scholarly journals Effects of Tai Chi on Biomarkers and Their Implication to Neurorehabilitation – A Systemic Review

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 902-902
Author(s):  
Hao (Howe) Liu ◽  
Yasser Salem
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Neurotrophic Factors ◽  
Tai Chi ◽  
Exercise Program ◽  
Stress Factors ◽  
Systemic Review ◽  
Therapeutic Exercise ◽  
Reactive Protein ◽  
Necrosis Factor

Abstract Introduction As an effective holistic therapeutic exercise program, Tai Chi (TC) has been widely used for patients with a variety of neurological disorders. In last 1-2 decades, there has been an increase in the number of research studies that examined the TC effects on biomarkers including inflammatory cytokines, oxidative stressors, and neurotrophic factors. Thus, the purpose of this article is to review such effects and their possible implications to neurorehabilitation. Method: In this systematic review, we searched TC-related articles from the last 15 years until July 2020 that had investigated changes of biomarkers after TC practice. The search identified 24 studies that were included in our analysis. Results It is found that TC practice is able to 1) reduce pro-inflammatory and increase anti-inflammatory cytokines (including Interleukins -1, 6, 10, 12, tumor necrosis factor, the nuclear factor kappa-light-chain-enhancer of activated B cells, and the C-reactive protein); 2) decrease oxidative stress factors (like plasma 8-isoprostane, malondialdehyde, and protein carbonylation); and 3) increase neurotrophic factors (brain-derived neurotrophic factor (BDNF), and N-Acetylaspartate). Conclusions TC may take effect on patients with neurological dysfunctions through anti-inflammation, anti-oxidative stress, and neural health promotion.

scholarly journals MALONDIALDEHYDE, ADIPONECTIN, NITRIC OXIDE, C-REACTIVE PROTEIN, TUMOR NECROSIS FACTOR-ALPHA AND INSULIN RESISTANCE RELATIONSHIPS AND INTER-RELATIONSHIPS IN TYPE 2 DIABETES EARLY STAGE IS METFORMIN ALONE ADEQUATE IN THIS STAGE

2017 ◽  
Vol 9 (10) ◽  
pp. 176 ◽  
Author(s):  
Entsar A Saad ◽  
Salem A. Habib ◽  
Wael A. Refai ◽  
Amira A. Elfayoumy
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Type 2 Diabetes ◽  
Tumor Necrosis ◽  
Early Stage ◽  
Inflammation Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Necrosis Factor

Objective: Great interest is directed to inflammation and oxidative stress involvement in type 2 diabetes pathogenesis. Many researchers suggest they play roles but exactly how is still not clear enough. This encouraged us to investigate relations and potential inter-relationships between them and insulin resistance in type 2 diabetes in its early stage. Whether metformin drug alone, as frequently prescribed, is enough for type 2 diabetes management in this early stage was an objective.Methods: Blood sugar indices, adiponectin (ADIPOQ), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), nitric oxide (NO), C-reactive protein (CRP), liver and kidney function tests and lipid profile were monitored in non-diabetic volunteers, pre-diabetic and newly diagnosed type 2 diabetic patients before and after metformin drug utilization for 5 mo.Results: MDA, inflammation markers and alanine aminotransferase (ALT) were elevated, and blood sugar indices and lipid profile showed pathological alterations in diabetics compared to non-diabetics; changes were worse in type 2 cases. They were improved to different degrees by metformin treatment except for pancreatic β-cells function and ADIPOQ level showed no significant improvements and it couldn’t normalize ALT.Conclusion: Results reflected significant relations and inter-relationships between oxidative stress and inflammation markers in type 2 diabetes in its early stage and indicated that metformin may need to be combined with another drug. 

scholarly journals The Influence of Sevelamer Hydrochloride and Calcium Carbonate on Markers of Inflammation and Oxidative Stress in Hemodialysis at Six Months of Follow-Up

2021 ◽  
Vol 8 ◽  
Author(s):  
Elodia Nataly Díaz-De la Cruz ◽  
José Ignacio Cerrillos-Gutiérrez ◽  
Andrés García-Sánchez ◽  
Carlos Gerardo Prado-Nevárez ◽  
Jorge Andrade-Sierra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Calcium Carbonate ◽  
Inflammatory Cytokines ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Sevelamer Hydrochloride ◽  
Tnf Α ◽  
Compensatory Effect ◽  
Pro Inflammatory Cytokines

Patients with end-stage renal disease (ESRD) present alterations in mineral and bone metabolism. Hyperphosphatemia in ESRD is considered an independent risk factor for cardiovascular disease (CVD), increasing morbidity, and mortality. Sevelamer hydrochloride is a calcium-free, non-absorbable phosphate-chelating polymer. Calcium carbonate chelator is helpful in controlling serum phosphate levels. There is insufficient information on the influence of sevelamer hydrochloride and calcium carbonate on the behavior of oxidative stress (OS) markers and inflammation in patients on hemodialysis (HD). A randomized open clinical trial was carried out on patients to evaluate sevelamer hydrochloride and calcium carbonate influence at 6 months of study follow-up. Levels of oxidants (LPO, NO, and 8-isoprostanes), antioxidants (SOD and TAC), oxidative DNA damage (8-OHdG and hOGG1), pro-inflammatory cytokines (IL-6 and TNF-α), and inflammation markers (ferritin and C-reactive protein) were measured with colorimetric and ELISA methods. We found a significant increase in oxidants LPO and NO, and antioxidants SOD and TAC, and downregulation of IL-6 and TNF-α. Ferritin decrease at 6 months follow-up in the sevelamer hydrochloride group. Increase in C-reactive protein was found in the group of patients treated with calcium carbonate. In conclusion, we found an oxidative state imbalance with increase in LPO and NO oxidants. The activity of the antioxidant enzymes (SOD and TAC) was also found to increase, suggesting a compensatory effect in the face of increase in oxidants. The same phenomenon was observed with increase in the oxidative damage marker to DNA and the increase in the DNA repair enzyme, suggesting a compensatory effect. Pro-inflammatory cytokines were predominantly downregulated by TNF-α in the group that ingested sevelamer hydrochloride in the final determination at 6 months of follow-up. Serum ferritin levels decreased significantly at the end of follow-up in patients on HD in the sevelamer hydrochloride group. The management of hyperphosphatemia with sevelamer hydrochloride appears to have obvious anti-inflammatory and antioxidant benefits.

A Pilot Study to Evaluate the Effects of Oral N-Acetyl Cysteine on Inflammatory and Oxidative Stress Biomarkers in Rheumatoid Arthritis

2019 ◽  
Vol 15 (3) ◽  
pp. 246-253 ◽  
Author(s):  
Ghazal Hashemi ◽  
Mahtabalsadat Mirjalili ◽  
Zahra Basiri ◽  
Ahmad Tahamoli-Roudsari ◽  
Nejat Kheiripour ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Placebo Group ◽  
Inflammatory Cytokines ◽  
Serum Levels ◽  
Stress Factors ◽  
Oxidative Stress Biomarkers ◽  
Significant Difference ◽  
Acetyl Cysteine ◽  
And Oxidative Stress

<P>Background: Rheumatoid Arthritis (RA) is a common inflammatory disease of the joints. Due to the importance of inflammation and oxidative stress in the pathogenesis of RA, drugs that have anti-oxidant and anti-inflammatory properties, such as N-acetyl Cysteine (NAC), can be used as adjunctive therapy in patients with RA. </P><P> Aims: The aim of this study was to evaluate the effects of oral NAC on inflammatory cytokines and oxidative stress in patients with RA. </P><P> Methods: Adjunct to standard treatment, the NAC group (23 patients) received 600 mg of NAC twice daily and the placebo group (19 patients) received identical placebo twice daily for 12 weeks. Serum levels of Total Oxidant Status (TOS), Total Antioxidant Capacity (TAC), nitric oxide (NO), Total Thiol Groups (TTG), Malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-&#945;), interleukin- 6 (IL-6), C-reactive Protein (CRP), and Erythrocyte Sedimentation Rate (ESR) were measured at baseline and at the end of the study. </P><P> Results: Results showed that in the NAC group, the serum levels of MDA, NO, IL-6, TNF-&#945;, ESR and CRP were significantly lower than the baseline. Also, the serum level of TAC and TTG, as antioxidant parameters, increased significantly. However, only NO, MDA and TTG showed a significant difference in the NAC group as compared to the placebo group at the end of study. </P><P> Conclusion: According to the results of this study, oral NAC can significantly reduce the several oxidative stress factors and inflammatory cytokines. These results need to be confirmed in larger studies while considering clinical outcomes of RA patients.</P>

Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment

2015 ◽  
Vol 45 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Seyed Isaac Hashemy ◽  
Shideh Gharaei ◽  
Samaneh Vasigh ◽  
Sanaz Kargozar ◽  
Banafsheh Alirezaei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Stress Factors ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Oral Lichen

scholarly journals The Effect of Aerobic Exercise & L-Carnitine Consumption on Diabetes Induced Apoptosis & Oxidative Stress Factors in Rat

2020 ◽  
Author(s):  
Meisam Soheil Pour ◽  
Nader Shakeri ◽  
Khosrow Ebrahim ◽  
Farshad Ghazalian
Keyword(s):  
Oxidative Stress ◽  
Aerobic Exercise ◽  
Exercise Program ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Stress Factors ◽  
P Value ◽  
Mitochondrial Enzymes ◽  
Enzymatic Antioxidants ◽  
Induced Apoptosis

Objective: The use of non-enzymatic antioxidants in the form of dietary supplements has a positive effect on reducing oxidative stress, and preventing apoptosis as they interrupt free radicals. The aim of this study was to investigate the aerobic exercise and Lcarnitine consumption impacts on diabetes induced apoptosis, oxidative stress factors, and mitochondrial enzymes in rats. Materials and Methods: In this Clinical trial study, 45 male Wistar rats (200-300 g) were divided into six groups including sham, healthy control, diabetic control, diabetic & L-carnitine, diabetic & aerobic exercise, diabetic receiving L-carnitine & aerobic exercise . The rats attained a diabetic state with a single dose of STZ intraperitoneal injection (55 mg/kg body weight) and receiving Lcarnitine 100 mg per day. The aerobic exercise protocol including five sessions per week was administered. The heart tissues of the dependent variables were measured by ELISA 24 hours after the last session of the exercise program. One-way ANOVA and Tukey's post hoc test at P -value< 0.05 were used to analyze the data. Results: result show that aerobic exercise and L-carnitine consumption have a significant effect on BAX ( P -value= 0.001), Bcl-2 ( P -value= 0.001), and SOD ( P -value= 0.001) in diabetic rats. Conclusion: The results of the present study confirm the role of aerobic exercise and L-carnitine in improving the indices of apoptosis and oxidative stress in type 2 diabetic rats.

Treatment of vertebral fractures due to osteoporosis

2015 ◽  
Vol 24 (01) ◽  
pp. 7-10 ◽  
Author(s):  
M. Pfeifer ◽  
M. Sinaki
Keyword(s):  
Exercise Program ◽  
Therapeutic Exercise ◽  
Training Support ◽  
Axial Stability ◽  
Extensor Muscles ◽  
Therapeutic Exercises ◽  
Increase Risk ◽  
Risk Of Falls ◽  
Risk Of Fall

SummaryThe objective of exercise in the treatment of osteoporosis is to improve axial stability through strengthening of back extensor muscles. Therefore, a back extension exercise program specific to one’s musculoskeletal competence and pain can be performed in a sitting position and later advanced to the prone position. When fragility is resolved, back extension is performed against resistance applied to the upper back. A significant reduction in back pain, kyphosis, and risk of falls and an improvement in the level of physical activity have been achieved through the SPEED (Spinal Proprioceptive Extension Exercise Dynamic) program. In addition, the application of a “Posture Training Support” (PTS) using a backpack may decrease kyphosis and pain related not only to compression fractures but also reduce iliocostal friction. Therapeutic exercise should address osteo - porosis-related deformities of axial posture, which can increase risk of fall and fracture. Thus, the role of a therapeutic exercise program is to increase muscle strength safely, decrease immobility-related complications, and prevent fall and fracture. As with pharmacotherapy, therapeutic exercises are individualized.

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