Recent advancements in flexible and wearable sensors for biomedical and healthcare applications

2021 ◽  
Author(s):  
Yan Wang ◽  
Ben Yang ◽  
Zhekun Hua ◽  
Junyao Zhang ◽  
Pu Guo ◽  
...  
Keyword(s):  
Health Management ◽  
Wearable Sensors ◽  
Response Speed ◽  
Great Promise ◽  
Healthcare Applications ◽  
Wearable Sensing ◽  
Sensing Platform ◽  
Recent Developments ◽  
Body Sensors ◽  
Sensitivity And Selectivity

Abstract In the past decades, with the increasing awareness of personal health management, various types of flexible and wearable body sensors have been developed. Thanks to the superiorities of advanced wearable technologies, including miniaturization and portability, stretchability and comfortability, intelligent human-machine interface, etc., flexible and wearable body sensors hold great promise in the next generation biomedicine and healthcare applications. Unfortunately, the data precision, response speed, sensitivity and selectivity, durability, compatibility with flexible substrates, and preparation technics still need to be enhanced and refined to meet the requirements of clinical evaluations or even commercialization. According to the working principles, flexible and wearable sensing platform can be roughly divided into four categories: physical sensors, chemical sensors, biosensors, and the fusion of different types of sensors. Here, a brief review focused on recent developments of these flexible and wearable sensors applied especially to biomedicine and healthcare is presented. In addition, the existing challenges and potential opportunities ahead in flexible and wearable sensor technologies are discussed. At last, an outlook of wearable sensing platforms in biomedicine and healthcare is proposed. We hope this review can provide guidance for superior flexible and wearable sensing technologies in the future.

Schottky diodes based on 2D materials for environmental gas monitoring: a review on emerging trends, recent developments and future perspectives

2021 ◽  
Author(s):  
Minu Mathew ◽  
Chandra Sekhar Rout
Keyword(s):  
Gas Sensing ◽  
2D Materials ◽  
Schottky Diodes ◽  
High Sensitivity ◽  
Future Perspectives ◽  
Working Temperature ◽  
Emerging Trends ◽  
Gas Sensing Properties ◽  
Recent Developments ◽  
Sensitivity And Selectivity

This review details the fundamentals, working principles and recent developments of Schottky junctions based on 2D materials to emphasize their improved gas sensing properties including low working temperature, high sensitivity, and selectivity.

Application of Advanced Electrochemical Methods with Nanomaterial-based Electrodes as Powerful Tools for Trace Analysis of Drugs and Toxic Compounds

2019 ◽  
Vol 15 (2) ◽  
pp. 143-151 ◽  
Author(s):  
Parviz Norouzi ◽  
Bagher Larijani ◽  
Taher Alizadeh ◽  
Eslam Pourbasheer ◽  
Mostafa Aghazadeh ◽  
...  
Keyword(s):  
Trace Analysis ◽  
High Speed ◽  
Portable Devices ◽  
Great Opportunity ◽  
Toxic Compounds ◽  
High Speed Analysis ◽  
Recent Developments ◽  
Sensitivity And Selectivity ◽  
Trace Measurement ◽  
Health Application

Background: The new progress in electronic devices has provided a great opportunity for advancing electrochemical instruments by which we can more easily solve many problems of interest for trace analysis of compounds, with a high degree of accuracy, precision, sensitivity, and selectivity. On the other hand, in recent years, there is a significant growth in the application of nanomaterials for the construction of nanosensors due to enhanced chemical and physical properties arising from discrete modified nanomaterial-based electrodes or microelectrodes. Objective: Combination of the advanced electrochemical system and nanosensors make these devices very suitable for the high-speed analysis, as motioning and portable devices. This review will discuss the recent developments and achievements that have been reported for trace measurement of drugs and toxic compounds for environment, food and health application.

scholarly journals Fatigue Testing of Wearable Sensing Technologies: Issues and Opportunities

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4070
Author(s):  
Andrea Karen Persons ◽  
John E. Ball ◽  
Charles Freeman ◽  
David M. Macias ◽  
Chartrisa LaShan Simpson ◽  
...  
Keyword(s):  
Fatigue Life ◽  
Prediction Models ◽  
Fatigue Testing ◽  
Low Cycle Fatigue ◽  
Wearable Sensors ◽  
Fatigue Tests ◽  
Proof Of Concept ◽  
Cycle Fatigue ◽  
Wearable Sensing ◽  
Failure Data

Standards for the fatigue testing of wearable sensing technologies are lacking. The majority of published fatigue tests for wearable sensors are performed on proof-of-concept stretch sensors fabricated from a variety of materials. Due to their flexibility and stretchability, polymers are often used in the fabrication of wearable sensors. Other materials, including textiles, carbon nanotubes, graphene, and conductive metals or inks, may be used in conjunction with polymers to fabricate wearable sensors. Depending on the combination of the materials used, the fatigue behaviors of wearable sensors can vary. Additionally, fatigue testing methodologies for the sensors also vary, with most tests focusing only on the low-cycle fatigue (LCF) regime, and few sensors are cycled until failure or runout are achieved. Fatigue life predictions of wearable sensors are also lacking. These issues make direct comparisons of wearable sensors difficult. To facilitate direct comparisons of wearable sensors and to move proof-of-concept sensors from “bench to bedside,” fatigue testing standards should be established. Further, both high-cycle fatigue (HCF) and failure data are needed to determine the appropriateness in the use, modification, development, and validation of fatigue life prediction models and to further the understanding of how cracks initiate and propagate in wearable sensing technologies.

Telemedical Wearable Sensing Platform for Management of Chronic Venous Disorder

2015 ◽  
Vol 44 (7) ◽  
pp. 2282-2291 ◽  
Author(s):  
Ruya Li ◽  
Baoqing Nie ◽  
Chengwei Zhai ◽  
Jennifer Cao ◽  
Jian Pan ◽  
...  
Keyword(s):  
Wearable Sensing ◽  
Sensing Platform

scholarly journals Wearable sensors: modalities, challenges, and prospects

Lab on a Chip ◽  
2018 ◽  
Vol 18 (2) ◽  
pp. 217-248 ◽  
Author(s):  
J. Heikenfeld ◽  
A. Jajack ◽  
J. Rogers ◽  
P. Gutruf ◽  
L. Tian ◽  
...  
Keyword(s):  
Human Body ◽  
Wearable Sensors ◽  
Chemical Information ◽  
Non Invasive ◽  
Wearable Sensing ◽  
Sensing Technology

Non-invasive wearable sensing technology extracts mechanical, electrical, optical, and chemical information from the human body.

scholarly journals Possibilities of Virtual Reality Technologies for the Development of Gaming Applications

2021 ◽  
Vol 25 (5) ◽  
pp. 31-40
Author(s):  
E. V. Romanova ◽  
L. V. Kurzaeva ◽  
L. Z. Davletkireeva ◽  
T. B. Novikova
Keyword(s):  
Virtual Reality ◽  
Augmented Reality ◽  
Computer Games ◽  
Rapid Development ◽  
Wearable Sensors ◽  
Body Sensors ◽  
Virtual And Augmented Reality ◽  
It Training ◽  
Almost All ◽  
Practical Task

The rapid development of virtual and augmented reality technologies is currently taking place in almost all spheres of activity. Elements of virtual and augmented reality are used in such areas as education, medicine, transport, gaming, tourism and others. The active spread of these technologies causes the emergence of special competencies in the IT labor market and, as a result, the formation of new professions.Many Russian universities are training students in IT training areas. Specialization in the development of computer games and virtual reality applications has begun recently. The provision of practical classes is accompanied by specific tasks, which gives students the opportunity to improve the use of software and technical devices.The relevance of the research is determined by the current demand for the use of the latest technologies by IT developers in the field of creating computer games. Today, technologies that provide a player’s immersion in virtual reality are becoming more and more popular. One of these technologies is a suit with wearable sensors that track a person’s position in space in real time. However, there are quite a few real described projects in the literature and on the Internet. This study examines the process of developing a task for creating a game application using virtual reality technology: a suit with wearable sensors for teaching students.Materials and methods of research. Timely identification of the needs of the IT market in personnel training allows educational organizations to form new training programs of different levels of training. This approach makes it possible to target the educational and methodological materials being developed to use the latest achievements in the development of the field under study.Using a systematic approach, the study characterizes virtual reality suits and sensors for monitoring the position in the user’s space. Thus, the goal of the task was to ensure the immersiveness and convenience of interaction between the player and the game environment.Based on materials on software, position sensors in space, the approach of pedagogical design was applied and the procedure was formed for a practical task, reflecting the relevant competencies.Results. The study was conducted on the basis in the framework of laboratory and practical work of students, as well as at a real enterprise. Training in the new profile of the direction of training “Applied informatics” is fully equipped with all the latest technologies in this field. As a result of the work, the content of the practical task was developed.Real development of virtual and augmented reality applications is conducted jointly with students. Almost all projects used a suit with body sensors.Conclusion. Our study examines in detail the process of developing an application using a suit with wearable sensors for further training of students. Based on the results, work can be carried out on real projects for any field. Based on the research materials, it is planned to issue a textbook for students with the profile of developing computer games and virtual / augmented reality applications.

Communication Issues in Pervasive Healthcare Systems and Applications

2010 ◽  
pp. 197-227 ◽  
Author(s):  
Demosthenes Vouyioukas ◽  
Ilias Maglogiannis
Keyword(s):  
Healthcare Delivery ◽  
Communication Technologies ◽  
Mobile Technologies ◽  
Future Trends ◽  
Healthcare Applications ◽  
Comprehensive Overview ◽  
Systematic Analysis ◽  
Pervasive Healthcare ◽  
Body Sensors

This book chapter provides a systematic analysis of the communication technologies used in healthcare and homecare, their applications and the utilization of the mobile technologies in the healthcare sector by using in addition case studies to highlight the successes and concerns of homecare projects. There are several software applications, appliances, and communication technologies emerging in the homecare arena, which can be combined in order to create a pervasive mobile health system. This study highlights the key areas of concern and describes various types of applications in terms of communications’ performance. A comprehensive overview of some of these homecare, healthcare applications and research are presented. The technologies regarding the provision of these systems are described and categorised in two main groups: synchronous and asynchronous communications’ systems and technologies. The recent advances in homecare using wireless body sensors and on/off-body networks technologies are discussed along with the provision of future trends for pervasive healthcare delivery. Finally, this book chapter ends with a brief discussion and concluding remarks in succession to the future trends.

scholarly journals Radar-Based Non-Contact Continuous Identity Authentication

2020 ◽  
Vol 12 (14) ◽  
pp. 2279 ◽  
Author(s):  
Shekh Md Mahmudul Islam ◽  
Olga Borić-Lubecke ◽  
Yao Zheng ◽  
Victor M. Lubecke
Keyword(s):  
Doppler Radar ◽  
Vital Signs ◽  
Identity Authentication ◽  
Future Research ◽  
Great Promise ◽  
Healthcare Applications ◽  
Privacy Concerns ◽  
Vital Signs Monitoring ◽  
Wide Range ◽  
Physiological Sensing

Non-contact vital signs monitoring using microwave Doppler radar has shown great promise in healthcare applications. Recently, this unobtrusive form of physiological sensing has also been gaining attention for its potential for continuous identity authentication, which can reduce the vulnerability of traditional one-pass validation authentication systems. Physiological Doppler radar is an attractive approach for continuous identity authentication as it requires neither contact nor line-of-sight and does not give rise to privacy concerns associated with video imaging. This paper presents a review of recent advances in radar-based identity authentication systems. It includes an evaluation of the applicability of different research efforts in authentication using respiratory patterns and heart-based dynamics. It also identifies aspects of future research required to address remaining challenges in applying unobtrusive respiration-based or heart-based identity authentication to practical systems. With the advancement of machine learning and artificial intelligence, radar-based continuous authentication can grow to serve a wide range of valuable functions in society.

scholarly journals 3D kidney organoids for bench-to-bedside translation

2020 ◽  
Author(s):  
Navin Gupta✉ ◽  
Emre Dilmen ◽  
Ryuji Morizane
Keyword(s):  
Collecting Duct ◽  
Developmental Toxicity ◽  
Human Kidney ◽  
Great Promise ◽  
Duct Systems ◽  
Recent Developments ◽  
Induced Pluripotent ◽  
Kidney Organoids

Abstract The kidneys are essential organs that filter the blood, removing urinary waste while maintaining fluid and electrolyte homeostasis. Current conventional research models such as static cell cultures and animal models are insufficient to grasp the complex human in vivo situation or lack translational value. To accelerate kidney research, novel research tools are required. Recent developments have allowed the directed differentiation of induced pluripotent stem cells to generate kidney organoids. Kidney organoids resemble the human kidney in vitro and can be applied in regenerative medicine and as developmental, toxicity, and disease models. Although current studies have shown great promise, challenges remain including the immaturity, limited reproducibility, and lack of perfusable vascular and collecting duct systems. This review gives an overview of our current understanding of nephrogenesis that enabled the generation of kidney organoids. Next, the potential applications of kidney organoids are discussed followed by future perspectives. This review proposes that advancement in kidney organoid research will be facilitated through our increasing knowledge on nephrogenesis and combining promising techniques such as organ-on-a-chip models.

scholarly journals Recent Approaches to Chiral 1,4-Dihydropyridines and their Fused Analogues

Catalysts ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1019
Author(s):  
Martins Rucins ◽  
Aiva Plotniece ◽  
Eiva Bernotiene ◽  
Wei-Bor Tsai ◽  
Arkadij Sobolev
Keyword(s):  
Kinetic Resolution ◽  
Stereoselective Synthesis ◽  
Biological Activities ◽  
Great Promise ◽  
Racemic Mixtures ◽  
Treatment Of Hypertension ◽  
Opposite Action ◽  
Recent Developments ◽  
Substantial Progress ◽  
Active Calcium

The purpose of this review is to highlight recent developments in the synthesis of chiral 1,4-dihydropyridines and their fused analogues. 1,4-Dihydropyridines are among the most active calcium antagonists that are used for the treatment of hypertension. Enantiomers of unsymmetrical 1,4-dihydropyridines often show different biological activities and may have even an opposite action profile. Hantzsch synthesis usually produces racemic mixtures of unsymmetrical 1,4-dihydropyridines. Therefore, the development of stereoselective synthesis of 1,4-dihydropyridines is one of the priorities of medicinal chemistry. Over the years, numerous methodologies have been developed for the production of enantiopure 1,4-dihydropyridines, such as stereoselective synthesis using chiral auxiliaries and chiral cyclocondensation partners, chromatographical methods, resolution of diastereomeric 1,4-dihydropyridine salts, enzyme catalysed kinetic resolution, or asymmetrisation of ester groups of 1,4-dihydropyridines. These approaches have been studied in detail and are relatively well established. The catalytic asymmetric approach holds the greatest promise in delivering the most practical and widely applicable methods. Substantial progress has been made toward the development of enantioselective organocatalytic methods for the construction of the chiral dihydropyridines. However, most of them do not provide a convenient way to pharmacologically important 1,4-dihydropyridine-3,5-dicarboxylates. Organocatalytic enantioselective desymmetrisation of prochiral 1,4-dihydropyridine-3,5-dicarbaldehydes also has great promise in the synthesis of pharmacologically important 1,4-dihydropyridine-3,5-dicarboxylates.

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