Angina pectoris and intermittent claudication are independent predictors of CHD- and all-cause mortality in Russian men. More than 30-years follow-up

Abstract Background Angina pectoris (AP) and intermittent claudication (IC) are transient ischemic conditions provoked by exertion due to an imbalance of oxygen supply and demand to the skeletal leg muscle and/or myocardium. They have the similar etiology, both are accepted markers of diffuse atherosclerotic vascular disease and increased mortality risk. But these conditions were rarely studied in community-based cohorts, including comparison with each other or with individuals without symptoms. Aim To investigate the relationship between AP and IC and to evaluate their impact on the survival among Russian men during 30-years follow-up. Methods The data was obtained from representative samples observed in Moscow and Leningrad (now Saint-Petersburg) from 1975 to 1986. Men (10953) aged 35–71 years (mean age 48.8±6.61yrs) were examined by the same core protocol. AP and IC were determined by the original Rose questionnaires. We identified five risk groups of participants: 1) AP and IC; 2) AP without IC; 3) IC without AP; 4) without AP and IC, suffering from chest or leg pain that makes them stop (mixed group); and 5) men without pain, that makes them stop (no pain). During the 31-year follow up period (median time to event – 21.9 years) 7893 deaths from all-causes including 2673 from CHD occurred. We used Kaplan-Meier curves to investigate the relationship between risk groups and survival. Individual impact of AP and IC into mortality was evaluated by multivariate age-adjusted Cox proportional hazards model. For this, we divided participants with AP into three groups: with typical AP, with chest pain that makes them stop, but without AP (mixed group) and other (no pain); and with IC into four groups: with typical IC, with atypical IC, with no pain in legs and all other (mixed group). Results Only 4.8% men with AP had IC, whereas 28.6% with IC had AP. All-cause mortality Kaplan-Meier curves were pairwise different, except groups with “IC without AP” and “AP without IC”. The same results were obtained for CHD mortality. Difference of 17.2 years for median survival times were observed between “no pain” and “AP and IC” groups (Figure 1). We revealed significant impact of each IC and AP group on all-cause mortality. The same results were obtained for CHD mortality except for mixed IC group. Hazard ratios (95% confidence interval) for typical AP and typical IC groups were 1.99 (1.18–2.27) and 2.47 (1.84–3.30) compared to “no pain” group, respectively. They did not significanly differ from each other. Limitations We observed natural history of IC using the original Rose questionnaire in baseline. No modern methods of diagnostics were used that time. Conclusion The greatest decrease in life expectancy of 17.2 years was among participants with “AP and IC”. Survival curves of “IC without AP” and “AP without IC” groups didn't differ. IC and AP significantly independent age-adjusted impacts on all-cause and CHD mortality. Survival curves for all-cause mortality Funding Acknowledgement Type of funding source: None

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Outcomes of endovascular treatment of patients with intermittent claudication due to femoropopliteal disease

Vascular ◽

10.1177/17085381211039668 ◽

2021 ◽

pp. 170853812110396

Author(s):

Ahmed A Naiem ◽

Robert James Doonan ◽

Oren K Steinmetz ◽

Kent S MacKenzie ◽

Elie Girsowicz ◽

...

Keyword(s):

Endovascular Treatment ◽

Intermittent Claudication ◽

Symptomatic Improvement ◽

Adverse Outcomes ◽

Survival Curves ◽

Surgical Revascularization ◽

Careful Patient ◽

Kaplan Meier ◽

All Cause Mortality

Objective Our objective was to evaluate the outcomes of endovascular treatment in patients with moderate and severe claudication due to femoropopliteal disease, that is, disease of the superficial femoral and popliteal arteries. Methods A retrospective review of all patients with moderate and severe claudication (Rutherford 2 and 3) undergoing endovascular treatment for FP disease between January 2012 and December 2017 at two university-affiliated hospitals was performed. All procedures were performed by vascular surgeons. Primary outcomes were mortality, freedom from reintervention, major adverse limb events defined as major amputations, open surgical revascularization, or progression to chronic limb-threatening ischemia (CLTI) at 30 days, 1 year, 2 years, and last follow-up. Unadjusted odds ratios were calculated to identify variables associated with adverse outcomes, and Kaplan–Meier survival curves were used to determine mortality and freedom from reintervention. Results Eighty-five limbs in 74 patients were identified on review. Mean age was 69.6 ± 9.8 years and 74.3% were males. At a median follow-up of 49.0 ± 25.5 months, all-cause mortality rate was 8.1% (6 patients) with 16.7% being due to cardiovascular causes. Reintervention rates were 1.2%, 16.5%, and 21.2% at 30 days, 1 year, and 2 years, respectively. Major adverse limb events occurred in 3 patients and rates were 0%, 1.2%, and 2.4% at 30 days, 1 year, and 2 years, respectively. Progression to CLTI was 0%, 1.2%, and 1.2% at 30 days, 1 year, and 2 years, respectively. Claudication had improved or resolved in 55.6% ( n = 34 patients), stable in 38.9% ( n = 21 patients), and worse in 5.6% ( n = 3 patients) Age ≥ 70 years (OR = 4.09 (1.14–14.66), p = 0.027), TASCII A lesion (OR = 4.67 (1.14–19.17), p = 0.025), and presence of 3-vessel runoff (OR = 3.70 (1.18–11.59), p = 0.022) predicted symptoms’ improvement. TASCII A lesions were less likely to require reintervention (OR = 0.23 (0.06–0.86), p = 0.020). Reintervention within 1 year (OR = 11.67 (0.98–138.94), p = 0.017), reintervention with a stent (OR = 14.40 (1.19–173.67), p = 0.008) and more than one reintervention (OR = 39.00 (2.89–526.28), p < 0.001) predicted major adverse limb events. Conclusions Careful patient selection is important when planning endovascular treatment in patients with intermittent claudication and FP disease. This could result in symptomatic improvement in more than half of the patients. Adverse outcomes such as major adverse limb events, progression to CLTI, and amputations occur at low rates.

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Claudication, in contrast to angina pectoris, independently predicts mortality risk in the general population

VASA ◽

10.1024/0301-1526/a000172 ◽

2012 ◽

Vol 41 (2) ◽

pp. 105-113 ◽

Cited By ~ 5

Author(s):

G. Kieback ◽

Lorbeer ◽

Wallaschofski ◽

Ittermann ◽

Völzke ◽

...

Keyword(s):

Angina Pectoris ◽

Mortality Rate ◽

Cardiovascular Mortality ◽

Proportional Hazards ◽

Population Based ◽

Cox Proportional Hazards ◽

Kaplan Meier ◽

All Cause Mortality ◽

Study Population

Background: The aim of our analyses was to investigate whether claudication and angina pectoris, each defined and based on the answer to a single question, are predictive of future mortality. Probands and methods: The study population consisted of 3995 subjects selected from the population-based Study of Health In Pomerania (SHIP). Kaplan-Meier analysis and multivariable Cox proportional hazards regression analysis were used to analyze the association of angina pectoris and claudication with all-cause and cardiovascular mortality adjusted for major cardiovascular risk factors. Results: At baseline, 417 individuals had symptoms of angina pectoris, and 323 had symptoms of claudication. During a median follow-up of 8.5 years, 277 individuals died. Individuals with claudication had a higher fully-adjusted all-cause mortality rate (Hazard Ratio (HR) 1.79; 95 % CI 1.34, 2.39, p < 0.001) and a higher sex- and age-adjusted cardiovascular mortality rate (HR 1.76; 95 % CI 1.03, 2.99, p = 0.038) compared to subjects without claudication. In contrast, subjects with angina pectoris had neither an elevated fully-adjusted all-cause mortality rate (HR 1.15; 95 % CI 0.82, 1.61, p = 0.413) nor sex- and age-adjusted cardiovascular mortality rate (HR 0.71; 95 % CI 0.34, 1.48, p = 0.363) compared to those without this symptom. Conclusions: Claudication, in contrast to angina pectoris, is a strong, independent predictor of all-cause mortality.

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Are Russian Men with Intermittent Claudication and/or Angina Pectoris Have the Same Cardiovascular and All-Cause Mortality Risks? The Data of the Prospective Population-Based Study

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2020-10-01 ◽

2020 ◽

Vol 16 (5) ◽

pp. 787-797

Author(s):

S. A. Shalnova ◽

E. V. Yarovaya ◽

Yu. K. Makarova ◽

V. A. Kutsenko ◽

A. V. Kapustina ◽

...

Keyword(s):

Blood Pressure ◽

Angina Pectoris ◽

Survival Time ◽

Intermittent Claudication ◽

Cardiovascular Mortality ◽

Pain Syndrome ◽

Risk Groups ◽

Male Population ◽

Significant Difference

Aim. To investigate the distribution of the intermittent claudication(IC) and/or angina pectoris (AP) and to evaluate the risk of cardiovascular and allcause mortality in Russian male population with pain syndrome of varying severity during more than 30-year observation period.Material and methods. The data were obtained from representative samples observed in Moscow and Saint-Petersburg (former Leningrad) from 1975 to 1986 with 75% response. Men (n=10953) aged 35-71 years (mean age 48.8±6.6 years) were examined by the same protocol which includes standard questionnaire, blood biochemistry, blood pressure (BP) and heart rate measurements, anthropometry and electrocardiography (ECG) in 12 leads. The original Rose questionnaire to determine the IC and AP was used. There were defined five risk groups with different pain features. The first group – no pain; the second group – mixed pain in legs and/or in chest including the pain connected with the effort, but without typical IC and AP features; the third group – only IC without AP; the fourth group – only AP without IC; finally, the fifth group – both IC and AP. The median follow-up period was 21.9 years with interquartile range of 13.4-33.5 years. During the follow-up 7893 all-cause deaths including 4220 cardiovascular deaths were found. The Kaplan-Meier method was applied to find out the associations between risk groups and survival. Mortality risk, including cardiovascular mortality, was evaluated by the Cox proportional hazard model.Results. There were 38.7% men with any pain. The prevalence of IC without AP was 0.7% and the prevalence of AP without IC was 5.8%. Only 0.3% of the population had both IC and AP. The prevalence of both parameters increased with age. As expected, men with no pain live longer than others. Median of the survival time in this group, which means the point when half of the population dies, was 24.9 years. Only in this group the value when 75% of population dies was not reached. Compared to no pain group, loss of the life expectancy of only IC group was 10.9 years, only AP group – 9.2 years, IC and AP group – 17.9 years. Both IC and AP had statistically significant contribution to mortality adjusted for high blood pressure, smoking, presence of ECG disturbances, history of myocardial infarction. Survival curves of isolated IC and AP groups did not have statistically significant difference which means that both diseases have the same contribution to mortality. Similar results were obtained for cardiovascular mortality.Conclusion. The prevalence of IC without AP was 0.7% and the prevalence of AP without IC was 5.8%. IC and AP are independent factors of all-cause and cardiovascular mortality among the Russian male population aged 35-71 years. However, no statistically significant difference was found between groups only with IC and only with AP for cardiovascular and all-cause deaths. The presence of both conditions in combination reduces the median survival time by 17.9 years compared to the group with no pain.

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The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients

Blood Purification ◽

10.1159/000515639 ◽

2021 ◽

pp. 1-7

Author(s):

Emre Erdem ◽

Ahmet Karatas ◽

Tevfik Ecder

Keyword(s):

Serum Ferritin ◽

Hemodialysis Patients ◽

Rank Test ◽

Significant Difference ◽

All Cause Mortality ◽

Group 3 ◽

Group 2 ◽

The Relationship ◽

Group 1

Introduction: The effect of high serum ferritin levels on long-term mortality in hemodialysis patients is unknown. The relationship between serum ferritin levels and 5-year all-cause mortality in hemodialysis patients was investigated in this study. Methods: A total of 173 prevalent hemodialysis patients were included in this study. The patients were followed for up to 5 years and divided into 3 groups according to time-averaged serum ferritin levels (group 1: serum ferritin <800 ng/mL, group 2: serum ferritin 800–1,500 ng/mL, and group 3: serum ferritin >1,500 ng/mL). Along with the serum ferritin levels, other clinical and laboratory variables that may affect mortality were also included in the Cox proportional-hazards regression analysis. Results: Eighty-one (47%) patients died during the 5-year follow-up period. The median follow-up time was 38 (17.5–60) months. The 5-year survival rates of groups 1, 2, and 3 were 44, 64, and 27%, respectively. In group 3, the survival was lower than in groups 1 and 2 (log-rank test, p = 0.002). In group 1, the mortality was significantly lower than in group 3 (HR [95% CI]: 0.16 [0.05–0.49]; p = 0.001). In group 2, the mortality was also lower than in group 3 (HR [95% CI]: 0.32 [0.12–0.88]; p = 0.026). No significant difference in mortality between groups 1 and 2 was found (HR [95% CI]: 0.49 [0.23–1.04]; p = 0.063). Conclusion: Time-averaged serum ferritin levels >1,500 ng/mL in hemodialysis patients are associated with an increased 5-year all-cause mortality risk.

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Elevated plasma growth and differentiation factor 15 predicts incident anemia in older adults aged 60 years and older

The Journals of Gerontology Series A ◽

10.1093/gerona/glaa324 ◽

2020 ◽

Author(s):

Yuko Yamaguchi ◽

Marta Zampino ◽

Toshiko Tanaka ◽

Stefania Bandinelli ◽

Yusuke Osawa ◽

...

Keyword(s):

Older Adults ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Differentiation Factor ◽

Hazards Model ◽

Increased Risk ◽

The Relationship

Abstract Background Anemia is common in older adults and associated with greater morbidity and mortality. The causes of anemia in older adults have not been completely characterized. Although elevated circulating growth and differentiation factor 15 (GDF-15) has been associated with anemia in older adults, it is not known whether elevated GDF-15 predicts the development of anemia. Methods We examined the relationship between plasma GDF-15 concentrations at baseline in 708 non-anemic adults, aged 60 years and older, with incident anemia during 15 years of follow-up among participants in the Invecchiare in Chianti (InCHIANTI) Study. Results During follow-up, 179 (25.3%) participants developed anemia. The proportion of participants who developed anemia from the lowest to highest quartile of plasma GDF-15 was 12.9%, 20.1%, 21.2%, and 45.8%, respectively. Adults in the highest quartile of plasma GDF-15 had an increased risk of developing anemia (Hazards Ratio 1.15, 95% Confidence Interval 1.09, 1.21, P<.0001) compared to those in the lower three quartiles in a multivariable Cox proportional hazards model adjusting for age, sex, serum iron, soluble transferrin receptor, ferritin, vitamin B12, congestive heart failure, diabetes mellitus, and cancer. Conclusions Circulating GDF-15 is an independent predictor for the development of anemia in older adults.

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U-survival for prognostic prediction of disease progression and mortality of patients with COVID-19

Scientific Reports ◽

10.1038/s41598-021-88591-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Janne J. Näppi ◽

Tomoki Uemura ◽

Chinatsu Watari ◽

Toru Hironaka ◽

Tohru Kamiya ◽

...

Keyword(s):

Risk Groups ◽

Healthcare Services ◽

Chest Ct ◽

Prediction Performance ◽

Survival Prediction ◽

Concordance Index ◽

Survival Curves ◽

Analysis Methodology ◽

Kaplan Meier ◽

Prognostic Prediction

AbstractThe rapid increase of patients with coronavirus disease 2019 (COVID-19) has introduced major challenges to healthcare services worldwide. Therefore, fast and accurate clinical assessment of COVID-19 progression and mortality is vital for the management of COVID-19 patients. We developed an automated image-based survival prediction model, called U-survival, which combines deep learning of chest CT images with the established survival analysis methodology of an elastic-net Cox survival model. In an evaluation of 383 COVID-19 positive patients from two hospitals, the prognostic bootstrap prediction performance of U-survival was significantly higher (P < 0.0001) than those of existing laboratory and image-based reference predictors both for COVID-19 progression (maximum concordance index: 91.6% [95% confidence interval 91.5, 91.7]) and for mortality (88.7% [88.6, 88.9]), and the separation between the Kaplan–Meier survival curves of patients stratified into low- and high-risk groups was largest for U-survival (P < 3 × 10–14). The results indicate that U-survival can be used to provide automated and objective prognostic predictions for the management of COVID-19 patients.

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Macronutrient Quality and All-Cause Mortality in the SUN Cohort

Nutrients ◽

10.3390/nu13030972 ◽

2021 ◽

Vol 13 (3) ◽

pp. 972

Author(s):

Susana Santiago ◽

Itziar Zazpe ◽

Cesar I. Fernandez-Lazaro ◽

Víctor de la de la O ◽

Maira Bes-Rastrollo ◽

...

Keyword(s):

Quality Index ◽

Inverse Relationship ◽

A Priori ◽

The Sun ◽

Significant Inverse Relationship ◽

Carbohydrate Quality ◽

All Cause Mortality ◽

Middle Aged Adults ◽

The Relationship

No previous study has assessed the relationship between overall macronutrient quality and all-cause mortality. We aimed to prospectively examine the association between a multidimensional macronutrient quality index (MQI) and all-cause mortality in the SUN (Seguimiento Universidad de Navarra) (University of Navarra Follow-Up) study, a Mediterranean cohort of middle-aged adults. Dietary intake information was obtained from a validated 136-item semi-quantitative food-frequency questionnaire. We calculated the MQI (categorized in quartiles) based on three quality indexes: the carbohydrate quality index (CQI), the fat quality index (FQI), and the healthy plate protein source quality index (HPPQI). Among 19,083 participants (mean age 38.4, 59.9% female), 440 deaths from all causes were observed during a median follow-up of 12.2 years (IQR, 8.3–14.9). No significant association was found between the MQI and mortality risk with multivariable-adjusted hazard ratio (HR) for the highest vs. the lowest quartile of 0.79 (95% CI, 0.59–1.06; Ptrend = 0.199). The CQI was the only component of the MQI associated with mortality showing a significant inverse relationship, with HR between extreme quartiles of 0.64 (95% CI, 0.45–0.90; Ptrend = 0.021). In this Mediterranean cohort, a new and multidimensional MQI defined a priori was not associated with all-cause mortality. Among its three sub-indexes, only the CQI showed a significant inverse relationship with the risk of all-cause mortality.

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Calcium Channel Autoantibodies Predicted Sudden Cardiac Death and All-Cause Mortality in Patients with Ischemic and Nonischemic Chronic Heart Failure

Disease Markers ◽

10.1155/2014/796075 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 8

Author(s):

Haiyun Yu ◽

Juanhui Pei ◽

Xiaoyan Liu ◽

Jingzhou Chen ◽

Xian Li ◽

...

Keyword(s):

Heart Failure ◽

Multivariate Analysis ◽

Sudden Cardiac Death ◽

Chronic Heart Failure ◽

Cardiac Death ◽

Independent Predictor ◽

All Cause Mortality ◽

Patient Prognosis ◽

The Relationship

The purpose of this study was to evaluate whether CC-AAbs levels could predict prognosis in CHF patients. A total of 2096 patients with CHF (841 DCM patients and 1255 ICM patients) and 834 control subjects were recruited. CC-AAbs were detected and the relationship between CC-AAbs and patient prognosis was analyzed. During a median follow-up time of 52 months, there were 578 deaths. Of these, sudden cardiac death (SCD) occurred in 102 cases of DCM and 121 cases of ICM. The presence of CC-AAbs in patients was significantly higher than that of controls (bothP<0.001). Multivariate analysis revealed that positive CC-AAbs could predict SCD (HR 3.191, 95% CI 1.598–6.369 for DCM; HR 2.805, 95% CI 1.488–5.288 for ICM) and all-cause mortality (HR 1.733, 95% CI 1.042–2.883 for DCM; HR 2.219, 95% CI 1.461–3.371 for ICM) in CHF patients. A significant association between CC-AAbs and non-SCD (NSCD) was found in ICM patients (HR = 1.887, 95% CI 1.081–3.293). Our results demonstrated that the presence of CC-AAbs was higher in CHF patients versus controls and corresponds to a higher incidence of all-cause death and SCD. Positive CC-AAbs may serve as an independent predictor for SCD and all-cause death in these patients.

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Evaluation of a multimarker panel in chronic heart failure: a 10-year follow-up

Biomarkers in Medicine ◽

10.2217/bmm-2020-0722 ◽

2021 ◽

Author(s):

Susanne Bauer ◽

Christina Strack ◽

Ekrem Ücer ◽

Stefan Wallner ◽

Ute Hubauer ◽

...

Keyword(s):

Heart Failure ◽

Prognostic Role ◽

Blood Samples ◽

Kaplan Meier ◽

Risk Of Mortality ◽

Patients With Heart Failure ◽

All Cause Mortality ◽

Long Time

Aim: We assessed the 10-year prognostic role of 11 biomarkers with different pathophysiological backgrounds. Materials & methods/results: Blood samples from 144 patients with heart failure were analyzed. After 10 years of follow-up (median follow-up was 104 months), data regarding all-cause mortality were acquired. Regarding Kaplan–Meier analysis, all markers, except TIMP-1 and GDF-15, were significant predictors for all-cause mortality. We created a multimarker model with nt-proBNP, hsTnT and IGF-BP7 and found that patients in whom all three markers were elevated had a significantly worse long-time-prognosis than patients without elevated markers. Conclusion: In a 10-year follow-up, a combination of three biomarkers (NT-proBNP, hs-TnT, IGF-BP7) identified patients with a high risk of mortality.

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Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as a risk factor for mortality in peruvian adults with chronic kidney disease.

10.22541/au.161224727.78237032/v1 ◽

2021 ◽

Author(s):

Gianfranco Umeres-Francia1 ◽

María Rojas-Fernández ◽

Percy Herrera Añazco ◽

Vicente Benites-Zapata

Keyword(s):

Risk Factor ◽

Cox Regression ◽

Outcome Variable ◽

Lymphocyte Ratio ◽

Hazard Ratios ◽

Ckd Stage ◽

All Cause Mortality ◽

The Relationship ◽

Crude Analysis

Objective: To assess the association between NLR and PLR with all-cause mortality in Peruvian patients with CKD Methods: We conducted a retrospective cohort study in adults with CKD in stages 1 to 5. The outcome variable was mortality and as variables of exposure to NLR and PLR. Both ratios were categorized as high with a cut-off point of 3.5 and 232.5; respectively. We carried out a Cox regression model and calculated crude and adjusted hazard ratios (HR) with their 95% confidence interval (95%CI). Results: We analyzed 343 participants with a median follow-up time of 2.45 years (2.08-3.08). The frequency of deaths was 17.5% (n=60). In the crude analysis, the high NLR and PLR were significantly associated with all-cause mortality (HR=2.01; 95% CI:1.11-3.66) and (HR=2.58; 95% CI:1.31-5.20). In the multivariate model, after adjusting for age, sex, serum creatinine, CKD stage, albumin and hemoglobin, the high NLR and PLR remained as an independent risk factor for all-cause mortality, (HR=2.10; 95% CI:1.11-3.95) and (HR=2.71; 95% CI:1.28-5.72). Conclusion: Our study suggests the relationship between high NLR and PLR with all-cause mortality in patients with CKD.

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