scholarly journals Assessment of rs4588 Allele Impact on 25-OH-D Concentration in Blood of Caucasian Adults

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 935-935
Author(s):  
Emmanuel Baah ◽  
Martin Kohlmeier
Keyword(s):  
Vitamin D ◽  
Skin Pigmentation ◽  
Healthy Adults ◽  
Funding Sources ◽  
Nutrition Research ◽  
Internal Support ◽  
25Ohd Concentration ◽  
25 Hydroxy Vitamin D ◽  
Relative Differences ◽  
The Impact

Abstract Objectives An important point of contention is whether genetic variation has meaningful impact on vitamin D adequacy on top of known modulators like season, fat mass, skin pigmentation and geographic latitude. Answers could come from information generated by numerous published studies. As a first step towards integration of these often diverse data, the impact of the commonly measured single nucleotide variant rs4588 of the GC gene on 25-hydroxy vitamin D (25OHD) concentration in blood of healthy Caucasian adults was assessed with a systematic review and metaanalysis of published findings. Methods Selection criteria for inclusion of studies in the analyses were Caucasian healthy adults and listing of average 25OHD concentration in plasma or serum by rs4588 or the tightly linked rs2282679 genotypes. Percent differences between genotypes were extracted from included publications. A random-effects model of metaanalysis was performed using STAT 16. Results Of the studies meeting inclusion criteria, published between 2005 and 2019, 35 reported genotype-specific 25OHD concentrations in a total of 59,939 Caucasian adults. The weighted averages were 25.3, 23.2 and 20.4 ng/ml for the GC rs4588 CC, AC and AA genotypes. Relative differences are more informative than absolute concentrations since they are much less affected by calibration discrepancies. The CA carriers had 6.8% lower concentrations than CC carriers and AA carriers 15% lower concentrations when using averages weighted by cohort size. Eight of the included studies with a total number of 15,329 individuals reported standard deviations for the genotype-specific 25OHD concentrations and only these were included for the metaanalysis. The average effect size was −0.44 (95% CI; −0.89, 0.01) for carriers of a single rs4588 A allele, and −0.59 (95% CI; −0.94, −0.23) for carriers of two AA alleles. Heterogeneity was high and statistically significant. Conclusions The combined data indicate that 25OHD concentrations differ by GC rs4588 genotype in healthy adults with predominantly Caucasian ancestry with an additive effect of about 9% per allele. The much lower than average 25OHD concentrations in the about 8% GC rs4588 AA genotype carriers should draw attention to this commonly ignored group when it comes to health risks related to vitamin D deficiency. Funding Sources UNC Nutrition Research Institute internal support

scholarly journals Vitamin D assessment in perioperative medicine and critical care

2019 ◽  
Author(s):  
Paul Zajic ◽  
Stefan Heschl ◽  
Michael Schörghuber ◽  
Petra Srekl-Filzmaier ◽  
Tatjana Stojakovic ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
False Positive Rate ◽  
Fluid Loading ◽  
Vitamin D Levels ◽  
Positive Rate ◽  
25 Hydroxy Vitamin D ◽  
The Mean ◽  
Clinical Trials Registry ◽  
The Impact

Summary Background There is controversy about the impact of acute illness on vitamin D levels. This study was carried out to assess the influence of perioperative fluid loading on 25-hydroxy-vitamin D [25(OH)D] levels. The study evaluated the clinical utility of a commonly available chemiluminescence assay (ECLIA, IDS-iSYS) and liquid chromatography/mass spectrometry (LC-MS/MS) in the diagnosis of vitamin D deficiency in this setting. Methods In this prospective observational pilot study in adult patients undergoing cardiovascular surgery on cardiopulmonary bypass (CPB), blood samples drawn at preoperative baseline (t1), after weaning from CPB (t2), on intensive care unit (ICU) admission (t3) and on the first (t4) and second (t5) postoperative days were analyzed. Results A total of 26 patients (130 samples) were included in this study. Fluid loading by CPB led to a median reduction of 25(OH)D by −22.6% (range −54.5% to −19.5%) between t1 and t2. Cohen’s kappa (κ) for method agreement for vitamin D deficiency (tested cut-off values 20 ng/ml and 12 ng/ml), was κ = 0.291 (p < 0.001) and κ = 0.469 (p < 0.001), respectively. The mean difference between measurements by ECLIA and LC-MS/MS was 4.8 ng/ml (±5.7), Pearson’s r for correlation was 0.73 (p < 0.001). The biologically inactive C3-epimer did not contribute to 25(OH)D levels assessed by LC-MS/MS. Conclusion The 25(OH)D measurements by chemiluminescence assays can noticeably deviate from those measured by LC-MS/MS, which can be considered the unequivocal gold standard. These assays may still be acceptably reliable in the screening for vitamin D deficiency, especially in the setting of low vitamin D levels. Stricter definitions, e.g. serum 25(OH)D levels lower than 12 ng/ml, may be used to diagnose deficiency with low false positive rate. Trial Registration DRKS00009216, German Clinical Trials Registry (www.drks.de)

scholarly journals The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults

2004 ◽  
Vol 89 (3) ◽  
pp. 1196-1199 ◽  
Author(s):  
Shamik J. Parikh ◽  
Marni Edelman ◽  
Gabriel I. Uwaifo ◽  
Renee J. Freedman ◽  
Mariama Semega-Janneh ◽  
...  
Keyword(s):  
Vitamin D ◽  
African American ◽  
Body Fat ◽  
Fat Mass ◽  
Healthy Adults ◽  
Body Fat Mass ◽  
Intact Pth ◽  
Hormonal Mechanism ◽  
25 Hydroxy Vitamin D

Abstract Several previous reports of small cohorts have found significantly higher serum 1,25-dihydroxy vitamin D (1,25-vit D) in obese compared with nonobese whites. Based on these reports and on recent in vitro studies of adipocytes which suggest that administration of 1,25-vit D can stimulate lipogenesis and inhibit lipolysis, some investigators have proposed that high 1,25-vit D may play a role in promoting or maintaining adipocyte triglyceride stores in obese adults. To test the hypothesis that obesity is commonly associated with increased 1,25-vit D, we examined the relationships between calciotropic hormones and body adiposity in a large cohort of healthy adults. Serum intact PTH, 25-hydroxy vitamin D, and 1,25-vit D were measured in the postabsorptive state in 302 healthy adults who were Caucasian (n = 190; 71% female), African-American (n = 84; 89% female), and of other race/ethnicity (n = 28; 61% female). Results from the 154 obese subjects [body mass index (BMI) 37.3 ± 5.8 kg/m2; range, 30.1–58.2 kg/m2] were compared with those from 148 nonobese (BMI 25.6 ± 2.9 kg/m2; range, 18.0–29.9 kg/m2) age-, race-, and sex-matched participants. Body composition was measured by dual energy x-ray absorptiometry. Serum intact PTH was positively correlated with both BMI (r = 0.42; P &lt; 0.0001) and body fat mass (r = 0.37; P &lt; 0.0001). Serum 25-hydroxy vitamin D was negatively correlated with BMI (r = −0.4; P &lt; 0.0001) and body fat mass (r = −0.41; P &lt; 0.0001). Serum 1,25-vit D was also negatively correlated with BMI (r = −0.26; P &lt; 0.0001) and body fat mass (r = −0.25; P = 0.0001). Serum 1,25-vit D was significantly lower in obese than nonobese subjects (105.7 ± 41.1 vs. 124.8 ± 36.7 pmol/liter; P &lt; 0.0001) in both Caucasian and African-American adults. We conclude that, because 1,25-vit D concentrations fall with increasing adiposity, it appears unlikely that elevation in 1,25-vit D is an important hormonal mechanism causing or maintaining obesity in adults.

scholarly journals Effect of vitamin D on sleep quality in hemodialysis patients

2020 ◽  
Vol 10 (4) ◽  
pp. e32-e32
Author(s):  
Narges Sadat Zahed ◽  
Maryam Namakchian ◽  
Zahra Davoudi ◽  
Adineh Taherkhani
Keyword(s):  
Vitamin D ◽  
Sleep Quality ◽  
Vitamin D Deficiency ◽  
Controlled Trial ◽  
Life Quality ◽  
Hemodialysis Patients ◽  
25 Hydroxy Vitamin D ◽  
The Mean ◽  
The Impact

Introduction: Quality of sleep is among the factors that affect the improvement of life quality. The previous studies showed that 50%-80% of hemodialysis patients experience sleeping disturbances. Additionally, dialysis patients commonly experience vitamin D deficiency. Objectives: We aimed to determine the impact of vitamin D deficiency therapy on sleep quality of hemodialysis patients. Patients and Methods: Thirty hemodialysis patients with 25-hydroxy vitamin D deficiency and Pittsburgh Sleep Quality Index (PSQI) ≥5 were enrolled in this clinical trial. Patients were treated with 50000-unit vitamin D per week for 12 weeks. After treatment, the PSQI score was recalculated for each patient. Results: Nineteen out of 30 patients (63.3%) were men and 11(36.7%) were women, with a mean age of 56.7 ± 14.3 years. The mean of vitamin D level was 18.61 ± 6.32 ng/mL before treatment and 41.14 ± 9.62 ng/mL after the treatment. The mean of PSQI score at the start of study was 9.97 and after treatment with vitamin D3, it was 9.47 (P > 0.05). Conclusion: Treatment of vitamin D deficiency did not have any effect on the sleep quality according to the PSQI score in hemodialysis patients. Trial registration: This randomized controlled trial was registered in the Iranian Registry of Clinical Trials (identifier: IRCT20200223046593N1; https://en.irct.ir/trial/46126, ethical code; IR.SBMU.RETECH.REC.1397.1277).

scholarly journals High Prevalence and Its Influencing Factors of Vitamin D Deficiency Among Women of Reproductive Age in Central China (P10-119-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yuan Zhang ◽  
Xinming Song ◽  
Lifang Jiang ◽  
Jilei Wu ◽  
Gong Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Influencing Factors ◽  
Reproductive Age ◽  
Central China ◽  
Women Of Reproductive Age ◽  
Hydroxyvitamin D ◽  
Funding Sources ◽  
Nutrition Research ◽  
Research And Education

Abstract Objectives To examine the prevalence and its influencing factors of vitamin D deficiency. among women of reproductive age in central China. Methods A total of 1151 women of reproductive age were from an established Women's Reproductive Health Cohort Study, and their exposure factors, blood samples were collected between 2009 and 2010 in four counties of Henan Province, China. Pregnancy outcomes were followed up and a nested case control study was performed reproductive to estimate prevalence and its influencing factors of vitamin D deficiency according to serum 25-hydroxyvitamin D [25(OH)D] < 26.0 ng/mL. Results The prevalence of Vitamin D deficiency among women of reproductive age in central China was 61.5%. Significant determinants of serum 25(OH)D deficiency among women of reproductive age in central China were nutrition supplement (aOR 0.53, 95% CI 0.40–0.71), intake frequency of eggs (aOR 1.61, 95%CI 1.11–2.33) and fruits (aOR 2.50, 95% CI 1.43–4.37), Hemoglobin (aOR 2.25, 95% CI 1.38–3.66), gravidity (aOR 1.79,95% CI:1.27–2.51), family annual income (aOR 1.48, 95% CI 1.11–1.98) and passive smoking (aOR 1.56, 95% CI :1.20–2.03). Conclusions Vitamin D deficiency among women of reproductive age in central China should have high degree of concern, we should pay more attention on the nutritional status improvement and health education of women of reproductive age in central China. Funding Sources National Natural Science Foundation of China; Dietary Nutrition Research and Education Fund of Danone Nutrition Center. Supporting Tables, Images and/or Graphs

Serum Urate Lowering Therapy Using Allopurinol Improves Serum 25 Hydroxy Vitamin D in Stage 3-5 CKD Patients: A Pilot Study

Nephron ◽  
2020 ◽  
pp. 1-4
Author(s):  
AbdelAal Mohammed ◽  
Mohamed A. Marie ◽  
Dina O. Abdulazim ◽  
Mohammed Hassan ◽  
Olfat Shaker ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Urate ◽  
Control Group ◽  
Urine Protein ◽  
Group I ◽  
Ckd Stage ◽  
25 Hydroxy Vitamin D ◽  
The Impact ◽  
Group Serum ◽  
Control Group Group

<b><i>Background:</i></b> Recent studies have demonstrated negative associations of serum uric acid (SUA) with serum 25 hydroxy vitamin D (25 [OH] vit D) among CKD patients. <b><i>Objective:</i></b> The aim of the study was to look for the impact of hypouricemic therapy using allopurinol on serum level of 25 (OH) vit D in CKD patients. <b><i>Cases and Methods:</i></b> Seventy-two CKD stage 3–5 patients were selected to this study. Patients with SUA above 7 mg/dL were allocated to hypouricemic therapy using allopurinol (group I). A control group of cases not suffering marked increase in SUA were included as control group (group II). All cases were followed up for 3 months. Serum Cr, SUA, ionized calcium (SiCa), phosphorus, 25 (OH) vitD, parathyroid hormone (PTH), and 24-h urine protein were estimated at entry and by the end of the study. <b><i>Results:</i></b> At least 20 cases completed the study in each group. Serum 25 (OH) vit D significantly increased in group I (26.4 [14.1] vs. 39.6 [14.8] at entry vs. at end of the study, <i>p</i> &#x3c; 0.001). In addition, SUA, PTH, and urine protein significantly decreased (11 [1.6] vs. 3.95 [0.58] mg/dL, 267.5 [97.5] vs. 225.5 [153] ng/mL, and 2.7 [1.18] vs. 1.5 [1.08] gm/day, <i>p</i> &#x3c; 0.001, = 0.043, and &#x3c;0.001 respectively). SiCa and phosphorus significantly increased (4.4 [0.3] vs. 5.2 [0.5] mg/dL and 4.25 [0.72] vs. 4.9 [0.75] mg/dL, <i>p</i> &#x3c; 0.001 and = 0.007, respectively). <b><i>Conclusion:</i></b> This study supports a negative causal relationship between SUA and serum 25 (OH) vit D. Further studies are still needed to confirm this conclusion.

scholarly journals Vitamin D Food Fortification is an Effective Approach for Improving Vitamin D Status; A Systematic Review

2019 ◽  
Author(s):  
Roya Sakhaei ◽  
Nasir Talenezhad ◽  
Mohammad Mohammadi ◽  
Nahid Ramezani-Jolfaie
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Serum Levels ◽  
Food Sources ◽  
Food Fortification ◽  
The People ◽  
25 Hydroxy Vitamin D ◽  
Limited Food ◽  
Effect Of Food ◽  
The Impact

Background: Low vitamin D (vit D) serum levels have been linked to various diseases such as multiple sclerosis, cardiovascular diseases, and diabetes. Maintenance of optimal vit D level should be supported by foods and supplements. Limited food sources of vit D made researchers focus on food fortification in recent years. Methods: A systematic review of randomized controlled trials reporting the impact of vit D food fortification on 25-hydroxy vitamin D [25(OH)D] level was conducted on PubMed, Scopus, ISI Web of Science and Google Scholar from inception up to August 2017. Results: Sixteen studies met the inclusion criteria and most of them (n =14) have represented the significant effect of food fortification on the improvement of vit D status of the participants. However, two studies failed to find any reasonable associations. Furthermore, it was observed that vit D food fortification has a greater impact on the people with lower 25(OH)D serum levels. Conclusions: Fortification of foods with vit D has a significant impact on serum 25(OH)D concentrations. Therefore, food enrichment is an economical and effective approach for different populations to prevent vit D deficiency.

scholarly journals The impact of pretransplant 25-hydroxy vitamin D deficiency on subsequent graft function: An observational study

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Hyunwook Kim ◽  
Shin-Wook Kang ◽  
Tae-Hyun Yoo ◽  
Myoung Soo Kim ◽  
Soon Il Kim ◽  
...  
Keyword(s):  
Vitamin D ◽  
Observational Study ◽  
Vitamin D Deficiency ◽  
Graft Function ◽  
25 Hydroxy Vitamin D ◽  
The Impact

scholarly journals Influence of 25-Hydroxy-Vitamin D Insufficiency on Maximal Aerobic Power in Elite Indoor Athletes: A Cross-Sectional Study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Astrid Most ◽  
Oliver Dörr ◽  
Holger Nef ◽  
Christian Hamm ◽  
Timm Bauer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Physical Performance ◽  
Aerobic Power ◽  
Cross Sectional Study ◽  
Vitamin D Insufficiency ◽  
Maximal Aerobic Power ◽  
Cross Sectional ◽  
25 Hydroxy Vitamin D ◽  
25 Oh Vitamin D ◽  
The Impact

Abstract Background The impact of vitamin D on musculoskeletal health is well-established, although its influence on physical performance is unclear. Therefore, we conducted this study to evaluate the impact of 25-hydroxy-vitamin D (25-OH vitamin D) concentrations with maximal aerobic power of professional indoor athletes. Results A total of 112 male professional athletes were included in this cross-sectional study, consisting of 88 handball and 24 ice hockey players. The maximal aerobic power was assessed with a standardized cycling ergometer test. Athletes were assigned to two groups according to their 25-OH vitamin D status: insufficient (< 30 ng/mL) and sufficient (≥ 30 ng/mL). Thirty-four players (30.4%) displayed insufficient (21.9 ± 5.9 ng/mL) and 78 (69.6%) sufficient 25-OH vitamin D concentrations (41.6 ± 8.6 ng/mL). Athletes with sufficient levels achieved a higher maximal aerobic power (3.9 ± 0.9 vs. 3.5 ± 0.8 W/kg, p = 0.03) compared to those with insufficient levels. Conclusions There is a high prevalence of 25-OH vitamin D insufficiency in professional indoor athletes, even in summer. Insufficient 25-OH vitamin D concentrations were associated with lower maximal aerobic power in male professional indoor athletes. Further, the 25-OH vitamin D concentration was identified as the only independent predictor of maximal aerobic power in these athletes, highlighting the impact of 25-OH vitamin D on physical performance. Therefore, 25-OH vitamin D concentrations of ≥ 30 ng/mL should be maintained to ensure optimal physical performance in these athletes.

scholarly journals Potential of Vitamin D Food Fortification in Prevention of Cancer Deaths—A Modeling Study

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3986
Author(s):  
Tobias Niedermaier ◽  
Thomas Gredner ◽  
Sabine Kuznia ◽  
Ben Schöttker ◽  
Ute Mons ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Mortality ◽  
Vitamin D Supplementation ◽  
Food Fortification ◽  
Vitamin D Levels ◽  
Total Cancer ◽  
25 Hydroxy Vitamin D ◽  
Prevention Of Cancer ◽  
Meta Analyses ◽  
The Impact

Meta-analyses of randomized controlled trials (RCTs) have estimated a 13% reduction of cancer mortality by vitamin D supplementation among older adults. We evaluated if and to what extent similar effects might be expected from vitamin D fortification of foods. We reviewed the literature on RCTs assessing the impact of vitamin D supplementation on cancer mortality, on increases of vitamin D levels by either supplementation or food fortification, and on costs of supplementation or fortification. Then, we derived expected effects on total cancer mortality and related costs and savings from potential implementation of vitamin D food fortification in Germany and compared the results to those for supplementation. In RCTs with vitamin D supplementation in average doses of 820–2000 IU per day, serum concentrations of 25-hydroxy-vitamin D increased by 15–30 nmol/L, respectively. Studies on food fortification found increases by 10–42 nmol/L, thus largely in the range of increases previously demonstrated by supplementation. Fortification is estimated to be considerably less expensive than supplementation. It might be similarly effective as supplementation in reducing cancer mortality and might even achieve such reduction at substantially larger net savings. Although vitamin D overdoses are unlikely in food fortification programs, implementation should be accompanied by a study monitoring the frequency of potentially occurring adverse effects by overdoses, such as hypercalcemia. Future studies on effectiveness of vitamin D supplementation and fortification are warranted.

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