SKIN MICROVASCULAR REACTIVITY AND SUBENDOCARDIAL VIABILITY RATIO IN RELATION TO LIPID PROFILE AND METABOLIC STATUS, IN PRIMARY HYPERTENSION: THE DOXAZOSIN RAMIPRIL STUDY

The beneficial effect of omega-3 polyunsaturated fatty acids (PUFA) supplementation on the cardiovascular (CV) system is well supported in CV patients; however, the effect of the consumption of omega-3 PUFA-enriched functional food in healthy individuals is still not fully elucidated. This study aimed to determine the effect of the consumption of omega-3 PUFA-enriched hen eggs on the microvascular reactivity (primary outcome), blood pressure (BP), and serum lipid profile in young healthy individuals. The control group (N = 16) ate 3 ordinary hen eggs (277 mg of omega-3 PUFAs/day), and the OMEGA-3 group (N = 20) ate 3 omega-3 PUFA-enriched eggs containing 259 mg of omega-3 PUFAs/egg daily (α-linolenic acid (ALA), 167 mg/egg; eicosapentaenoic acid (EPA), 7 mg/egg; docosahexaenoic acid (DHA), 84 mg/egg) for 3 weeks (777 mg of omega-3 PUFA/day). Postocclusive reactive hyperemia (PORH) in skin microcirculation assessed by laser Doppler flowmetry, serum lipid profile, fasting blood glucose, high-sensitivity C-reactive protein (hsCRP), and arterial BP were measured in all subjects before and after the protocol. PORH was significantly enhanced, and triglycerides, hsCRP, and BP were significantly decreased in the OMEGA-3 group compared with baseline measurements, whereas there was no significant difference in the control group after the protocol when compared with baseline. To the best of our knowledge, this is the first study to demonstrate that consumption of a mixture of omega-3 PUFA (ALA + EPA + DHA), provided via enriched hen eggs, elicits changes in the microvascular reactivity, BP, and triglyceride level in healthy subjects that are associated with CV benefits, thus suggesting that daily consumption of omega-3 PUFA-enriched eggs in healthy individuals may potentially contribute to CV risk factor attenuation and disease prevention.

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IMPAIRED MICROVASCULAR REACTIVITY IN NON-DIABETIC PRIMARY HYPERTENSION IS INVERSELY RELATED TO LOW HDL CHOLESTEROL AND REDUCED GLUCOSE TOLERANCE

Journal of Hypertension ◽

10.1097/01.hjh.0000570348.10524.21 ◽

2019 ◽

Vol 37 ◽

pp. e94

Author(s):

A. Jekell ◽

M. Kalani ◽

T. Kahan

Keyword(s):

Glucose Tolerance ◽

Hdl Cholesterol ◽

Primary Hypertension ◽

Microvascular Reactivity ◽

Low Hdl

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Skin microvascular reactivity and subendocardial viability ratio in relation to dyslipidaemia and signs of insulin resistance in non‐diabetic hypertensive patients

Microcirculation ◽

10.1111/micc.12747 ◽

2021 ◽

Author(s):

A Jekell ◽

M Kalani ◽

T Kahan

Keyword(s):

Insulin Resistance ◽

Hypertensive Patients ◽

Microvascular Reactivity ◽

Subendocardial Viability Ratio

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Serum Carnitine Levels, Lipid Profile, and Metabolic Status of Patients on Continuous Ambulatory Peritoneal Dialysis

Peritoneal Dialysis International ◽

10.1177/089686089301302s111 ◽

1993 ◽

Vol 13 (2_suppl) ◽

pp. 440-443 ◽

Cited By ~ 5

Author(s):

Theodoros Pliakogiannis ◽

Christos Chatzidimitriou ◽

Athanasios Evangeliou ◽

Hans Josef Söhles ◽

Kleonikos Kalaitzidis

Keyword(s):

Body Weight ◽

Peritoneal Dialysis ◽

Lipid Profile ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Total Protein ◽

Skinfold Thickness ◽

Metabolic Status ◽

Serum Total Protein ◽

Relative Body Weight ◽

Triceps Skinfold Thickness

The purpose of our study was to evaluate the influence of serum carnitine levels on the metabolic status and lipid profile of patients on continuous ambulatory peritoneal dialysis (CAPD). We studied the lipid profile, the metabolic status (triceps, skinfold thickness, midarm muscle circumference, relative body weight, serum total protein, albumin), and serum carnitine levels in 22 patients (11 male, 11 female) on CAPD. The results are summarized as follows: mean serum total camitine (TC) was normal, free carnitine (FC) was reduced, while acylcarnitine (AC) was elevated in our patients (p<0.001). A positive correlation was found between TC (p<0.02), FC (p<0.05), and serum total protein. A positive correlation was also found between TC (p<0.05), AC (p<0.02), ACIFC (p<0.02), and relative body weight, and TC (p<0.001), FC (p<0.02), AC (p<0.01), ACIFC (p<0.02), and triglycerides. No correlation was found between carnitine and midarm muscle circumference, triceps skinfold thickness, albumin, total cholesterol, and HDL. or LDL-cholesterol. Further studies are needed to confirm our results.

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