scholarly journals Surface adsorption and survival of SARS-CoV-2 on frozen meat

2021 ◽  
Vol 854 (1) ◽  
pp. 012101
Author(s):  
B Velebit ◽  
L Milojevic ◽  
V Jankovic ◽  
B Lakicevic ◽  
T Baltic ◽  
...  
Keyword(s):  
Virus Transmission ◽  
Surface Adsorption ◽  
Water Film ◽  
Disease Spread ◽  
Cooh Group ◽  
Hydroxyl Groups ◽  
Meat Industry ◽  
First Case ◽  
Protonated Amine ◽  
Strong Surface

Abstract The first case of a severe acute respiratory syndrome caused by coronavirus-2 was reported in December 2019 in China. The disease spread globally quickly, causing the 2019–2021 COVID-19 pandemic. The meat industry became concerned over the possibility of transmitting the virus in the slaughterhouse environment. The level of air exchange strongly affects the distribution of SARS-CoV-2 aerosols within the slaughterhouses. The adsorption of the SARS-CoV-2 virus on the surface of the frozen meat is dictated mainly by the interplay of electrostatic forces between the virion and tissue (pH) and environmental conditions (temperature and humidity) in the vicinity of adsorption micro-location. Suppose the virus contaminates the meat surface, whereby pH is 5.5 or less. In that case, it firmly adsorbs due to bonds established by protonated amine group and a hydrogen bond between the COOH group of the viral protein and oxygen in hydroxyl groups present on meat surfaces. The meat surface, coated with a thin water film, interacts with the SARS-CoV-2 virions by establishing strong hydrogen bonds. Although there is no proof of COVID-19 contraction by food consumption, the strong surface adsorption and ability of SARS-CoV-2 to survive meat freezing indicate a potential risk of virus transmission by meat.

Preventive Measures for COVID - 19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1902-1904
Author(s):  
Lavi Arya
Keyword(s):  
Social Life ◽  
Preventive Measures ◽  
Disease Spread ◽  
Health Economy ◽  
Wuhan City ◽  
First Case ◽  
Spread Pattern ◽  
Sudden Outburst ◽  
Mode Of Transmission ◽  
Day By Day

COVID-19 sudden outburst is declared as a serious public medical health issue worldwide by WHO, in March 2020. The first case of COVID-19 was seen officially in Wuhan City, China, in December 2019. It’s a pandemic to which all the countries has to take action in the detection of the infection and prevention of it’s spread. Despite global efforts to contain the disease spread, the outbreak is still on the rise because of the community spread pattern of this infection. Earlier the mode of transmission of the virus was seen in animal to person but now the transmission is from person to person through respiratory droplet infection the confirmed case is seen in many countries and are increasing day by day Fever, cough and cold, difficulty in breathing, tiredness can be seen in the patients suffering. The virus is affecting our health, economy, social life. Till the time we don’t have any medication at least we should try to prevent the spread of the virus. The points which can help in the prevention of the spread of the virus in the community are maintaining of hand sanitation, social distancing, Avoiding person to person contact and Quarantine. Increase in a number of testing, detecting COVID-19 positive patients will also help to reduce the spread of virus and secondary cases with strict quarantine rules.

scholarly journals Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group

2013 ◽  
Vol 57 (8) ◽  
pp. 3815-3822 ◽  
Author(s):  
Anna N. Tevyashova ◽  
Evgenia N. Olsufyeva ◽  
Svetlana E. Solovieva ◽  
Svetlana S. Printsevskaya ◽  
Marina I. Reznikova ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Cooh Group ◽  
Hydroxyl Groups ◽  
Activity Data ◽  
Oh Groups ◽  
Polyene Antibiotics ◽  
High Antifungal Activity

ABSTRACTA comprehensive comparative analysis of the structure-antifungal activity relationships for the series of biosynthetically engineered nystatin analogues and their novel semisynthetic derivatives, as well as amphotericin B (AMB) and its semisynthetic derivatives, was performed. The data obtained revealed the significant influence of the structure of the C-7 to C-10 polyol region on the antifungal activity of these polyene antibiotics. Comparison of positions of hydroxyl groups in the antibiotics andin vitroantifungal activity data showed that the most active are the compounds in which hydroxyl groups are in positions C-8 and C-9 or positions C-7 and C-10. Antibiotics with OH groups at both C-7 and C-9 had the lowest activity. The replacement of the C-16 carboxyl with methyl group did not significantly affect thein vitroantifungal activity of antibiotics without modifications at the amino group of mycosamine. In contrast, the activity of the N-modified derivatives was modulated both by the presence of CH3or COOH group in the position C-16 and by the structure of the modifying substituent. The most active compounds were testedin vivoto determine the maximum tolerated doses and antifungal activity on the model of candidosis sepsis in leukopenic mice (cyclophosphamide-induced). Study of our library of semisynthetic polyene antibiotics led to the discovery of compounds, namely,N-(l-lysyl)-BSG005 (compound 3n) and, especially,l-glutamate of 2-(N,N-dimethylamino)ethyl amide of S44HP (compound 2j), with high antifungal activity that were comparable inin vitroandin vivotests to AMB and that have better toxicological properties.

scholarly journals Confronting COVID-19 - The case of PPE and Medical Devices production using Digital Fabrication at PUC-Rio

2020 ◽  
Vol 13 (3) ◽  
pp. 488-501
Author(s):  
Jorge Roberto Lopes Dos Santos ◽  
João Victor Correia de Melo ◽  
Leonardo Frajhof ◽  
Aline Reis Kauffmann
Keyword(s):  
Medical Devices ◽  
Personal Protective Equipment ◽  
Laser Cutting ◽  
Digital Fabrication ◽  
Disease Spread ◽  
Protective Equipment ◽  
Academic Environment ◽  
Construction Of Knowledge ◽  
First Case ◽  
The City

At the end of 2019, the first cases of COVID-19 were registered. As the disease spread across continents culminating in a pandemic, countries suffered from a shortage of personal protective equipment. In Brazil, the first case was recorded on February 2020. This study aims to describe the experience of creating an interinstitutional network to meet the pandemic’s demands and the experience of transforming an academic design laboratory into space for the production of personal protective equipment using 3D printing and laser cutting techniques. The actions described in this study, made it possible to meet the high emergency demand for PPE in the city of Rio de Janeiro, as well as the construction of knowledge both within the scope of building networks to solve complex social problems and about the possibilities of production in an academic environment. The work addresses and reflexes this action on society's perception of Design professionals.

scholarly journals African swine fever virus – the possible role of flies and other insects in virus transmission

2020 ◽  
Vol 64 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Mateusz Fila ◽  
Grzegorz Woźniakowski
Keyword(s):  
African Swine Fever Virus ◽  
Animal Health ◽  
Virus Transmission ◽  
Disease Outbreaks ◽  
African Swine Fever ◽  
Disease Spread ◽  
The Baltic ◽  
Haemorrhagic Disease ◽  
And Control

AbstractAfrican swine fever (ASF) is an acute viral haemorrhagic disease of pigs and wild boars. It presents a serious threat to pig production worldwide, and since 2007, ASF outbreaks have been recorded in the Caucasus, Eastern Europe, and the Baltic States. In 2014, the disease was detected in Poland. ASF is on the list of notifiable diseases of the World Organisation for Animal Health (OIE). Due to the lack of an available vaccine and treatment, the countermeasures against the disease consist in early detection of the virus in the pig population and control of its spread through the elimination of herds affected by disease outbreaks. Knowledge of the potential vectors of the virus and its persistence in the environment is crucial to prevent further disease spread and to understand the new epidemiology for how it compares to the previous experience in Spain gathered in the 1970s and 1980s.

scholarly journals Examining the Interplay between Face Mask Usage, Asymptomatic Transmission, and Social Distancing on the Spread of COVID-19

2020 ◽  
Author(s):  
Adam Catching ◽  
Sara Capponi ◽  
Ming Te Yeh ◽  
Simone Bianco ◽  
Raul Andino
Keyword(s):  
Virus Transmission ◽  
Face Mask ◽  
Agent Based Modeling ◽  
Disease Spread ◽  
Social Functions ◽  
Agent Based ◽  
Social Distancing ◽  
Worldwide Population ◽  
Asymptomatic Individuals ◽  
High Virus

AbstractThe COVID-19 global crisis is facilitated by high virus transmission rates and high percentages of asymptomatic and presymptomatic infected individuals. Containing the pandemic hinged on combinations of social distancing and face mask use. Here we examine the efficacy of these measures, using an agent-based modeling approach that evaluates face masks and social distancing in realistic confined spaces scenarios. By explicitly considering different fractions of asymptomatic individuals, as well as a realistic hypothesis of face mask protection during inhaling and exhaling, we find that face masks are more effective than social distancing in curbing the infection. Importantly, combining face masks with even moderate social distancing provides optimal protection. The finding that widespread usage of face masks limits COVID-19 outbreaks can inform policies to reopening of social functions.Author summaryThe COVID-19 outbreak has created an enormous burden on the worldwide population. Among the various ways of preventing the spread of the virus, face masks have been proposed as a main way of reducing transmission. Yet, the interplay between the usage of face mask and other forms of Non-Pharmaceutical Intervention is still not completely clear. In this paper we introduce a stochastic individual-based model which aims at producing realistic scenarios of disease spread when mask wearing with different inward and outward efficacy and social distancing are enforced. The model elucidates the conditions which make the two forms of intervention synergistic in preventing the spread of the disease.

scholarly journals Impact of Government Interventions on Corona Virus Transmission in Nigeria

2020 ◽  
Vol 5 (7) ◽  
pp. 7-16
Author(s):  
Muhyideen Oloyede
Keyword(s):  
State Government ◽  
Logistic Model ◽  
Model Simulation ◽  
Virus Transmission ◽  
African Countries ◽  
Government Interventions ◽  
State Population ◽  
Intervention Measures ◽  
First Case ◽  
Before And After

Many measures such as multi-sectoral National Coronavirus Preparedness Group and social interventions were instituted by Nigerian governments before and after the first case of COVID-19 was recorded on February 27, 2020. Impacts of these intervention measures on COVID-19 transmission were assessed within the first 82 days in Nigeria and in the first 38 days in Kano state. These approaches toward containing the spread of COVID-19 include nonpharmaceutical intervention measures, multi-sectoral Emergency Operations Centre (EOC) was activated at Level 3, expansion of labouratories, RRT deployment etc which resulted in the slow transmission trajectory and low COVID-19 burden and death burden on the people. The analysis of the COVID-19 data obtained between February 27 and May 20, 2020 (82 days period) showed that Nigeria recorded lower death burden of one (1) per million population compare with other African countries like South Africa with death burden of 6 death per million population each and other countries, death burden increases (> 1) as COVID-19 cases increases. Similarly, COVID-19 burden of Nigeria is 33 cases per million which is also very low compared to other African countries and other highly affected countries like US and UK. By 20th May 2020, 6,677 confirmed cases and 202 deaths and 1,860 recovered from COVID-19 have occurred in Nigeria. At day 82, the exponential growth rate calculated was 0.05. The result of this study also provides epidemiological analysis of the first 40 days of COVID-19 outbreak in in the most populous state in Nigeria-Kano. Using this logistic model equation [y= 1.5*(1.3)x] generated from the curve, a total of 31,158 infections was averted in Kano state by the federal and state government intervention measures and citizen level of compliances as well as additional effort of WHO official which altogether brought the total infections to 900 as against 32,058 infections predicted by logistic model. Simulation of the same model predicts total infections of 6,092,642 by 9th of June more than half of state population in the absence of aforementioned interventions while by 11th of June 11,435,884 infections (state population). The results show COVID-19 positive cases are higher in the states with high population densities

Strong surface adsorption of aqueous sodium nitrite as an ion pair

2012 ◽  
Vol 519-520 ◽  
pp. 45-48 ◽  
Author(s):  
D.E. Otten ◽  
R. Onorato ◽  
R. Michaels ◽  
J. Goodknight ◽  
R.J. Saykally
Keyword(s):  
Sodium Nitrite ◽  
Surface Adsorption ◽  
Ion Pair ◽  
Aqueous Sodium ◽  
Strong Surface

scholarly journals Epidemiological analysis of classical swine fever in wild boars in Japan

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Yumiko Shimizu ◽  
Yoko Hayama ◽  
Yoshinori Murato ◽  
Kotaro Sawai ◽  
Emi Yamaguchi ◽  
...  
Keyword(s):  
Wild Boar ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Classical Swine Fever ◽  
Disease Spread ◽  
Wild Boar Population ◽  
Wild Boars ◽  
First Case ◽  
Forest Continuity ◽  
In The Wild

Abstract Background Classical swine fever (CSF) is a contagious disease of pigs and wild boars that is transmitted through direct/indirect contact between animals or CSF virus-contaminated fomites. When the disease re-emerged in 2018 in Japan, a CSF-infected wild boar was reported shortly after the initial pig farm outbreak; subsequently, the disease spread widely. To control the disease spread among wild boars, intensive capturing, fencing, and oral bait vaccination were implemented with concomitant virological and serological surveillance. This study aimed to describe the disease spread in the wild boar population in Japan from September 2018, when the first case was reported, to March 2020, based on the surveillance data. We conducted statistical analyses using a generalized linear mixed model to identify factors associated with CSF infection among wild boars. Moreover, we descriptively assessed the effect of oral bait vaccination, which started in March 2019 in some municipalities in the affected areas. Results We observed a faster CSF infection spread in the wild boar population in Japan compared with the CSF epidemics in European countries. The infection probability was significantly higher in dead and adult animals. The influence of the multiple rounds of oral bait vaccination was not elucidated by the statistical modeling analyses. There was a decrease and increase in the proportion of infected and immune animals, respectively; however, the immunization in piglets remained insufficient after vaccination for 1 year. Conclusions Conditions regarding the wild boar habitat, including forest continuity, higher wild boar population density, and a larger proportion of susceptible piglets, were addressed to increase the infection risk in the wild boar population. These findings could improve the national control strategy against the CSF epidemic among wild boars.

scholarly journals Transmission Dynamics of Bovine Viral Diarrhea Virus in Hokkaido, Japan by Phylogenetic and Epidemiological Network Approaches

Pathogens ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 922
Author(s):  
Shizuka Hirose ◽  
Kosuke Notsu ◽  
Satoshi Ito ◽  
Yoshihiro Sakoda ◽  
Norikazu Isoda
Keyword(s):  
Animal Movement ◽  
Hot Spot ◽  
Virus Transmission ◽  
Economic Loss ◽  
Disease Spread ◽  
Bovine Viral Diarrhea ◽  
Large Network ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Cattle Movements

Bovine viral diarrhea (BVD) caused by BVD virus (BVDV) leads to economic loss worldwide. Cattle that are persistently infected (PI) with BVDV are known to play an important role in viral transmission in association with the animal movement, as they shed the virus during their lifetime. In this research, the “hot spot” for BVD transmission was estimated by combining phylogenetic and epidemiological analyses for PI cattle and cattle that lived together on BVDV affected farms in Tokachi district, Hokkaido prefecture, Japan. Viral isolates were genetically categorized into BVDV-1a, 1b, and 2a, based on the nucleotide sequence of the entire E2 region. In BVDV genotype 1, subgenotype b (BVDV-1b), cluster I was identified as the majority in Tokachi district. Network analysis indicated that 12 of the 15 affected farms had cattle movements from other facilities (PI-network) and farms affected with BVDV-1b cluster I consisted of a large network. It was implied that the number of cattle movements themselves would be a risk of BVD transmission, using the PageRank algorithm. Therefore, these results demonstrate that cattle movements would contribute to disease spread and the combination of virological and epidemiological analysis methods would be beneficial in determining possible virus transmission routes.

scholarly journals Managing The COVID-19 Pandemic in The Community-Based Mountain Eruption Zone, Cangkringan Sub-District, in Yogyakarta

2021 ◽  
Vol 6 (2) ◽  
pp. 269-279
Author(s):  
Maryanto Maryanto ◽  
Mangapul Parlindungan Tambunan ◽  
Isranto Handoyo Putra
Keyword(s):  
Local Government ◽  
Natural Disaster ◽  
Virus Transmission ◽  
Surrounding Area ◽  
Community Based ◽  
Probability Map ◽  
First Case ◽  
Transmission Case ◽  
Level Data

Background: First case in Indonesia was reported in March 2, 2020 and until November, it has infected more than 400.000 people, with more than 300.000 recovered and 15.000 deaths in total. Especially in Cangkringan District and surrounding area, the latest natural disaster is happening in the midst of a COVID-19 pandemic that is eruption of Mount Merapi which encourage local government and outposts to prepare camps for people nearby who suffered from Mount Merapi eruption. Meanwhile, in evacuation camp, the chance of infected by COVID-19 is high and it is a main problem and a purpose of this research.Methods: Methods that is conducted in this research by obtaining vulnerability level data against the outbreak and making a probability map of virus transmission mainly in the eruption red zone.Result: The outcome of this research is COVID-19 mitigation map within eruption red zone of this regency and recommendations about how to control the outbreak among refugees.Conclusion: Therefore, evacuation can be conducted in the midst of pandemic situation because the transmission case is low.

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