapters may be clustered together based on their shared themes and subthemes, identifying two general themes of more micro and more macro topics. The identification of both more and less common topics and themes can provide the basis for understanding the landscape of prior research, what areas need to be included in ongoing research, and what research areas might benefit from more attention. The chapter ends with some recommendations for such ongoing and future research in the rich, important, and challenging area of digital technology and society.

scholarly journals Music, Politics, and History: An Introduction

2021 ◽  
Vol 60 (2) ◽  
pp. 362-374
Author(s):  
David Kennerley
Keyword(s):  
Sound Studies ◽  
The Body ◽  
Future Research ◽  
Short Article ◽  
Distinctive Features ◽  
Music And Politics ◽  
Introductory Article ◽  
History Of ◽  
Eighteenth And Nineteenth Centuries ◽  
The Relationship

AbstractMusic has been steadily rising up the historical agenda, a product of the emergence of sound studies, the history of the senses, and a mood of interdisciplinary curiosity. This introductory article offers a critical review of how the relationship between music and politics has featured in extant historical writing, from classic works of political history to the most recent scholarship. It begins by evaluating different approaches that historians have taken to music, summarizes the important shifts in method that have recently taken place, and advocates for a performance-centered, contextualized framework that is attentive to the distinctive features of music as a medium. The second half examines avenues for future research into the historical connections between music and politics, focusing on four thematic areas—the body, emotions, space, and memory—and closes with some overarching reflections on music's use as a tool of power, as well as a challenge to it. Although for reasons of cohesion, this short article focuses primarily on scholarship on Britain and Ireland in the eighteenth and nineteenth centuries, its discussion of theory and methods is intended to be applicable to the study of music and political culture across a broad range of periods and geographies.

scholarly journals Involvement of Probiotics and Postbiotics in the Immune System Modulation

Biologics ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 89-110
Author(s):  
Neslihan Yeşilyurt ◽  
Birsen Yılmaz ◽  
Duygu Ağagündüz ◽  
Raffaele Capasso
Keyword(s):  
Immune System ◽  
Pharmaceutical Industry ◽  
Intestinal Microbiota ◽  
Health Benefits ◽  
The Body ◽  
Future Research ◽  
Immune Systems ◽  
Advantages And Disadvantages ◽  
Immune System Modulation ◽  
Molecular Patterns

Intestinal microbiota interacts with other systems, especially the immune system, which is responsible for protecting the body by recognizing “stranger” (pathogen associated molecular patterns-PAMPs) and “danger” (damage-associated molecular patterns-DAMPs) molecular motifs. In this manner, it plays an important role in the pathogenesis of various diseases and health. Despite the use of probiotics that modulate the intestinal microbiota in providing health benefits and in the treatment of diseases, there are some possible concerns about the possibility of developing adverse effects, especially in people with suppressed immune systems. Since probiotics provide health benefits with bioactive compounds, studies are carried out on the use of products containing non-living probiotic microorganisms (paraprobiotics) and/or their metabolites (postbiotics) instead of probiotic products. It is even reported that these microbial compounds have more immunomodulatory activities than living microorganisms via some possible mechanism and eliminates some disadvantages of probiotics. Considering the increasing use of functional foods in health and disease, further studies are needed with respect to the benefits and advantages of parabiotic and/or postbiotic use in the food and pharmaceutical industry as well as immune system modulation. Although probiotics have been extensive studied for a long time, it seems that postbiotics are promising tools for future research and applications according to the recent literature. This review aimed to evaluate the interaction of probiotics and postbiotics with the immune systems and also their advantages and disadvantages in the area of food-pharmaceutical industry and immune system modulation.

Event innovation induced corporate branding

2017 ◽  
Vol 29 (3) ◽  
pp. 862-882 ◽  
Author(s):  
Fiona X. Yang ◽  
Sherry Xiuchang Tan
Keyword(s):  
Corporate Branding ◽  
Structural Equation ◽  
Corporate Image ◽  
The Body ◽  
Equation Modeling ◽  
Future Research ◽  
Event Management ◽  
Content Type ◽  
Body Of Knowledge ◽  
Corporate Loyalty

Purpose This paper aims to empirically investigate how event innovation may induce desirable corporate branding. Design/methodology/approach A survey yielded 280 complete responses from tourists who had attended an event in Macau. Structural equation modeling was used to test the innovation-corporate loyalty framework through perceived event value and corporate image, with a multi-group comparison to examine differences between first-time and repeat customers. Findings The results indicate that innovation is not only the key to value enhancement of the event but also an efficacious instrument of branding the parent company and building corporate loyalty; only product-related innovation has a significant impact on event value; both functional and emotional values induce a more favorable corporate image; and event-induced corporate branding is more effective in securing repeat business than attracting new clientele. Practical implications The findings help hospitality operators and event planners to leverage innovative events for corporate branding and cater to different customer segments by providing distinct marketing strategies. Originality/value The study contributes to the body of knowledge regarding event management and corporate branding and sheds light on future research to explore the initiative and benefit of pushing forward event innovation.

The putative effects of green tea on body fat: an evaluation of the evidence and a review of the potential mechanisms

2011 ◽  
Vol 106 (9) ◽  
pp. 1297-1309 ◽  
Author(s):  
Navamayooran Thavanesan
Keyword(s):  
Weight Loss ◽  
Green Tea ◽  
Body Fat ◽  
Fatty Acid Synthase ◽  
The Body ◽  
Alternative Methods ◽  
Future Research ◽  
Prevalence Of Obesity ◽  
Simultaneous Inhibition

The increase in the prevalence of obesity in recent years has prompted research into alternative methods of modulating body weight and body fat. The last decade has reflected this with a surge in studies investigating the potential of green tea as a natural agent of weight loss, with a view to confirming and elucidating the mechanisms underlying its effect on the body. Currently, it is widely believed that the polyphenolic components present in green tea have an anti-obesogenic effect on fat homeostasis, by increasing thermogenesis or reducing fat absorption among other ways. The data published to date, however, are inconsistent, with numerous putative modes of action suggested therein. While several unimodal mechanisms have been postulated, a more plausible explanation of the observed results might involve a multimodal approach. Such a mechanism is suggested here, involving simultaneous inhibition of the enzymes catechol-O-methyltransferase, acetyl-CoA carboxylase, fatty acid synthase and impeding absorption of fat via the gut. An evaluation of the available evidence supports a role of green tea in weight loss; however the extent of the effects obtained is still subject to debate, and requires more objective quantification in future research.

scholarly journals Cyber-Flirting: An Examination of Men's and Women's Flirting Behaviour Both Offline and on the Internet

2004 ◽  
Vol 21 (2) ◽  
pp. 115-126 ◽  
Author(s):  
Monica T. Whitty
Keyword(s):  
Physical Attractiveness ◽  
The Body ◽  
Nonverbal Cues ◽  
Future Research ◽  
The Internet ◽  
Research Needs ◽  
Men And Women ◽  
Face To Face ◽  
Online Interactions

AbstractWhile flirting is a relatively underresearched area within psychology, even less is known about how people cyber-flirt. This paper explores how often individuals flirt offline compared to online. Moreover, it attempts to examine how men and women flirt within these different spaces. Five thousand, six hundred and ninety-seven individuals, of which 3554 (62%) were women and 2143 (38%) were men, completed a survey about their flirting behaviour both in face-to-face interactions and in chatrooms. The first hypothesis, which stated that the body would be used to flirt with as frequently online as offline, was partly supported. However, it was found that individuals downplayed the importance of physical attractiveness online. Women flirted by displaying nonverbal signals (offline) or substitutes for nonverbal cues (online), to a greater extent than men. In chatrooms men were more likely than women to initiate contact. It is concluded that cyber-flirting is more than simply a meeting of minds and that future research needs to consider the role of the body in online interactions.

scholarly journals The emulation theory of representation: Motor control, imagery, and perception

2004 ◽  
Vol 27 (3) ◽  
pp. 377-396 ◽  
Author(s):  
Rick Grush
Keyword(s):  
Motor Control ◽  
Sensory Feedback ◽  
Sensory Input ◽  
Neural Circuits ◽  
Sensory Information ◽  
The Body ◽  
Feedback Delay ◽  
Run Off ◽  
Effects Of Feedback ◽  
The Brain

The emulation theory of representation is developed and explored as a framework that can revealingly synthesize a wide variety of representational functions of the brain. The framework is based on constructs from control theory (forward models) and signal processing (Kalman filters). The idea is that in addition to simply engaging with the body and environment, the brain constructs neural circuits that act as models of the body and environment. During overt sensorimotor engagement, these models are driven by efference copies in parallel with the body and environment, in order to provide expectations of the sensory feedback, and to enhance and process sensory information. These models can also be run off-line in order to produce imagery, estimate outcomes of different actions, and evaluate and develop motor plans. The framework is initially developed within the context of motor control, where it has been shown that inner models running in parallel with the body can reduce the effects of feedback delay problems. The same mechanisms can account for motor imagery as the off-line driving of the emulator via efference copies. The framework is extended to account for visual imagery as the off-line driving of an emulator of the motor-visual loop. I also show how such systems can provide for amodal spatial imagery. Perception, including visual perception, results from such models being used to form expectations of, and to interpret, sensory input. I close by briefly outlining other cognitive functions that might also be synthesized within this framework, including reasoning, theory of mind phenomena, and language.

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