scholarly journals Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in Patients With Coronavirus Disease 2019

2020 ◽  
Vol 222 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Qing-Lei Zeng ◽  
Zu-Jiang Yu ◽  
Jian-Jun Gou ◽  
Guang-Ming Li ◽  
Shu-Huan Ma ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
Plasma Treatment ◽  
Critically Ill Patients ◽  
Plasma Therapy ◽  
Viral Shedding ◽  
Almost All ◽  
End Stage

Abstract Currently, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported in almost all countries globally. No effective therapy has been documented for COVID-19, and the role of convalescent plasma therapy is unknown. In the current study, 6 patients with COVID-19 and respiratory failure received convalescent plasma a median of 21.5 days after viral shedding was first detected, all tested negative for SARS-CoV-2 RNA within 3 days after infusion, and 5 eventually died. In conclusion, convalescent plasma treatment can end SARS-CoV-2 shedding but cannot reduce the mortality rate in critically ill patients with end-stage COVID-19, and treatment should be initiated earlier.

scholarly journals Convalescent plasma therapy: a promising coronavirus disease 2019 treatment strategy

Open Biology ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 200174 ◽  
Author(s):  
Ravikant Piyush ◽  
Keshav Rajarshi ◽  
Rajni Khan ◽  
Shashikant Ray
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health ◽  
H1n1 Pandemic ◽  
Plasma Therapy ◽  
Therapeutic Drugs ◽  
The World ◽  
Health Organization ◽  
Almost All ◽  
Day By Day

The world is passing through a very difficult phase due to the coronavirus disease 2019 (COVID-19) pandemic, which has disrupted almost all spheres of life. Globally, according to the latest World Health Organization report (10 August 2020), COVID-19 has affected nearly 20 million lives, causing 728 013 deaths. Due to the lack of specific therapeutic drugs and vaccines, the outbreak of disease has spawned a corpus of contagious infection all over the world, day by day, without control. As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a very rapid infection rate, it is essential to develop a novel ameliorative and curative strategy as quickly as possible. Convalescent plasma (CP) therapy is a type of adaptive immunity that has already been found to be effective in confronting several infectious diseases from the last two decades. For example, CP therapy was used in the treatment of viral-induced diseases like SARS-CoV epidemics, Middle East respiratory syndrome coronavirus (MERS-CoV) pandemics, Ebola epidemics and H1N1 pandemic. In this review, we have mainly focused on the therapeutic role of CP therapy and its neutralizing effect to fight against the COVID-19 outbreak.

Plasma therapy a possible hope to fight against COVID-19

2020 ◽  
Author(s):  
Ravikant Piyush ◽  
Aroni Chatterjee ◽  
Shashikant Ray
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Disease ◽  
Plasma Therapy ◽  
Therapeutic Drugs ◽  
Wild Fire ◽  
The World ◽  
Short Span ◽  
Game Changer

The world is currently going through a disastrous event and a catastrophic upheaval caused by the coronavirus disease 2019 (COVID-19). The pandemic has resulted in loss of more than 150000 deaths across the globe. Originating from China and spreading across all continents within a short span of time, it has become a matter of international emergency. Different agencies are adopting diverse approaches to stop and spread of this viral disease but still now nothing confirmatory has come up. Due to lack of vaccines and proper therapeutic drugs, the disease is still spreading like wild fire without control. An Old but very promising method- the convalescent plasma therapy could be the key therapy to stop this pandemic. This method has already proven its mettle on several occasions previously and has been found to be effective in curing the pandemics induced by Ebola, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the same group of β-Coronavirus that has resulted in the above diseases. Therefore, the role of plasma therapy is being explored for treatment of this disease. In this review, we have mainly focused on the role of convalescent plasma therapy and why its use should be promoted in fight against COVID-19, as it could turn out to be a game changer.

scholarly journals Thromboses and Hemostasis Disorders Associated with Coronavirus Disease 2019: The Possible Causal Role of Cross-Reactivity and Immunological Imprinting

2021 ◽  
Author(s):  
Darja Kanduc
Keyword(s):  
Immune System ◽  
Severe Acute Respiratory Syndrome ◽  
Natural Infection ◽  
Vascular Diseases ◽  
Cross Reactivity ◽  
Active Immunization ◽  
Thromboembolic Complications ◽  
Human Proteins ◽  
Almost All

AbstractBy examining the issue of the thromboses and hemostasis disorders associated with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) through the lens of cross-reactivity, it was found that 60 pentapeptides are shared by SARS-CoV-2 spike glycoprotein (gp) and human proteins that— when altered, mutated, deficient or, however, improperly functioning— cause vascular diseases, thromboembolic complications, venous thrombosis, thrombocytopenia, coagulopathies, and bleeding, inter alia. The peptide commonality has a relevant immunological potential as almost all of the shared sequences are present in experimentally validated SARS-CoV-2 spike gp-derived epitopes, thus supporting the possibility of cross-reactions between the viral gp and the thromboses-related human proteins. Moreover, many of the shared peptide sequences are also present in pathogens to which individuals have previously been exposed following natural infection or vaccinal routes, and of which the immune system has stored imprint. Such an immunological memory might rapidly trigger anamnestic secondary cross-reactive responses of extreme affinity and avidity, in this way explaining the thromboembolic adverse events that can associate with SARS-CoV-2 infection or active immunization.

scholarly journals Investigation of the Role of the Spike Protein in Reversing the Virulence of the Highly Virulent Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strains and Its Attenuated Counterpart

Viruses ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 41 ◽  
Author(s):  
Chi-Fei Kao ◽  
Hui-Wen Chang
Keyword(s):  
Mortality Rate ◽  
Porcine Epidemic Diarrhea Virus ◽  
Rational Design ◽  
Economic Losses ◽  
Diarrhea Virus ◽  
Viral Shedding ◽  
S Gene ◽  
Porcine Epidemic Diarrhea ◽  
Highly Virulent

Porcine epidemic diarrhea virus (PEDV) has continuously caused severe economic losses to the global swine industries; however, no successful vaccine against PEDV has been developed. In this study, we generated four autologous recombinant viruses, including the highly virulent iPEDVPT-P5, attenuated iPEDVPT-P96, and two chimeric viruses (iPEDVPT-P5-96S and iPEDVPT-P96-5S) with the reciprocally exchanged spike (S) gene, to study the role of the S gene in PEDV pathogenesis. A deeper understanding of PEDV attenuation will aid in the rational design of a live attenuated vaccine (LAV) using reverse genetics system. Our results showed that replacing the S gene from the highly virulent iPEDVPT-P5 led to complete restoration of virulence of the attenuated iPEDVPT-P96, with nearly identical viral shedding, diarrhea pattern, and mortality rate as the parental iPEDVPT-P5. In contrast, substitution of the S gene with that from the attenuated iPEDVPT-P96 resulted in partial attenuation of iPEDVPT-P5, exhibiting similar viral shedding and diarrhea patterns as the parental iPEDVPT-P96 with slightly severe histological lesions and higher mortality rate. Collectively, our data confirmed that the attenuation of the PEDVPT-P96 virus is primarily attributed to mutations in the S gene. However, mutation in S gene alone could not fully attenuate the virulence of iPEDVPT-P5. Gene (s) other than S gene might also play a role in determining virulence.

scholarly journals Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy

Circulation ◽  
2020 ◽  
Vol 142 (12) ◽  
pp. 1176-1189 ◽  
Author(s):  
Leo Nicolai ◽  
Alexander Leunig ◽  
Sophia Brambs ◽  
Rainer Kaiser ◽  
Tobias Weinberger ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Severe Acute Respiratory Syndrome ◽  
Disease Severity ◽  
Severe Pneumonia ◽  
Corona Virus ◽  
Coagulation Tests ◽  
Myocardial Involvement ◽  
Platelet Aggregates ◽  
Polymerase Chain

Background: Severe acute respiratory syndrome corona virus 2 infection causes severe pneumonia (coronavirus disease 2019 [COVID-19]), but the mechanisms of subsequent respiratory failure and complicating renal and myocardial involvement are poorly understood. In addition, a systemic prothrombotic phenotype has been reported in patients with COVID-19. Methods: A total of 62 subjects were included in our study (n=38 patients with reverse transcriptase polymerase chain reaction–confirmed COVID-19 and n=24 non–COVID-19 controls). We performed histopathologic assessment of autopsy cases, surface marker–based phenotyping of neutrophils and platelets, and functional assays for platelet, neutrophil functions, and coagulation tests, as well. Results: We provide evidence that organ involvement and prothrombotic features in COVID-19 are linked by immunothrombosis. We show that, in COVID-19, inflammatory microvascular thrombi are present in the lung, kidney, and heart, containing neutrophil extracellular traps associated with platelets and fibrin. Patients with COVID-19 also present with neutrophil-platelet aggregates and a distinct neutrophil and platelet activation pattern in blood, which changes with disease severity. Whereas cases of intermediate severity show an exhausted platelet and hyporeactive neutrophil phenotype, patients severely affected with COVID-19 are characterized by excessive platelet and neutrophil activation in comparison with healthy controls and non–COVID-19 pneumonia. Dysregulated immunothrombosis in severe acute respiratory syndrome corona virus 2 pneumonia is linked to both acute respiratory distress syndrome and systemic hypercoagulability. Conclusions: Taken together, our data point to immunothrombotic dysregulation as a key marker of disease severity in COVID-19. Further work is necessary to determine the role of immunothrombosis in COVID-19.

scholarly journals Analysis of the Effect of Emergency Ventilators on the Treatment of Critical Illness Based on Smart Medical Big Data

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Haiwang Sha ◽  
Fen He
Keyword(s):  
Respiratory Failure ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Pulmonary Ventilation ◽  
Clinical Manifestations ◽  
Effective Rate ◽  
Control Group ◽  
Oxygen Balance ◽  
Respiratory Muscle Fatigue

Respiratory failure refers to pulmonary ventilation and ventilatory dysfunction caused by various reasons, which makes the patient unable to maintain the gas exchange required for stillness and causes a series of pathophysiological changes and corresponding clinical manifestations. In order to solve the problem of respiratory failure in critically ill patients, it is of great significance to analyze the role of microprocessor-based emergency ventilator in the treatment of critically ill patients. This article aims to study the role of microprocessor-based emergency ventilator in the treatment of critically ill patients. This paper presents the key technology based on the ARM11 processor. A breathing motion model is detected and established through a ventilator. The research objects are mainly divided into group A and group B. By comparing the two groups of emergency ventilator ventilation, it can effectively prevent the increase in respiratory muscle fatigue, reduce oxygen consumption, improve the patient's ventilation function and oxygen balance, quickly correct hypoxia and carbon dioxide storage, cooperate with drug treatment, and quickly take out the ventilator after relief. Good treatment results were achieved. The results show that the emergency ventilator controlled by a microcomputer is effective. The total effective rate of the control group was 71.11%, which was significantly lower than that of the observation group (86.67%).

Impact Analysis of Machine Learning Techniques for COVID-19 Diagnosis: A Critical Review

2021 ◽  
Vol 12 (2) ◽  
pp. 510-516
Author(s):  
Anshul, Et. al.
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Severe Acute Respiratory Syndrome ◽  
Impact Analysis ◽  
Machine Learning Techniques ◽  
X Ray ◽  
Learning Techniques ◽  
The World ◽  
Almost All

COVID-19 virus belongs to the severe acute respiratory syndrome (SARS) family raised a situation of health emergency in almost all the countries of the world. Numerous machine learning and deep learning based techniques are used to diagnose COVID positive patients using different image modalities like CT SCAN, X-RAY, or CBX, etc. This paper provides the works done in COVID-19 diagnosis, the role of ML and DL based methods to solve this problem, and presents limitations with respect to COVID-19 diagnosis.

scholarly journals Upregulated IL-6 Indicates a Poor COVID-19 Prognosis: A Call for Tocilizumab and Convalescent Plasma Treatment

2021 ◽  
Vol 12 ◽  
Author(s):  
Jian Wu ◽  
Jiawei Shen ◽  
Ying Han ◽  
Qinghua Qiao ◽  
Wei Dai ◽  
...  
Keyword(s):  
Body Temperature ◽  
Severe Acute Respiratory Syndrome ◽  
Poor Prognosis ◽  
Health Conditions ◽  
Comprehensive Understanding ◽  
Dynamic Changes ◽  
Plasma Therapy ◽  
Inflammatory Conditions ◽  
Underlying Diseases

A comprehensive understanding of the dynamic changes in interleukin-6 (IL-6) levels is essential for monitoring and treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). By analyzing the correlations between IL-6 levels and health conditions, underlying diseases, several key laboratory detection indices, and the prognosis of 1,473 patients with the coronavirus disease 2019 (COVID-19), the role of IL-6 during SARS-CoV-2 infection was demonstrated. Our results indicated that IL-6 levels were closely related to age, sex, body temperature, oxygen saturation (SpO2) of blood, and underlying diseases. As a stable indicator, the changes in IL-6 levels could indicate the inflammatory conditions during a viral infection. Two specific treatments, namely, tocilizumab and convalescent plasma therapy (CPT), decreased the level of IL-6 and relieved inflammation. CPT has an important role in the therapy for patients with critical COVID-19. We also found that patients with IL-6 levels, which were 30-fold higher than the normal level, had a poor prognosis compared to patients with lower levels of IL-6.

scholarly journals GAMBARAN PERSEPSI MASYARAKAT TERHADAP PERAN DAN MOTIVASI BIDAN UNTUK MENURUNKAN ANGKA KESAKITAN DBD DI DESA SIAGA MORGO MULYO TAHUN 2017

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Rina Rina
Keyword(s):  
Infectious Disease ◽  
Mortality Rate ◽  
Dengue Fever ◽  
Sampling Technique ◽  
High Rate ◽  
Purposive Sampling ◽  
Descriptive Research ◽  
People’S Perception ◽  
Almost All

The high rate of morbidity and death from dengue fever is an infectious disease whose efforts to reduce the case related to national commitment and often appear as extraordinary events, this is seen from the high number of dengue cases in Indonesia as many as 8,487 people with Dengue Fever with the number of deaths 108 people and Bengkulu Province case encountered as many as 925 cases, and died 19 people, so the role of midwife as the spearhead in society is needed. This research aimed to find out the perception of society to the Role and Motivation of Midwife to Reduce the Figures of Dengue Fever in Siaga Morgo Mulyo village in 2017.This research is a descriptive research, the population were all families in Siaga Morgo Mulyo village in 2017 totaled 320 heads of family and the sample taken 39 people with purposive sampling sampling technique, with inclusion criterion sample which were those who were willing to become respondents and had an ability in read and writing.The results of this study indicated that people's perception on the role and motivation of midwives to reduce Dengue Fever morbidity in Siaga Morgo Mulyo village in 2017, most of the respondents (62.5%) had less perception on the role of midwives and almost all respondents (51.3 %) had less perception on midwife’s motivation to Reduce Dengue Fever Mortality Rate In Siaga Morgo Mulyo village in 2017.It is expected that medics especially midwives can emphasize by performing their role and motivation as midwife in reducing Dengue Fever morbidity.

scholarly journals Severe acute respiratory syndrome-coronavirus 2 in domesticated animals and its potential of transmission: A meta-analysis

2021 ◽  
pp. 2782-2792
Author(s):  
Yos Adi Prakoso ◽  
Chylen Setiyo Rini ◽  
Yuli Purwandari Kristianingrum ◽  
Nurul Hidayah ◽  
Dyah Widhowati ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Neutralizing Antibodies ◽  
Meta Analysis ◽  
Clinical Signs ◽  
Etiologic Agent ◽  
Domesticated Animals ◽  
Viral Shedding ◽  
Pubmed Database ◽  
Short Period

Background and Aim: The coronavirus diseases-2019 (COVID-19) pandemic has caused a global lockdown, which has limited the mobility of the public, and thus, more time is spent with their pets. Unfortunately, many social media have blamed pet animals as a reservoir of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, triggering a panic abandonment of pets. However, no article has summarized the information regarding the role of pets as SARS-CoV-2 reservoirs. This study aimed to evaluate the role of pets as a reservoir of SARS-CoV-2 on the basis of research papers (i.e., animal model, surveillance, and case report) published in 2020. Materials and Methods: The review was conducted using articles from the PubMed database in 2020, using the keywords "COVID-19 in domesticated animals," which were screened and analyzed. Only the data from research articles were mimicked and transformed to conduct a meta-analysis. The meta-analysis was conducted regarding the effects of inhabitation and viral shedding in pets. In this study, we used 95% confidence intervals. Results: A total of 132 papers in PubMed were related to the keywords, whereas only 12 papers were appropriate to answer the dynamics of the role of pets as the reservoir for SARS-CoV-2. Seven studies indicated the potential of cat-cat (4/7), human-cat (2/7), and human-dog (1/7) SARS-CoV-2 transmission. No study proved the presence of cat-human transmission. Another study showed that comingling did not affect SARS-CoV-2 viral shedding among a cat and dog. Furthermore, the viral shedding of cats and dogs caused asymptomatic manifestations and generated neutralizing antibodies within a short period of time. Conclusion: SARS-CoV-2 transmission is present in domesticated animals, especially in pet cats and dogs, and transmission occurs between animals of the same species (cat-cat). The reverse zoonosis (zooanthroponosis) was found from human to cat/dog (comingled) with asymptomatic clinical signs due to the representation of neutralizing antibodies.

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