Prominent antibacterial effect of sub-5 nm Cu nanoparticles/MoS2 composite under visible light

2021 ◽  
Author(s):  
Jingze Li ◽  
Jiaxin Ma ◽  
Liu Hong ◽  
Cheng Yang
Keyword(s):  
Visible Light ◽  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
Bactericidal Effect ◽  
Metal Nanoparticle ◽  
Oxygen Species ◽  
Cu Nanoparticles ◽  
Cost Performance ◽  
E Coli ◽  
Cu Ions

Abstract Achieving an efficient and inexpensive bactericidal effect is a key point for the design of antibacterial agent. Recent advances have proved molybdenum disulfide (MoS2) as a promising platform for antimicrobial applications, while the combination of metal nanoparticle would promote the antibacterial efficiency. Nevertheless, the dispersivity, cheapness and safety of metal nanoparticle loaded on MoS2 raised some concerns. In this paper, we successfully realized a uniform decoration of copper nanoparticles (CuNPs) on surface of MoS2 nanosheets, and the size of CuNPs could be controlled below 5 nm. Under 5 min irradiation of 660 nm visible light, the synthesized CuNPs/MoS2 composite demonstrated superior antibacterial performances (almost 100% bacterial killed) towards both Gram-negative E. coli and Gram-positive S. aureus over the single component (Cu or MoS2), while the bactericidal effect could last for at least 6 h. The synergism of photodynamic generated hydroxyl radical (∙OH), oxidative stress without reactive oxygen species (ROS) production and the release of Cu ions was considered as the mechanism for the antibacterial properties of CuNPs/MoS2. Our findings provided new insights into the development of two-dimensional antibacterial nanomaterials of high cost performance.

scholarly journals Bactericides Properties of Chitosan Metal Quantum Dots Microbial Pathogenicity Against E. coli, S. aureus, and S. Typhi

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Galo Cárdenas-Triviño ◽  
María J. Saludes-Betanzo ◽  
Luis Vergara-González
Keyword(s):  
Quantum Dots ◽  
Antibacterial Properties ◽  
Inhibition Zone ◽  
Bactericidal Effect ◽  
Salmonella Typhi ◽  
Disk Diffusion ◽  
Initial Inoculum ◽  
E Coli ◽  
Growth Inhibition Zone ◽  
Average Size

The nanotechnology is considered as a tool to overcome antibiotic-resistant infections. The aim of this study was to investigate the antibacterial properties of quantum dots (QDs) of Au, Ag, and Cu supported in chitosan against Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), and Salmonella Typhi (ATCC 9993) strains. The QDs were synthesized by the method (Chemical Liquid Deposition, CLD) using 2-ethoxyethanol as solvent (1×10−3 M approximate dispersion concentration). Then, NPs supported in chitosan were synthesized by solvated metal atom dispersion (SMAD) in two concentrations, labelled [A] and [B] (0.05 and 0.1 g/L) for each metal with chitosan resulting in an average size of Au 10±2.0, Ag 6±1.3, and Cu 10±2.4 nm, respectively. Several other techniques were performed such as TEM, SEM/EDX, TGA, DSC, and FT-IR for characterizing QDs. The antibacterial assay was performed with 8 agents on cultures of E. coli, S. aureus, and S. Typhi by disk diffusion, broth macrodilution, and determining death curve to the most sensitive pathogen. The antibacterial effect of the nanoparticles was compared using the diameter of growth inhibition zone by agar disk diffusion and through the minimal inhibitory concentration (MIC) and minimal bactericide concentration (MBC) obtained by macrodilution in batch culture with an initial inoculum of 5×105 CFU/mL. The highest bactericidal effect was obtained with nanoparticles of Au, Ag, and Cu (0.1 g/L) with MIC and MBC of 200 and 400 mg/mL, respectively. The greatest bactericidal effect considering the three pathogens turned out to be Ag QDs (0.05 and 0.1 g/L). A bactericidal effect of metal nanoparticles is affected mainly by the electronegativity, the concentration of nanoparticles, and the bacterial age culture.

scholarly journals Considerable Variation of Antibacterial Activity of Cu Nanoparticles Suspensions Depending on the Storage Time, Dispersive Medium, and Particle Sizes

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Olga V. Zakharova ◽  
Anna Yu. Godymchuk ◽  
Alexander A. Gusev ◽  
Svyatoslav I. Gulchenko ◽  
Inna A. Vasyukova ◽  
...  
Keyword(s):  
Storage Time ◽  
Antibacterial Properties ◽  
Physiological Solution ◽  
Cu Nanoparticles ◽  
E Coli ◽  
New Class ◽  
Low Concentrations ◽  
Nanoparticle Suspensions ◽  
Sodium Dichloroisocyanurate ◽  
Average Size

Suspensions of Cu nanoparticles are promising for creating the new class of alternative antimicrobial products. In this study we examined copper nanoparticles of various sizes obtained by the method of wire electric explosion: nanopowder average size 50 nm (Cu 50) and 100 nm (Cu 100). The paper presents the complex study of the influence of physicochemical properties such as particle size and concentration of the freshly prepared and 24-hour suspensions of Cu nanoparticles in distilled water and physiological solution upon their toxicity to bacteriaE. coliM-17. Ionic solution of Cu2+and sodium dichloroisocyanurate was used for comparison study. It has been shown that decrease in the nanoparticle size leads to changes in the correlation between toxicity and concentration as toxicity peaks are observed at low concentrations (0.0001⋯0.01 mg/L). It has been observed that antibacterial properties of Cu 50 nanoparticle suspensions are ceased after 24-hour storage, while for Cu 100 suspensions no correlation between antibacterial properties and storage time has been noted. Cu 100 nanoparticle suspensions at 10 mg/L concentration display higher toxicity at substituting physiological solution for water than Cu 50 suspensions. Dependence of the toxicity on the mean particle aggregates size in suspension was not revealed.

scholarly journals Antibacterial properties of graphene and its derivatives

2020 ◽  
Vol 68 (4) ◽  
pp. 69-84
Author(s):  
Anna Romiszewska ◽  
Aneta Bombalska
Keyword(s):  
Reactive Oxygen Species ◽  
Graphene Oxide ◽  
Biofilm Formation ◽  
Culture Medium ◽  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
Oxygen Species ◽  
Bacterial Cells ◽  
Reduced Graphene ◽  
Sharp Edges

The work presents a literature review on the use of graphene and its derivatives as the potential protection against bacterial microflora. Addressed issues relate to an attempt to explain the mechanisms of impact of graphene and its derivatives: graphene oxide (GO) and reduced graphene oxide (rGO) on the bacterial cells. Interaction of graphene materials (G, GO, rGO) with Gram(+) and Gram(-) were compared with regard to the concentration of the preparations, the nature of the culture medium and surface of graphene deposition. Issues related to the development of reactive oxygen species (ROS) were discussed, the effect of sharp edges of GM’s (nano-knife), biofilm formation and the potential application of graphene in nanomedicine. Keywords: biomedicine, graphene, graphene oxide antibacterial effect, biofilm

scholarly journals New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6281
Author(s):  
Denis N. Chausov ◽  
Dmitriy E. Burmistrov ◽  
Alexander D. Kurilov ◽  
Nikolay F. Bunkin ◽  
Maxim E. Astashev ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Composite Material ◽  
Zinc Oxide Nanoparticles ◽  
Antibacterial Properties ◽  
Comprehensive Analysis ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Zno Nps ◽  
E Coli ◽  
Positive Effect

The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.

scholarly journals A Mini Review of Antibacterial Properties of ZnO Nanoparticles

2021 ◽  
Vol 9 ◽  
Author(s):  
Sergey V. Gudkov ◽  
Dmitriy E. Burmistrov ◽  
Dmitriy A. Serov ◽  
Maxim B. Rebezov ◽  
Anastasia A. Semenova ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
World Health ◽  
Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
E Coli ◽  
Antibacterial Potential

The development of antibiotic resistance of bacteria is one of the most pressing problems in world health care. One of the promising ways to overcome microbial resistance to antibiotics is the use of metal nanoparticles and their oxides. In particular, numerous studies have shown the high antibacterial potential of zinc oxide nanoparticles (ZnO-NP) in relation to gram-positive and gram-negative bacteria. This mini-review includes an analysis of the results of studies in recent years aimed at studying the antibacterial activity of nanoparticles based on zinc oxide. The dependence of the antibacterial effect on the size of the applied nanoparticles in relation to E. coli and S. aureus is given. The influence of various ways of synthesis of zinc oxide nanoparticles and the main types of modifications of NP-ZnO to increase the antibacterial efficiency are also considered.

scholarly journals Impact of decalcification on antibacterial properties of eggshell against selected poultry pathogens

2021 ◽  
Vol 22 (2) ◽  
pp. 204-210
Author(s):  
T.V. Balogu ◽  
B.C. Chukwueze ◽  
T.P. Okonkwo
Keyword(s):  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
Fine Powder ◽  
Inhibitory Effect ◽  
Diffusion Method ◽  
Mean Values ◽  
Significance Level ◽  
E Coli ◽  
Zone Diameter ◽  
The Mean

Background: Eggshell which is primarily composed of more than 98% calcium carbonate crystal, serves as the physical protective and active barrier structure of egg content. Recently, antimicrobial properties of eggshell are fast becoming center of interest among stakeholders of poultry industry. However, few studies have focused on the rigidity factor of calcium components of eggshell as antimicrobial agent. Thus, this study was designed to determine the effect of decalcification on the ability of eggshell to inhibit common poultry and egg bacterial pathogens.Methods: Raw eggshell denoted as calcified eggshell (CES) and decalcified eggshell (DES) were extracted and made into fine powder. Standard protocol was used for preparations of CES and DES at concentrations of 10, 5, 2.5 and 1.25 mg/ml, and their antibacterial assays on selected bacterial pathogens (Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Salmonella Typhi) were performed by agar diffusion method. Gentamicin 80mg solution (CC1) and distilled water (CC2) served as controls. Data were analysed with SPSS version 20.0 and presented as mean±SD for descriptive statistics. Friedman's two-way test ANOVA was used to compare the differences in mean values between CES, DES, CC1 and CC2 at significance level of p<0.05.Results: The mean zone diameter of inhibition produced by DES (range 13–28mm) for the isolates was significantly higher (p<0.05) than that produced by CES (range 10-21mm). However, the mean zone diameter of inhibition produced by CC1 (gentamicin) (range 16-40mm) was higher than that produced by DES or CES (p<0.05). The concentrations of DES and CES have no significant antibacterial effect on B. subtilis and K. pneumoniae (p>0.05), but had inverse effect on P. aeruginosa. Overall, DES had a better inhibitory effect than CES against B. subtilis, K. pneumoniae and P. aeruginosa, but notably, neither DES nor CES had inhibitory effect on E. coli and S. Typhi.Conclusion: Poor antibacterial effect of CES may be attributed to the calcium-protein interactions within bacterial cell membrane, which hinders absorption or mobility mechanism of the antibacterial factor of the eggshell, but decalcification had significant impact on the antibacterial profile of the eggshell for some bacterial isolates. However, S. Typhi and E. coli were totally resistant to both DES and CES. Breed of eggs with minimal calcified eggshell to withstand transportation fragility, may enhance antibacterial index and shelf-life of table eggs. Keywords: Decalcification; Antibacterial; Eggshell; Poultry; Pathogens

scholarly journals Antimicrobial activity of Lippia sidoides Cham. (Verbenaceae) essential oil against Staphylococcus aureus and Escherichia coli

2011 ◽  
Vol 13 (3) ◽  
pp. 293-297 ◽  
Author(s):  
C.E Castro ◽  
J.M Ribeiro ◽  
T.T Diniz ◽  
A.C Almeida ◽  
L.C Ferreira ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Essential Oil ◽  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Antibacterial Effect ◽  
Bactericidal Effect ◽  
Bacterial Cells ◽  
E Coli ◽  
Lippia Sidoides

The antibacterial effect of Lippia sidoides (rosemary pepper) essential oil was tested against the bacteria Staphylococcus aureus and Escherichia coli isolated from homemade Minas cheese produced in Brazil. The Minimum Inhibitory Concentration (MIC) determined in the Dilution Test was 13 µL oil mL-1 for both bacteria, which characterizes inhibitory action in broth for a 24-hour interaction period. The Minimum Bactericidal Concentration (MBC) determined in the Suspension Test, with one minute of contact, was 25 µL oil mL-1 for both tested bacteria, obtaining at this concentration a bactericidal effect of 99.9% on the viable bacterial cells from each sample. Results demonstrated the bacterial activity of Lippia sidoides essential oil against S. aureus and E. coli, suggesting its use as an antibacterial agent in foods.

scholarly journals Effect of vermicompost on yield, quality and antibacterial activity of garlic.

2019 ◽  
Vol 9 (4) ◽  
pp. 499-504
Author(s):  
V. Yatsenko ◽  
O. Ulianych ◽  
S. Shchetyna ◽  
G. Slobodyanyk ◽  
N. Vorobiova ◽  
...  
Keyword(s):  
Mycobacterium Smegmatis ◽  
Nutritional Value ◽  
Allium Sativum ◽  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
Total Content ◽  
Inhibition Zone ◽  
The Body ◽  
E Coli ◽  
Yield Quality

We studied the influence of humus and different norms of vermicompost on the yield, nutritional value, and antibacterial properties of common garlic (Allium sativum L.). The use of the vermicompost caused an increase in the garlic yield by 1.7-3.9 t ha-1 for cultivar "Prometei" compared to the control "Sofiiskyi" and by 2.2-5.2 t ha-1 in relation to the control of cultivar "Prometei". It was established that the calory content could increase up to 22.68 g 100 g1 of fresh weight with vermicompost manure 5 t ha-1, and the total content of sugar is increasing by 21.52-40.81% depending on the cultivar. The content of vitamins increased alongside with rate of vermicompost introduction. We also revealed the influence of variety factor on the accumulation of vitamins. The antibacterial effect of the garlic essential oils against Staphylococcus aureus, Escherichia coli and Bacillus subtilis was significant; the diameters of the inhibition zone were for S. aureus 21.35-27.10 mm, for E. coli - 16.97-26.46 mm, and for B. subtilis - 16.42-25.36 mm. The number of Mycobacterium smegmatis colonies decreased by 23.96-43.44%. This study has been proved that garlic juice had considerable antibacterial effect on the studied bacteria (S. aureus, E. coli and B. subtilis); therefore, it can replace chemical antibiotics that have undesirable effects on the body, like allergy and antimicrobial resistance. Our data shows that using of vermicompost was more effective than humus.

scholarly journals Metal nanoparticle antibacterial effect оn antibiotic-resistant strains of bacteria

2021 ◽  
Vol 11 (4) ◽  
pp. 771-776
Author(s):  
E. S. Udegova ◽  
K. A. Gildeeva ◽  
T. V. Rukosueva ◽  
S. Baker
Keyword(s):  
Metal Nanoparticles ◽  
High Efficiency ◽  
Antibacterial Effect ◽  
Curcuma Longa ◽  
Synthesis Method ◽  
Antibacterial Properties ◽  
Metal Nanoparticle ◽  
Biological Method ◽  
Antibacterial Drugs ◽  
Strain Collection

The rapid formation of microbial resistance to modern antibacterial drugs requires to search for new, alternative therapies. It is known that some organisms, such as plants, algae, fungi, are able to convert inorganic metal ions into metal nanoparticles due to the recovery process carried out by proteins, sugars and metabolites contained in the tissues and cells of these organisms. At the same time, many plants (e.g., plantain, yarrow, wormwood, turmeric long, calendula, marsh bagulnik, etc.) and metals (copper, silver, gold, zinc, etc.) themselves have antibacterial properties, so that metal nanoparticles obtained by biological method, or via “Green” synthesis method, from extracts of such plants can become a current alternative to many modern antibacterial drugs. The antibacterial mechanism of action of nanoparticles depends on the type of microorganisms affected, as well as on the type of nanoparticles, their concentration, size, and how they are obtained. Based on this, the study of the antibacterial effect of nanoparticles is one of the promising directions of solving the problem of microbial antibiotic resistance. There was examined antibacterial effect of metal nanoparticles containing silver, copper and gold obtained by biological method from the salts of AgNO3, CuSO4, H[AuCl4] metals, respectively, and the extract of the plant — turmeric long (lat. Curcuma longa) — related to the following bacteria strain collection: E. coli (ATCC 25922), S. aureus (ATCC 25923), MRSA (ATCC 38591) and polyresistant clinical strains isolated from patients of the Regional clinical hospital (Krasnoyarsk) — К. рneumoniae, strain 104, P. аeruginosa, strain 40, P. аeruginosa, strain 215, А. baumannii, strain 210, А. baumannii, strain 211. Study allowed to identify the minimum suppressive concentration of nanoparticles by the method of serial dilutions (MUK 4.2.1890-04) with azurin dye. It was proved that metal nanoparticles exhibit different antibacterial efficacy depending on the type of nanometals used and bacterial cultures. Copper nanoparticles have the highest antibacterial activity, and gold nanoparticles have the lowest. The most marked antibacterial effect was observed against clinical polyresistant strains. Metal nanoparticles can become an alternative to the currently known antibacterial drugs, but despite the high efficiency of nanoparticles against polyresistant to antibacterial drugs microorganisms in vitro, it is necessary to take into account their possible toxic effect on live tissues, which requires further study in experiments in vivo.

Antibacterial activity of granulated carbon sorbents

2017 ◽  
pp. 76-82
Author(s):  
В.Т. Долгих ◽  
Л.Г. Пьянова ◽  
Т.И. Долгих ◽  
В.А. Лихолобов ◽  
О.В. Корпачева ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
Petri Dish ◽  
Klebsiella Pneumonia ◽  
Carbon Sorbents ◽  
E Coli ◽  
Petri Dishes

Цель исследования - изучение антибактериальной активности гранулированных углеродных сорбентов по отношению к патогенной микрофлоре в условиях различной продолжительности контакта с сорбентом. Методика. Исследовали антибактериальные свойства гранулированного сорбента ВНИИТУ-1, обработанного гидромеханически, окисленного и стабилизированного до нормативных значений рН и модифицированного поли-N-винилпирролидоном (ПВП) ВНИИТУ-1 по отношению к патогенным микроорганизмам: Staphylococcus aureus, Pseudomonas aeroginosa, Klebsiella pneumonia, Escherichia coli, Streptococcus agalactiae, а также к их смесям. Все микроорганизмы представляли собой клинические штаммы, выделенные из ран пациентов. Предварительно тест-микроорганизмы были исследованы на чувствительность к современным антибиотикам. Опытным путем подбирали такие разведения и количество засеваемого материала, чтобы выросшие на чашке Петри колонии можно было сосчитать. Бактерии сорбировали из физиологического раствора с концентрацией микробных клеток 3 х 10 колониеобразующих единиц в 1 мл исследуемой пробы (КОЕ/мл). В пробирку типа Эппендорф вносили сорбент в количестве 0,5 мл, добавляли 1 мл микробной взвеси, встряхивали для удаления пузырьков воздуха и выдерживали в термостате в течение 1, 3, 6 и 24 ч. По истечении заданного времени контакта сорбента с патогенной микрофлорой отбирали надосадочную жидкость в объеме 100 мкл, засевали на стерильные агаровые пластины чашек Петри с питательной средой ГМФ-агар. Засеянные чашки Петри помещали в СО-инкубатор 15АС (Япония) вверх дном и инкубировали при температуре 37 ± 1°С в течение 24 ± 2 ч. При подсчете колоний, выросших на чашке Петри, учитывали только те чашки, на которых выросло более 300 изолированных колоний. Результаты. Гранулированный сорбент ВНИИТУ-1 обладает антибактериальным действием в отношении как грамположительных, так и грамотрицательных бактерий, а также их смеси. Сроки проявления антибактериального эффекта сорбента зависят от вида микроорганизмов и времени их контакта с образцом. Присутствие в составе сорбента модификатора ПВП усиливает его антибактериальные свойства. Полимермодифицированный образец обладает пролонгированным антибактериальным эффектом в отношении широкого спектра микроорганизмов (E. coli, St. aureus, P. aeruginosae и St. aureus) и смеси их культур. Заключение. Показана возможность повышения антибактериальных свойств гранулированных углеродных сорбентов по отношению к патогенной микрофлоре путем их модификации поли-N-винилпирролидоном. Дальнейшая разработка и применение углеродных сорбентов как средств сорбционной терапии является перспективным подходом к местному лечению гнойных ран. The purpose: Study the antibacterial activity of granulated carbon sorbents in relation to the pathogenic microflora under the conditions of different period of contact with sorbent. Methods. It has been investigated the antibacterial properties of VNIITU-1 granulated sorbent, which was hydromechanically treated, oxidized and stabilized up to pH standard parameters and VNIITU-1 modified poly-N-vinylpyrrolidone (PVP) against the pathogenic micro-organisms, including Staphylococcus aureus, Pseudomonas aeroginosa, Klebsiella pneumonia, Escherichia coli, Streptococcus agalactiae, and their mixes. All bacteria were clinical strains derived from the wounds of patients. Dilutions and amount of inoculated material were experimentally selected for further calculation of the grown colonies on the Petri dish. Bacteria were sorbed from the saline solution with bacteria concentration of 3 х 10 of the colony forming units in 1 ml of test sample (CFU/ ml). Eppendorf tube was added the sorbent 0.5 ml and bacterial suspension 1 ml; then the tube was shaken to remove the air bubbles and incubated for 1, 3, 6 and 24 hr. Upon the expiry of the target time for sorbent with pathogenic flora contact the supernatant fluid was collected in 100 ul and inoculated on the sterile agar plates of the Petri dishes with GMF agar nutrient medium. Inoculated Petri dishes were placed upside down in СО incubator 15AC (Japan) and incubated at 37 ± 1°C for 24 ± 2 hours. When counting the colonies growing on the Petri dish, they took into consideration only the dishes where more than 300 isolated colonies were grown. If more than 300 colonies were grown, «> 3x102 CFU/ml» was recorded in the protocol. Results. Granulated sorbent VNIITU-1 has an antibacterial effect against both gram-positive and gram-negative bacteria, and their mixes. Time period for manifestations of the sorbent antibacterial effect depends on the type of microorganisms and time of contact. PVP presence in sorbent composition enhances the antibacterial effect of the sorbent. Resin-modified sample has a prolonged antibacterial effect against a broad spectrum of microorganisms (E. coli, St. aureus, P. aeruginosae and St. aureus) and mixtures of their cultures. Conclusion. It has been determined the possibility for increasing of antibacterial properties of granulated carbon sorbents against the pathogenic microflora by their modification with poly-N-vinylpyrrolidone. Further development and application of carbon sorbents as the means for sorption therapy is a perspective approach for the local treatment of purulent wounds.

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