scholarly journals 2304. Incidence and Risk Factors for Herpes Zoster among Diabetes Patients at Siriraj Hospital; Results from a 10-year Cohort

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S789-S789
Author(s):  
Nalinee Chuanchaiyakul ◽  
Nuntakorn Thongtang ◽  
Pinyo Rattanaumpawan
Keyword(s):  
Risk Factors ◽  
Herpes Zoster ◽  
Incidence Rate ◽  
Protective Factor ◽  
Herbal Remedies ◽  
P Value ◽  
Varicella Zoster ◽  
Icd 10 ◽  
Siriraj Hospital ◽  
Nested Case Control

Abstract Background Herpes Zoster (HZ) is the reactivation of latent varicella-zoster virus. Diabetes Mellitus (DM) is one of well-known risk factors for HZ. Nowsday, the knowledge on the incidence of and risk factors for HZ among Thai DM patients is limited. Methods We conducted a nested case–control study of DM patients who attended the Siriraj DM clinic for ≥6 consecutive months during 2005–2014. Eligible subjects were identified through the DM clinic registry database (n = 1,427). Cases were those who had ≥1 episode of HZ while controls were those without evidence of HZ during the study period. We captured 40 cases and randomly sampled 175 controls (1 case: 4 controls). All data were obtained via chart-review, the ICD-10, pharmacy and laboratory databases Results During the 10-year study period, the cumulative incidence and the incidence rate of HZ were 0.28% [95% CI: 0.20–0.38%] and 3.96 [95% CI: 2.90–5.28] per 1,000 person-years. The most common sites were trunk (27.5%), followed by herpes opthalmicus (22.5%). Thirty-five percent had post-herpetic neuralgia and only 1 case required hospitalization. Independent risk factors for HZ [adjusted odd ratio; 95% CI; P-value] identified from multivariate analysis included underlying hypertension [3.48; 1.28–9.43; P = 0.01], number of hypoglycemic drug used [1.46; 1.03–2.08; P = 0.04] and previous use of herbal remedies [3.83; 1.06–13.84; P = 0.04]. Furthermore, higher body mass index was an independent protective factor [0.89;0.81–0.98; P = 0.02]. Conclusion The incidence rate of HZ among DM patients at our institute was comparable to other Asian countries. Risk factors for HZ can be used to identify patients who would benefit the most from preventive interventions. Disclosures All authors: No reported disclosures.

Delayed Varicella Zoster Virus (VZV) Infection Following Hematopoietic Cell Transplantation (HCT).

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3366-3366
Author(s):  
Liton Francisco ◽  
Mary Harton ◽  
Can-Lan Sun ◽  
Andrea R. Carter ◽  
John Zaia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Mycophenolate Mofetil ◽  
Herpes Zoster ◽  
Immunosuppressive Agents ◽  
Unrelated Donor ◽  
Varicella Zoster ◽  
Increased Risk ◽  
Autologous Hct ◽  
Varicella Zoster Infection

Abstract Patients undergoing HCT are at an increased risk of developing primary and reactivated VZV infection, with the majority of reactivations occurring within the first year post-HCT. Short term use of acyclovir as prophylaxis has been shown to be effective in reducing VZV risk, however prolonged use of acyclovir as prophylaxis is controversial, and the long term incidence of delayed VZV infection, and hence the recommended duration of antiviral prophylaxis is not clear. To assess the incidence and risk factors associated with delayed VZV infection (occurring one or more years after HCT), we conducted a retrospective chart review of 1578 consecutive patients undergoing HCT at City of Hope Cancer Center between 1976 and 1998, and surviving one or more years after HCT. Diagnosis of VZV was based on the clinic note dictated by the physician, with validation using appropriate laboratory tests in those individuals diagnosed with VZV. Information on pre-transplant therapeutic exposures and post-transplant health complications was obtained via medical record abstraction. The median age at HCT was 35 years (range, 0.6–71.5), median length of follow-up 6.4 years, and the cohort included 934 males (59.2%). In total, 178 patients (11.3%) developed VZV infection after surviving at least one year after HCT (19 patients (1.2%) had primary VZV (chickenpox), 138 patients (8.7%) localized herpes zoster, and 21 patients (1.3%) disseminated herpes zoster). The overall cumulative incidence was 13.9% (95% Confidence Interval [CI], 11.6–16.2%) at 15 years from HCT for the first reported VZV infection developing one or more years after HCT. (autologous HCT: 10.2% [7.2–13.3%] at 10 years); allogeneic sibling donor HCT survivors: 14.2% [11.6–16.8%]; unrelated donor HCT: 21.5% [12.3–30.7%]). Multivariate analysis of the allogeneic transplant cohort showed that prophylaxis/treatment of GvHD with prednisone (Relative risk (RR), 2.14; 95% CI, 1.27 to 3.61) and Mycophenolate Mofetil (RR, 1.93; 95% CI, 1.08 to 3.45) were associated with increased risk. No risk factors were identified for the development of VZV among autologous HCT recipients by multivariate analysis. VZV infection is a frequent and significant source of morbidity after HCT (bacterial superinfection, scarring, post-herpetic neuralgia), and can be potentially fatal if disseminated. This study describes the magnitude of risk of delayed VZV infection in autologous and allogeneic HCT recipients and identifies the use of immunosuppressive agents such as Prednisone and Mycophenolate Mofetil as risk factors, suggesting the possible use of acyclovir as prophylaxis during prolonged periods of immune suppression. Incidence of Delayed Varicella Zoster in 1+ Year Survivors of HCT Incidence of Delayed Varicella Zoster in 1+ Year Survivors of HCT Delayed Varicella Zoster Infection in 1+ Year Survivors of HCT (by Type of Transplant) Delayed Varicella Zoster Infection in 1+ Year Survivors of HCT (by Type of Transplant)

scholarly journals Association between Herpes Zoster and Osteoporosis: A Nested Case-Control Study Using a National Sample Cohort

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Chanyang Min ◽  
Woo Jin Bang ◽  
Dong Jun Oh ◽  
Songyong Sim ◽  
Hyo Geun Choi
Keyword(s):  
Herpes Zoster ◽  
Conditional Logistic Regression ◽  
National Sample ◽  
Chronic Inflammatory Disease ◽  
Control Group ◽  
Subgroup Analyses ◽  
Region Of Residence ◽  
Icd 10 ◽  
Nested Case Control ◽  
Age And Sex

Objectives. Chronic inflammatory disease might affect osteoporosis; however, few studies have reported the association between herpes zoster and osteoporosis. The goal of this study was to estimate the association between herpes zoster and osteoporosis in Korean residents. Methods. The Korean National Health Insurance Service-National Sample Cohort, which includes individuals aged ≥ 50 years, was assessed from 2002 to 2013. In total, 68,492 osteoporosis participants were matched with 68,492 control participants at a ratio of 1:1 by age, sex, income, and region of residence. We assayed the prior histories of herpes zoster in the osteoporosis and control groups. The diagnoses of herpes zoster and osteoporosis were based on ICD-10 codes and claim codes. Crude and adjusted models of odds ratios (ORs) were explored using conditional logistic regression analyses, and the 95% confidence intervals (CIs) were computed. The participants were stratified according to age, sex, income, and region of residence. Subgroup analyses were performed to investigate the role of age and sex. Results. The rate of herpes zoster in the osteoporosis group (5.1% [3,487/68,492]) was higher than that in the control group (4.0% [2,738/68,492]). The adjusted OR of herpes zoster in the osteoporosis group was 1.17 (95% CI = 1.11-1.24). In the subgroup analyses, the adjusted OR was 1.34 (95% CI = 1.01-1.78) among males aged < 65 years, 1.20 (95% CI = 1.12-1.29) among females aged < 65 years, and 1.19 (95% CI = 1.04-1.36) among males aged ≥ 65 years. Conclusion. The ORs of herpes zoster were increased among the osteoporosis patients. This correlation was reliable in all subgroups by age and sex except group of women ≥ 65 years old.

scholarly journals Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015–2017 Cohort from Tashkent, Uzbekistan

2021 ◽  
Vol 18 (11) ◽  
pp. 5746
Author(s):  
Dilbar Sadirova ◽  
Ruzanna Grigoryan ◽  
Nargiza Parpieva ◽  
Venera Barotova ◽  
Aleksandr Trubnikov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Incidence Rate ◽  
Secondary Data ◽  
Hazard Ratio ◽  
Active Tuberculosis ◽  
P Value ◽  
People Living With Hiv ◽  
Newly Diagnosed ◽  
Immunodeficiency Virus ◽  
Living With Hiv

People living with the human immunodeficiency virus (PLHIV) have a higher risk of developing active tuberculosis (TB) disease, and TB remains a major cause of death in PLHIV. Uzbekistan is facing a substantial TB epidemic, which increases the risk of PLHIV developing active TB. Our retrospective cohort study aimed to evaluate the incidence rate and assess the risk factors for developing active TB among PLHIV. We collected secondary data extracted from medical charts of all patients, newly diagnosed at the AIDS Center in Tashkent, during the period of 2015–2017. The incidence rate of TB among PLHIV was 5.1 (95% CI: 4.5–6.0) per 1000 person/month. Adjusted regression analysis showed three major risk factors for TB, namely, being less than 15 years old (hazard ratio (HR) 5.83; 95% CI: 3.24–10.50, p value = 0.001),low CD4 count (adjusted hazard ratio(aHR) 21.0; 95% CI: 9.25–47.7, p value < 0.001), and antiretroviral therapy (ART) interruption/not receiving ART (aHR 5.57; 95% CI: 3.46–8.97 and aHR 6.2; 95% CI: 3.75–10.24, p value < 0.001, respectively) were significantly associated with developing active TB among PLHIV. Our findings indicate that taking prescribed ART without interruptions and maintaining CD4cell counts higher than 320 cells/μL are essential to prevent the development of active TB among PLHIV.

scholarly journals Prevalence and associated factors of myopia among school children in Bahir Dar city, Northwest Ethiopia, 2019

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248936
Author(s):  
Abel Sinshaw Assem ◽  
Mebratu Mulusew Tegegne ◽  
Sofonias Addis Fekadu
Keyword(s):  
Risk Factors ◽  
School Children ◽  
Associated Factors ◽  
Protective Factor ◽  
Northwest Ethiopia ◽  
P Value ◽  
Bahir Dar ◽  
Outdoor Activity ◽  
Cross Sectional ◽  
Working Distance

Background Myopia is the leading cause of correctable visual impairment and preventable blindness worldwide. Genetic and environmental factors contribute to the development of myopia. Myopia is appearing with greater prevalence in young children. Objective This study aimed to assess the prevalence and associated factors of myopia among school children in Bahir Dar city, Northwest Ethiopia, 2019. Methods and materials A school-based cross-sectional study was conducted among school children of 6 to 18 years of age in Bahir Dar city from October to November 2019. A pretested interviewer-administered structured questionnaire was used to collect data among 634 participants using a multi-stage sampling technique from primary and secondary schools. Cycloplegic refraction was performed by optometrists for each student with 1% cyclopentolate eye drop, and subjective refraction was carried out to determine the final prescription of the students. Myopia was defined as spherical equivalent refractive error of ≥ 0.5 diopter in either eye. Data were entered into Epi Info version 7 and exported to Statistical Package for Social Sciences version 23 for analysis. Tables, frequency, and mean were used for descriptive statistics. Bivariable and multivariable logistic regression analyses were done to identify risk factors of myopia. Odds ratio with 95% confidence level was determined and variables with p–value of < 0.05 were considered as statistically significant. Results Among a total of 601 study participants, 51 (8.49%) were myopic. Age group of 10–13 years (AOR = 6.54: 95% CI = 5.56–10.86), 14–18 years (AOR = 6.32: 95% CI = 5.32–9.69), 2–4 hour per day mobile exposure (AOR = 3.69: 95% CI = 1.63–8.38), > 4 hour per day mobile exposure (AOR = 11.6: 95% CI = 4.41–30.42), near working distance of < 33 centimeter (AOR = 6.89: 95% CI = 2.71–17.56) and outdoor activity (AOR = 3.94: 95% CI = 1.87–8.31) were significantly associated with myopia. Conclusions The prevalence of myopia was high among school children in Bahir Dar city. Older age, longer duration of mobile exposure, shorter near working distance were the risk factors for the development of myopia whereas having outdoor activity was the protective factor.

scholarly journals Clinical Manifestations of Herpes Zoster Associated with Complications in Children

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 845
Author(s):  
Dong Ha Kang ◽  
Byung Ok Kwak ◽  
A Young Park ◽  
Han Wool Kim
Keyword(s):  
Herpes Zoster ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Primary Diagnosis ◽  
Cell Mediated Immunity ◽  
Specific Cell ◽  
Vaccination Programs ◽  
Varicella Zoster ◽  
Before And After ◽  
Icd 10

Herpes zoster (HZ) is caused by latent varicella-zoster virus (VZV) reactivation when VZV-specific cell-mediated immunity declines. Information on HZ in children is limited. Therefore, we retrospectively investigated HZ’s clinical course and complications in children. We extracted the outpatient and hospitalization medical records of pediatric patients (<19 years) primarily diagnosed with HZ (ICD-10 B02 code) between January 2010 and November 2020. HZ was defined as a typical unilateral dermatomal vesicular rash where HZ was the treating physician’s primary diagnosis. Recognized HZ complications included combined bacterial skin infection, ophthalmic zoster, zoster oticus without facial paralysis, meningitis, and PHN. We identified 602 HZ cases, among which 54 developed HZ complications and were included in our analysis. The median age was 14.7 years, most patients were aged ≥13 years (42, 79%), and none were aged <4 years. Fifty-three were immunocompetent, and only one had systemic lupus erythematosus. The most frequent complication was zoster ophthalmicus (n = 26, 48%). HZ complications were also observed in immunocompetent or vaccinated children exhibiting a head or neck rash before and after VZV immunization. Current VZV vaccination programs may be insufficient in preventing HZ complications. Therefore, close varicella and HZ burden monitoring and the establishment of effective VZV vaccination programs are imperative.

scholarly journals Risk of herpes zoster in patients with rheumatoid arthritis in the biologics era from 2011 to 2015 and its association with methotrexate, biologics, and corticosteroids

2021 ◽  
Author(s):  
Rei Yamaguchi ◽  
Eiichi Tanaka ◽  
Ayako Nakajima ◽  
Eisuke Inoue ◽  
Mai Abe ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Herpes Zoster ◽  
Incidence Rate ◽  
Medical Records ◽  
Cox Regression ◽  
Health Assessment ◽  
Japanese Version ◽  
Cox Regression Analysis ◽  
Assessment Questionnaire

ABSTRACT Objectives To elucidate the incidence and risk factors of herpes zoster (HZ) in patients with rheumatoid arthritis (RA) in the biologics era. Methods We determined the rate of HZ occurrence among the RA patients that participated in the Institute of Rheumatology, Rheumatoid Arthritis surveys from 2011 to 2015, by assessing medical records. The standardised incidence rate per 1000 patient-years with a 95% confidence interval (CI) was calculated, and risk factors for HZ were analysed using a time-dependent Cox regression analysis. Results Among 7815 patients (female, 84.7%) contributing to 25,863 patient-years of observation, 340 HZ events in 309 patients were confirmed. The standardised incidence rate (95% CI) per 1000 patient-years was 8.5 (6.9–10.5) in total, 6.0 (3.7–9.2) in men, and 11.0 (8.7–13.7) in women. Risk factors for HZ were age per 10 years (hazard ratio 1.14, 95% CI 1.03–1.26, p &lt; .05), Japanese version of the Health Assessment Questionnaire (J-HAQ) score of 0.5–1.5 (versus J-HAQ = 0; 1.51, 1.09–2.10, p &lt; .05), methotrexate use (1.58, 1.06–2.36, p &lt; .05), and biologic use (1.88, 1.44–2.47, p &lt; .01). Conclusions In the era when biologics were frequently used and corticosteroid use and doses were decreasing, methotrexate and biologics increased the risk for HZ.

scholarly journals Trends in the Prevalence and Incidence of Anxiety and Depression in Adult Population in Iran: Findings from Kerman Coronary Artery Diseases Risk factors Study (KERCADRS)

2020 ◽  
Author(s):  
Hamid Najafipour ◽  
mohadeseh Shojaei Shahrokhabadi ◽  
Ghodsyeh Banivaheb ◽  
Abdolreza Sabahi ◽  
Mitra Shadkam ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Young Adults ◽  
Coronary Artery ◽  
Incidence Rate ◽  
Disease Risk ◽  
Common Mental Disorders ◽  
Anxiety And Depression ◽  
P Value ◽  
Targeted Interventions

Abstract Background: Anxiety and depression (A&D) are common mental disorders with high economical and health burdens. This study aimed to investigate the prevalence and the incidence rate of A&D and their relationship with socio-demographic and other risk factors and co-morbidities in adults living in southeastern Iran.Method: We recruited adults (15 to 80 years) in two rounds (2009-2012, 2014-2018) of a population-based cohort study called Kerman coronary artery disease risk factors study (KERCADRS) in Kerman, Iran. The age-standardized A&D prevalence was measured among all participants (n=9996) and the five-year A&D incidence rate was measured in those who were free of A&D in the first round (n = 2813). The relationship between A&D and demographic characteristics, smoking, opium use, obesity and physical activity was assessed by logistic regression models. Results: Overall, the prevalence of anxiety (48.1% to 16.4%, P-value <0.001) and depression (5.9% to 1.3% P-value <0.001) decreased between the two rounds. The highest prevalence of anxiety was among people who were unemployed (%?), smokers (%?), and opium users (%?). Young adults, women, those divorced or widowed, and those with obesity and low physical activity had a higher chance for anxiety. The five-year incidence rate (person/1000 person-years) was 15.0 for anxiety and 3.9 for depression.Conclusion: Despite the overall decrease in the prevalence of A&D, certain groups such as young adults, women, unemployed and those who smoke cigarettes or opium, people with low physical activity and obesity are in need of more targeted interventions.

scholarly journals Malaria Outbreak Investigation in Siansundu, Binga District, Matabeleland North Province, Zimbabwe, 2013

2021 ◽  
Vol 9 (2) ◽  
pp. 35-44
Author(s):  
Cynthia Ncube
Keyword(s):  
Risk Factors ◽  
Emergency Preparedness ◽  
Protective Factor ◽  
Case Fatality ◽  
P Value ◽  
Educational Strategies ◽  
Public Health Importance ◽  
Mosquito Nets ◽  
Response Team ◽  
Emergency Preparedness And Response

Malaria Is Of Public Health Importance In Zimbabwe. A Sharp Rise In The Number Of Malaria Cases In Binga District Was Noted During Week Five In 2013. On Further Analysis, The Siansundu Clinic Was Found To Be In An Outbreak Situation. The Study Was Conducted To Determine Factors Associated With Contracting Malaria In Binga District, Matabeleland North, Zimbabwe. An Unmatched 1: 1 Case-Control Study Was Conducted In Siansundu, Binga, Among 124 Residents. A Case Was A Person Who Presented With Malaria Symptoms, A Control Was A Person Who Was A Neighbour Of A Case And Did Not Suffer From Typical Malaria Symptoms Or Had A Negative RDT Result From The 1st Of January 2013. A Pre-Tested Interviewer-Administered Questionnaire And A Checklist Were Used To Collect Data. Data Were Analyzed Using Epi Info, Where Odds Ratios And P Values Were Calculated. Risk Factors For Contracting Malaria Were: Fetching Water At Night (OR 2.55, P-Value 0.04); Having Inadequate Mosquito Nets Per Sleeping Space (OR 3.596, P-Value 0.036); Worshipping And Praying Outside At Night (OR 3.417, P-Value 0.0006). Wearing Long Clothing At Night Was A Protective Factor Against Contracting Malaria (OR 0.156, P-Value 0.001). The Case Fatality Rate Was 0.43%. The District Was Not Prepared For The Outbreak And Responded Late. Educational Strategies To Address The Risk Factors For Malaria And Regular Meetings By The Emergency Preparedness And Response Team Were Recommended To Prevent Future Outbreaks And Aid Outbreak Preparedness.

scholarly journals Risk Factors for Herpes Zoster Among Adults

2016 ◽  
Vol 3 (3) ◽  
Author(s):  
Mona Marin ◽  
Rafael Harpaz ◽  
John Zhang ◽  
Peter C. Wollan ◽  
Stephanie R. Bialek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Herpes Zoster ◽  
Virus Reactivation ◽  
Varicella Zoster ◽  
Medical Sector ◽  
Risk Factor Data ◽  
Potential Risk Factors ◽  
Factor Data ◽  
Record Review

Abstract Background.  The causes of varicella-zoster virus reactivation and herpes zoster (HZ) are largely unknown. We assessed potential risk factors for HZ, the data for which cannot be obtained from the medical sector. Methods.  We conducted a matched case-control study. We established active surveillance in Olmsted County, Minnesota to identify HZ occurring among persons age ≥50 years during 2010–2011. Cases were confirmed by medical record review. Herpes zoster-free controls were age- and sex-matched to cases. Risk factor data were obtained by telephone interview. Results.  We enrolled 389 HZ case patients and 511 matched controls; the median age was 65 and 66 years, respectively. Herpes zoster was associated with family history of HZ (adjusted odds ratio [aOR] = 1.65); association was highest with first-degree or multiple relatives (aOR = 1.87 and 3.08, respectively). Herpes zoster was also associated with prior HZ episodes (aOR = 1.82), sleep disturbance (aOR = 2.52), depression (aOR = 3.81), and recent weight loss (aOR = 1.95). Stress was a risk factor for HZ (aOR = 2.80), whereas a dose-response relationship was not noted. All associations indicated were statistically significant (P &lt; .05). Herpes zoster was not associated with trauma, smoking, tonsillectomy, diet, or reported exposure to pesticides or herbicides (P &gt; .1). Conclusions.  We identified several important risk factors for HZ; however, the key attributable causes of HZ remain unknown.

Sign in / Sign up

Export Citation Format

Share Document