scholarly journals Impact of the COVID-19 pandemic in the MR availability for iron overloaded patients

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
A Pepe ◽  
L Pistoia ◽  
G Restaino ◽  
A Vallone ◽  
R Righi ◽  
...  
Keyword(s):  
Iron Overload ◽  
Negative Impact ◽  
Vertical Axis ◽  
Healthcare Services ◽  
The Other ◽  
Private Company ◽  
Significant Drop ◽  
Mri Scans ◽  
The Impact ◽  
T2 Mri

Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): The E-MIOT project receives “no-profit support” from industrial sponsorships (Chiesi Farmaceutici S.p.A. and Bayer). Background The T2* magnetic resonance imaging (MRI) technique for the noninvasive quantification of iron overload has significantly improved the survival of patients with hemoglobinopathies by tailoring the chelation therapy. In Italy, the E-MIOT (Extension-Myocardial Iron Overload in Thalassemia) Network, a collaborative project among MRI and hematological centers, has assured high-quality quantification of iron in vital organs such as heart, liver, and pancreas. The COVID-19 pandemic has disrupted healthcare services around the world, also leading to postpone  or delete deferable diagnostic evaluations. Aim   We evaluated the impact of the COVID-19 pandemic on MRI services for iron overload quantification in Italy. Methods The activity of the MRI centers of the E-MIOT Network in the year 2020 was compared to the activity in the same months of 2019. A specific survey was filled out by the MRI operators to evaluate if the availability of MRI slots for patients with hemoglobinothies was reduced and the reasons. Results In comparison with the year 2019, in 2020 there was a significant reduction in the number of T2* MRIs performed (350 vs 656; P < 0.0001). The comparison month by month between the two years highlighted a marked decline (86.9%) in the four-month period March-June 2020, a reduction in the gap between the two years in the three-month period July-September, and a new decline (41.4%) in the three-month period October-December (Figure 1). No patient with hemoglobinopathy could undergo an MRI scan during the Italian lockdown (9 March-10 May 2020). Figure 2 shows the percentage of  decline (year 2020 vs 2019) in the number of T2*MRI scans for each MRI center. If no decline or an increase were present, the vertical axis was set at 0. All centers experienced a significant drop in the number of the T2* MRIs in the four-month period March-June (from 75 to 100%). In the three-month period July-September only the centers of Pisa and Taranto dropped the number of T2* MRIs due to the rescheduling of the other MRI appointments deleted during the lockdown. In the three-month period October-December a reduction of the T2* MRI scans was experienced by all centers, except for Campobasso. In the centers of Ferrara and Lamezia Terme the reduction was the consequence of the general reduction in the number of the total MRIs scheduled per day for the  sanitation procedures. In the other centers, the availability for T2* MRI scans was unchanged in comparison to 2019, but the patients refused the MRI follow up for fear of getting sick of COVID. Conclusion The COVID-19 pandemic is having a strong negative impact on the quantification of iron overload by MRI, which may seriously worsen the prognosis of patients with hemoglobinopathies. Strategies to ensure proved lifesaving MRI exam and to reassure patients about the health safety of the hospitals are recommended. Abstract Figure 1Abstract Figure 2

scholarly journals Polyphenol Profiling of Chestnut Pericarp, Integument and Curing Water Extracts to Qualify These Food By-Products as a Source of Antioxidants

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2335
Author(s):  
Gabriella Pinto ◽  
Sabrina De Pascale ◽  
Maria Aponte ◽  
Andrea Scaloni ◽  
Francesco Addeo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Negative Impact ◽  
Tap Water ◽  
Time Of Flight ◽  
The Other ◽  
Curing Process ◽  
Flight Mass Spectrometry ◽  
Water Curing ◽  
The Impact ◽  
By Products

Plant polyphenols have beneficial antioxidant effects on human health; practices aimed at preserving their content in foods and/or reusing food by-products are encouraged. The impact of the traditional practice of the water curing procedure of chestnuts, which prevents insect/mould damage during storage, was studied to assess the release of polyphenols from the fruit. Metabolites extracted from pericarp and integument tissues or released in the medium from the water curing process were analyzed by matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) and electrospray-quadrupole-time of flight-mass spectrometry (ESI-qTOF-MS). This identified: (i) condensed and hydrolyzable tannins made of (epi)catechin (procyanidins) and acid ellagic units in pericarp tissues; (ii) polyphenols made of gallocatechin and catechin units condensed with gallate (prodelphinidins) in integument counterparts; (iii) metabolites resembling those reported above in the wastewater from the chestnut curing process. Comparative experiments were also performed on aqueous media recovered from fruits treated with processes involving: (i) tap water; (ii) tap water containing an antifungal Lb. pentosus strain; (iii) wastewater from a previous curing treatment. These analyses indicated that the former treatment determines a 6–7-fold higher release of polyphenols in the curing water with respect to the other ones. This event has a negative impact on the luster of treated fruits but qualifies the corresponding wastes as a source of antioxidants. Such a phenomenon does not occur in wastewater from the other curing processes, where the release of polyphenols was reduced, thus preserving the chestnut’s appearance. Polyphenol profiling measurements demonstrated that bacterial presence in water hampered the release of pericarp metabolites. This study provides a rationale to traditional processing practices on fruit appearance and qualifies the corresponding wastes as a source of bioactive compounds for other nutraceutical applications.

Communication Process in Family Reinforcing the Gender Differences in Bangladesh

2016 ◽  
pp. 137-147
Author(s):  
Sabiha Yeasmin Rosy ◽  
Md. Mynul Islam
Keyword(s):  
Gender Differences ◽  
Negative Impact ◽  
The Other ◽  
Communication Process ◽  
Human Being ◽  
The Feminine ◽  
The World ◽  
Public World ◽  
And Behavior ◽  
The Impact

Family is an important institution to build a person's personality, morality, value and attitude. When this institution communicates properly, it shows the impact e.g. a boy or a girl becomes social human being. Unfortunately in our family gender biasness is reinforced continuously by starting to behave differently with boys and girls from the childhood. Parents communicate with them in a different way which constructs the traits of “masculinity” and “femininity”. Girls are compelled to learn the feminine role with politeness, submissiveness and their mobility is restricted in public world. It is a family which trains a girl to be a good mother, wife, sister or daughter, on the other hand a boy learns to be social, intellectual, able to run the world and strong. This different formation of role and behavior results in the ongoing discrimination everywhere in the society. This reinforcement is sort of relief from social stigmatization but has overall negative impact on life and through this family can be counted as the main birthplace of discrimination against women. Girls and boys must be raised neutrally to eradicate the gender differences and ensure the equality.

Digital Media and Memory Balkanization

2021 ◽  
Author(s):  
Francis L.F. Lee ◽  
Joseph M. Chan
Keyword(s):  
Social Media ◽  
Hong Kong ◽  
Collective Memory ◽  
Digital Media ◽  
Negative Impact ◽  
The Other ◽  
Other Hand ◽  
Political Forces ◽  
The One ◽  
The Impact

Chapter 8 discusses the impact of digital media on collective memory. The chapter examines both the positive and negative impact of digital and social media. On the one hand, the analysis notes how digital media provided the channels for memory mobilization and the archives for memory transmission. On the other hand, the analysis examines the problematics of memory balkanization. It explicates how political forces have shaped the development of digital and social media in Hong Kong and how competing representations of the Tiananmen Incident and commemoration activities are articulated and reinforced within distinctive memory silos.

scholarly journals The Impact of Primary Care: A Focused Review

Scientifica ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-22 ◽  
Author(s):  
Leiyu Shi
Keyword(s):  
Primary Care ◽  
Health Outcomes ◽  
Negative Impact ◽  
Healthcare Services ◽  
The United States ◽  
Emergency Department Visits ◽  
Care Practice ◽  
Quality Healthcare ◽  
The Usa ◽  
The Impact

Primary care serves as the cornerstone in a strong healthcare system. However, it has long been overlooked in the United States (USA), and an imbalance between specialty and primary care exists. The objective of this focused review paper is to identify research evidence on the value of primary care both in the USA and internationally, focusing on the importance of effective primary care services in delivering quality healthcare, improving health outcomes, and reducing disparities. Literature searches were performed in PubMed as well as “snowballing” based on the bibliographies of the retrieved articles. The areas reviewed included primary care definitions, primary care measurement, primary care practice, primary care and health, primary care and quality, primary care and cost, primary care and equity, primary care and health centers, and primary care and healthcare reform. In both developed and developing countries, primary care has been demonstrated to be associated with enhanced access to healthcare services, better health outcomes, and a decrease in hospitalization and use of emergency department visits. Primary care can also help counteract the negative impact of poor economic conditions on health.

Serum Ferritin and Cardiac/Liver Magnetic Resonance Imaging In Evaluating Iron Overload for Patients with Bone Marrow Failure Conditions Undergoing Non-Myeloablative HSCT

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1331-1331
Author(s):  
Victoria J Tindell ◽  
Victoria T Potter ◽  
Rachel Kesse-Adu ◽  
Laura Reiff-Zall ◽  
Aloysius Y Ho ◽  
...  
Keyword(s):  
Iron Overload ◽  
Serum Ferritin ◽  
Bone Marrow Failure ◽  
Acute Phase Reactant ◽  
Hepatic Iron ◽  
Red Cell ◽  
Resonance Imaging ◽  
Phase Reactant ◽  
The Impact ◽  
T2 Mri

Abstract Abstract 1331 Several groups have identified iron overload, in terms of raised pre-transplant serum ferritin levels, as an independent adverse prognostic factor for patients undergoing myeloablative HSCT. While serum ferritin has been used as a common marker in clinical studies to evaluate the impact of iron overload following allogeneic transplantation, there are limitations to its use with it being an acute phase reactant, as well as its lack of specificity for predicting end-organ toxicities. Patients undergoing HSCT for bone marrow failure (BMF) syndromes usually have a significant red cell transfusion history, and although the majority of these patients receive non-myeloablative HSCT regimens, it is unclear as to the impact of iron overload in these patients on subsequent transplant outcomes. In order to address these questions, we performed a prospective study evaluating the pre-transplant serum ferritin together with concurrent T2* cardiac magnetic resonance imaging (MRI) and R2 liver MRI in 18 patients with BMF syndromes undergoing allogeneic HSCT. The diagnosis of the patients included MDS (RCMD/hypoplastic MDS) =10, acquired aplastic anaemia =7, fanconi anaemia =1. The median age of the patients at transplantation was 42 years, and all patients received a T-cell depleted non-myeloablative HSCT. All patients were transfusion dependent pre-HSCT, with a median number of red cell transfusions of 45 (range: 8–115). Pre-HSCT ferritin was performed within 2 weeks of HSCT, and the results were correlated with albumin and C-reactive protein to reduce the impact of ferritin as an acute phase reactant. T2* and R2 MRI were similarly performed within 2 weeks of HSCT. The median pre-HSCT ferritin was significantly raised at 2119 ug/l(range: 559–12235). In contrast, the T2* cardiac MRI was normal for all but one patient who had evidence of mild cardiac iron overload. All patients had a corresponding cardiac echocardiogram performed with an ejection fraction within normal limits. For the liver T2* MRI, 7 patients had evidence of none or mild hepatic iron overload, while 11 patients had moderate to severe iron overload. There was no correlation between pre-HSCT transfusion burden and serum ferritin levels. Furthermore, there was no correlation between either the transfusion burden or serum ferritin, and the T2*MRI readings. In terms of HSCT outcome, the median time to neutrophil engraftment was 14 days. 2 patients had primary graft failure and only 1 patient died within 100 days due to an intra-cerebral haemorrhage. No patients had any clinical features of hepatic veno-occlusive disease (VOD), and 5 patients had evidence of grade I-II acute grade versus-host-disease. Data were also collected on the incidence of bacterial, fungal and viral infections post-HSCT for the cohort. There was however no significant association between transfusion burden, serum ferritin or T2* imaging and any of the HSCT outcomes (engraftment/day 100 TRM, GvHD, VOD or infections). In the context of heavily transfused BMF patients receiving allogeneic HSCT, serum ferritin does not correlate with end-organ deposition of iron. Despite the high transfusion burden in our cohort of patients, cardiac deposition of iron appears minimal while hepatic iron deposition is significant in a large proportion of patients. Reassuringly, a raised iron overload by either of the above mentioned parameters had no effect on HSCT outcomes. Our findings highlight the limitations of using serum ferritin as a marker of iron overload pre-HSCT. The role of active pre-HSCT chelation of BMF patients receiving non-myeloablative HSCT regimens remains unclear, and further studies are warranted. Disclosures: No relevant conflicts of interest to declare.

scholarly journals MODELING OF THE OPTIMAL DISTRIBUTION OF MOTORWAY OVERPASSES ON THE EXAMPLE OF THE A4 MOTORWAY SECTION

2018 ◽  
Author(s):  
Stanisław BACIOR ◽  
Barbara PRUS ◽  
Małgorzata DUDZIŃSKA
Keyword(s):  
Agricultural Production ◽  
Agricultural Land ◽  
Negative Impact ◽  
The Other ◽  
Toxic Impact ◽  
Innovative Method ◽  
Alternative Location ◽  
Under Construction ◽  
The Impact

The developed, innovative method of estimating the impact of motorway on agricultural land allows determination of all the losses associated with the directions of this impact. The basis for the determination of losses is the analysis of variability in land use and the quality classes and location of access roads to the land along the axis of the planned motorway. The approved measure of the multidirectional impact of the motorway on agricultural land is a change in the value of land, which is designated taking into account the differentiation of their suitability for agricultural production. The developed method of determining the impact of motorway on agricultural land was presented on the example of A4 motorway section between Bratkowice and Mrowla. The existing section of motorway was assessed and then for the same section the calculations were made again, but with an alternative location of the motorway overpasses. In the case of the existing section, the construction of one kilometer of the section of motorway under consideration will result in a reduction in the value of agricultural land of 1725 cereal units. Acquisition of land for the construction of the motorway and its negative impact cover about 69% of the total reduction in value of agricultural land. The remaining 31% of the land value reduction is related to the increase in transport and the deterioration of the parcels layout. On the other hand, in the case of the section with alternative arrangement of viaducts, the value of agricultural land is reduced of 1538 cereal units. Acquisition of land under construction and its toxic impact will be equal 75%, while the combined effect of transport growth and deterioration of the layout makes 25%.

scholarly journals THE ESSENCE OF THE POTENTIAL OF OVERCOMING THE GLOBAL ECONOMIC CRISIS CONSEQUENCES

2021 ◽  
Vol 1 (22(50)) ◽  
pp. 17-23
Author(s):  
Yuliia Lola
Keyword(s):  
Economic Growth ◽  
Public Administration ◽  
Global Financial Crisis ◽  
Negative Impact ◽  
Economic Effect ◽  
Economic Potential ◽  
Social Production ◽  
Significant Drop ◽  
Digital World ◽  
The Impact

The technical structure of society and the existing concept of capitalist economic development cannot meet the current challenges of the XXI century, so it is important to consider the anti-crisis potential of countries, taking into account the conditions of its formation and use. Radical changes in the conditions of formation and attraction of anti-crisis potential require clarification of its essence taking into account the adaptability of public administration, technical capabilities of social production, as well as the human ability to make complex decisions on more efficient combination of resources in uncertainty. In terms of the 6th and 7th technological system, the "potential of regional development" is proposed to be defined as the ability of societies of certain territories to create metacognitive technologies to increase resource efficiency and the ability of societies to quickly integrate into the digital world. The development potential provides the system's ability to adapt to crisis phenomena and maintain the trend of economic growth. The anti-crisis potential (as additional), is involved in the impact of crisis phenomena and helps to overcome the negative impact that has led to a sharp decline in economic growth. A characteristic feature of the "crisis potential" concept is the ability to attract additional resources during the crisis, with the decisive role played by the level of adaptability of public administration, technical capabilities of social production, as well as the ability of labor to make complex decisions in uncertainty. Anti-crisis potential is an opportunity that in the process of anti-crisis management is transformed into an effective mechanism for counteracting crisis phenomena. In countries with strong economies (USA, Austria, Germany, France, Spain) there is a significant drop in GDP per capita during the global financial crisis of 2020, which was triggered by the coronavirus SARS-CoV-2. At the same time, there are countries (Israel, China), whose economic condition not only has not deteriorated, but undergone even further sustainable development. This trend is due to the fact that for some systems the crisis is not only a threat, but also provides opportunities for the formation of new combinations of resources, which leads to a significant economic effect and further development. If we conduct research the trends of countries' response to global crises and exit from crises, we can see different trajectories. It has been proven that some countries in the world are strengthening their economies after economic crises, so the term "economic potential of the global crisis" has been proposed. The economic potential of the crisis is the possibility for strong economic growth in the region, the ability of the national economy to achieve a strategic goal by using changes in the international market, changing the positions on the international arena.

The Impact of Anneal on Electromigration of Copper Interconnect and the Optimized Anneal Technology Study

2012 ◽  
Vol 482-484 ◽  
pp. 1188-1191
Author(s):  
Ming Du ◽  
Pei Jun Ma ◽  
Yue Hao
Keyword(s):  
Negative Impact ◽  
The Other ◽  
Technology Study ◽  
Accelerated Failure ◽  
Cu Interconnect ◽  
Interconnect System ◽  
The Impact ◽  
Interconnect Technology ◽  
Anneal Temperature ◽  
Anneal Time

The theoretical and experimental work is executed for study the impact of anneal on the grain size, electromigration (EM) reliability of copper (Cu) interconnect system, and subsequently find the optimized anneal condition. EM accelerated failure tests are carried on the Cu interconnect samples with 0.2μm line width, which are produced at different anneal conditions. It is shown that anneal can lead the grains to grow to become larger, and lessen the EM diffuse path. As a result, the EM diffuse active energy (Ea) of Cu interconnect is enhanced, and the ability against the EM of Cu interconnect is improved. By comparing the EM character of Cu interconnects produced at different anneal conditions, results can be obtained as below: the anneal time should be maintained 40 minutes at least in order to achieve fully anneal and excellent ability against the EM; the anneal temperature should be set about 350°C approximately, because high temperature (beyond 400°C) anneal can induce the other reliability issues, which will have a strong negative impact on the EM reliability. The results in this paper are significance for Cu interconnect technology optimize and are beneficial to improve the EM reliability of the Cu interconnect system.

scholarly journals Dampak Pembangunan Obyek Wisata Waterboom dalam Kehidupan Sosial-Ekonomi Masyarakat Desa Mekar Jaya Kabupaten Belitung Timur

2021 ◽  
Vol 7 (3) ◽  
pp. 531
Author(s):  
Yuliana Krismonni ◽  
Putra Pratama Saputra
Keyword(s):  
Negative Impact ◽  
Positive Impact ◽  
Secondary Data ◽  
Economic Life ◽  
The Other ◽  
Primary Data ◽  
Tourist Attraction ◽  
Other Hand ◽  
The People ◽  
The Impact

ABSTRAKPembangunan merupakan suatu proses yang mengarah pada perubahan dalam kehidupan masyarakatnya, baik dari kehidupan sosial, ekonomi, politik dan lain sebagainya menuju arah yang lebih baik lagi. Pada dasarnya dalam suatu pembangunan ditujukan bagi masyarakatnya. Disisi lain hal ini juga bisa berimplikasi atau berdampak bagi kehidupan masyarakatnya. Pembangunan yang tidak berorientasi pada masyarakatnya tentunya akan memberikan dampak yang negatif pula kepada masyarakatnya, dan sebaliknya pembangunan yang berorientasikan kepada masyarakatnya tentu akan memberikan dampak yang positif pula tidak hanya bagi masyarakatnya, juga bagi pihak yang terlibat dalam proses pembangunan tersebut.Adapun tujuan penelitian ini adalah untuk melihat bagaimana dampak yang ditimbulkan dari adanya pembangunan objek wisata ini bagi kehidupan sosial-ekonomi masyarakatnya, dan melihat apakah dengan adanya objek wisata ini dapat mensejahterahkan hidup masyarakatnya. Penelitian ini menggunakan pendekatan deskriptif kualitatif, dengan data primer yang diperoleh dari wawancara dengan informan, dan data sekunder berupa beberapa jurnal, literatur review, dan bebetapa penelitian terdahulu, penelitian ini dilakukan di Desa Mekar Jaya Kecamatan Manggar Kabupaten Belitung Timur. Hasil dari penelitian ini yakni adanya pembangunan unit usaha waterboom ini pada kenyataannya belum terlalu memberikan dampak yang cukup signifikan bagi kehidupan sosial ekonomi masyarakatnya. Hal tersebut dapat terlihat karena dari segi pembangunan yang dilakukan belum terlaksana sepenuhnya, karena terkendala dalam beberapa hal. Sehingga hal ini menghambat dalam proses pembangunan yang ada.  ABSTRACTDevelopment is a process that leads to changes in the life of the people, from social, economic, political and other life towards a better direction. Basically, in a development aimed at the community. On the other hand, this can also have implications or impacts on the life of the community. Development that is not oriented towards the community will certainly have a negative impact on the community, and on the other hand, development that is oriented towards the community will certainly have a positive impact not only on the community, but also for those involved in the development process.The purpose of this research is to see how the impact of the development of this tourist attraction for the socio-economic life of the people, and to see whether the existence of this tourist attraction can make the lives of the people prosperous. This study uses a qualitative descriptive approach, with primary data obtained from interviews with informants, and secondary data in the form of several journals, literature reviews, and some previous research. The result of this research is that the development of the waterboom business unit has not had a significant impact on the socio-economic life of the community. This can be seen because from a development perspective it has not been fully implemented, due to constraints in several ways. So that this hinders the existing development process.

scholarly journals Airport Railroad Service Kualanamu Elasticity (Airport Railink Service)

2018 ◽  
Vol 2 (1) ◽  
pp. 22-33
Author(s):  
Mariana Diah Puspitasari ◽  
Dedik Tri Istiantara
Keyword(s):  
Travel Time ◽  
The Other ◽  
Demand Elasticity ◽  
Private Company ◽  
Train Station ◽  
Ticket Price ◽  
International Airport ◽  
Link Service ◽  
The Impact ◽  
First Time

In July 25th, 2013 Indonesia for the first time provided rail link service from and to an airport. It particularly was operated from and to Kualanamu International Airport (KNIA), Deli Serdang, North Sumatera, which was also operated for the first time on that date. Managing the airport rail link service, a private company namely PT. Railink basically is the subsidiary company of PT. Angkasa Pura II (Persero) and PT. Kereta Api Indonesia (Persero). The price of train ticket, in fact, is getting higher as time goes by. It is noted that the ticket price has increased from IDR 80K to IDR 100K since January 15th, 2015. Concerning this situation, this study is conducted to investigate the demand elasticity of the airport rail link service from and to Kualanamu International Airport as well as factors in taking the airport rail link. The result of the study reveals that the demand of airport rail link service as the impact of the increasing of the ticket price is inelastic since its value of elasticity reaches -0.38. The other result, moreover, finds six reasons influencing people to go with airport rail link: comfort, punctuality, speed or travel time, practicality, access to train station, and other modes’ tariff.

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