scholarly journals Contribution of Vitamin D2 and D3 and Their Respective 25-Hydroxy Metabolites to the Total Vitamin D Content of Beef and Lamb

2020 ◽  
Author(s):  
Kevin D Cashman ◽  
Siobhan M O'Sullivan ◽  
Karen Galvin ◽  
Michelle Ryan
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Daily Intake ◽  
Meat Products ◽  
Food Composition ◽  
Vitamin D2 ◽  
Total Vitamin ◽  
Food Composition Tables ◽  
Beef Steak ◽  
The Mean

Abstract Background Red meat and meat products can contribute meaningfully to the mean daily intake of vitamin D. Beef and lamb can contain vitamin D3 and 25-hydroxyvitamin D3 (25(OH)D3) but also potentially vitamin D2 and 25-hydroxyvitamin D2 (25(OH)D2), all of which contribute to meat's vitamin D activity. Objective To measure vitamin D3, vitamin D2, 25(OH)D3 and 25(OH)D2 content of Irish beef and lamb. Methods Full striploin steaks (Longissimus dorsi) (n = 39) from beef cattle slaughtered in Winter, Spring, Summer and Autumn as well as lamb steaks (hind leg) from sheep slaughtered in Autumn (n = 8) were sourced and homogenized. The contents of all four vitamin D-related compounds were analysed using a liquid chromatography-tandem mass spectrometry method in conjunction with the National Institute of Standards and Technology's standard reference material no. 1546a-Meat Homogenate. The total vitamin D activity of meat was defined as: [vitamin D3 + (25(OH)D3 × 5) + vitamin D2 + (25(OH)D2 × 5)]. Results The median (inter-quartile range) total vitamin D activity of striploin beef steak (n = 39, irrespective of season) was 0.56 (0.37–0.91) μg/100 g. The content of all four vitamin D compounds in beef steak varied significantly (P < 0.0001) with season (n = 8–11/season group). Median total vitamin D activity of beef steak increased in a stepwise manner (P < 0.0001) from Winter to the following Autumn (increasing from 0.31 to 1.07 μg/100 g). The mean total vitamin D activity of lamb samples (n = 8) from Autumn was 0.47 μg/100 g. Conclusions About a third of the total vitamin D activity of Irish beef was attributable to its combined vitamin D2 and 25(OH)D2 content, estimates of which are largely or completely missed in food composition tables. There was significant seasonal variation in all four vitamin D compounds as well as in total vitamin D activity, which has implications for vitamin D nutrient claims for beef.

scholarly journals Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial

2019 ◽  
Vol 104 (12) ◽  
pp. 5831-5839 ◽  
Author(s):  
Adrian R Martineau ◽  
Kenneth E Thummel ◽  
Zhican Wang ◽  
David A Jolliffe ◽  
Barbara J Boucher ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Bolus Dose ◽  
Total Serum ◽  
Vitamin D2 ◽  
Serum Concentrations ◽  
Vitamin D Metabolism ◽  
Dihydroxyvitamin D3 ◽  
Differential Effects ◽  
The Mean

Abstract Context Vitamin D2 and vitamin D3 have been hypothesized to exert differential effects on vitamin D metabolism. Objective To compare the influence of administering vitamin D2 vs vitamin D3 on metabolism of vitamin D3. Methods We measured baseline and 4-month serum concentrations of vitamin D3, 25-hydroxyvitamin D3 [25(OH)D3], 25-hydroxyvitamin D2, 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3], 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], and 4β,25-dihydroxyvitamin D3 [4β,25(OH)2D3] in 52 adults randomized to receive a total of four oral bolus doses of 2.5 mg vitamin D2 (n = 28) or vitamin D3 (n = 24) over four months. Metabolite-to-parent compound ratios were calculated to estimate hydroxylase activity. Pairwise before vs after comparisons were made to evaluate effects of vitamin D2 and vitamin D3 on metabolism of vitamin D. Mean postsupplementation metabolite-to-parent ratios were then compared between groups. Results Vitamin D2 was less effective than vitamin D3 in elevating total serum 25(OH)D concentration. Vitamin D2 suppressed mean four-month serum concentrations of 25(OH)D3, 24R,25(OH)2D3, 1α,25(OH)2D3, and 4β,25(OH)2D3 and mean ratios of 25(OH)D3 to D3 and 1α,25(OH)2D3 to 25(OH)D3, while increasing the mean ratio of 24R,25(OH)2D3 to 25(OH)D3. Vitamin D3 increased mean four-month serum concentrations of 25(OH)D3, 24R,25(OH)2D3, 1α,25(OH)2D3, and 4β,25(OH)2D3 and the mean ratio of 24R,25(OH)2D3 to 25(OH)D3. Participants receiving vitamin D2 had lower mean postsupplementation ratios of 25(OH)D3 to vitamin D3 and 1α,25(OH)2D3 to 25(OH)D3 than those receiving vitamin D3. Mean postsupplementation ratios of 24R,25(OH)2D3 to 25(OH)D3 and 4β,25(OH)2D3 to 25(OH)D3 did not differ between groups. Conclusions Bolus-dose vitamin D2 is less effective than bolus-dose vitamin D3 in elevating total serum 25(OH)D concentration. Administration of vitamin D2 reduces 25-hydroxylation of vitamin D3 and 1-α hydroxylation of 25(OH)D3, while increasing 24R-hydroxylation of 25(OH)D3.

scholarly journals Vitamin D Intake in a Population-Based Sample of Young Polish Women, Its Major Sources and the Possibility of Meeting the Recommendations

Foods ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1482
Author(s):  
Zofia Utri ◽  
Dominika Głąbska
Keyword(s):  
Vitamin D ◽  
Daily Intake ◽  
Meat Products ◽  
Population Based ◽  
Sampling Procedure ◽  
Dietary Vitamin ◽  
Youth Organizations ◽  
Total Vitamin ◽  
Vitamin D Intake ◽  
Habitual Intake

The recommendations of vitamin D intake are commonly not met, which results from the fact that fish, being its major sources, are commonly rarely consumed. Consequently, a reliable estimation of its habitual intake is also difficult, as its daily intake is highly variable. The aim of the study was to analyze vitamin D intake from food, its major sources and the possibility to meet its recommendations in a population-based sample of young Polish women. The study was conducted in a sample of Polish women aged 15–30 years, recruited in cooperation with local students’ and youth organizations from all regions of Poland (convenience sampling with the snowball effect), while the stratified sampling procedure was applied with a random quota sampling for voivodeships (an administrative subdivision), to obtain an adequate distribution regarding the general population of young Polish women (n = 1,032). The vitamin D intake was assessed while using the validated Vitamin D Estimation Only—Food Frequency Questionnaire (VIDEO-FFQ) and was compared with the recommended 10 µg. The median vitamin D intake in the study group was 3.09 µg (0.00–24.52 µg) and in 95% of participants was lower than recommended, while the highest vitamin D intake was observed for the following sources: eggs (0.50 µg), meat and meat products (0.49 µg), herring, sardine and tuna products (0.41 µg) and dairy products (0.40 µg). The correlation between total vitamin D intake and its intake from its sources was strongest for eggs (p < 0.0001; R = 0.5989) and for herring, sardine and tuna products (p < 0.0001; R = 0.5314), while the correlation between total vitamin D intake and the number of servings was strongest for herring, sardine and tuna products (p < 0.0001; R = 0.5314). At the same time, while compared with other fish species, consuming herring was the strongest predictor of meeting the recommended vitamin D level of 10 µg (p = 0.0292; odds ratio (OR) = 1.94; 95% confidence interval (CI) 1.07–3.52), but also of 5 µg (p < 0.0001; OR = 2.54; 95% CI 1.85–3.47). Therefore, taking into account the relatively low prices of herring, its high vitamin D content, as well as its influence on total vitamin D intake, it could be beneficial to recommend young women to increase herring intake in order to increase dietary vitamin D intake and to meet its recommendations.

scholarly journals Vitamins D3 and D2 and Their Association with Symptoms of Depression in Adults in the United States

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1780-1780
Author(s):  
Galya Bigman
Keyword(s):  
United States ◽  
Vitamin D ◽  
Depressive Symptoms ◽  
Vitamin D3 ◽  
The United States ◽  
Vitamin D2 ◽  
Total Vitamin ◽  
Low Level ◽  
Symptoms Of Depression ◽  
High Level

Abstract Objectives To examine the association between Vitamin D3 and depressive symptoms in a representative national sample of United States (U.S.) adults, and whether such association depends on the Vitamin D2 status. We hypothesize that participants with insufficient Vitamin D3 and a low level of Vitamin D2 are more likely to report depressive symptoms compared with participants with sufficient Vitamins D3 and D2. Methods A population-based cross-sectional study utilizing data from the U.S. National Health and Nutrition Examination Survey (2007–2011, 2013–2014). Depressive symptoms were assessed using the 9-item Patient Health Questionnaire (PHQ-9) with total scores between 0 and 27. Those with PHQ-9 total scores  ≥  5 were considered as having mild to serious depression. Serum 25-hydroxyvitamin D3 (25OHD3) and D2 (25OHD2), the clinical markers of Vitamins D3 and D2, respectively, were measured. Weighted logistic regression models were utilized to examine the adjusted association between 25OHD3 and depression, and the effect modification of 25OHD2. Results Overall, the sample included 11,468 participants aged 20–80 years. Of those, 23.6% reported symptoms of depression from mild to serious, 28.9% had insufficient serum 25(OH)D3 (&lt;30 ng/ml), and 22% had a high level of 25(OH)D2(&gt;1.5 ng/ml). In the multivariable model, participants with a high level of serum 25(OH)D2 and insufficient serum 25(OH)D3 were more likely by 54% to report symptoms of depression (OR = 1.54, 95% CI: 1.14–2.07). In fact, among participants with a low level of serum 25(OH)D2 and insufficient serum 25(OH)D3, a significantly higher prevalence of depression was not observed (OR = 1.11, 95% CI: 0.94–1.31) compared with participants with sufficient serum 25(OH)D3 after adjustment for age, gender, race/ethnicity, income, education, BMI, alcohol consumption, smoking status, physical activity, diabetes, season of examination, and calorie intake and total vitamin D intake a day. Conclusions The study findings indicate that both forms of Vitamin D, D2 and D3, have significant roles in mood regulation. Further research is needed to elucidate the mechanisms of these two forms of vitamin D on depression, as oppose to total vitamin D since it may mask the unique and independent effects of each source of Vitamins D on mental health. Funding Sources N/A.

scholarly journals The Clinical Effect of Oral Vitamin D2 Supplementation on Psoriasis: A Double-Blind, Randomized, Placebo-Controlled Study

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Wareeporn Disphanurat ◽  
Wongsiya Viarasilpa ◽  
Panlop Chakkavittumrong ◽  
Padcha Pongcharoen
Keyword(s):  
Vitamin D ◽  
Placebo Group ◽  
Adverse Events ◽  
Clinical Effect ◽  
Vitamin D Supplementation ◽  
P Value ◽  
Vitamin D2 ◽  
Oral Vitamin ◽  
Pasi Score ◽  
The Mean

Background. There are limited randomized controlled trials of oral vitamin D supplementation in psoriasis, especially in Asia, and the results are inconclusive. Objective. To investigate the clinical effect of oral vitamin D supplementation on psoriasis. Methods. Patients with psoriasis were randomized to receive vitamin D2 60,000 IU or similar-looking placebo pills once every 2 weeks for 6 months. The primary outcome was improvement of the Psoriasis Area and Severity Index (PASI) score at 3 and 6 months after treatment. Serum levels of 25(OH)D, calcium, phosphate, parathyroid hormone, and C-reactive protein and adverse events were monitored. The chi-square test, Fisher’s exact test, Student’s t-test, and Spearman’s correlation analysis were used in statistical analysis. Results. Of 50 subjects screened, 45 were eligible and randomized to the oral vitamin D2 group (n=23) or placebo group (n=22). At enrollment, the mean PASI score was 4.45, and 26.7% of patients had vitamin D deficiency. At 3 months, the oral vitamin D2 group had significantly higher PASI improvement than the placebo group (mean PASI improvement: 1.43 versus [vs.] -0.33, p-value=0.034; mean %PASI improvement: 34.21% vs. -1.85%, p-value=0.039). The mean serum 25(OH)D level was significantly higher in the oral vitamin D group than in the placebo group (27.4 vs. 22.4 ng/mL, p-value=0.029). Serum 25(OH)D concentrations were significantly inversely correlated with PASI scores at the 6-month follow-up. No major adverse event was observed overall. Conclusion. Oral vitamin D2 supplementation in patients with psoriasis increased the serum vitamin D level and significantly improved the treatment outcome without increasing adverse events. Trial Registration. This trial is registered with Thai Clinical Trials Registry TCTR20180613001.

Metabolism of vitamin D in patients with primary biliary cirrhosis and alcoholic liver disease

1985 ◽  
Vol 69 (5) ◽  
pp. 561-570 ◽  
Author(s):  
E. Barbara Mawer ◽  
H. J. Klass ◽  
T. W. Warnes ◽  
Jacqueline L. Berry
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Primary Biliary Cirrhosis ◽  
Alcoholic Liver Disease ◽  
Vitamin D3 ◽  
Control Group ◽  
Biliary Cirrhosis ◽  
Vitamin D2 ◽  
Dihydroxyvitamin D3 ◽  
Poor Renal Function

1. The metabolism of isotopically labelled vitamin D2 and D3 has been investigated in eight patients with primary biliary cirrhosis and in five controls. The concentration of labelled vitamin D2 was lower than that of vitamin D3 in serum of patients with primary biliary cirrhosis on days 1 and 2 after intravenous injection (P < 0.005 and P < 0.05, respectively) but no difference was seen in controls. 2. Similar amounts of labelled 25-hydroxyvitamin D2 and D3 were seen in serum of the control group; the same pattern was observed in the primary biliary cirrhosis group, and no significant differences were observed between the two groups. 3. In both control and primary biliary cirrhosis groups, the serum concentration of labelled 24,25-dihydroxyvitamin D2 exceeded that of 24,25-dihydroxyvitamin D3 (significant for controls on day 2, P < 0.02) but concentrations in the two groups were not different. 4. Concentrations of labelled 25,26-dihydroxyvitamin D3 were significantly higher than those of 25,26-dihydroxyvitamin D2 in the primary biliary cirrhosis group at all times and in the control group on days 2 and 3. Both 25,26-dihydroxyvitamin D2 and D3 were higher in the serum of patients with primary biliary cirrhosis than in controls (significant on day 1, P < 0.05). 5. Urinary excretion over days 0–3 of radioactivity from both vitamins D2 and D3 was significantly higher in the primary biliary cirrhosis group than in controls: 12.03 vs 1.80% for vitamin D2 and 8.98 vs 1.76% for vitamin D3(P < 0.005). Vitamin D2-derived urinary radioactivity in primary biliary cirrhosis correlated strongly with serum bilirubin (P = 0.005). 6. The metabolism of labelled vitamin D3 was studied in seven patients with alcoholic liver disease, three of whom showed low serum concentrations of labelled 25-hydroxyvitamin D3 suggesting impaired hepatic synthesis. The 25-hydroxylation response was quantified as the relative index of 25-hydroxylation and was significantly related to two other indices of liver function. It is concluded that impaired 25-hydroxylation of vitamin D may occur in alcoholic liver disease and results from hepatocellular dysfunction. 7. Less than the predicted amounts of 1,25-dihydroxyvitamin D3 were produced in four of the seven patients with alcoholic liver disease; this defect may be attributable in part to decreased precursor 25-hydroxyvitamin D and to poor renal function.

scholarly journals Oral Vitamin D3 Supplementation for Femtosecond LASIK–Associated Dry Eye

2021 ◽  
Author(s):  
Ying Lin ◽  
Huanjun Su ◽  
Jianbin Wu ◽  
Muzhi Yuan ◽  
Yong Zhang
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Control Group ◽  
Oral Vitamin ◽  
Serum Vitamin D ◽  
The Mean ◽  
Experimental Group ◽  
Schirmer I Test

Abstract Purpose: To assess the effect of oral vitamin D3 supplementation in dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Setting: Liuzhou Worker’s Hospital.Design: This prospective study included 90 patients selected between January and December in 2019, who underwent fs-lasik operation in our hospital and had obvious symptoms indicating dry eyes one month after operation. The subjects were randomly divided into two groups: the experimental group (n = 45) received vitamin D3 2000 IU / D continuously for 12 weeks; the control group (n = 45) did not take vitamin D3 orally. Ocular surface disease index（OSDI）, tear breakup time（TBUT）and Schirmer’s Test I were evaluated pre-medication and 1,3,6 months after treatment. Serum vitamin D level, and the mean concentration of cytokine IL-6, IL-17, IL-23 in tears were also measured. Results: One month after treatment, the mean OSDI score of the experimental group (11.67 ± 8.53) was significantly lower than that of the control group (23.82 ± 13.22) (P = 0.007). TBUT (10.71±1.02s) and Schirmer I (9.36±0.40mm) of the experimental group were higher than those of the control group (7.49±1.29 s and 7.51±0.44 mm). The OSDI (10.25 ± 5.49), TBUT (10.75±1.09 seconds) and Schirmer I test value (11.34±0.39 mm) of the experimental group were significantly lower than those of the control group (20.22±6.23, 8.36±1.23， 8.12±0.50) at 3 months after treatment. There were significant differences in OSDI, TBUT (P ＜ 0.05) and Schirmer I test value between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with OSDI score (r=-0.90；P=0.00), and positively correlated with Schirmer I test (r=0.88；P=0.00), TBUT score (r=0.89；P=0.00) and TMH (r=0.80；P=0.00). IL-17 level was shown to be significantly correlated with TBUT (r=-0.25, P=0.014) and Schirmer I test (r=-0.21, P=0.018). IL-6 level was significantly correlated with OSDI (R=0.18, P = 0.020) and TBUT (R=0.20, P = 0.019).

Zinc Content of Cereals and Pulses in Delhi

2018 ◽  
Vol 55 (2) ◽  
pp. 216
Author(s):  
Shipra Gupta ◽  
Kirti Arora ◽  
Geeta Trilok-Kumar
Keyword(s):  
Nutritional Assessment ◽  
Zinc Content ◽  
Food Composition ◽  
Mean Values ◽  
Cereal Products ◽  
The North ◽  
Bengal Gram ◽  
Food Composition Tables ◽  
The Mean ◽  
Indian Food

Severe zinc deficiency is rare in India but mild to moderate deficiency could be widespread. There is little data on zinc intakes based on nutritional assessment methods, mainly because the Indian Food Composition Tables that were available until recently gave incomplete zinc content values in foods. A pilot study was, therefore, undertaken to assess the zinc content of cereals and pulses consumed in Delhi and to compare the values with those given in the latest Indian Food Composition Tables. Four hundred and twenty six samples of twenty three varieties of cereals / cereal products and fifteen varieties of pulses, collected from wholesale suppliers in the north, south, east and west zones of Delhi, were analyzed for zinc using atomic absorption spectrophotometer. The concentration of zinc in a given cereal or pulse varied widely between the different zones. Cereals like pearl millet, Italian millet, dry maize, whole wheat and its flour and pulses like roasted Bengal gram and dry peas, Bengal gram dhal and lentil dhal were identified as rich sources of zinc. The mean zinc content in most of the foods analysed in the laboratory showed significant differences when compared with the mean values for cereals and pulses reported in the Indian Food Composition Tables given by the National Institute of Nutrition - Indian Council of Medical Research in 2017. A region specific food composition database is urgently needed as there seem to be huge differences in the zinc values of cereals and pulses consumed in Delhi as compared to the average values representative of all states given in the latest food composition database.

Analysis of Fat-Soluble Vitamins. XX. Determination of Vitamin D in Multivitamin Preparations. Second Collaborative Study

1978 ◽  
Vol 61 (3) ◽  
pp. 735-745
Author(s):  
Ellen J De Vries ◽  
Frits J Mulder ◽  
Ben Borsje
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Test Data ◽  
Vitamin D3 ◽  
Collaborative Study ◽  
Three Samples ◽  
The Mean ◽  
Fat Soluble Vitamins

Abstract The official first action method for determining vitamin D in multivitamin preparations was modified. The method was collaboratively studied by 7 laboratories, using 6 preparations in oil. The preparations consisted of vitamin D at various levels and at various ratios (in w/w) to vitamin A. Three samples contained cholecalciferol and 3 samples contained vitamin D3 from vitamin D3 resin. After outliers were eliminated by the Dixon test, data were analyzed and averages were compared with amounts of vitamin D known to be in each sample. For samples with vitamin D: vitamin A ratios of 1:0.5, 1:5, and 1:10, the mean vitamin D recoveries were 98.8, 94.6, and 90.7%, respectively. The method has been adopted as official final action.

scholarly journals Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1743 ◽  
Author(s):  
Valeria Polzonetti ◽  
Stefania Pucciarelli ◽  
Silvia Vincenzetti ◽  
Paolo Polidori
Keyword(s):  
Vitamin D ◽  
Older People ◽  
Dietary Intake ◽  
Vitamin D3 ◽  
Calcium Absorption ◽  
Daily Intake ◽  
Winter Season ◽  
The United States ◽  
Ultraviolet B ◽  
Dietary Vitamin

Background: Vitamin D and calcium are important dietary compounds that affect bone mass, even if other minerals (potassium, zinc, etc.) and vitamins (A, C and K) are also involved. Vitamin D and certain minerals, in fact, play an important role in calcium homeostasis and calcium absorption. Hip fracture incidence is higher in Europe and the United States, where calcium is frequently included in the human diet; while the occurrence of these fractures is lower in developing countries, where diets are often poor in calcium. This condition is named the “calcium paradox”, and may be partially explained by phosphate toxicity, which can negatively affect mineral metabolism. It is important to maintain correct dietary calcium-phosphate balance in order to have a healthy life, reducing the risk of osteoporotic fractures in older people. Vitamin D can also act as a hormone; vitamin D2 (ergocalciferol) is derived from the UV-B radiation of ergosterol, the natural vitamin D precursor detected in plants, fungi, and invertebrates. Vitamin D3 (cholecalciferol) is synthesized by sunlight exposure from 7-dehydrocholesterol, a precursor of cholesterol that can also act as provitamin D3. Dietary intake of vitamin D3 is essential when the skin is exposed for short periods to ultraviolet B light (UV-B), a category of invisible light rays such as UV-A and UV-C. This can be considered the usual situation in northern latitudes during the winter season, or the typical lifestyle for older people and/or for people with very white delicate skin. The actual recommended daily intake of dietary vitamin D is strictly correlated with age, ranging from 5 μg for infants, children, teenagers, and adults—including pregnant and lactating women—to 15 μg for people over 65 years.

Vitamin D – Funktionen und Versorgung

2017 ◽  
Vol 32 (02) ◽  
pp. 57-58
Author(s):  
Tilman Grune
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Vitamin D2

Die Bezeichnung Vitamin D ist ein Sammelbegriff für verschiedene Substanzen, die aus Cholesterol (Vitamin-D3-Derivate) und Ergosterol (Vitamin-D2-Derivate) synthetisiert werden. Der Stoffwechsel des Vitamin D und die Bildung seiner Wirk- und Transportformen ist ausführlich beschrieben [1, 2] und soll deshalb hier nicht erwähnt werden – nur an die Notwendigkeit von UV-Strahlung für einen zentralen Syntheseschritt in der Haut sei erinnert. Da diese UV-Strahlung offensichtlich nicht unter allen Umständen ausreicht, ist Vitamin D ein essenzieller Nahrungsbestandteil.

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