scholarly journals P1361IS THE INFLAMMATORY STATE A DETERMINING FACTOR OF THE PRIMARY PERMEABILITY OF ARTERIOVENOUS FISTULES?

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
LUIS GUILLERMO PICCONE SAPONARA ◽  
MARIA PAZ CASTRO FERNÁNDEZ ◽  
NANCY GIOVANNA URIBE HEREDIA ◽  
Agustin Carreno ◽  
SARA ANAYA FERNANDEZ ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Vascular Access ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Statin Treatment ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
Low Grade ◽  
Cross Sectional ◽  
Inflammatory Parameters

Abstract Background and Aims Clinical practice guidelines recommend an arteriovenous fistula (AVF) as the preferred vascular access for hemodialysis and are associated with a lower incidence of morbidity and mortality. However, primary vascular access (AV) failure is not uncommon. Low-grade inflammation is present in ERCT. We identify the inflammatory parameters that influence the primary permeability of vascular access for hemodialysis. Method Cross-sectional study; We include all the AVs performed in the HGUCR. We evaluate the initial operation after the creation of the AV. Demographic variables (age, sex), aetiology of CKD and associated comorbidity were collected. Statistical analysis with SPSS 25.0. Categorical variables are expressed as percentages and are compared using the Chi2 Test. Quantitative variables are expressed as mean ± standard deviation and the t-student was used to compare them. We performed a multivariate analysis to determine those factors involved in the primary failure of the VA. Statistical significance for a value of p <0.05. Results 600 VA performed on 466 patients were reviewed between October 2009 and December 2019. 492 autologous VA (86.8%) and 75 prosthetic VA (13.2%) were performed. The mean age of the patients was 65.3 ± 14.2 years and 66.2% were male. The most frequent etiology of CKD was diabetic nephropathy (29.9%), followed by non-affiliated (18%) and glomerulonephritis (16.5%). 90.8% of the patients had arterial hypertension (HT), diabetes mellitus (DM) 48%. 77.2% of AV presented primary permeability. In the univariate analysis using Chi2 and T student, statistical age (p = 0.017), HT (p = 0.002), statin treatment (p = 0.002), antiplatelet therapy (p = 0.001), low ferritin levels (p = 0.011) and PCR (p = 0.019). When performing a multivariate analysis, the high CRP figures (OR: 0.64 95% CI 0.42-0.98 p = 0.043) and ferritinemia (OR: 1.04 95% CI 1.01-1.06 p = 0.013) are predictive factors of primary AV failure. Conclusion In our study, high CRP decreases the probability of primary functioning of AVFs by 36% and elevated ferritin levels are predictors of primary failure after adjusting for age and sex in the multivariate model.

MO775CONTROL OF BONE DISEASE ASSOCIATED WITH CHRONIC KIDNEY DISEASE AS A PREDICTOR OF PRIMARY PERMEABILITY AFTER THE CREATION OF THE VASCULAR ACCESS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Luis Guillermo Piccone Saponara ◽  
Maria Paz Castro Fernández ◽  
Nancy Giovanna Uribe Heredia ◽  
Agustin Carreno ◽  
Sara Anaya Fernandez ◽  
...  
Keyword(s):  
Antiplatelet Therapy ◽  
Vascular Access ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Primary Patency ◽  
Categorical Variables ◽  
Cross Sectional ◽  
High Phosphorus ◽  
The Creation ◽  
Phosphorus Levels

Abstract Background and Aims Clinical practice guidelines recommend an arteriovenous fistula (AVF) as the preferred vascular access for hemodialysis. Patency of the arteriovenous access is important for effective hemodialysis. However, maintaining the patency of the AVF remains a challenge. We determined those independent prognostic factors for the patency of the AVF at the time of its creation. Method Cross-sectional study; We include all AVFs performed at the HGUCR in the last 2 decades. Demographic variables (age, sex), etiology of CKD and associated comorbidity were collected. We determine the factors involved in the primary patency of AVFs. Statistical analysis with SPSS 25.0. Categorical variables are expressed as percentages and are compared using the Chi2 test. Quantitative variables are expressed as mean ± standard deviation and the Mann Whitney Student-T/U was used to compare them. Statistical significance for a value of p <0.05. Results 622 AVFs performed in 482 patients were reviewed. 86.8% were autologous. The mean age was 65.4±14 years; 66.6% were male. The most frequent etiologies of CKD were diabetic nephropathy (30.2%), unknown (18%), and glomerulonephritis (16.6%). 91.2% had arterial hypertension (HBP) and diabetes mellitus (DM) 47.9%. 48.7% received antiplatelet therapy and 15.6% anticoagulation prior to the creation of the AVF. 27% presented primary failure. The univariate analysis showed statistical significance for the qualitative variables HTA (p=0.002), treatment with statins (p<0.01) and antiplatelet (p<0.01), and for the quantitative variables fibrinogen (p=0.048), serum phosphorus (p=0.001), CRP (p=0.004), triglycerides (p=0.05), ferritin (p=0.006) and age (p=0.05). When performing a multivariate analysis using logistic regression, HTA (OR: 0.46 95% CI 0.22-0.95 p = 0.036), high phosphorus levels (OR: 1.22 95% CI 1.08-1, 49 p = 0.004) and statin treatment (OR: 0.58 95% CI 0.36-0.96 p = 0.004) are predictors of primary VA failure. Conclusion In our study, HTA and antiplatelet therapy prior to the creation of the VA behave as protective factors for primary failure, with high phosphorus levels being an independent factor for primary failure of AVFs.

scholarly journals Utilization and associated factors of reproductive health services among 20–39-year-old women in rural China: a cross-sectional study

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Jing Yue ◽  
Yang Luo ◽  
Chen Xu ◽  
Si Qin ◽  
Yanting Meng ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Rural China ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Hunan Province ◽  
Categorical Variables ◽  
Utilization Rate ◽  
Sample Population ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background The use of reproductive health (RH) services is important to promote RH. However, little is known about RH services in rural areas, especially in low- and middle-income countries. China is the most populous country in the world, and 40.4% of its population is rural. Our study determined the utilization of and factors associated with RH services in rural China. Methods A cross-sectional study of 978 20- to 39-year-old women was performed in four villages of four cities in Hunan Province. A researcher-created structured questionnaire was used to collect the data. The data were entered into EpiData v3.0 and analysed using SPSS v18.0. Statistical significance was defined as a two-sided P-value of less than 0.05. Descriptive statistics were used to examine the socio-demographic factors and the use of RH services by the sample population. Chi-square tests were used to assess associations between categorical variables. Logistic regression analyses were performed to examine factors that correlated with the use of RH services. Results The top three services used were antenatal examinations (90.2%), postpartum visits (73.0%) and free folic acid supplements (71.6%). Age, monthly household income, employment, spousal education level, and artificial abortion history were associated with RH service utilization (P < 0.05). The most desired RH service was cervical/breast cancer prevention services (58.9%). The most preferred method participants used to obtain information on RH services was the internet. Conclusions The utilization rate for RH services in rural China needs improvement. Future efforts should target high-risk populations of women by providing them with RH-related information and cultivating positive attitudes towards RH services.

scholarly journals Factors Affecting the Prevalence of Skin Disorders among Human Immunodeficiency Virus (HIV) Infected Children in Aminu Kano Teaching Hospital (AKTH) Kano, Nigeria

2021 ◽  
Vol 2 (4) ◽  
pp. 223-227
Author(s):  
YA Muhammad
Keyword(s):  
Multivariate Analysis ◽  
Teaching Hospital ◽  
Immune Status ◽  
Univariate Analysis ◽  
Categorical Variables ◽  
P Value ◽  
Skin Disorders ◽  
Cross Sectional ◽  
Female Ratio ◽  
Factors Affecting

Introduction: Among HIV infected children, skin disorders are vital as they give a clue to diagnosis of the HIV disease. Various factors are associated with occurrence of skin disorders among HIV infected children. Objectives: To determine the factors associated with prevalence of skin disorders among HIV infected children in Aminu Kano Teaching Hospital (AKTH) Kano, Nigeria. Materials and Methods: It was a cross-sectional study conducted to determine the factors affecting skin disorders among HIV infected children attending Paediatric Infectious Disease Clinic of Aminu Kano Teaching Hospital, Kano, Nigeria. A total of 223 HIV infected participants aged 6weeks to14 years were recruited for this study. Chi-square test or Fishers exact test where necessary were used to determine the difference between proportions of categorical variables and level of significance was set at 0.05. Multivariate analysis was used to further analyse significant relationships from the univariate analysis. The confidence level was set at 95% and a p-value less than 0.05 was considered statistically significant Results: There were 110 (49.3%) males and 113 females (50.7%). The male to female ratio was found to be 1:1.1. Seventy-eight percent (78%) of the children had skin disorder. A multivariate analysis showed that only age, social class and immune status were significantly associated with the occurrence of skin disorders. Conclusion: Among the HIV infected children, age, socioeconomic class and immune status were the factors found to determine the Prevalence of skin disorders.

scholarly journals Access to childbirth care by adolescents and young people in the Northeastern region of Brazil

2016 ◽  
Vol 50 (0) ◽  
Author(s):  
Érida Zoé Lustosa Furtado ◽  
Keila Rejane Oliveira Gomes ◽  
Silvana Granado Nogueira da Gama
Keyword(s):  
Multivariate Analysis ◽  
Health Insurance ◽  
Young People ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Northeast Region ◽  
Childbirth Care

ABSTRACT OBJECTIVE To identify the factors that interfere with the access of adolescents and young people to childbirth care for in the Northeast region of Brazil. METHODS Cross-sectional study with 3,014 adolescents and young people admitted to the selected maternity wards to give birth in the Northeast region of Brazil. The sample design was probabilistic, in two stages: the first corresponded to the health establishments and the second to women who had recently given birth and their babies. The data was collected by means of interviews and consulting the hospital records, from pre-tested electronic form. Descriptive statistics were used for the univariate analysis, Pearson’s Chi-square test for the bivariate analysis and multiple logistic regressions for the multivariate analysis. Sociodemographic variables, obstetrical history, and birth care were analyzed. RESULTS Half of the adolescents and young people interviewed had not been given guidance on the location that they should go to when in labor, and among those who had, 23.5% did not give birth in the indicated health service. Furthermore, one third (33.3%) had to travel in search of assisted birth, and the majority (66.7%) of the postpartum women came to maternity by their own means. In the bivariate analysis, the variables marital status, paid work, health insurance, number of previous pregnancies, parity, city location, and type of health establishment showed a significant association (p < 0.20) with inadequate access to childbirth care. The multivariate analysis showed that married adolescents and young people (p < 0.015), with no health insurance (p < 0.002) and from the countryside (p < 0.001) were more likely to have inadequate access to childbirth care. CONCLUSIONS Adolescents and young women, married, without health insurance, and from the countryside are more likely to have inadequate access to birth care. The articulation between outpatient care and birth care can improve this access and, consequently, minimize the maternal and fetal risks that arise from a lack of systematic hospitalization planning.

scholarly journals Knowledge and attitude towards pain relief in labor among final year midwifery students: A cross-sectional study

2019 ◽  
Author(s):  
Nigussie Simeneh Endalew ◽  
Hailu Yimer Tawye ◽  
Zewuditu Abdissa Denu
Keyword(s):  
Pain Relief ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Labour Pain ◽  
Cross Sectional Study ◽  
Labour Analgesia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Knowledge And Attitudes ◽  
Knowledge And Attitude

Abstract Background: Poor attitudes and lack of knowledge about labour pain has long been demonstrated to burden the health professionals, as well as the women. In developing countries, labour analgesia practice is not well established and undermined. Therefore, the aim of this study was to explore final year midwifery students’ knowledge and attitudes towards pain relief during labour, at University of Gondar, Northwest Ethiopia.Methods: A cross-sectional study was conducted among final year undergraduate midwifery students using structured, and self-administered questionnaire(n=130). Descriptive statistics were performed. Results were presented using narrations, means and standard deviations, percentage, figure and tables. Univariate analysis was used to assess the association between demographic variables with poor knowledge and attitudes. P-value below 0.05 level of significance was used to identify the statistical significance of factors for knowledge and attitude about pain relief during labour.Results: Of 130 students participated, the majority, 88% of respondents understood that women can feel moderate to severe pain during labour. However, only less than half of the participants had knowledge of labour pain should be relieved. The majority, 70% of students did not have awareness about the methods of labour analgesia.Conclusion: Although the majority of final year midwifery students were agreed with women can feel moderate to severe labour pain, almost more than half of the students were not aware of the painless labour in hospital. Most of the students believed that pharmacologic methods of labour analgesia will affect the labour, baby, and mother. Therefore, considerable attention in preservice teaching and training about labour pain and analgesia for midwifery students is recommended.

Socio-Economic Analysis and Incidence of Sexually Transmitted Infections in North Sumatra Province

2021 ◽  
Vol 3 (1) ◽  
pp. 29
Author(s):  
Samsul Askhori
Keyword(s):  
Multivariate Analysis ◽  
Sexually Transmitted Infections ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
The Government ◽  
North Sumatra

<p><strong><em>Introduction:</em></strong> <em>Until now, Sexually Transmitted Infections (STIs) are still a health problem in the world, both developed and developing countries continue to strive to face and find solutions to overcome this disease, although prevention efforts carried out in various countries do not seem to have yielded satisfactory results. The purpose of this study was to analyze the determinants of sexually transmitted infections (STIs) based on data from the 2017 North Sumatra IDHS. <strong>Method: </strong>This type of research is an observational analytic study using a cross-sectional study design based on data from the 2017 North Sumatra Province IDHS. The population of this study was women aged 15-49 years who have had sexual relations. After cleaning the data, 1728 samples were included in the study. The data analysis technique used the frequency distribution of categorical variables, the analysis of the relationship between the independent variable and the dependent variable used the chi-square test, then the multivariate analysis used logistic regression test. <strong>Result :</strong> The results showed that the prevalence of sexually transmitted infections among women of childbearing age in North Sumatra was 25% (95% CI = 23.7% - 27.7%). The results showed that there was a significant relationship between age, education level and area of residence with the incidence of sexually transmitted infections (STIs). Then the multivariate analysis showed that the area of residence variable was the most dominant risk factor in causing the incidence of sexually transmitted infections (STIs). It is hoped that the government can overcome the problem of STIs through interventions on risk factors by providing education related to STIs in the community, especially women of childbearing age.</em></p>

Plasma Irisin Levels in Subjects with Type 1 Diabetes: Comparison with Healthy Controls

2018 ◽  
Vol 50 (11) ◽  
pp. 803-810 ◽  
Author(s):  
Anastasios Tentolouris ◽  
Ioanna Eleftheriadou ◽  
Dimitrios Tsilingiris ◽  
Ioanna Anastasiou ◽  
Ourania Kosta ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 1 Diabetes ◽  
Multivariate Analysis ◽  
Waist Circumference ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Serum Triglycerides ◽  
Cross Sectional

AbstractIrisin is a myokine that increases energy expenditure. In this cross-sectional study, we examined for differences in plasma irisin concentrations between subjects with type 1 diabetes mellitus and healthy individuals and searched for associations between plasma irisin levels and clinical and biochemical characteristics as well as self-reported physical activity. A total of 79 subjects with type 1 diabetes [age 38.2±12.5 years, men/women (n): 27/52], were consecutively recruited. Moreover, 53 healthy controls, matched for age and body mass index with those with diabetes were recruited. Plasma irisin was measured with ELISA. Participants were asked about their physical activity during the last week. We also measured trunk and visceral fat. Circulating irisin levels were lower in subjects with diabetes than in controls [median value (interquartile range): 53.0 (35.2, 106.3) vs. 178.1 (42.6, 641.6) ng/ml, respectively, p<0.001]. In the group of diabetes, univariate analysis showed that irisin levels were associated with waist circumference (beta=–0.283, p=0.023), serum triglycerides (beta=–0.282, p=0.031), and trunk fat (beta=–0.324, p=0.012). In multivariate analysis after adjustment for potential confounders, irisin levels were associated independently only with waist circumference (beta=–0.403, p=0.005). Among controls, multivariate analysis demonstrated that irisin levels were associated with pack-years of smoking (beta=–0.563, p=0.012) and fasting triglycerides (beta=–0.338, p=0.041). Circulating irisin levels were lower in subjects with diabetes in comparison with healthy-matched controls. In conclusion, plasma irisin concentrations in subjects with diabetes were associated with waist circumference, while in controls with serum triglycerides and pack-years of smoking.

scholarly journals Schizophrenia among patients with systemic lupus erythematosus: population-based cross-sectional study

2016 ◽  
Vol 26 (4) ◽  
pp. 424-429 ◽  
Author(s):  
S. Tiosano ◽  
A. Farhi ◽  
A. Watad ◽  
N. Grysman ◽  
R. Stryjer ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Multivariate Analysis ◽  
Lupus Erythematosus ◽  
Univariate Analysis ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Medical Database ◽  
Systemic Lupus ◽  
Cross Sectional

Aims.Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease involving multiple organs, including the central nervous system. Evidence of immune dysfunction exists also in schizophrenia, a psychiatric illness involving chronic or recurrent psychosis. The aim of our study was to investigate if there is an epidemiological association between SLE and schizophrenia.Method.A cross-sectional study was conducted comparing patients with SLE with age and gender-matched controls regarding the proportion of patients with comorbid schizophrenia. χ2- and t-tests were used for univariate analysis, and interaction of schizophrenia with SLE across strata of covariates was checked. A logistic regression model was used for multivariate analysis. The study was performed utilising the medical database of Clalit Health Services in Israel.Results.The study included 5018 patients with SLE and 25 090 controls. SLE patients had a female predominance, and a higher proportion of smoking compared with age and sex-matched controls. In multivariate analysis, SLE was found to be independently associated with schizophrenia while controlling for age, gender, socioeconomic status (SES) and smoking (OR 1.33, p = 0.042).Conclusions.We found a positive association between SLE and schizophrenia across patients of different age, gender and SES. This association can contribute to understanding the pathophysiology of the two disorders and may also have clinical implications for earlier as well as better diagnosis and treatment.

scholarly journals Profile of Self-Reported Physical Tasks and Physical Training in Brazilian Special Operations Units: A Web-Based Cross-Sectional Study

2020 ◽  
Vol 17 (19) ◽  
pp. 7135
Author(s):  
Eduardo Marins ◽  
Ossian Barbosa ◽  
Eduardo Machado ◽  
Robin Orr ◽  
Jay Dawes ◽  
...  
Keyword(s):  
Physical Training ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Climatic Conditions ◽  
Categorical Variables ◽  
Cross Sectional ◽  
Special Operations ◽  
Occupational Tasks ◽  
Demographic Performance ◽  
Response Group

There is limited research examining the physical tasks that Brazilian special policemen groups can perform in the line of duty. The aims of this study were to (a) identify the occupational tasks of specialist police personnel serving in the Rapid Response Group (GRR) and Tactical Operations Command (COT), and to profile the frequency, difficulty, and importance of these tasks, and (b) to explore the current physical training these special operations police units (SOPUs) officers undertake to maintain their operational fitness. Univariate analysis for numerical variables (mean and standard deviation (SD)), as well as the absolute and relative frequencies for categorical variables were performed. Two Brazilian SOPUs performed a questionnaire with demographic, performance, and physical training sections. A total of 78 respondents (24 of the GRR and 54 of the COT) completed the survey. “Standing and/or sitting with complete equipment for long periods in different climatic conditions”, and “lifting/pushing/pulling heavier objects” were the most frequent and difficult occupational tasks of both SOPUs, respectively. “Shooting a long weapon” and “breaking a door” were the most important for GRR and COT, respectively. All officers undertook regular physical training (~9 h/week), in an unstructured manner, without supervision, and planning of physical training is carried out autonomously (COT) or a mixture of autonomously and directed (GRR), with the main objectives of developing aerobic endurance and muscle strength. It is important that SOPUs teams train their members’ physical capabilities to perform the tasks identified in this study, as well as follow a structured, supervised, and planned physical training program.

scholarly journals Laboratorial Aspects of Cytolytic Vaginosis and Vulvovaginal Candidiasis as a Key for Accurate Diagnosis: A Pilot Study

2020 ◽  
Vol 42 (10) ◽  
pp. 634-641
Author(s):  
José Marcos Sanches ◽  
Paulo César Giraldo ◽  
Marcela Grigol Bardin ◽  
Rose Amaral ◽  
Michelle Garcia Discacciati ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Cross Sectional Study ◽  
Vulvovaginal Candidiasis ◽  
Categorical Variables ◽  
Fungal Culture ◽  
Cross Sectional ◽  
Significance Level ◽  
Clinical Criteria ◽  
Patient Interview ◽  
Vaginal Ph

Abstract Objective To identify clinical, microscopic, and biochemical characteristics that differentiate cytolytic vaginosis (CV) from vulvovaginal candidiasis (VVC). Methods The present cross-sectional study analyzed the vaginal contents of 24 non-pregnant women aged 18 to 42 years who were attended at the Genital Infections Clinic at Centro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas (CAISM-UNICAMP). They were diagnosed either with (CV = 8, VVC = 8) or without vulvovaginitis or vaginal dysbiosis (controls). The socio-demographic, clinical, and gynecological data were obtained from a detailed patient interview. Samples of the vaginal contents were collected for analysis of vaginal pH, gram stain, and specific fungal culture. The Kruskal-Wallis and Fisher exact tests were used to compare the differences between the groups. Odds ratios were used to compare the categorical variables. The significance level was considered at p < 0.05. Results Both women with CV and VVC had a lumpy vaginal discharge (p = 0,002) and vaginal hyperemia (p = 0.001), compared with controls. The inflammatory process was more intense in the VVC group (p = 0.001). In the CV group, there was statistical significance for the lactobacillus amount (p = 0.006), vaginal epithelium lysis (p = 0.001), and vaginal pH (p = 0.0002). Conclusion Cytolytic vaginosis and VVC diagnoses rarely differ on clinical characteristics but have different laboratorial findings. The present study highlights the importance of conducting an accurate investigation through laboratory tests rather than clinical criteria to avoid misdiagnosis.

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