scholarly journals Changes in the Dietary Inflammatory Index Over Time and Cancer Development Within Rural Post-Menopausal Women

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 319-319
Author(s):  
Mariah Dougherty ◽  
Joan Lappe ◽  
Patrice Watson ◽  
Dianne Travers-Gustafson ◽  
Robert Recker ◽  
...  
Keyword(s):  
Calcium Supplementation ◽  
Treatment Success ◽  
Cancer Development ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Menopausal Women ◽  
Significant Difference ◽  
Post Menopausal ◽  
The Impact ◽  
Over Time

Abstract Objectives The objective of this study was to determine the extent to which diets with a higher inflammatory potential, as measured by the Dietary Inflammatory Index (DII), are associated with cancer development in a cohort of rural post-menopausal women. Methods This study was a secondary analysis of participants of a randomized control trial evaluating the effect of vitamin D and calcium supplementation on cancer development in rural, post-menopausal women in Nebraska. From this cohort, diets were evaluated via a 2005 Block Food Frequency Questionnaire (FFQ) at baseline and four years later (Visit 9). DII scores were calculated at both time points for each participant, including an unadjusted and energy-adjusted DII score. The relationship with DII scores and cancer development were evaluated using a chi-squared test and logistic regression, controlling for pertinent confounders. The difference in DII scores at baseline and Visit 9 for participants who developed cancer and non-cancer participants was examined via a repeated measure ANOVA test. Results There were 1977 participants with baseline and Visit 9 DII scores available for analysis. There was a significant difference in DII scores between baseline and Visit 9, with a significantly larger change in DII scores in the participants who developed cancer (p = 0.0194), shifting to higher pro-inflammatory scores at Visit 9. Cancer status was not associated with baseline DII scores, nor was DII score a predictor of cancer status, when controlling for confounders. Conclusions These findings illustrate how dietary patterns in persons diagnosed with cancer had significant changes over time, increasing inflammatory diet potential. This increase in inflammatory potential in cancer patients may impact outcomes like treatment success, overall survival, and cancer recurrence, creating a need for more research to further analyze the impact of cancer diagnoses on diet changes, and if these changes are detrimental to cancer survivor outcomes. Funding Sources None.

scholarly journals The Association of Dietary Fiber and Cancer Development in Rural Post-menopausal Women of Nebraska

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 268-268
Author(s):  
Mariah Jackson ◽  
Ruiqian Wu ◽  
Lynette Smith ◽  
Joan Lappe ◽  
Corrine Hanson
Keyword(s):  
Vitamin D ◽  
Dietary Fiber ◽  
Calcium Supplementation ◽  
Secondary Analysis ◽  
Cancer Development ◽  
Fiber Intake ◽  
Cancer Group ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Vegetable Fiber

Abstract Objectives Determine the extent to which diets with higher fiber intakes (g) at baseline are independently associated with cancer development by final study visit in a cohort of rural post-menopausal women. Methods This study was a secondary analysis of participants in a four-year randomized controlled trial evaluating the effect of vitamin D and calcium supplementation (2000 IU/d vitamin D3 and 1500 mg/d calcium) on cancer development in rural post-menopausal women in Nebraska (June 2009-August 2015). Diets, including fiber intake (total, soluble, fruit-vegetable, grain and bean fiber), were evaluated via a 2005 Block Food Frequency Questionnaire at baseline. T-tests were used to evaluate the difference in dietary fiber intakes between all-type cancer and non-cancer groups. Logistic regression models, controlling for pertinent covariates, were used to determine if dietary fiber intake at baseline is associated with the cancer development. Dietary fiber variables were log-transformed and stratified by treatment group. Results There were 1977 participants available for analysis. Median total fiber intake was 14.35 g or 65% of the Dietary Reference Intake. There was no significant difference between dietary fiber intakes at baseline between the cancer group and non-cancer group. For people on vitamin D and calcium supplementation, higher dietary soluble fiber and fruit-vegetable fiber intakes at baseline were protective against cancer development [Soluble OR: 0.50; 95% CI (0.26, 0.96); Fruit-vegetable OR: 0.56; 95% CI (0.33, 0.94)]. In participants without vitamin D and calcium supplementation, the odds of having higher bean fiber intake was 1.62 times higher in those with cancer [OR: 1.62 (95% CI (1.07, 2.47)]. Total fiber and grain fiber intakes were not significantly associated with cancer development. Conclusions While low fiber intake is prevalent among rural post-menopausal women, those with higher intakes of soluble and fruit-vegetable fiber may be more protected against development of all-type cancer when supplemented with calcium and vitamin D. Further analysis should examine the relationship between supplementation and bean fiber intake on the development of cancer. Funding Sources The original study was funded by the National Cancer Institute and Creighton University internal funding. No additional funding was used for the secondary analysis.

scholarly journals Quality of life assessments in clinical practice using either the EORTC-QLQ-C30 or the SEIOQL-DW: a randomized study

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Åsa Kettis ◽  
Hanna Fagerlind ◽  
Jan-Erik Frödin ◽  
Bengt Glimelius ◽  
Lena Ring
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Significant Difference ◽  
Patient Reported ◽  
Health Related Qol ◽  
Health Related ◽  
Secondary Outcomes ◽  
The Impact ◽  
Over Time

Abstract Background Effective patient-physician communication can improve patient understanding, agreement on treatment and adherence. This may, in turn, impact on clinical outcomes and patient quality of life (QoL). One way to improve communication is by using patient-reported outcome measures (PROMs). Heretofore, studies of the impact of using PROMs in clinical practice have mostly evaluated the use of standardized PROMs. However, there is reason to believe that individualized instruments may be more appropriate for this purpose. The aim of this study is to compare the effectiveness of the standardized QoL-instrument, the European Organization for Research and Treatment of Cancer Quality of Life C-30 (EORTC-QOL-C30) and the individualized QoL instrument, the Schedule for the Evaluation of Individual Quality of Life-Direct Weighting (SEIQoL-DW), in clinical practice. Methods In a prospective, open-label, controlled intervention study at two hospital out-patient clinics, 390 patients with gastrointestinal cancer were randomly assigned either to complete the EORTC-QOL-C30 or the SEIQoL-DW immediately before the consultation, with their responses being shared with their physician. This was repeated in 3–5 consultations over a period of 4–6 months. The primary outcome measure was patients’ health-related QoL, as measured by FACIT-G. Patients’ satisfaction with the consultation and survival were secondary outcomes. Results There was no significant difference between the groups with regard to study outcomes. Neither intervention instrument resulted in any significant changes in health-related QoL, or in any of the secondary outcomes, over time. This may reflect either a genuine lack of effect or sub-optimization of the intervention. Since there was no comparison to standard care an effect in terms of lack of deterioration over time cannot be excluded. Conclusions Future studies should focus on the implementation process, including the training of physicians to use the instruments and their motivation for doing so. The effects of situational use of standardized or individualized instruments should also be explored. The effectiveness of the different approaches may depend on contextual factors including physician and patient preferences.

113 Effects of Sleep on Intrusive Symptoms and Emotion Reactivity in a Laboratory-Based Film Analogue Study

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A46-A46
Author(s):  
Anna Marie Nguyen ◽  
Rebecca Campbell ◽  
Abigail Vance ◽  
Ellen Leen-Feldner
Keyword(s):  
Sleep Deprivation ◽  
Control Group ◽  
Significant Interaction Effect ◽  
Emotion Reactivity ◽  
Negative Valence ◽  
Significant Difference ◽  
Regulation Strategies ◽  
Acute Sleep Deprivation ◽  
The Impact ◽  
Over Time

Abstract Introduction Recent literature highlights the need to focus on the impact of intrusive symptoms as a possible risk factor for the development and maintenance of PTSD. Cognitive and sleep models also contribute to the further understanding of intrusive symptoms. Further emotion work emphasizes that disgust is an emotion closely associated with the emergence of posttraumatic stress symptomology following traumatic events. Methods This study utilized a film eliciting disgust to examine the effects of acute sleep deprivation on the intensity of intrusive symptoms and emotion reactivity. Forty-nine college students were randomly assigned to sleep as usual or an acute sleep deprivation after watching a disturbing film. It was hypothesized that, relative to the control group, participants who were acutely sleep deprived would report higher frequency of intrusive symptoms and higher negative valence. Results Findings were partially consistent with hypotheses. There were no group or interaction effects on intrusive symptoms, although participants across both groups reported significant decreases in negative valence and intrusive symptoms across the study (F(1, 47) = 10.30, p < 0.01). There was a significant interaction effect between sleep group and self-reported negative valence, where individuals in the sleep deprived group reported significantly higher valence than individuals in the control group, despite significant decreases in negative valence over time (F(1, 48) = 7.869, p < 0.01). Conclusion Possible mechanisms that may contribute to the significant difference in valence may be due to higher order emotion regulation strategies that are compromised due to sleep loss. However, the significant decreases in negative valence and intrusive symptoms over time may be due to methodological factors or the type of sleep manipulation. Further work can address these challenges by using a larger sample size or examining the effects of chronic, partial sleep deprivation. Support (if any):

scholarly journals An overview of the phytoestrogen effect on vaginal health and dyspareunia in peri- and post-menopausal women

2019 ◽  
Vol 25 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Fatemeh R Dizavandi ◽  
Masoumeh Ghazanfarpour ◽  
Nasibeh Roozbeh ◽  
Leila Kargarfard ◽  
Talat Khadivzadeh ◽  
...  
Keyword(s):  
Similar Efficacy ◽  
Cochrane Central Register ◽  
Vaginal Atrophy ◽  
Pueraria Mirifica ◽  
Menopausal Women ◽  
Significant Difference ◽  
Vaginal Health ◽  
Post Menopausal ◽  
Intermediate Cells ◽  
Conjugated Estrogen

Objective The aim of this overview was to evaluate the effectiveness of phytoestrogens on vaginal health and dyspareunia in peri- and post-menopausal women. Material and methods Three databases including MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials were from inception to August 2017. Result Two systematic reviews and 11 RCTs were included in the overview. According to the findings, isoflavones increased the maturation value and attenuated the vaginal atrophy in the post-menopausal women. Topical isoflavones had beneficial effects on the vaginal atrophy. Similar efficacy was found in Pueraria mirifica and conjugated estrogen cream on dryness ( p = 0.277), soreness ( p = 0.124) and irritation ( p = 0.469), as well as discharge ( p = 0.225) and dyspareunia ( p = 0.089). However, the conjugated estrogen cream was more effective compared to Pueraria mirifica ( p > 0.005) regarding maturation index improvement. Comparison of fennel 5% vaginal cream and placebo gel showed significant difference in superficial cells ( p < 0.01), parabasal cells ( p < 0.01) and intermediate cells ( p < 0.01), whereas no difference was found between the oral fennel and placebo in terms of superficial, parabasal and intermediate cells as well as Maturation value. Administration of 80 mg red clover oil had a significant effect on superficial ( p < 0.005), intermediate ( p < 0.005) and parabasal and vaginal dryness ( p < 0.005) compared to the placebo. Flaxseed had also a trivial effect on maturation value. Genistein had a more prominent effect on the genital score. The severity of dyspareunia decreased by 27%. Conclusion Phytoestrogens have various effects based on administration route and type on the vaginal atrophy.

scholarly journals Prospective Analysis of Food Consumption and Nutritional Status and the Impact on the Dietary Inflammatory Index in Women with Breast Cancer during Chemotherapy

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2610 ◽  
Author(s):  
Isis Danyelle Dias Custódio ◽  
Fernanda de Paula Franco ◽  
Eduarda da Costa Marinho ◽  
Taísa Sabrina Silva Pereira ◽  
Mariana Tavares Miranda Lima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nutritional Status ◽  
Food Consumption ◽  
Vegetable Consumption ◽  
Dietary Inflammatory Index ◽  
Food Groups ◽  
Time Points ◽  
Inflammatory Index ◽  
The Impact ◽  
Time Point

Considering the implications of adverse effects of chemotherapy (CT) and the potential impact of diet on patients’ recovery, this study aimed to prospectively evaluate the association between the consumption of food groups, patients’ Dietary Inflammatory Index (DII®) scores, and their nutritional status. Anthropometric and dietary assessments of 55 women with breast cancer (BC) were performed at three time points. T0 is the time point after the first CT cycle, T1 is the time point after the intermediate CT cycle, and T2 is the time point after the last CT cycle. We identified a significant increase in weight, body mass index, and waist circumference during CT. Consumption of poultry and eggs was higher in T1 when compared to T2, while consumption of total fruit and total vegetables was higher at T0 compared to T1 and T2. The diet became more pro-inflammatory over the course of treatment (X2(2) = 61.127), and was related to higher abdominal adiposity. Total fruit (T0: R2 = 0.208, T1: R2 = 0.095, T2: R2 = 0.120) and total vegetable consumption (T0: R2 = 0.284, T1: R2 = 0.365, T2: R2 = 0.580) predicted DII® change at the three-time points. Meanwhile, consumption of total grains was significantly associated only with T1 (R2 = 0.084) and T2 (R2 = 0.118), and consumption of simple sugars was significantly associated only with T0 (R2 = 0.137) and T1 (R2 = 0.126). Changes in food consumption led to an increase in the inflammatory profile of the diet, suggesting the necessity to improve the guidelines during and after CT. These results reinforce the need to promote healthier eating practices in concert with maintaining a healthy nutritional status in women with BC treated with CT.

scholarly journals Effect of tetracycline treatment regimens on antibiotic resistance gene selection over time in nursery pigs

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kaare Græsbøll ◽  
Inge Larsen ◽  
Julie Clasen ◽  
Anna Camilla Birkegård ◽  
Jens Peter Nielsen ◽  
...  
Keyword(s):  
Gene Selection ◽  
Efflux Pump ◽  
Animal Health ◽  
Antibiotic Resistance Gene ◽  
Response To Treatment ◽  
Nursery Pigs ◽  
Gene Abundance ◽  
Significant Difference ◽  
The Impact ◽  
Over Time

Abstract Background The majority of antimicrobials given during the production of pigs are given to nursery pigs. The influence of antimicrobial use on the levels of antimicrobial resistant (AMR) genes is important to quantify to be able to assess the impact of resistance on the food chain and risk to human and animal health. Results This study investigated the response on the levels of nine AMR genes to five different treatment strategies with oxytetracycline, and the dynamics of gene abundance over time by following 1167 pigs from five different farms in Denmark. The results showed no significant difference between treatments and an increase in abundance for the efflux pump encoding tet(A) gene and the genes encoding the ribosomal protection proteins tet(O) and tet(W) tetracycline resistant genes following treatment, while tet(M) showed no response to treatment. However, it was also observed that the levels of tet(O), tet(W), and ermB in some farms would drift more over time compared to a single treatment-course with antibiotic. Conclusion This study underlines the large variation in AMR levels under natural conditions and the need for increased investigation of the complex interactions of antimicrobial treatment and other environmental and managerial practices in swine production on AMR gene abundance.

scholarly journals Positive Association between Dietary Inflammatory Index and the Risk of Osteoporosis: Results from the KoGES_Health Examinee (HEXA) Cohort Study

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1999 ◽  
Author(s):  
Hye Sun Kim ◽  
Cheongmin Sohn ◽  
Minji Kwon ◽  
Woori Na ◽  
Nitin Shivappa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Large Scale ◽  
Similar Magnitude ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Menopausal Women ◽  
Osteoporosis Risk

Previous studies have found that diet’s inflammatory potential is related to various diseases. However, little is known about its relationship with osteoporosis. The aim of this study was to investigate the association between the dietary inflammatory index (DII®) and osteoporosis risk in a large-scale prospective cohort study in Korea. This prospective cohort study included 159,846 participants (men 57,740; women 102,106) from South Korea with a mean follow-up of 7.9 years. The DII was calculated through a validated semi-quantitative FFQ (SQFFQ), and information on osteoporosis was self-reported by the participants. Analyses were performed by using a multivariable Cox proportional hazard model. Higher DII scores were associated with higher osteoporosis risk (HR 1.33; 95% CI 1.12–1.58). In women, a higher DII score indicated a higher risk of osteoporosis (HR 1.33; 95% CI 1.11–1.59). However, a hazards ratio of similar magnitude in men was not significant (HR 1.32; 95% CI 0.64–2.71). Post-menopausal women had higher risks of osteoporosis for higher DII scores (HR 1.33; 95% CI 1.09–1.63), whereas among pre-menopausal women, the relationship was not statistically significant (HR 1.39; 95% CI 0.87–2.21). Also, there was an increase in osteoporosis risk when the DII increased among women participants with irregular physical activity (HR 1.53; 95% CI 1.17–2.01); however, there was no statistically significant increase in osteoporosis risk among women participants with regular physical activity (HR 1.19; 95% CI 0.93–1.52). A more pro-inflammatory diet was significantly associated with higher osteoporosis risk in women. Given the similar magnitude of the hazards ratio, studies with sufficient numbers of men are warranted.

scholarly journals Assessment of effectiveness of spinal exercises and body mechanics on low back pain among post menopausal women

2015 ◽  
Vol 1 (4) ◽  
pp. 191 ◽  
Author(s):  
Angel Rajakumari G ◽  
Soli T. K. ◽  
Malathy D
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Control Group ◽  
Low Back ◽  
Menopausal Women ◽  
Significant Difference ◽  
Post Test ◽  
Quasi Experimental ◽  
Equivalent Control ◽  
Post Menopausal

Aim: To assessment of effectiveness of spinal exercises and body mechanics on low back pain among post menopausal women.Participants and setting: A quasi experimental non equivalent control group pretest post test design was adapted. The study was conducted in the urban area of suryapet. 40 post menopausal women who fulfilled the inclusion criteria were selected by nonprobability purposive sampling technique.Intervention: The intervention such as spinal exercises and body mechanics were performed to overcome the level of low back pain among post menopausal women. The pre and post assessment was done by using a combined numerical and categorical pain scale.Measurement and findings: The women completed the demographic and obstetrical information and pain was measured by 0- 10 Modified combined numerical categorical pain intensity scale. This study revealed that there was high significant difference found in low back pain at p<0.001level between study group.Conclusion: The overall findings in the present study revealed that the spinal exercises and body mechanics was effectives and had brought about significant change in the reduction of low back pain among post menopausal women compared to pre test level of low back pain.

A Longitudinal Analysis of Efficacy Expectations and Exercise in Older Adults

2004 ◽  
Vol 18 (4) ◽  
pp. 331-344 ◽  
Author(s):  
Barbara Resnick
Keyword(s):  
Older Adults ◽  
Physical Health ◽  
Self Efficacy ◽  
Outcome Expectations ◽  
Analysis Of Covariance ◽  
Regular Exercise ◽  
Significant Difference ◽  
Efficacy Expectations ◽  
The Impact ◽  
Over Time

The purpose of this study was to consider the longitudinal changes in self-efficacy and outcome expectations for exercise and the impact of these variables on maintaining regular exercise over a 4-year period in a group of older adults living in a continuing care retirement community. There were 78 individuals who completed all four surveys. The participants had at least a high school education, and the majority were Caucasian (99%), female (83%) and either widowed or never married (80%). The mean age of the participants was 84.4 ± 5.1 years. Based on repeated measure analysis of covariance, controlling for mental and physical health, there was not a statistically significant difference in self-efficacy expectations (F = 2.0, p > .05) or outcome expectations (F = 2.2, p > .05) over time. There was a statistically significant decrease in exercise over time (F = 9.9, p < .05). Using path analysis it was demonstrated that self-efficacy expectations, outcome expectations, and physical health directly and indirectly influenced maintenance of regular exercise. Age, gender, and mental health had a limited and inconsistent influence on maintenance of exercise. Future research and clinical work should focus on developing and testing interventions that strengthen both self-efficacy and positive outcome expectations in older adults to facilitate maintenance of exercise behavior over time.

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