Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle

2021 ◽  
Author(s):  
N G Briggs ◽  
B C Silva ◽  
L A Godoi ◽  
J P Schoonmaker
Keyword(s):  
Negative Impact ◽  
Average Daily Gain ◽  
Mucosal Injury ◽  
Feedlot Cattle ◽  
Carcass Composition ◽  
Leaky Gut ◽  
Marbling Score ◽  
Amyloid A ◽  
Negative Impacts

Abstract The negative impacts of stress on gastrointestinal (GIT) barrier function can result in compromised animal growth and health. Aspirin is known to cause mucosal injury leading to increased gut permeability and tight junction damage and can be used as a model to study leaky gut in cattle. The objective of this study was to determine the long-term impact of aspirin induced chronic leaky gut on cattle growth and carcass attributes. Two treatments were evaluated in 2 studies: control (no aspirin) or 0.25% of the diet DM aspirin fed daily. Diets consisted of 50% corn, 24% dried distillers grains, 20% corn silage and 6 % supplement on a DM basis. In experiment 1, sixteen Angus x Simmental heifers, allotted by BW and breed composition, were fed diets for 154 d. On day 155, heifers were dosed with 1 L of a 180 mM Cr-EDTA solution using an esophageal tube and had urine collected every 1.5 to 3 h for 48 h for analysis of Cr as a measure of gut leakiness. In experiment 2, ninety-six Simmental x Angus steers (355.0 ± 14.8 kg) were allotted by body weight and breed composition and fed treatment diets for 159 d. Weight was recorded monthly and serum was collected on d 159 and analyzed for lipopolysaccharide binding protein (LBP), interleukin-6 (IL-6), serum amyloid A (SAA), haptoglobin, and aspartate aminotransferase (AST). Data were analyzed using the MIXED procedure of SAS. Heifers fed 0.25% aspirin in experiment 1 excreted more Cr into urine compared to heifers not fed aspirin (overall treatment effect, P = 0.01). In experiment 2, aspirin tended to increase serum LBP (P = 0.06), but had no effect on concentrations of IL-6, haptoglobin, SAA, or AST (P ≥ 0.25). Aspirin tended to decrease average daily gain (P = 0.10), decreased hot carcass weight and rib-eye area (P ≤ 0.05), and increased fat thickness, marbling score, and yield grade (P ≤ 0.02). Aspirin tended to increase KPH% (P = 0.10) and had no effect on liver abscesses (P ≥ 0.80). This study indicates that leaky gut induced by long-term administration of aspirin has negative impacts on feedlot performance and carcass composition. The negative impact of aspirin induced leaky gut on animal performance suggests that chronic leaky gut caused by other factors (subacute acidosis, stress) may be a significant problem for the feedlot industry.

scholarly journals PSII-12 Effect of aspirin to intentionally induce leaky gut on performance, blood markers of stress, and carcass characteristics of feedlot cattle

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 398-399
Author(s):  
Nathan Briggs ◽  
Jon P Schoonmaker
Keyword(s):  
Body Weight ◽  
Negative Impact ◽  
Animal Health ◽  
Average Daily Gain ◽  
Feedlot Cattle ◽  
Leaky Gut ◽  
Marbling Score ◽  
Amyloid A ◽  
Negative Impacts

Abstract The negative impacts of stress on gastrointestinal (GIT) barrier function can result in compromised animal health. Aspirin (acetylsalicylic acid) is known to cause mucosal injury leading to increased gut permeability and tight junction damage. The objective of this study was to determine the long-term impact of leaky gut on animal physiology. In this experiment, 96 Simmental x Angus steers (355 ± 14.8 kg) were allotted by body weight and breed into two treatments: control (no aspirin) or aspirin fed at 50 mg/kg/d for 159 d. Steers were housed in 16 pens (8 pens/treatment) with 6 steers in each pen. Weight was recorded monthly and serum was collected on d 159 to be analyzed for lipopolysaccharide binding protein (LBP), interleukin-6 (IL-6), serum amyloid A (SAA), haptoglobin, and aspartate aminotransferase (AST). Data were analyzed using the MIXED procedure of SAS. Average daily gain (ADG) tended to decrease in cattle fed aspirin (P= 0.10). Aspirin decreased hot carcass weight (P= 0.05) and rib-eye area (P= 0.01)and increased fat thickness (P= 0.02), marbling score (P = 0.003), and yield grade (P = 0.01). Percent KPH tended to increase (P= 0.10) for steers fed aspirin. Aspirin had no effect on body weight, dry matter intake, gain:feed, days on feed, dressing percentage, liver abscess score, or percent liver abscesses. Aspirin tended to increase serum LBP (P= 0.07), but had no effect on serum concentrations of IL-6, haptoglobin, SAA, and AST (P≥ 0.30). This study indicates that leaky gut induced by long-term administration of aspirin has negative impacts on feedlot performance and carcass leanness. The negative impact of aspirin induced leaky gut on animal performance suggests that leaky gut caused by other factors (subacute acidosis, stress) may be a significant problem for the feedlot industry.

Carcass characteristics and tissue-mineral contents of steers fed supplemental chromium

1992 ◽  
Vol 72 (3) ◽  
pp. 663-669 ◽  
Author(s):  
X. Chang ◽  
D. N. Mowat ◽  
G. A. Spiers
Keyword(s):  
Average Daily Gain ◽  
Carcass Characteristics ◽  
Liver Weight ◽  
Carcass Composition ◽  
Marbling Score ◽  
Mineral Contents ◽  
Tissue Samples ◽  
Growing Period ◽  
Finishing Steers ◽  
Kidney Fat

This study investigated the effects of supplemental chromium (Cr) (0 or 0.2 mg kg−1 from high-Cr yeast) on performance, carcass characteristics and tissue-mineral contents of growing–finishing steers fed corn silage supplemented with either urea–corn or soybean meal during the growing period and a high-grain diet during the finishing period. Ninety-six Charolais-crossed steers, divided into four treatment groups with 24 animals each, were fed for a 70-d growing period followed by a 68-d finishing period. After continuous supplemental Cr, steers were commercially slaughtered and their carcass characteristics were evaluated. Tissue samples, including loin-eye lean and rib fat, liver and kidney, were analyzed for Cr and other minerals (P, Ca, Mg, Fe, Zn and Cu). Supplemental Cr had no effects (P > 0.05) on average daily gain (ADG), dry-matter intake, (DMI), feed efficiency (ADG/DMI), and carcass characteristics, including dressing percentage, loin-eye area, backfat thickness, marbling score, kidney fat and liver weight. Proportion of lean, fat and bone in rib sections was not affected (P > 0.05) by Cr supplementation. Supplemental Cr also did not affect (P > 0.05) total-tissue Cr and other mineral concentrations. However, supplemental Cr increased (P < 0.05) the Cu level of livers in steers fed urea–corn supplements during the growing period. This study showed that continuous supplementation of Cr (0.2 mg kg−1) to unstressed growing-finishing steers had no effect on carcass composition and several minerals in various tissues. Key words: Chromium, steer, carcass, tissue

scholarly journals The influence of shade allocation or total shade plus overhead fan on growth performance, efficiency of dietary energy utilization, and carcass characteristics of feedlot cattle under tropical ambient conditions

2020 ◽  
Vol 33 (6) ◽  
pp. 1034-1041
Author(s):  
Beatriz I. Castro-Pérez ◽  
Alfredo Estrada-Angulo ◽  
Francisco G. Ríos-Rincón ◽  
Víctor H. Núñez-Benítez ◽  
Carlos R. Rivera-Méndez ◽  
...  
Keyword(s):  
Growth Performance ◽  
Energy Requirement ◽  
Average Daily Gain ◽  
Carcass Characteristics ◽  
Feedlot Cattle ◽  
Energy Utilization ◽  
Maximum Temperature ◽  
Dietary Energy ◽  
Marbling Score ◽  
Quadratic Effect

Objective: The objective of this experiment was to evaluate the effect of shade allocation and shade plus fan on growth performance, dietary energy utilization and carcass characteristics of feedlot cattle under tropical ambient conditionsMethods: Two trials were conducted, involving a total of 1,560 young bulls (289±22 kg BW) assigned to 24 pens (65 bulls/pen and 6 pens/treatment). Pens were 585 m<sup>2</sup> with 15 m fence line feed bunks. Shade treatments (m<sup>2</sup> shade/animal) were: i) limited shade (LS) to 1.2 m<sup>2</sup>shade/animal (LS<sub>1.2</sub>); ii) limited shade to 2.4 m<sup>2</sup> shade/animal (LS<sub>2.4</sub>); iii) total shade (TS) which correspond to 9 m<sup>2</sup>/animal, and iv) total shade equipped with fans (TS+F). Trials lasted 158 and 183 days. In both studies, the average weekly maximum temperature exceeded 34°C.Results: Increasing shade allocation tended (p = 0.08) to linearly increases average daily gain (ADG), and dry matter intake (DMI, quadratic effect, p = 0.03). This effect was most apparent between LS<sub>1.2</sub> and LS<sub>2.4</sub>. Shade allocation, per se, did not affect gain efficiency or estimated dietary net energy (NE). Compared with TS, TS+F increased (p<0.05) ADG, gain efficiency, and tended (p = 0.06) to increase dietary NE. There was a quadratic effect of shade on <i>longissimus</i> area and marbling score, with values being lower (p<0.01) for LS<sub>2.4</sub> than for LS<sub>1.2</sub> or TS. Likewise, marbling score was lower for TS+F than for TS. Percentage kidney, pelvic, and heart (KPH) linearly decreased with increasing shade. In contrast, KPH was greater for TS than for TS+F.Conclusion: Providing more than 2.4 m<sup>2</sup> shade/animal will not further enhance feedlot performance. The use of fans in combination with shade increases ADG and gain efficiency beyond that of shade, alone. These enhancements were not associated with increased DMI, but rather, to an amelioration of ambient temperature humidity index on maintenance energy requirement.

scholarly journals PSI-4 Effect of rumen protected capsaicin on dry matter intake, average daily gain, and carcass characteristics in finishing beef cattle

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 290-290 ◽  
Author(s):  
John C Eidsvik ◽  
John J McKinnon ◽  
Diego Moya Fernandez ◽  
Alexandra Blanchard
Keyword(s):  
Dry Matter ◽  
Average Daily Gain ◽  
Carcass Characteristics ◽  
Feedlot Cattle ◽  
Dry Matter Intake ◽  
Canola Meal ◽  
High Dose ◽  
Marbling Score ◽  
Mineral Supplement ◽  
Dressing Percentage

Abstract The objective was to evaluate growth performance and carcass characteristics for feedlot cattle fed two sources of rumen protected capsaicin at two dose rates. A total of 450 steers, stratified by BW, were assigned into 30 pens. Pens were randomly assigned to receive 1 of 5 treatments containing (DM basis) of 86.2% barley grain, 6.0% barley silage, 6.2% canola meal, and 1.6% vitamin and mineral supplement. Treatments contained no additive (CON) or included a low or high dose of Nexulin (100 mg/d for NEXLO and 330 mg/d for NEXHI) or CapsXL (77 mg/d CAPLO or 250 mg/d for CAPHI). Steers averaged 507 kg BW at the start of the study and 686 kg at the end of the study (69 days on feed) with no differences among treatments (P &gt; 0.28). Dry matter intake, ADG, gain:feed, dressing percentage, backfat thickness, and rib-eye area were not affected by treatment (P &gt; 0.33). Steers fed CAPLO and NEXLO tended (P = 0.07) to have lesser marbling scores than CON, CAPHI and NEXHI. The proportion of steers in Canadian yield grades 1 and 2 did not differ among treatments, while those in yield grade 3 were greater (P = 0.03) in NEXLO (29%) than the CON (10.0%) and NEXHI (12.2%) treatments, with those fed CAPLO (20%) and CAPHI (19%) being intermediate but not different. Treatment did not affect the proportion of steers in quality grades B4, A, or prime, but tended to increase the proportion of steers grading AAA (P = 0.08) and decrease the proportion grading AA (P = 0.06). Overall, the data from this experiment suggest the potential for capsaicin to affect carcass yield grade, marbling score and quality grades without affecting DMI, ADG, or dressing percentage.

scholarly journals The potential impact of the COVID-19 pandemic on tuberculosis: a modelling analysis

2020 ◽  
Author(s):  
Lucia Cilloni ◽  
Han Fu ◽  
Juan F Vesga ◽  
David Dowdy ◽  
Carel Pretorius ◽  
...  
Keyword(s):  
Negative Impact ◽  
Negative Effects ◽  
High Burden ◽  
Targeted Interventions ◽  
Modelling Analysis ◽  
Incidence And Mortality ◽  
Negative Impacts ◽  
Epidemiological Impact ◽  
The Impact

Background Routine services for tuberculosis (TB) are being disrupted by stringent lockdowns against the novel SARS-CoV-2 virus. We sought to estimate the potential long-term epidemiological impact of such disruptions on TB burden in high-burden countries, and how this negative impact could be mitigated. Methods We adapted mathematical models of TB transmission in three high-burden countries (India, Kenya and Ukraine) to incorporate lockdown-associated disruptions in the TB care cascade. The anticipated level of disruption reflected consensus from a rapid expert consultation. We modelled the impact of these disruptions on TB incidence and mortality over the next five years, and also considered potential interventions to curtail this impact. Results Even temporary disruptions can cause long-term increases in TB incidence and mortality. We estimated that a 3-month lockdown, followed by 10 months to restore normal TB services, would cause, over the next 5 years, an additional 1.92 million TB cases (Crl 1.74 - 2.15) and 488,000 TB deaths (CrI 449 - 541 thousand) in India, 48,000 (33,400 - 72,320) TB cases and 16,800 deaths (11.9 - 21.9 thousand) in Kenya, and 9,100 (6,980 - 11,200) cases and 1,960 deaths (1,620 - 2,350) in Ukraine. However, any such negative impacts could be averted through supplementary 'catch-up' TB case detection and treatment, once restrictions are eased. Interpretation Lockdown-related disruptions can cause long-lasting increases in TB burden, but these negative effects can be mitigated with targeted interventions implemented rapidly once lockdowns are lifted.

scholarly journals Effect of oscillating feeding time and corn processing on performance and carcass characteristics of feedlot steers

2020 ◽  
Vol 4 (2) ◽  
pp. 974-979
Author(s):  
Alejandro E Relling ◽  
David Douglas Clevenger ◽  
Francis L Fluharty
Keyword(s):  
Body Weight ◽  
Growth Performance ◽  
Average Daily Gain ◽  
Carcass Characteristics ◽  
Feedlot Cattle ◽  
Feeding Time ◽  
Marbling Score ◽  
Similar Time ◽  
Corn Processing ◽  
Animal Growth

Abstract The objectives of this experiment were to evaluate the effect of oscillating feeding time (OFT) and corn processing (CoP) on performance and carcass characteristics of feedlot cattle. One hundred sixty-five steers (initial body weight [BW] 277.2 ± 27.80 kg) were blocked by initial BW and allotted to 24 pens. Pens within each block were randomly assigned based on a 2 × 2 factorial arrangement of treatments. The two factors were CoP (whole shelled corn vs. ground corn [GC]) and feeding time (FT) (constant FT vs. 2 hours OFT). Animals were fed the same diet, only changing the CoP method depending on the treatment. Feed offered and feed refusals were collected daily. Body weight was collected at starting day of the experiment (d1) and every 28 d until the end of the experiment. At the end of the experiment, animals were harvested in a commercial slaughter facility, and carcass data were collected by a USDA grader. Animal growth performance and carcass characteristics data were analyzed with the PROC Mixed procedure (SAS) using CoP, FT, and their interaction as fixed variables; and treatments × pen within each block and block were considered random variables. There was no CoP by FT interaction differences (P &gt; 0.10) on animal growth performance variables, nor on hot carcass weight, back fat, rib eye area, or the percentage of kidney, pelvic, and heart fat. There was a tendency for an interaction (P = 0.08) for marbling score, where the steers from the GC processing fed on the oscillating time had a lesser marbling score than the other three treatments. Oscillating feeding time improved (P = 0.05) average daily gain; but did not affect (P ≥ 0.11) dry matter intake (DMI), nor carcass characteristics compared with feeding at a similar time every day. There were no effects (P ≥ 0.11) of CoP on growth performance, nor carcass characteristics. In conclusion, a 2-hour oscillation in FT might not decrease steer feedlot performance. This may be due to the high degree of control of DMI with feed bunk management.

scholarly journals Assessing The Macroeconomic Effects Of Water Scarcity In South Africa Using A Water-CGE Model

2021 ◽  
Author(s):  
Anne Briand ◽  
Arnaud Reynaud ◽  
Franck Viroleau ◽  
Vasileos Markantonis ◽  
Giuliana Branciforti
Keyword(s):  
South Africa ◽  
South African ◽  
Water Scarcity ◽  
Computable General Equilibrium ◽  
Negative Impact ◽  
Cge Model ◽  
Policy Simulations ◽  
Negative Impacts ◽  
Long Term Impact

Abstract We develop a dynamic computable general equilibrium (CGE) model to assess the macroeconomic impacts of water scarcity and water (in)security in South Africa. The water-CGE model which includes a detailed representation of water flows (surface water, groundwater, wastewater, and seawater) has been calibrated with an updated social accounting matrix enabling to conduct policy simulations up to 2030. We show that water scarcity will have an impact on the South African economy. With an increase of water scarcity by 17%, the CGE model predicts a decrease of South African GDP by -0.34% in 2030. The long-term impact of water scarcity varies from one sector to another, with the most negatively impacted sectors being those related to water (loss of GDP up to -2.48%). Due to the increase of water scarcity, the unemployment rate is expected to be 0.1% higher in 2020 which represents a loss of 18,000 jobs compared to the baseline year (2013). The 17% increase in water scarcity is also expected to have a negative impact on household welfare: by 2030, household consumption may decrease by -0.26%. Some policies can mitigate the negative impacts of water scarcity, the most promising one being to promote water saving.

scholarly journals The Effect of the Slaughter Weight on Carcass Composition, Body Measurements and Veal Quality of Holstein Calves

2019 ◽  
Vol 67 (5) ◽  
pp. 1235-1243
Author(s):  
Klára Vavrišínová ◽  
Katarína Hozáková ◽  
Ondřej Bučko ◽  
Peter Haščík ◽  
Peter Juhás
Keyword(s):  
Negative Impact ◽  
Average Daily Gain ◽  
Carcass Composition ◽  
Strong Impact ◽  
Body Measurements ◽  
Slaughter Weight ◽  
Holstein Calves ◽  
Daily Gain ◽  
Linear Body

The aim of this study was to investigate the growth, fattening characteristics and veal quality of MLT from Holstein calves (total number of 40 heads) produced from 4 slaughter weight groups (130, 150, 180 and 210 kg). Calves were fed in the same conditions. Average daily gains ranged from 660 g in slaughter weight 130 kg to 840 g in weight 210 kg (P < 0.001). The most important changes of linear body measurements were revealed in hip height and withers height (P < 0.001). Slaughter weight had strong impact on average daily gain and most of body measurements (P < 0.01). Slaughter weight influenced proportion of kidney, rumen and intestinal fat, while highest proportion was found in the group of 180 kg (P < 0.001). Calves of slaughter weight 180 kg had lowest proportion of bones (P < 0.001) and highest proportion of meat (P < 0.001) from right – half carcass. Highest proportion of separable fat had calves of 210 kg as well as 150 kg. In terms of nutritional quality of veal, we found significant and high individual differences in intramuscular fat content (P < 0.01) as well as between monitored groups. The lightness of the meat was highest in the group of 180 kg (P < 0.05). Protein content of the loin muscle had negative impact on intramuscular and moisture content (P < 0.001). Parameter pH strongly positively influenced drip loss value and negatively electrical conductivity.

scholarly journals Impact of increasing levels of fumonisin on performance, liver toxicity, and tissue histopathology of finishing beef steers

2020 ◽  
Vol 98 (12) ◽  
Author(s):  
Jenny S Jennings ◽  
Steve M Ensley ◽  
Wyatt N Smith ◽  
Taylor C Husz ◽  
Ty E Lawrence
Keyword(s):  
Skeletal Muscle ◽  
Treatment Period ◽  
Linear Response ◽  
Mixed Model ◽  
Liver Toxicity ◽  
Average Daily Gain ◽  
Alcohol Concentration ◽  
Feedlot Cattle ◽  
Marbling Score ◽  
The Impact

Abstract To address the gaps in current scientific knowledge, the objective of the present study was to investigate the impact of fumonisin exposure on feedlot cattle intake and performance. Fifty steers were received (day 0; 361 ± 6.4 kg), housed individually and fed once daily at 0800 hours. All steers were transitioned to a dry-rolled corn-based finishing diet from days 0 to 21 and then were fed the control finishing diet until day 50. Treatment diets were formulated to achieve ≤5 (CON), 15 (15PPM), 30 (30PPM), 60 (60PPM), or 90 ppm (90PPM) of total dietary fumonisin. Steers were fed the fumonisin treatment diets from day 50 until harvest on day 160; individual animal body weights (BW) were measured on days 0, 50, 100, 150, 159, and 160. Liver, kidney, and skeletal muscle tissue samples were collected at harvest for histopathological analyses, and liver samples were further analyzed for sphinganine (SA) and sphingosine (SO) concentration. Animal performance, carcass data, and liver enzyme concentration were analyzed using a mixed model; categorical data were analyzed via nonparametric models. Contrasts were used to test for linear and quadratic responses. Throughout the study, there was no effect of treatment (P &gt; 0.60), or a linear response (P &gt; 0.16) from increasing fumonisin levels, on BW or dry matter intake (DMI). However, CON tended to have a lower average daily gain (ADG) than the fumonisin treatments during the fumonisin treatment period (P = 0.10), and there was a positive linear response (P = 0.02) of ADG to fumonisin during the treatment period. There were no treatment differences in hot carcass weight, dressing percentage, marbling score, ribeye area, or yield grade. There were no effects of treatment on either liver abscesses (P = 0.95) or telangiectasis (P = 0.13). We observed a treatment difference for SA and SA:SO (P &lt; 0.01), as well as a quadratic response (P &lt; 0.02); both SA and SA:SO increased as dietary fumonisin increased. There were no observed differences between treatments for histopathology scores of kidney (P = 0.16), liver (P = 0.25), or skeletal muscle (P = 0.59) tissue. No adverse effects were observed in steers fed increasing dietary levels of fumonisin for 110 d prior to harvest. While elevated liver amino alcohol concentration did occur, negative effects on growth and carcass characters were not observed.

scholarly journals Ruminally protected and unprotected Saccharomyces cerevisiae fermentation products as alternatives to antibiotics in finishing beef steers1

2019 ◽  
Vol 97 (10) ◽  
pp. 4323-4333 ◽  
Author(s):  
Yizhao Shen ◽  
Taylor Davedow ◽  
Tao Ran ◽  
Atef M Saleem ◽  
Ilkyu Yoon ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Blood Glucose ◽  
Antimicrobial Resistance ◽  
Feed Efficiency ◽  
Acute Phase Proteins ◽  
Average Daily Gain ◽  
Barley Grain ◽  
Marbling Score ◽  
Fermentation Products ◽  
Amyloid A

Abstract The objectives of this study were to assess the effects of Saccharomyces cerevisiae fermentation products (SCFP; NaturSafe, SCFPns; and Original XPC, XPC; Diamond V) on growth performance, carcass traits, immune response, and antimicrobial resistance in beef steers fed high-grain diets. Ninety Angus steers (initial body weight [BW], 533 ± 9.8 kg) were assigned to a randomized complete design with 6 treatments (n = 15/treatment): 1) control, 2) low (12 g SCFPns·steer−1·d−1), 3) medium (15 g SCFPns·steer−1·d−1), 4) high SCFP (18 g SCFPns·steer−1·d−1), 5) encapsulated XPC (eXPC; 7 g XPC·steer−1·d−1 encapsulated with 9 g capsule material), and 6) antibiotics (ANT; 330 mg monensin + 110 mg tylosin·steer−1·d−1). Steers were fed ad libitum a diet containing 10% barley silage and 90% barley grain concentrate mix (dry matter basis) for 105 d. Increasing SCFPns tended (P < 0.09) to linearly increase feed efficiency. Average daily gain (ADG) tended (P < 0.10) to be greater in steers supplemented with eXPC than control. The SCFPns also tended (P < 0.10) to linearly increase marbling score. Proportion of severely abscessed livers tended (P < 0.10) to be lower in steers supplemented with medium and high SCFPns, eXPC, or ANT. A treatment × days on feed interaction were noticed (P < 0.01) for blood glucose, blood urea nitrogen (BUN), and acute phase proteins. The concentration of blood glucose responded quadratically (P < 0.05) on days 28 and 56, whereas BUN linearly (P < 0.01) increased on day 105 with increasing SCFPns dose. The SCFPns linearly increased haptoglobin (P < 0.03) and serum amyloid A (SAA;P < 0.05) concentrations on day 105, and lipopolysaccharide binding protein (LBP;P < 0.01) on days 56 and 105. The percentage of erythromycin-resistant and erythromycin + tetracycline-resistant enterococci was greater (P < 0.05) with ANT than control, SCFPns, and eXPC, whereas no difference was observed among control, SCFPns, and eXPC. No treatment effect was detected on the percentage of tetracycline-resistant enterococci. These results indicate that feeding SCFPns and eXPC was beneficial in improving ADG, feed efficiency and decreasing liver abscesses in a manner comparable to ANT. Unlike antibiotics, SCFPns or eXPC did not increase antimicrobial resistance. Both SCFPns and eXPC are potential alternatives to in-feed antibiotics.

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