scholarly journals Pure shear deformation and its induced mechanical responses in metallic glasses

2019 ◽  
Vol 475 (2231) ◽  
pp. 20190486
Author(s):  
Zhukun Zhou ◽  
Hao Wang ◽  
Mo Li
Keyword(s):  
Shear Deformation ◽  
Pure Shear ◽  
Deformation Mode ◽  
Disordered Materials ◽  
Mechanical Responses ◽  
New Class ◽  
Volume Dilatation ◽  
Property Changes ◽  
Finite Deformation Theory ◽  
First Time

Shear is a basic deformation mode governing yielding, plasticity and fracture in metallic solids. For amorphous metals, due to various constraints, little work is available in addressing directly shear deformation and shear-induced mechanical property changes which are vital to the mechanistic understanding of this new class of disordered materials. Here, by using a finite deformation theory, we examine the pure shear deformation in a bulk metallic glass in a large range of shear strains. With the continuum approach, we show systematically for the first time the detailed shear deformation behaviours, shear-induced normal stress and strain relations, softening in the elastic constants, volume dilatation and free energy change induced by the shear deformation. These results point to two major consequences from the shear deformation, one is the mechanical degradations and the other material degradation which is responsible for the changes in the mechanical properties of the disordered materials.

Realizing pure shear mode of dielectric elastomers by tuning biaxial prestress of a deformation controller

2021 ◽  
Author(s):  
Liling Tang ◽  
Yuxi Ding ◽  
Lei Liu ◽  
Junshi Zhang
Keyword(s):  
Large Deformation ◽  
Shear Deformation ◽  
Pure Shear ◽  
Deformation Mode ◽  
Experimental Results ◽  
Free State ◽  
Dielectric Elastomers ◽  
Shear Mode ◽  
Mechanical Loads ◽  
Soft Actuators

Abstract In this article, we propose a method to realize the pure shear deformation mode of dielectric elastomer (DE) membranes by tuning two in-plane prestresses. With utilization of carbon grease electrodes, VHB 4905 membranes are prestretched and attached into a retractable device, forming a pure-shear deformation controller. Experimental results demonstrate that, accurate pure shear deformation mode of DEs can be realized by tuning the mechanical loads in the two directions of the deformation controller. Furthermore, large deformation in the direction of free state can be achieved without electromechanical instabilities. The designed deformation controller accurately realizes the specific pure shear deformation mode of DEs and can be utilized to help design the practical soft actuators.

scholarly journals The antimicrobial potential of cannabidiol

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Mark A. T. Blaskovich ◽  
Angela M. Kavanagh ◽  
Alysha G. Elliott ◽  
Bing Zhang ◽  
Soumya Ramu ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Modern Medicine ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
New Class ◽  
Clostridioides Difficile ◽  
Excellent Activity ◽  
Induce Resistance ◽  
First Time

AbstractAntimicrobial resistance threatens the viability of modern medicine, which is largely dependent on the successful prevention and treatment of bacterial infections. Unfortunately, there are few new therapeutics in the clinical pipeline, particularly for Gram-negative bacteria. We now present a detailed evaluation of the antimicrobial activity of cannabidiol, the main non-psychoactive component of cannabis. We confirm previous reports of Gram-positive activity and expand the breadth of pathogens tested, including highly resistant Staphylococcus aureus, Streptococcus pneumoniae, and Clostridioides difficile. Our results demonstrate that cannabidiol has excellent activity against biofilms, little propensity to induce resistance, and topical in vivo efficacy. Multiple mode-of-action studies point to membrane disruption as cannabidiol’s primary mechanism. More importantly, we now report for the first time that cannabidiol can selectively kill a subset of Gram-negative bacteria that includes the ‘urgent threat’ pathogen Neisseria gonorrhoeae. Structure-activity relationship studies demonstrate the potential to advance cannabidiol analogs as a much-needed new class of antibiotics.

scholarly journals Increase in Total Elongation Caused by Pure Shear Deformation in Ultra-Fine-Grained Cu Processed by Equal-Channel Angular Pressing

Metals ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 654
Author(s):  
Ryosuke Matsutani ◽  
Nobuo Nakada ◽  
Susumu Onaka
Keyword(s):  
Shear Deformation ◽  
Equal Channel Angular Pressing ◽  
Pure Shear ◽  
Three Dimensional ◽  
Tensile Tests ◽  
Total Elongation ◽  
Local Deformation ◽  
Image Correlation ◽  
Fine Grained ◽  
Angular Pressing

Ultra-fine-grained (UFG) Cu shows little total elongation in tensile tests because simple shear deformation is concentrated in narrow regions during the initial stage of plastic deformation. Here, we attempted to improve the total elongation of UFG Cu obtained by equal-channel angular pressing. By making shallow dents on the side surfaces of the plate-like specimens, this induced pure shear deformation and increased their total elongation. During the tensile tests, we observed the overall and local deformation of the dented and undented UFG Cu specimens. Using three-dimensional digital image correlation, we found that the dented specimens showed suppression of thickness reduction and delay in fracture by enhancement of pure shear deformation. However, the dented and undented specimens had the same ultimate tensile strength. These results provide us a new concept to increase total elongation of UFG materials.

scholarly journals Phenotypic Susceptibility to Bevirimat in Isolates from HIV-1-Infected Patients without Prior Exposure to Bevirimat

2010 ◽  
Vol 54 (6) ◽  
pp. 2345-2353 ◽  
Author(s):  
Nicolas A. Margot ◽  
Craig S. Gibbs ◽  
Michael D. Miller
Keyword(s):  
Recombinant Viruses ◽  
Gag Polyprotein ◽  
New Class ◽  
Major Mutation ◽  
Hiv Drugs ◽  
The Impact ◽  
First Time ◽  
Hiv 1

ABSTRACT Bevirimat (BVM) is the first of a new class of anti-HIV drugs with a novel mode of action known as maturation inhibitors. BVM inhibits the last cleavage of the Gag polyprotein by HIV-1 protease, leading to the accumulation of the p25 capsid-small peptide 1 (SP1) intermediate and resulting in noninfectious HIV-1 virions. Early clinical studies of BVM showed that over 50% of the patients treated with BVM did not respond to treatment. We investigated the impact of prior antiretroviral (ARV) treatment and/or natural genetic diversity on BVM susceptibility by conducting in vitro phenotypic analyses of viruses made from patient samples. We generated 31 recombinant viruses containing the entire gag and protease genes from 31 plasma samples from HIV-1-infected patients with (n = 21) or without (n = 10) prior ARV experience. We found that 58% of the patient isolates tested had a >10-fold reduced susceptibility to BVM, regardless of the patient's ARV experience or the level of isolate resistance to protease inhibitors. Analysis of mutants with site-directed mutations confirmed the role of the V370A SP1 polymorphism (SP1-V7A) in resistance to BVM. Furthermore, we demonstrated for the first time that a capsid polymorphism, V362I (CA protein-V230I), is also a major mutation conferring resistance to BVM. In contrast, none of the previously defined resistance-conferring mutations in Gag selected in vitro (H358Y, L363M, L363F, A364V, A366V, or A366T) were found to occur among the viruses that we analyzed. Our results should be helpful in the design of diagnostics for prediction of the potential benefit of BVM treatment in HIV-1-infected patients.

Production and Technical Characteristics of a New Class of Amorphous Metals

1995 ◽  
Vol 400 ◽  
Author(s):  
R.T. Malkhassian
Keyword(s):  
Amorphous Phase ◽  
Quantum Chemical ◽  
New Technology ◽  
Chemical Technology ◽  
Quantum Level ◽  
Vibrationally Excited ◽  
New Class ◽  
The Third ◽  
Hydrogen Molecules ◽  
First Time

AbstractA new technology for obtainment of amorphous single-component metals is presented.For the first time the reduction of molybdenum oxide with formation of its amorphous phase is realized in conditions of a given quantum-chemical technology by means of vibrationally excited to the third quantum level hydrogen molecules with 1.5 ± 0.2 eV energy. The evidences of formation of this nonequilibrium amorphous phase are presented along with certain physicochemical properties of the obtained amorphous molybdenum.A model is proposed for the origin of amorphous phase under the influence of nonequilibrium quantum-chemical technology.

Graphite/UPE Nanocomposite: Transport, Thermal, Mechanical and Viscoelastic Properties

2019 ◽  
Vol 23 ◽  
pp. 201-212
Author(s):  
Shivkumari Panda ◽  
Dibakar Behera ◽  
Tapan Kumar Bastia
Keyword(s):  
Transport Properties ◽  
Unsaturated Polyester ◽  
Homogeneous Distribution ◽  
Thermo Gravimetric ◽  
New Class ◽  
The Matrix ◽  
Novel Method ◽  
Water Transport Properties ◽  
First Time

This chapter presents the preparation and characterization of some unique properties of nanocomposites by dispersing graphite flakes in commercial unsaturated polyester (UPE) matrix. The composite was prepared by a novel method with the use of solvent swelling technique. Three different specimens of UPE/graphite nanocomposites were fabricated with addition of 1, 2 and 3 wt% of graphite flakes. Except mechanical, viscoelastic and thermo gravimetric properties, transport properties like electrical conductivity, thermal conductivity and water transport properties were studied for the first time. Graphite flakes propose enhanced properties to the composites suggesting homogeneous distribution of the nanofiller in the matrix and strong interaction with the matrix. 2wt% nanofiller loading showed superior essential characteristics and after that the properties reduced may be due to the nucleating tendency of the nanofiller particles. The XRD pattern showed the compatibility of the graphite flakes by introducing a peak around 26.550 in the nanocomposites. SEM Properties are also in agreement with the compatibility. Nanocomposite with 2wt% graphite also showed remarkable enhancement in transport, mechanical, viscoelastic and thermo gravimetric properties. So by introduction of a small quantity of graphite endow the new class of multiphase nanocomposites with inimitable structure and tremendous application.

scholarly journals Kinematics and Timing Constraints in a Transpressive Tectonic Regime: The Example of the Posada-Asinara Shear Zone (NE Sardinia, Italy)

Geosciences ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 288
Author(s):  
Rodolfo Carosi ◽  
Alessandro Petroccia ◽  
Salvatore Iaccarino ◽  
Matteo Simonetti ◽  
Antonio Langone ◽  
...  
Keyword(s):  
Shear Zone ◽  
Finite Strain ◽  
Pure Shear ◽  
Deformation Gradient ◽  
Shear Zones ◽  
Temperature Deformation ◽  
Timing Constraints ◽  
Important Variation ◽  
Deformation Phase ◽  
First Time

Detailed geological field mapping, integrated with meso- and microstructural investigations, kinematic of the flow and finite strain analyses, combined with geochronology, are fundamental tools to obtain information on the temperature–deformation–timing path of crystalline rocks and shear zone. The Posada-Asinara shear zone (PASZ) in northern Sardinia (Italy) is a steeply dipping km-thick transpressive shear zone. In the study area, located in the Baronie region (NE Sardinia), the presence of mylonites within the PASZ, affecting high- and medium-grade metamorphic rocks, provides an opportunity to quantify finite strain and kinematic vorticity. The main structures of the study area are controlled by a D2 deformation phase, linked to the PASZ activity, in which the strain is partitioned into folds and shear zone domains. Applying two independent vorticity methods, we detected an important variation in the percentage of pure shear and simple shear along the deformation gradient, that increases from south to north. We constrained, for the first time in this sector, the timing of the transpressive deformation by U–(Th)–Pb analysis on monazite. Results indicate that the shear zone has been active at ~325–300 Ma in a transpressive setting, in agreement with the ages of the other dextral transpressive shear zones in the southern Variscan belt.

scholarly journals On the Use of a New Class of Simplified Multi-Window Iris Notch in the Design of Ultra-Compact High-Rejection Waveguide Filters for Satellite Links

Electronics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1221
Author(s):  
Juan Luis Cano ◽  
Angel Mediavilla ◽  
Antonio Tazon
Keyword(s):  
High Performance ◽  
Symmetry Plane ◽  
Pass Band ◽  
Transmission Zero ◽  
New Class ◽  
X Band ◽  
Waveguide Filters ◽  
Field Symmetry ◽  
Insertion Losses ◽  
First Time

This work introduces a simplified multi-aperture iris notch suitable for designing waveguide filters having an extremely improved compactness/rejection ratio, regarding available solutions, and adequate pass-band performances. The proposed iris architecture, analyzed for the first time, exhibits a unique transmission zero in the waveguide mono-mode bandwidth which can be easily located below or above the pass-band. The frequency of this transmission zero is evaluated in terms of the iris dimensions thus providing useful guidelines for designing filters with suitable responses. As a consequence of this simplified topology, any designed filter can be easily manufactured by cutting along its E-field symmetry plane. This strategy greatly improves the filter’s insertion loss regarding classical implementations based on more complicated arrangements with piled thin metallic sheets. Two exemplary filters have been designed and tested to be used in a high-performance X-band SATCOM terminal with an 80% size reduction with respect to the existing systems. Both filters covering the Rx (7.25–75 GHz) and Tx (7.9–8.4 GHz) sub-bands show a reflection of −25 dB with insertion losses below 1 dB in the pass-band, whereas they present a very sharp out-of-band rejection of at least 90 dB, that is, a 600 dB/GHz slope at X band.

scholarly journals High-κ polymers of intrinsic microporosity: a new class of high temperature and low loss dielectrics for printed electronics

2020 ◽  
Vol 7 (2) ◽  
pp. 592-597 ◽  
Author(s):  
Zhongbo Zhang ◽  
Jifu Zheng ◽  
Kasun Premasiri ◽  
Man-Hin Kwok ◽  
Qiong Li ◽  
...  
Keyword(s):  
High Temperature ◽  
Gate Dielectric ◽  
Printed Electronics ◽  
Low Loss ◽  
New Class ◽  
Polymers Of Intrinsic Microporosity ◽  
First Time ◽  
Intrinsic Microporosity

For the first time, sulfonylated polymers of intrinsic microporosity (PIMs) are exploited for high-κ, high-temperature, and low-loss gate dielectric applications.

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