scholarly journals Community curation in PomBase: enabling fission yeast experts to provide detailed, standardized, sharable annotation from research publications

Database ◽  
2020 ◽  
Vol 2020 ◽  
Author(s):  
Antonia Lock ◽  
Midori A Harris ◽  
Kim Rutherford ◽  
Jacqueline Hayles ◽  
Valerie Wood
Keyword(s):  
Fission Yeast ◽  
Knowledge Integration ◽  
Added Value ◽  
Biological Knowledge ◽  
Published Data ◽  
Project Outcomes ◽  
Online Databases ◽  
Community Curation ◽  
The Impact ◽  
Fair Sharing

Abstract Maximizing the impact and value of scientific research requires efficient knowledge distribution, which increasingly depends on the integration of standardized published data into online databases. To make data integration more comprehensive and efficient for fission yeast research, PomBase has pioneered a community curation effort that engages publication authors directly in FAIR-sharing of data representing detailed biological knowledge from hypothesis-driven experiments. Canto, an intuitive online curation tool that enables biologists to describe their detailed functional data using shared ontologies, forms the core of PomBase’s system. With 8 years’ experience, and as the author response rate reaches 50%, we review community curation progress and the insights we have gained from the project. We highlight incentives and nudges we deploy to maximize participation, and summarize project outcomes, which include increased knowledge integration and dissemination as well as the unanticipated added value arising from co-curation by publication authors and professional curators.

scholarly journals Human allergy to cats: A review of the impact on cat ownership and relinquishment

2021 ◽  
pp. 1098612X2110130
Author(s):  
Andrew H Sparkes
Keyword(s):  
Adverse Effects ◽  
Companion Animals ◽  
Evidence Base ◽  
Published Data ◽  
Practical Relevance ◽  
Online Databases ◽  
Human Adults ◽  
The Impact

Practical relevance: Cats have become increasingly common as companion animals, and in many countries their popularity now exceeds that of dogs. At the same time, human allergies (including allergy to cats) have been increasing and it has been estimated that globally up to 10-20% of human adults are sensitised to cats. Aim: This review summarises the available published data on how human allergy to cats affects cat ownership and considers the implications of the findings on the wider human-cat bond and how adverse effects can be minimised. Evidence base: Online databases were searched for all original studies up to December 2020 that had quantified the impact of human allergy to cats on ownership or relinquishment. Objective quantifiable data appeared to fall into three broad outcomes - (1) choosing to avoid cat ownership; (2) relinquishment of owned cats; and (3) return of cats after acquisition from a rehoming centre. The data retrieved on these topics are the focus of this review. In some studies, data from cats and dogs were combined and these have also been included in the review.

Vulnerability of medical students and professionals to extreme work stress: A select review of the literature

2018 ◽  
Vol 14 (2) ◽  
pp. 181-187
Author(s):  
Maciej Walkiewicz ◽  
Małgorzata Tartas
Keyword(s):  
Medical Students ◽  
Work Stress ◽  
English Language ◽  
Psychological Intervention ◽  
Medical Professionals ◽  
Extreme Stress ◽  
Online Databases ◽  
Medical Career ◽  
Medical University ◽  
The Impact

The goal of the paper is to describe the extent to which medical students and professionals are vulnerable to extreme stress. A select review of existing literature on this area has been undertaken, using the English-language online databases EBSCO, Medline and PubMed. The search has identified 36 citations relating to 6324 medical students and 28,285 medical staff (physicians, residents, nurses). The review indicates that merely beginning medical studies is a risk factor for stress, and that medical professionals, who are vulnerable to extreme work stress, say that they do not receive enough support from their co-workers. They are also often notably impulsive, introverted, neurotic and perfectionist, with low emotional intelligence and agreeableness, as well as low and external locus of control. Additionally, from longitudinal studies we have been able to identify psychological factors underpinning admission to a medical university that may be useful for predicting future stress in medical career. The results of this study may be taken into account when organizing psychological intervention programs targeted at educating future medical professionals. It seems that early identification of people at risk could reduce the impact of stress related to medical career and enhance the somatic and mental health of medical professionals.

DMSP – Database for Modeling Signaling Pathways

2008 ◽  
Vol 47 (02) ◽  
pp. 104-148
Author(s):  
M. Breit ◽  
B. Pfeifer ◽  
C. Baumgartner ◽  
R. Modre-Osprian ◽  
B. Tilg ◽  
...  
Keyword(s):  
Knowledge Base ◽  
Signaling Pathways ◽  
Protein Interaction ◽  
Initial Step ◽  
Point Of View ◽  
Biological Knowledge ◽  
Literature Study ◽  
Online Databases ◽  
Qualitative Level ◽  
Pathway Models

Summary Objectives: Presently, the protein interaction information concerning different signaling pathways is available in a qualitative manner in different online protein interaction databases. The challenge here is to derive a quantitative way of modeling signaling pathways from qualitative way of modeling signaling pathways from a qualitative level. To address this issue we developed a database that includes mathematical modeling knowledge and biological knowledge about different signaling pathways. Methods: The database is part of an integrative environment that includes environments for pathway design, visualization, simulation and a knowledge base that combines biological and modeling information concerning pathways. The system is designed as a client-server architecture. It contains a pathway designing environment and a simulation environment as upper layers with a relational knowledge base as the underlying layer. Results: DMSP – Database for Modeling Signaling Pathways incorporates biological datasets from online databases like BIND, DIP, PIP, and SPiD. The modeling knowledge that has been incorporated is based on a literature study. Pathway models can be designed, visualized and simulated based on the knowledge stored in the DMSP. The user can download the whole dataset and build pathway models using the knowledge stored in our database. As an example, the TNF? pathway model was implemented and tested using this approach. Conclusion: DMSP is an initial step towards the aim of combining modeling and biological knowledge concerning signaling pathways. It helps in understanding pathways in a qualitative manner from a qualitative level. Simulation results enable the interpretation of a biological system from a quantitative and systemtheoretic point of view.

scholarly journals Physical activity in patients with rheumatoid arthritis - an agile lifelong behaviour: a qualitative meta-synthesis

RMD Open ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. e001635
Author(s):  
Emma Swärdh ◽  
Christina Opava ◽  
Nina Brodin
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity ◽  
Web Of Science ◽  
Body Awareness ◽  
Main Theme ◽  
Inclusion Criteria ◽  
Online Databases ◽  
Taking Action ◽  
The Impact

BackgroundPhysical activity (PA) in rheumatoid arthritis (RA) is considered a cornerstone in the treatment. To highlight aspects involved in supporting a positive PA behaviour, it is important to understand the patients’ perceptions of the phenomenon.ObjectiveThe aim of this qualitative meta-synthesis was to explore and synthesise patient perceptions of PA in RA.MethodsA purposeful search was conducted across three online databases (PubMed, CINAHL and Web of Science). The methodological quality of the included studies was appraised, and data were extracted and analysed using an interpretive inductive thematic synthesis.ResultsFifteen studies met the inclusion criteria and were included. PA was identified as an agile lifelong behaviour, with one main theme: The disease as a persistent catalyst for or against PA illustrating how the constant presence of the disease itself underlies the entire process of a life with or without regular PA. Seven subthemes: ‘considering aggravated symptoms’, ‘acknowledging the impact on health’, ‘becoming empowered and taking action’, ‘keeping informed to increase awareness’, ‘creating body awareness’, ‘dealing with social support’ and ‘feeling satisfied with circumstances and achievements’ were interpreted as facilitators and/or challenges.ConclusionThis synthesis has identified PA as an agile lifelong behaviour in which the disease pervades all aspects of an individuals’ perception of PA. Placed in a theoretical context, our findings outline a model for tailoring PA support to the drivers and determinants of a certain individual, which will improve clinical practice for the benefit of both health professionals and patients with RA.

scholarly journals SUPPORT FOR MANAGING PARTLY CONFIGURABLE MODULAR SYSTEMS

2021 ◽  
Vol 1 ◽  
pp. 2791-2800
Author(s):  
Jarkko Pakkanen ◽  
Teuvo Heikkinen ◽  
Nillo Adlin ◽  
Timo Lehtonen ◽  
Janne Mämmelä ◽  
...  
Keyword(s):  
Portfolio Management ◽  
Product Variety ◽  
Added Value ◽  
Modular System ◽  
Product Management ◽  
Design Decision ◽  
Product Portfolio ◽  
Modular Systems ◽  
Engineer To Order ◽  
The Impact

AbstractThe paper studies what kind of support could be applied to the management of partly configurable modular systems. The main tasks of product management, product portfolio management and product variety management are defined. In addition, a partly configurable product structure and modular system are defined. Because the limited support in the literature for managing partly configurable modular systems, the article reviews previous product development cases in which authors have been involved on lessons learnt basis, i.e., if the methods and tools used in the cases could provide support for the research objective. As a result, the existing definition of the modular system should be extended by the concepts of non-module and design decision sequence description when dealing with partly configurable modular systems. This is because engineer-to-order should be made possible in cases where it brings clear added value to the customer compared to completely pre-defined solutions that may limit the customer's interest in the offering. Tools to assess the impact of changes to the product offering are required. These should be taken into account in frameworks that are used in method and tool development.

scholarly journals Impact of pharmacist-conducted anticoagulation patient education and telephone follow-up on transitions of care: a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lamis R. Karaoui ◽  
Elsy Ramia ◽  
Hanine Mansour ◽  
Nisrine Haddad ◽  
Nibal Chamoun
Keyword(s):  
Tertiary Care ◽  
Intervention Group ◽  
Bleeding Event ◽  
Transitions Of Care ◽  
Control Group ◽  
Published Data ◽  
Post Discharge ◽  
Readmission Rates ◽  
The Impact

Abstract Background There is limited published data in Lebanon evaluating the impact of supplemental education for anticoagulants use, especially DOACs, on clinical outcomes such as bleeding. The study aims to assess the impact of pharmacist-conducted anticoagulation education and follow-up on bleeding and readmission rates. Methods This study was a randomized, non-blinded interventional study conducted between August 2017 and July 2019 in a tertiary care teaching Lebanese hospital. Participants were inpatients ≥18 years discharged on an oral anticoagulant for treatment. Block randomization was used. The control group received the standard nursing counseling while the intervention group additionally received pharmacy counseling. Phone call follow-ups were done on day 3 and 30 post-discharge. Primary outcomes included readmission rates and any bleeding event at day 3 and 30 post-discharge. Secondary outcomes included documented elements of education in the medical records and reported mortality upon day 30 post-discharge. Results Two hundred patients were recruited in the study (100 patients in each study arm) with a mean age of 73.9 years. In the pharmacist-counseled group, more patients contacted their physician within 3 days (14% versus 4%; p = 0.010), received explicit elements of education (p < 0.001) and documentation in the chart was better (p < 0.05). In the standard of care group, patients were more aware of their next physician appointment date (52% versus 31%, p < 0.001). No difference in bleeding rates at day 3 and 30 post-discharge was observed between the groups. Conclusions Although pharmacist-conducted anticoagulation education did not appear to reduce bleeding or readmission rates at day 30, pharmacist education significantly increased patient communication with their providers in the early days post-discharge. Trial registration Lebanon Clinical Trial Registry LBCTR2020033424. Retrospectively registered. Date of registration: 06/03/2020.

scholarly journals Mycosporine-Like Amino Acids from Red Macroalgae: UV-Photoprotectors with Potential Cosmeceutical Applications

2021 ◽  
Vol 11 (11) ◽  
pp. 5112
Author(s):  
Julia Vega ◽  
Geniane Schneider ◽  
Bruna R. Moreira ◽  
Carolina Herrera ◽  
José Bonomi-Barufi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acids ◽  
High Performance ◽  
Nitrogen Availability ◽  
Antioxidant Properties ◽  
Published Data ◽  
Diverse Group ◽  
Red Macroalgae ◽  
Thermo Stability ◽  
The Impact

Macroalgae belong to a diverse group of organisms that could be exploited for biomolecule application. Among the biocompounds found in this group, mycosporine-like amino acids (MAAs) are highlighted mainly due to their photoprotection, antioxidant properties, and high photo and thermo-stability, which are attractive characteristics for the development of cosmeceutical products. Therefore, here we revise published data about MAAs, including their biosynthesis, biomass production, extraction, characterization, identification, purification, and bioactivities. MAAs can be found in many algae species, but the highest concentrations are found in red macroalgae, mainly in the order Bangiales, as Porphyra spp. In addition to the species, the content of MAAs can vary depending on environmental factors, of which solar radiation and nitrogen availability are the most influential. MAAs can confer photoprotection due to their capacity to absorb ultraviolet radiation or reduce the impact of free radicals on cells, among other properties. To extract these compounds, different approaches can be used. The efficiency of these methods can be evaluated with characterization and identification using high performance liquid chromatography (HPLC), associated with other apparatus such as mass spectrometry (MS) and nuclear magnetic resonance (NMR). Therefore, the data presented in this review allow a broad comprehension of MAAs and show perspectives for their inclusion in cosmeceutical products.

scholarly journals Understanding Social Impact and Value Creation in Hybrid Organizations: The Case of Italian Civil Service

2021 ◽  
Vol 13 (7) ◽  
pp. 4058
Author(s):  
Paolo Esposito ◽  
Valerio Brescia ◽  
Chiara Fantauzzi ◽  
Rocco Frondizi
Keyword(s):  
Value Chain ◽  
Social Impact ◽  
Civil Service ◽  
Added Value ◽  
Hybrid Organizations ◽  
Case Study Analysis ◽  
Public Resources ◽  
Five Elements ◽  
Definition Of ◽  
The Impact

The aim of this paper is twofold: first, it aims to analyze what kind of value is generated by hybrid organizations and how; second, it aims to understand the role of social impact assessment (SIA) in the measurement of added value, especially in terms of social and economic change generated by hybrids. Hybrid organizations are a debated topic in literature and have different strengths in responding to needs, mainly in the public interest. Nevertheless, there are not many studies that identify the impact and change generated by these organizations. After highlighting the gap in the literature, the study proposes an innovative approach that combines SIA, interview, interventionist approach and documental analysis. The breakdown of SIA through the five elements of the value chain (inputs, activities, outputs, outcomes, and impact) guarantees a linear definition of the value generated through change with procedural objectivity capable of grasping hybrid organizations’ complexity. The value generated or absorbed is the change generated by the impact measured based on the incidence of public resources allocated. Through the SIA and counterfactual approach, the civil service case study analysis highlights how the value generated by public resources can be measured or more clearly displayed in the measurement process itself.

scholarly journals Leveraging Existing Data from CMS-Linked Cohort Studies for the Advancement and Translation of Frailty Research

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 777-777
Author(s):  
Qian-Li Xue ◽  
Kristine Ensrud ◽  
Shari Lin
Keyword(s):  
Cohort Studies ◽  
Healthcare Utilization ◽  
Risk Adjustment ◽  
Healthcare Services ◽  
Self Report ◽  
Added Value ◽  
Care Organization ◽  
Frailty Phenotype ◽  
Frailty Assessment ◽  
The Impact

Abstract As population aging is accelerating rapidly, there is growing concern on how to best provide patient-centered care for the most vulnerable. Establishing a predictable and affordable cost structure for healthcare services is key to improving quality, accessibility, and affordability. One such effort is the “frailty” adjustment model implemented by the Centers for Medicare & Medicaid Services (CMS) that adjusts payments to a Medicare managed care organization based on functional impairment of its beneficiaries. Earlier studies demonstrated added value of this frailty adjuster for prediction of Medicare expenditures independent of the diagnosis-based risk adjustment. However, we hypothesize that further improvement is possible by implementing more rigorous frailty assessment rather than relying on self-report of ADL difficulties as used for the frailty adjuster. This is supported by the consensus and clinical observations that neither multimorbidity nor disability alone is sufficient for frailty identification. This symposium consists of four talks that leverage data from three CMS-linked cohort studies to investigate the utility of assessment of the frailty phenotype for predicting healthcare utilization and costs. Talk 1 and 2 use data from the NHATS cohort to assess healthcare utilization by frailty status in the general population and the homebound subset. Talk 3 and 4 use data from the MrOS study and the SOF study to investigate the impact of frailty phenotype on healthcare costs. Taken together, their findings highlight the potential of incorporating phenotypic frailty assessment into CMS risk adjustment to improve the planning and management of care for frail older adults.

scholarly journals Geoinformation Technologies in Support of Environmental Hazards Monitoring under Climate Change: An Extensive Review

2021 ◽  
Vol 10 (2) ◽  
pp. 94
Author(s):  
Andreas Tsatsaris ◽  
Kleomenis Kalogeropoulos ◽  
Nikolaos Stathopoulos ◽  
Panagiota Louka ◽  
Konstantinos Tsanakas ◽  
...  
Keyword(s):  
Climate Change ◽  
Environmental Monitoring ◽  
Environmental Hazards ◽  
Geographic Information ◽  
Added Value ◽  
Spatial Data Analysis ◽  
Anthropogenic Factors ◽  
Geospatial Technologies ◽  
Main Challenge ◽  
The Impact

Human activities and climate change constitute the contemporary catalyst for natural processes and their impacts, i.e., geo-environmental hazards. Globally, natural catastrophic phenomena and hazards, such as drought, soil erosion, quantitative and qualitative degradation of groundwater, frost, flooding, sea level rise, etc., are intensified by anthropogenic factors. Thus, they present rapid increase in intensity, frequency of occurrence, spatial density, and significant spread of the areas of occurrence. The impact of these phenomena is devastating to human life and to global economies, private holdings, infrastructure, etc., while in a wider context it has a very negative effect on the social, environmental, and economic status of the affected region. Geospatial technologies including Geographic Information Systems, Remote Sensing—Earth Observation as well as related spatial data analysis tools, models, databases, contribute nowadays significantly in predicting, preventing, researching, addressing, rehabilitating, and managing these phenomena and their effects. This review attempts to mark the most devastating geo-hazards from the view of environmental monitoring, covering the state of the art in the use of geospatial technologies in that respect. It also defines the main challenge of this new era which is nothing more than the fictitious exploitation of the information produced by the environmental monitoring so that the necessary policies are taken in the direction of a sustainable future. The review highlights the potential and increasing added value of geographic information as a means to support environmental monitoring in the face of climate change. The growth in geographic information seems to be rapidly accelerated due to the technological and scientific developments that will continue with exponential progress in the years to come. Nonetheless, as it is also highlighted in this review continuous monitoring of the environment is subject to an interdisciplinary approach and contains an amount of actions that cover both the development of natural phenomena and their catastrophic effects mostly due to climate change.

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