Targeted Circuit Manipulations in the Modeling of OCD
Work in animal models has great potential to shed light on the neural circuit perturbations that lead to OCD-related behaviors. Circuit-specific manipulations allow testing of the causal role of the brain network abnormalities observed in clinical imaging studies, with a precision that is not possible in investigations in humans. In recent years, circuit-specific manipulations in animals using a range of technologies have confirmed that abnormalities in the cortico-striatal circuitry can produce repetitive behaviors, such as excessive grooming. This chapter summarizes these advances. Refining our understanding of the contribution of particular neural circuits to OCD-relevant behaviors can inform the development of anatomically targeted treatments, such as deep brain stimulation.