Compatibility of medications with intravenous lipid emulsions: Effects of simulated Y-site mixing

2020 ◽  
Vol 77 (23) ◽  
pp. 1980-1985
Author(s):  
Emma L Ross ◽  
Allison Salinas ◽  
Kirsten Petty ◽  
Cheng Her ◽  
John F Carpenter
Keyword(s):  
Lipid Emulsion ◽  
Room Temperature ◽  
Free Water ◽  
General Information ◽  
Lipid Emulsions ◽  
Analytical Technique ◽  
Light Obscuration ◽  
Different Types ◽  
Additional Testing ◽  
States Pharmacopeia

Abstract Purpose To determine the physical intravenous Y-site compatibility of 19 commonly used medications at pediatric concentrations with 3 different types of lipid emulsion. Methods Medications at commonly used pediatric concentrations were mixed in a 1:1 ratio with lipid emulsions (Intralipid, Nutrilipid, and Smoflipid) and incubated at room temperature for 4 hours to simulate Y-site administration. Each sample was then diluted with particle-free water and analyzed using the analytical technique of light obscuration recommended in United States Pharmacopeia (USP) general information chapter 729 (USP <729>). Physical compatibility was determined by measuring the percentage of fat residing in globules larger than 5 µm (PFAT5) per USP <729> recommendations. Results Most combinations tested were physically compatible based on USP <729> regulations. Incompatibilities differed for the different brands of lipid emulsion. The two combinations that met USP <729> criteria for physical incompatibility were cisatracurium 2 mg/mL with Intralipid and gentamicin 2 mg/mL with Smoflipid. Conclusion Three different lipid emulsions were physically compatible at the Y site with the majority of medications tested. Data regarding Y-site compatibility for one lipid emulsion product cannot be safely extrapolated to another without additional testing.

Processing of Copper by Equal Channel Angular Pressing (ECAP) – Microstructure Investigations

2015 ◽  
Vol 641 ◽  
pp. 286-293
Author(s):  
Beata Leszczyńska-Madej ◽  
Maria W. Richert ◽  
Agnieszka Hotloś ◽  
Jacek Skiba
Keyword(s):  
Equal Channel Angular Pressing ◽  
Room Temperature ◽  
Subgrain Size ◽  
Pure Copper ◽  
Shear Bands ◽  
Angular Pressing ◽  
Ecap Process ◽  
Transmission Electron ◽  
Different Types ◽  
Diffraction Patterns

The present study attempts to apply Equal-Channel Angular Pressing (ECAP) to 99.99% pure copper. ECAP process was realized at room temperature for 4, 8 and 16 passes through route BC using a die having angle of 90°. The microstructure of the samples was investigated by means both light and transmission electron microscopy. Additionally the microhardness was measured and statistical analysis of the grains and subgrains was performed. Based on Kikuchi diffraction patterns misorientation was determined. There were some different types of bands in the microstructure after deformation. The shear bands, bands and in the submicron range the microshear bands and microbands are a characteristic feature of the microstructure of copper. Also characteristic was increasing of the number of bands with increasing of deformation and mutually crossing of the bands. The intersection of a bands and microbands leads to the formation of new grains with the large misorientation angle. The measured grain/subgrain size show, that the grain size is maintained at a similar level after each stage of deformation and is equal to d = 0.25 – 0.32 μm.

scholarly journals Discussion on the interaction between laser-induced bubble ana several different types of solid plate in water at room temperature

2009 ◽  
Vol 29-1 (2) ◽  
pp. 1013-1013
Author(s):  
Yuki OSHIDA ◽  
Sho NAKAJIMA ◽  
Takeshi NISHIZAWA ◽  
Masanori OTA ◽  
Kazuo MAENO
Keyword(s):  
Room Temperature ◽  
Different Types ◽  
Solid Plate

scholarly journals Growth of Listeria monocytogenes within a Caramel-Coated Apple Microenvironment

mBio ◽  
2015 ◽  
Vol 6 (5) ◽  
Author(s):  
Kathleen A. Glass ◽  
Max C. Golden ◽  
Brandon J. Wanless ◽  
Wendy Bedale ◽  
Charles Czuprynski
Keyword(s):  
Listeria Monocytogenes ◽  
Water Activity ◽  
Room Temperature ◽  
Slow Growth ◽  
Free Water ◽  
Storage Conditions ◽  
Pathogenic Bacterium ◽  
Content Type ◽  
The Core ◽  
Serotype 4B

ABSTRACT A 2014 multistate listeriosis outbreak was linked to consumption of caramel-coated apples, an unexpected and previously unreported vehicle for Listeria monocytogenes. This outbreak was unanticipated because both the pH of apples (<4.0) and the water activity of the caramel coating (<0.80) are too low to support Listeria growth. In this study, Granny Smith apples were inoculated with approximately 4 log10 CFU of L. monocytogenes (a cocktail of serotype 4b strains associated with the outbreak) on each apple's skin, stem, and calyx. Half of the apples had sticks inserted into the core, while the remaining apples were left intact. Apples were dipped into hot caramel and stored at either 7°C or 25°C for up to 11 or 28 days, respectively. Data revealed that apples with inserted sticks supported significantly more L. monocytogenes growth than apples without sticks under both storage conditions. Within 3 days at 25°C, L. monocytogenes populations increased >3 log10 in apples with sticks, whereas only a 1-log10 increase was observed even after 1 week for caramel-coated apples without sticks. When stored at 7°C, apples with sticks exhibited an approximately 1.5-log10 increase in L. monocytogenes levels at 28 days, whereas no growth was observed in apples without sticks. We infer that insertion of a stick into the apple accelerates the transfer of juice from the interior of the apple to its surface, creating a microenvironment at the apple-caramel interface where L. monocytogenes can rapidly grow to levels sufficient to cause disease when stored at room temperature. IMPORTANCE Neither caramel nor apples are a food where the pathogenic bacterium Listeria monocytogenes should grow, as caramel does not contain enough free water and apples are too acidic. Caramel-coated apples, however, were recently linked to a deadly outbreak of listeriosis. We hypothesized that inserting a stick into the apple releases juice to the interface between the apple and caramel, providing a more hospitable environment than either component alone. To test this hypothesis, apples were inoculated with L. monocytogenes prior to caramel dipping. Some apples had sticks inserted into them before dipping, while others did not. No growth of L. monocytogenes occurred on refrigerated caramel apples without sticks, whereas slow growth was observed on refrigerated caramel apples with sticks. In contrast, significant pathogen growth was observed within 3 days at room temperature on caramel apples with sticks inserted. Food producers should consider interfaces between components within foods as potential niches for pathogen growth.

Alternative technology concepts for low-cost and high-speed 2D and 3D interconnect manufacturing

2013 ◽  
Vol 2013 (1) ◽  
pp. 000001-000006
Author(s):  
F. Roozeboom ◽  
M. Smets ◽  
B. Kniknie ◽  
M. Hoppenbrouwers ◽  
G. Dingemans ◽  
...  
Keyword(s):  
High Speed ◽  
Room Temperature ◽  
Microelectromechanical Systems ◽  
Low Cost ◽  
Industrial Process ◽  
Atomic Layer ◽  
Single Step ◽  
Thermal Mode ◽  
Different Types ◽  
Sidewall Passivation

The current industrial process of choice for Deep Reactive Ion Etching (DRIE) of 3D features, e.g. Through-Silicon Vias (TSVs), Microelectromechanical Systems (MEMS), etc., is the Bosch process, which uses alternative SF6 etch cycles and C4F8-based sidewall passivation cycles in a time-sequenced mode. An alternative, potentially faster and more accurate process is to have wafers pass under spatially-divided reaction zones, which are individually separated by so-called N2-gas bearings ‘curtains’ of heights down to 10–20 μm. In addition, the feature sidewalls can be protected by replacing the C4F8-based sidewall passivation cycles by cycles forming chemisorbed and highly uniform passivation layers of Al2O3 or SiO2 deposited by Atomic Layer Deposition (ALD), also in a spatially-divided mode. ALD is performed either in thermal mode, or plasma-assisted mode in order to achieve near room-temperature processing. For metal filling of 3D-etched TSVs, or for deposition of 2D metal conductor lines one can use Laser-Induced Forward Transfer (LIFT) of metals. LIFT is a maskless, ‘solvent’-free deposition method, utilizing different types of pulsed lasers to deposit thin material (e.g. Cu, Au, Al, Cr) layers with μm-range resolution from a transparent carrier (ribbon) onto a close-by acceptor substrate. It is a dry, single-step, room temperature process in air, suitable for different types of interconnect fabrication, e.g. TSV filling and redistribution layers (RDL), without the use of wet chemistry.

scholarly journals Detection of mRNA by Reverse Transcription-PCR as an Indicator of Viability in Escherichia coliCells

1998 ◽  
Vol 64 (4) ◽  
pp. 1313-1318 ◽  
Author(s):  
G. E. C. Sheridan ◽  
C. I. Masters ◽  
J. A. Shallcross ◽  
B. M. Mackey
Keyword(s):  
Reverse Transcription ◽  
Room Temperature ◽  
Cellular Viability ◽  
Ethanol Treatment ◽  
Rt Pcr ◽  
Promising Candidate ◽  
Mrna Targets ◽  
Reverse Transcription Pcr ◽  
Different Types ◽  
The Relationship

ABSTRACT The relationship between the detection of mRNA and cellular viability in Escherichia coli was investigated in cells killed by heat or ethanol. Reverse transcription-PCR (RT-PCR) methods were developed for detecting mRNA from rpoH,groEL, and tufA genes. mRNA from all three genes was detected immediately after the cells had been killed by heat or ethanol but gradually disappeared with time when dead cells were held at room temperature. In heat-killed cells, some mRNA targets became undetectable after 2 to 16 h, whereas after ethanol treatment, mRNA was still detected after 16 h. In contrast, 16S rRNA was detected by RT-PCR in all samples containing dead cells and did not disappear during a subsequent incubation of 16 h at room temperature. Of the different types of nucleic acid, mRNA is the most promising candidate for an indicator of viability in bacteria, but its persistence in dead cells depends on the inactivating treatment and subsequent holding conditions.

scholarly journals Solution for the Location of Rock Cutting Elements Relative to the Rotation Center of Geohod

2019 ◽  
Vol 105 ◽  
pp. 03001 ◽  
Author(s):  
Valery Nesterov ◽  
Vladimr Aksenov ◽  
Vladimir Sadovets ◽  
Dmitry Pashkov
Keyword(s):  
Cutting Forces ◽  
Complex Shape ◽  
Rock Cutting ◽  
General Information ◽  
Technical Solution ◽  
Helical Surface ◽  
Body Form ◽  
Rotation Center ◽  
Different Types ◽  
The Face

The article presents the technical solution for the location of cutting elements relative to the rotation center of Geohod for destructing rocks with a strength up to 1 of Protodyakonov hardness. The relevancy of the research is considered. General information about Geohod is given. The features of working body of Geohod are described, in particular, the formation of a complex shape of the face and the working body, and it is also said that in the case of screw movement of working body of Geohod to the face, the points of working body form a helicoidal (helical) surface. To set the purpose and objectives of the study the geometric parameters of generatrix are justified. The parameter depending on the number of blades and on the radius of location of the blade’s cut is identified. Based on the study, the dependence of the number of blades on their location from the center to the periphery is determined. The design of blade working body of Geohod for rocks with a strength f <1 of Protodyakonov hardness is offered. Also the directions for further research have been identified, which include: the development of methods for calculating cutting forces for a technical solution for the location of cutting elements relative to the center of rotation of Geohod for destructing rocks up to 1 of Protodyakonov hardness; the application of this technique for obtaining variants of the blade working body of Geohod of different types.

scholarly journals Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators

2013 ◽  
Vol 305 (11) ◽  
pp. G818-G828 ◽  
Author(s):  
Brian T. Kalish ◽  
Hau D. Le ◽  
Jonathan M. Fitzgerald ◽  
Samantha Wang ◽  
Kyle Seamon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fish Oil ◽  
Lipid Emulsion ◽  
Lipid Mediators ◽  
Lipid Emulsions ◽  
Serum Samples ◽  
Human Infants ◽  
Life Threatening ◽  
Small Cohort ◽  
Anti Inflammatory

Parenteral nutrition (PN)-associated liver disease (PNALD) is a life-threatening complication of the administration of PN. The development of PNALD may be partly due to the composition of the lipid emulsion administered with PN: soybean oil-based lipid emulsions (SOLE) are associated with liver disease, while fish oil-based lipid emulsions (FOLE) are associated with prevention and improvement of liver disease. The objective of this study was to determine how the choice of lipid emulsion modified the production of bioactive lipid mediators (LMs). We utilized a mouse model of steatosis to study the differential effect of FOLE and SOLE. We subsequently validated these results in serum samples from a small cohort of human infants transitioning from SOLE to FOLE. In mice, FOLE was associated with production of anti-inflammatory, proresolving LMs; SOLE was associated with increased production of inflammatory LMs. In human infants, the transition from SOLE to FOLE was associated with a shift toward a proresolving lipidome. Together, these results demonstrate that the composition of the lipid emulsion directly modifies inflammatory homeostasis.

scholarly journals Crystal structures of ZnCl2·2.5H2O, ZnCl2·3H2O and ZnCl2·4.5H2O

2014 ◽  
Vol 70 (12) ◽  
pp. 515-518 ◽  
Author(s):  
Erik Hennings ◽  
Horst Schmidt ◽  
Wolfgang Voigt
Keyword(s):  
Phase Diagram ◽  
Room Temperature ◽  
Three Dimensional ◽  
Water Molecules ◽  
Tetrahedral Coordination ◽  
Lattice Water ◽  
Octahedral Environment ◽  
Dimensional Network ◽  
Different Types ◽  
Solid Liquid

The formation of different complexes in aqueous solutions is an important step in understanding the behavior of zinc chloride in water. The structure of concentrated ZnCl2solutions is governed by coordination competition of Cl−and H2O around Zn2+. According to the solid–liquid phase diagram, the title compounds were crystallized below room temperature. The structure of ZnCl2·2.5H2O contains Zn2+both in a tetrahedral coordination with Cl−and in an octahedral environment defined by five water molecules and one Cl−shared with the [ZnCl4]2−unit. Thus, these two different types of Zn2+cations form isolated units with composition [Zn2Cl4(H2O)5] (pentaaqua-μ-chlorido-trichloridodizinc). The trihydrate {hexaaquazinc tetrachloridozinc, [Zn(H2O)6][ZnCl4]}, consists of three different Zn2+cations, one of which is tetrahedrally coordinated by four Cl−anions. The two other Zn2+cations are each located on an inversion centre and are octahedrally surrounded by water molecules. The [ZnCl4] tetrahedra and [Zn(H2O)6] octahedra are arranged in alternating rows parallel to [001]. The structure of the 4.5-hydrate {hexaaquazinc tetrachloridozinc trihydrate, [Zn(H2O)6][ZnCl4]·3H2O}, consists of isolated octahedral [Zn(H2O)6] and tetrahedral [ZnCl4] units, as well as additional lattice water molecules. O—H...O hydrogen bonds between the water molecules as donor and ZnCl4tetrahedra and water molecules as acceptor groups leads to the formation of a three-dimensional network in each of the three structures.

scholarly journals Adaptation of Conformable Residual Power Series Scheme in Solving Nonlinear Fractional Quantum Mechanics Problems

2020 ◽  
Vol 10 (3) ◽  
pp. 890 ◽  
Author(s):  
Mohammed Shqair ◽  
Mohammed Al-Smadi ◽  
Shaher Momani ◽  
Essam El-Zahar
Keyword(s):  
Quantum Mechanics ◽  
Power Series ◽  
Quantum Physics ◽  
Taylor Series Expansion ◽  
Fractional Quantum ◽  
Analytical Technique ◽  
Different Types ◽  
Residual Power Series ◽  
Residual Errors ◽  
Residual Power

In this paper, the general state of quantum mechanics equations that can be typically expressed by nonlinear fractional Schrödinger models will be solved based on an attractive efficient analytical technique, namely the conformable residual power series (CRPS). The fractional derivative is considered in a conformable sense. The desired analytical solution is obtained using conformable Taylor series expansion through substituting a truncated conformable fractional series and minimizing its residual errors to extract a supportive approximate solution in a rapidly convergent fractional series. This adaptation can be implemented as a novel alternative technique to deal with many nonlinear issues occurring in quantum physics. The effectiveness and feasibility of the CRPS procedures are illustrated by verifying three realistic applications. The obtained numerical results and graphical consequences indicate that the suggested method is a convenient and remarkably powerful tool in solving different types of fractional partial differential models.

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