scholarly journals B.1.1.7 Variant Outbreak in an Air Force Military Base—Real-World Data

2021 ◽  
Author(s):  
Maya Nitecki ◽  
Bella Savitsky ◽  
Inbal Akavian ◽  
Alexey Yakhin ◽  
Tamar Narkiss ◽  
...  
Keyword(s):  
Air Force ◽  
Smoking Status ◽  
Gastrointestinal Symptoms ◽  
Real World Data ◽  
Chi Square ◽  
Military Base ◽  
Period 2 ◽  
Gi Symptoms ◽  
Chi Square Test ◽  
Second Period

ABSTRACT Objective To assess the clinical features and infectivity of variant B.1.1.7 among healthy young adults in a military setting. Materials and Methods Positive cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a single military base (March 23, 2020 and February 16, 2021) were included. An epidemiological investigation conducted via phone included questions regarding symptoms, exposure history, smoking status, list of contacts, and recently visited places. Symptoms surveyed included fever, cough, shortness of breath, sore throat, loss of smell or taste, gastrointestinal symptoms (GI), headache, chest pain, and constitutional symptoms. Cases were divided before B.1.1.7 first reported case in Israel (December 23, 2020) (period 1) and after its identification (period 2). Symptom distribution and the risk of a contact to be infected were compared between the periods, using a chi-square test, and a negative binominal regression model, respectively. Results Of 293 confirmed cases, 89 were reported in the first period and 204 in the second. 56.0% were men with a median age of 19.5 years (interquartile range 18.6-20.5). GI symptoms, loss of taste or smell, headache, fever, and chills were more prevalent in the first period (P < .001, P = .026, P = .034, P = .001, and P < .001, respectively), while fatigue was more common in the second period (P = .008). The risk of a contact to be infected was three times higher in the second period (relative risk  = 3.562 [2.414-5.258]). Conclusion An outbreak of SARS-CoV-2 in young healthy adults, during a period with high national-wide B.1.1.7 variant prevalence, is characterized by decreased prevalence of fever, loss of taste or smell and GI symptoms, increased reports of fatigue, and more infected contacts for each index case.

Evolution of bipolar disorder over 12 years in a psychiatric hospital

2016 ◽  
Vol 33 (S1) ◽  
pp. S125-S125
Author(s):  
E. Ribera ◽  
M. Grifell ◽  
M.T. Campillo ◽  
I. Ezquiaga ◽  
L. Martínez ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Early Detection ◽  
Psychiatric Hospitals ◽  
Categorical Variables ◽  
Chi Square ◽  
Number Of Patients ◽  
Chi Square Test ◽  
The Mean ◽  
Second Period ◽  
Carlos Iii

IntroductionBipolar disorder is a leading cause of hospitalization in psychiatric hospitals. It is known that early detection of bipolar disorder is associated with a better prognosis.ObjectivesThe aim of this study is to conduct a demographic analysis of patients hospitalized for bipolar disorder in a single center between 2003 to 2014.MethodsRetrospective cohort study of 1230 patients admitted with bipolar disorder diagnosis from 2003 to 2014 at Centre Assistencial Emili Mira i López of Parc Salut Mar of Barcelona. We divided the study in two periods: 2003–2008 and 2009–2014. We analyzed the following variables: frequency of admissions, age, sex and days of hospital stay, comparing both periods. Chi-square test for categorical variables and Student t test for quantitative variables were applied.ResultsThe mean ages at the first and second period are 52 and 47, respectively (P < 0.001). There are no significant differences in sex and days of hospitalization. The frequency of admissions on the first and third trimesters is higher than in the second and fourth, although the differences are not statistically significant.ConclusionsDespite the large number of patients in the study, there are limitations, such as being a retrospective study and not being adjusted for confounding factors. The average age of patients in the second period is lower than in the first. This could suggest an improvement in early detection of bipolar disorder in the last years. Further research is needed to confirm this hypothesis.Disclosure of interestLG is funded by the Instituto de Salud Carlos III(CM14/00111).

A retrospective three-year analysis using real-world data on uptake of broad-based NextGen sequencing panels in community oncology practices.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13668-e13668
Author(s):  
Hinco J. Gierman ◽  
Nikhil Pai ◽  
Casey Catasus ◽  
Alvin Tam ◽  
Monica Labrador ◽  
...  
Keyword(s):  
Targeted Therapies ◽  
Single Gene ◽  
Tumor Type ◽  
Real World Data ◽  
Chi Square ◽  
Large Panels ◽  
Nextgen Sequencing ◽  
Community Oncology ◽  
Improved Outcomes ◽  
Chi Square Test

e13668 Background: There are over 100 FDA approved targeted therapies across 15 cancer types, offering improved outcomes over existing therapies. However, many of these require genetic testing, for example, advanced non-small cell lung cancer (aNSCLC) patients have over 15 targeted therapies requiring a DNA-based test. Doing multiple tests can exhaust sample, while increasing cost and turn-around time. NGS panels, often with hundreds of genes, can address some of these issues. Here we asked across aNSCLC patients if the use of NGS panels has increased over the last 3 years in community oncology practices. Methods: The Integra Connect database, which includes electronic medical record (EMR) and claims data on over 1,000,000 US cancer patients, was queried across five community oncology practices to identify aNSCLC patients (stage IIIB or IV) treated between January 2017 and January 2020. Manual chart review abstracted tumor type, stage, treatment, and testing. Patients tested for all 7 NCCN recommended genes (EGFR, ALK, ROS1, BRAF, MET, RET, ERBB2) were grouped as “NGS Panel”, patients with less genes as “Single Gene/Small Panel”, and patients with no evidence of testing as “No Test”. A Chi-Square test was used to compare actionable results between patients with NGS panels versus small panels. Results: 1,007 aNSCLC patients were analyzed and showed a doubling of the use of broad-based NGS testing from 13% in 2017 to 26% in 2019 across over 100 oncologists (table). 23% of patients had actionable results when tested on broad-based panels versus 17% using single gene or small panels (p = .048). Targeted therapies were used in 17% of broad-based tested patients, versus 15% in patients tested for single genes or small panels. Conclusions: We see an uptake of broad-based NGS testing in community oncology, which can lead to more actionable results and better utilization of targeted therapies for those patients. However, this seems to be caused by providers shifting from small panels to large panels, rather than an overall increase in testing, as we do not see the percentage of untested patients decrease. [Table: see text]

scholarly journals Gastrointestinal Symptoms and Elevated Levels of Anti-Saccharomyces cerevisiae Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
C. Romero-Sánchez ◽  
W. Bautista-Molano ◽  
V. Parra ◽  
J. De Avila ◽  
J. C. Rueda ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Disease Activity ◽  
Healthy Subjects ◽  
Clinical Status ◽  
Gastrointestinal Symptoms ◽  
Inflammatory Rheumatic Diseases ◽  
Chi Square ◽  
Gastrointestinal Manifestations ◽  
Chi Square Test ◽  
Inflammatory Bowel

Background. Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Objectives. To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD). Methods. 102 SpA patients, 29 IBD patients, and 117 HS were included. Autoantibodies as ASCA, ANCA, anti-tTG, anti-DGP, ANA, and IgA were measured. The patients were assessed to evaluate clinical and gastrointestinal symptoms. An association analysis was performed using Chi square test and a logistic regression. Results. Significant differences were found for ASCA levels in SpA (28.2%) compared to IBD (14.2%) and HS (6.0%) (p=0.029), as well as for ANAS in SpA (49.5%) and IBD (37.9%) (p<0.001) and abdominal pain (p=0.012) between SpA (54.3%) and IBD (27.5%). Significant associations were found between BASDAI > 4 and gastrointestinal symptoms (p<0.05) and IgA (p=0.007). The association for abdominal bloating was maintained (OR: 3.93, CI-95%, 1.14–13.56; p=0.030). Conclusions. Gastrointestinal symptoms, ASCA, ANAS, and IgA levels were associated with high disease activity in SpA compared with IBD and HS.

scholarly journals CATARACT SURGERY;

2017 ◽  
Vol 24 (12) ◽  
pp. 1812-1817
Author(s):  
Zulfiqar Ahmed Memon ◽  
Omar Zafar ◽  
Arsalan Farooq ◽  
Shabnam Memon ◽  
Najam ul Hassan ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Air Force ◽  
Prednisolone Acetate ◽  
Eye Drops ◽  
Single Drop ◽  
Treatment Results ◽  
Chi Square ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Chi Square Test

Objectives: To determine the efficacy of topical nepafenac 0.1% eye dropsas compared toprednisolone acetate 1% eye drops in the management of postoperativeinflammation after cataract surgery. Study Design: Randomized controlled clinical study.Place and Duration of study: Pakistan air force hospital Rafiqui from Oct 2016 to Feb 2017.Patients and methods: Two hundred and forty eight eyes were randomly divided in two equalgroups. Patients received nepafenac 0.1% or prednisolone acetate 1% as single drop 8 hourlybeginning 1 day preoperatively, continued till 2 weeks post-operatively. Efficacy of the drugwill be considered if there is no anterior chamber reaction along with no aqueous flare after 2weeks of treatment. Results: 85.5% of cases resolved with topical nepafenac 0.1%as comparedto 88.7% that were cured with prednisolone acetate 1%. Pearson chi square test indicates thatthere is no statistical significant difference (p= 0.449) between the efficacy of two modes oftreatment. Conclusion: Nepafenac 0.1% eye drops are as effective as prednisolone acetate 1%in the prevention of postoperative inflammation with cataract surgery.

scholarly journals The prevalence of olfactory dysfunction and its associated factors in patients with COVID-19 infection

2021 ◽  
Author(s):  
Md Mehedi Hasan ◽  
Naima Ahmed Tamanna ◽  
Mohammad Nasimul Jamal ◽  
Md Jamal Uddin
Keyword(s):  
Associated Factors ◽  
Smoking Status ◽  
Age Groups ◽  
Olfactory Dysfunction ◽  
Test Results ◽  
Chi Square ◽  
Younger Patients ◽  
Regular Screening ◽  
Chi Square Test ◽  
Observational Cohort

AbstractObjectiveTo determine the prevalence of olfactory dysfunctions, mainly, anosmia and to identify its associated factors in patients with COVID-19 infection.Study designA hospital-based prospective observational cohort studySettingA COVID dedicated hospital, Square Hospitals Ltd., Dhaka, Bangladesh.MethodsWe collected patients’ information including laboratory-confirmed COVID-19 test results. We used Pearson Chi-square test and logistic regression model to assess the associations between demographic and clinical characteristics and olfactory outcomes.ResultsOut of 600 COVID-19 positive patients, 38.7% were diagnosed with olfactory dysfunction. Our analyses showed that patients’ age, smoking status, cough, dyspnea, sore throat, asthenia, and nausea or vomiting were significantly associated with the anosmia. We observed the risk of developing anosmia was greater in younger patients than in older patients, and this risk decreased as age increased [odds ratio (OR) range for different age groups: 1.26 to 1.08]. Smoking patients were 1.73 times more likely to experience anosmia than non-smoking patients [OR=1.73, 95% confidence interval (CI) = 1.01-2.98]. In addition, patients complained asthenia had a significantly double risk of developing the anosmia [OR = 1.96, CI = 1.23-3.06].ConclusionsOur study shows that about 39% of patients diagnosed with olfactory dysfunction. Patients’ age, smoking status, and asthenia are significantly positively associated with the anosmia. Since anosmia can be a significant marker for the diagnosis of COVID-19, we suggest regular screening of olfactory dysfunction in patients with early symptoms of COVID-19, particularly younger patients, smoker, and complained asthenia.

Comparison of QOPI measure conformance between oncology fellows and attending physicians.

2013 ◽  
Vol 31 (31_suppl) ◽  
pp. 162-162
Author(s):  
Tian Zhang ◽  
Arif Kamal ◽  
Michael J. Kelley
Keyword(s):  
Best Practice ◽  
Smoking Status ◽  
Medical Center ◽  
Management Plan ◽  
Oral Chemotherapy ◽  
Chart Audit ◽  
Chi Square ◽  
Chi Square Test ◽  
Using Data ◽  
Attending Physicians

162 Background: Quality improvement measures are uniformly applied to all oncology providers, regardless of their positions. Little is known about differences in conformance to these measures between oncology fellows and attending physicians. In order to tailor improvement interventions to these groups, we investigated conformance across QOPI measures for oncology fellows and attending physicians at the Durham VA Medical Center (DVAMC). Methods: Using data collected from the Spring 2013 QOPI cycle, we abstracted information from patients who had received care at the DVAMC between 2011 and 2013 and separated them based on their provider. To validate the data, we abstracted a subset of patient charts, limited to oral chemotherapy quality measures. Descriptive statistics and the Chi square test were calculated for each measure between the two groups. Results: A total of 97 patients were reviewed at DVAMC. Of these, 21 had a fellow and 47 had an attending as their main provider. Fellows and attendings performed similarly on 119 of 125 QOPI measures (core, end of life, symptom, colorectal, and NSCLC modules). Fellows were less likely to assess pain on the most recent visits when compared to attendings (52% vs. 77%, p=0.046) but more likely to document a management plan if the patient had moderate or severe pain (86% vs 75%, p=0.09). Attendings documented the plan for oral chemotherapy more often (93% vs. 60%, p=0.07). However, after the chart audit, we found that fellows actually documented the plan for oral chemotherapy 80% of the time (p=0.21). Fellows were more likely to document smoking status (95% vs. 64%, p=0.007) and to address smoking cessation (86% vs. 62%, p=0.048). Conclusions: Patient care practices tend to be similar between attendings and fellows overall; some of the significant differences may not remain significant after chart audit. Fellows generally mirror behaviors of attending physicians, and attendings have an important role in modeling best practice behaviors for fellows. Different quality measure standards may not be necessary between fellows and attendings.

scholarly journals Profile of patients with lung cancer assisted at the National Cancer Institute, according to their smoking status, from 2000 to 2007

2014 ◽  
Vol 17 (1) ◽  
pp. 175-188 ◽  
Author(s):  
Mirian Carvalho de Souza ◽  
Ana Glória Godoi Vasconcelos ◽  
Marise Souto Rebelo ◽  
Paulo Antonio de Paiva Rebelo ◽  
Oswaldo Gonçalves Cruz
Keyword(s):  
Lung Cancer ◽  
National Cancer Institute ◽  
Multiple Correspondence Analysis ◽  
Smoking Status ◽  
Lung Cancer Mortality ◽  
Two Dimensions ◽  
Chi Square ◽  
Data Variability ◽  
Chi Square Test

INTRODUCTION: Tobacco use is directly related to the future incidence of lung cancer. In Brazil, a growing tendency in age-adjusted lung cancer mortality rates was observed in recent years. OBJECTIVE: To describe the profile of patients with lung cancer diagnosed and treated at the National Cancer Institute (INCA) in Rio de Janeiro, Brazil, between 2000 and 2007 according to their smoking status. METHODS: An observational study was conducted using INCA's database of cancer cases. To assess whether the observed differences among the categories of sociodemographic variables, characterization of the tumor, and assistance - pertaining to smokers and non-smokers - were statistically significant, a chi-square test was applied. A multiple correspondence analysis was carried out to identify the main characteristics of smokers and non-smokers. RESULTS: There was a prevalence of smokers (90.5% of 1131 patients included in the study). The first two dimensions of the multivariate analysis explained 72.8% of data variability. Four groups of patients were identified, namely smokers, non-smokers, small-cell tumors, and tumors in early stages. CONCLUSION: Smoking cessation must be stimulated in a disseminated manner in the population in order to avoid new cases of lung cancer. The Tumors in Initial Stages Group stood out with greater chances of cure.

scholarly journals Periodontal Status and Risk Factors among Adults of Sebha City (Libya)

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Syed Wali Peeran ◽  
A. J. A. Ranjith Singh ◽  
G. Alagamuthu ◽  
Syed Ali Peeran ◽  
P. G. Naveen Kumar
Keyword(s):  
Risk Factors ◽  
Smoking Status ◽  
Adult Population ◽  
Population Level ◽  
Target Population ◽  
Tooth Brushing ◽  
Chi Square ◽  
Periodontal Status ◽  
Significant Difference ◽  
Chi Square Test

The present study was aimed at assessing the periodontal status and risk factors like age, gender, tooth brushing habit, and smoking among the adult population of Sebha city, Libya. 452 adults, aged 35–54 years, comprised the study sample. 266 (58.84%) were females and 186 (41.15%) were males. Data was collected by interview and clinical examination using CPI of CPITN index. Chi-square test and ANOVA were used for statistical analysis at 5% level of significance. Results indicate that 76.32% used toothbrush and paste; 8.84% were current smokers and were all males. Majority, 52.65% were, detected with shallow pockets followed by 30.08% with calculus, 12.17% had deep pockets, 3.31% had bleeding, and only 1.33% were healthy. Age, gender, current smoking status and frequency of tooth brushing showed statistically significant difference with CPI codes. Health professionals can utilize this data to identify individuals at risk and to target population level interventions.

scholarly journals Physician Perception and Diagnosis of Intestinal Parasitic Infections among Patients with Gastrointestinal Symptoms in Ghana

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Verner N. Orish ◽  
Saviour Anorkplim Simpiney ◽  
Sylvester Yao Lokpo ◽  
Percival D. Agordoh ◽  
Duniesky Martinez Lopez ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Multivariate Logistic Regression Analysis ◽  
Parasitic Infections ◽  
Multivariate Logistic Regression ◽  
Cross Sectional Survey ◽  
Chi Square ◽  
Cross Sectional ◽  
Intestinal Parasitic Infections ◽  
Gi Symptoms ◽  
Physician Perception

This study evaluated physicians’ perception and diagnosis of intestinal parasitic infections (IPI) in patients with gastrointestinal (GI) symptoms. This cross-sectional survey used a Google form questionnaire distributed online. Demographic and clinical practice information was solicited, including if “IPI was considered as a diagnosis in the last patient seen,” “if stool investigation was requested among the last patients seen,” and physicians’ perception of the burden of IPI in the country. Using Pearson chi-square and multivariate logistic regression analysis, we tested the significance of the associations of the job cadre of the physicians and their perception of the IPI burden with consideration of IPI as a diagnosis in the last patient seen, request for stool investigation in the last patient seen, and overall frequency of the request for stool investigation. Ultimately, 184 physicians responded. The majority agreed to “often seeing patients with GI symptoms” (156, 84.7%), “not considering IPI among the last patient seen” (106, 57.6%), and “not requesting stool investigation among the last patient seen with symptoms” (136, 73.9%). House officers (81, 44.2%) constituted the highest proportion of physicians who considered IPI as a diagnosis among the last patient seen (39, 48.1%, p = 0.05 ). Most physicians (138, 75%) considered IPI as a burden in Ghana. They constituted significant proportions of the physicians who considered IPI as a diagnosis among their last patients seen (65, 83.3%, p = 0.02 ) and were twice more likely to consider IPI as a diagnosis among the last patients seen than their colleagues who did not consider IPI as a burden in Ghana (AOR 2.26, p = 0.04 ). The consideration of IPI as a diagnosis among patients with GI symptoms and request for stool investigations was low among physicians in this study. Further engagements with physicians in Ghana are needed to help improve their diagnosis of IPI in patients with GI symptoms.

scholarly journals Esophageal manometry in systemic sclerosis: findings and association with clinical manifestations

2020 ◽  
Vol 66 (1) ◽  
pp. 48-54
Author(s):  
Juliana Markus ◽  
Rogério de Melo Costa Pinto ◽  
Abadia Gilda Buso Matoso ◽  
Roberto Ranza
Keyword(s):  
Systemic Sclerosis ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Autoimmune Disorder ◽  
Cross Sectional Study ◽  
Unknown Etiology ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Diffuse Form

SUMMARY INTRODUCTION Systemic sclerosis (SSC) is an autoimmune disorder that affects several organs of unknown etiology, characterized by vascular damage and fibrosis of the skin and organs. Among the organs involved are the esophagus and the lung. OBJECTIVES To relate the profile of changes in esophageal electromanometry (EM), the profile of skin involvement, interstitial pneumopathy (ILD), and esophageal symptoms in SSC patients. METHODS This is an observational, cross-sectional study carried out at the SSC outpatient clinic of the Hospital de Clínicas of the Federal University of Uberlândia. After approval by the Ethics Committee and signed the terms of consent, 50 patients were initially enrolled, from 04/12/2014 to 06/25/2015. They were submitted to the usual investigations according to the clinical picture. The statistical analysis was descriptive in percentage, means, and standard deviation. The Chi-square test was used to evaluate the relationship between EM, high-resolution tomography, and esophageal symptoms. RESULTS 91.9% of the patients had some manometric alterations. 37.8% had involvement of the esophageal body and lower esophageal sphincter. 37.8% had ILD. 24.3% presented the diffuse form of SSC. No association was found between manometric changes and clinical manifestations (cutaneous, pulmonary, and gastrointestinal symptoms). CONCLUSION The present study confirms that esophageal motility alterations detected by EM are frequent in SSC patients, but may not be related to cutaneous extension involvement, the presence of ILD, or the gastrointestinal complaints of patients.

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