scholarly journals The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine

2020 ◽  
Author(s):  
Monica Rosas-Lemus ◽  
George Minasov ◽  
Ludmilla Shuvalova ◽  
Nicole L. Inniss ◽  
Olga Kiryukhina ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Severe Acute Respiratory Syndrome ◽  
Structural Genomics ◽  
Immune Surveillance ◽  
Healthcare Systems ◽  
Viral Mrna ◽  
Respiratory Complications ◽  
Mrna Transcripts ◽  
The World ◽  
Respiratory Coronavirus

AbstractSARS-CoV-2 is a member of the coronaviridae family and is the etiological agent of the respiratory Coronavirus Disease 2019. The virus has spread rapidly around the world resulting in over two million cases and nearly 150,000 deaths as of April 17, 2020. Since no treatments or vaccines are available to treat COVID-19 and SARS-CoV-2, respiratory complications derived from the infections have overwhelmed healthcare systems around the world. This virus is related to SARS-CoV-1, the virus that caused the 2002-2004 outbreak of Severe Acute Respiratory Syndrome. In January 2020, the Center for Structural Genomics of Infectious Diseases implemented a structural genomics pipeline to solve the structures of proteins essential for coronavirus replication-transcription. Here we show the first structure of the SARS-CoV-2 nsp10-nsp16 2’-O-methyltransferase complex with S-adenosylmethionine at a resolution of 1.80 Å. This heterodimer complex is essential for capping viral mRNA transcripts for efficient translation and to evade immune surveillance.

scholarly journals Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2

2020 ◽  
Author(s):  
Youngchang Kim ◽  
Robert Jedrzejczak ◽  
Natalia I. Maltseva ◽  
Michael Endres ◽  
Adam Godzik ◽  
...  
Keyword(s):  
Crystal Structure ◽  
High Resolution ◽  
Severe Acute Respiratory Syndrome ◽  
Infectious Diseases ◽  
High Throughput ◽  
Structural Genomics ◽  
Structure Determination ◽  
Protein Production ◽  
World Wide ◽  
The World

ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report the high-resolution crystal structure of endoribonuclease Nsp15/NendoU from SARS-CoV-2 – a virus causing current world-wide epidemics. We compare this structure with previously reported models of Nsp15 from SARS and MERS coronaviruses.

Digital credential infrastructure: gateways to the future of medicine (Preprint)

2021 ◽  
Author(s):  
James Brogan ◽  
Henry Goodier ◽  
Manreet Nijjar ◽  
Christian Rose
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Information Exchange ◽  
Digital Technologies ◽  
Healthcare Systems ◽  
Critical Moment ◽  
The World ◽  
The Future

UNSTRUCTURED The current credentialing process for physicians struggled to accommodate fluctuating regional demands for providers during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. This hurdle highlighted existing inefficiencies and difficulties facing healthcare systems across the world and led us to explore how credentialing can be improved using digital technologies. We explain how this is a critical moment to make the shift from physical to digital credentials by specifying how a digital credentialing system could simplify onboarding for providers, enable secure expansion of telehealth services, and enhance information exchange.

scholarly journals A Possible Path towards Rapid Development of Live-Attenuated SARS-CoV-2 Vaccines: Plunging into the Natural Pool

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1438
Author(s):  
German Todorov ◽  
Vladimir N. Uversky
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Distress ◽  
Vaccine Development ◽  
Wide Spectrum ◽  
Rapid Development ◽  
Healthcare Systems ◽  
Severe Respiratory Distress ◽  
The World ◽  
Fast Development ◽  
Life Threatening

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic spreading around the world, causing massive distress to the world’s economy and affecting healthcare systems worldwide. Although some exposed individuals have no symptoms and most symptomatic infections are not severe, COVID-19 cases span a wide spectrum, ranging from mild to critical and sometimes resulting in life-threatening complications, such as pneumonia, severe respiratory distress and cardiac problems. Currently, there is no curative drug for COVID-19 and vaccines are still under development. We are presenting here a strategy for the fast development of natural live-attenuated SARS-CoV-2 vaccines. Our proposed approach is based on screening for, identifying, analyzing and selecting naturally attenuated yet highly immunogenic SARS-CoV-2 strains, which may lead to a shorter cycle of vaccine development, as well as higher vaccine effectiveness.

scholarly journals COVID 19; A SURGICAL PERSPECTIVE

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Anwar Ul Haque
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Virus Disease ◽  
Unknown Origin ◽  
Healthcare Systems ◽  
Hubei Province ◽  
Causative Organism ◽  
The Novel ◽  
Contagious Disease ◽  
The World

The novel corona virus disease started  at Wuhan  in Hubei province of China as pneumonia of unknown origin  and it was found that  the causative organism of Coronavirus Disease 2019(COVID-19) was Severe Acute Respiratory Syndrome Coronavirus –type 2 (SARS-CoV-2).  Healthcare systems all over the world nearly collapsed due to unprecedented spread of the virus and the disease, COVID-19 was notified as a pandemic by WHO on March 11,2020.1,2  Until October 2020 more than 37 million cases and more than one million deaths have been reported worldwide from this highly contagious disease.

scholarly journals COVID-19 in 2020 – a look back from NHS frontline

2021 ◽  
Author(s):  
Julie Smith ◽  
Toni Collier ◽  
Karen Dixon ◽  
Morenike Adebusuyi ◽  
Tonye Sikabofori ◽  
...  
Keyword(s):  
National Health Service ◽  
Health Service ◽  
Severe Acute Respiratory Syndrome ◽  
Healthcare Workers ◽  
Healthcare Systems ◽  
World Health ◽  
Technological Advances ◽  
Look Back ◽  
The World ◽  
Health Organization

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 defined our world in 2020. In over a year since the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic, on 11th March 2020, over 130 million people have contracted the virus worldwide, of whom 2.9 million have died. Healthcare systems have weathered unprecedented stresses, but the modern medical and technological advances have come up with vaccines within a year of the WHO declaration. Consequently, as healthcare workers look forward to more normal and less stressful times, some United Kingdom National Health Service (NHS) colleagues have had a retrospective look at their experiences at the beginning of the pandemic.

scholarly journals AN APPROACH TOWARDS THE DIAGNOSIS AND MANAGEMENT OF COVID 19 AS PER AYURVEDA

2021 ◽  
Vol 9 (7) ◽  
pp. 1409-1418
Author(s):  
Manjusha Satish Desai ◽  
Varsha A. Samarai ◽  
Amrapali V. Done
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Therapeutic Strategy ◽  
Treatment Guidelines ◽  
Management Strategies ◽  
Healthcare Systems ◽  
World Community ◽  
The World ◽  
Novel Coronavirus ◽  
Developed Nations ◽  
Insight Into

The world community is facing an unprecedented pandemic of novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- 2). SARS CoV-2, a highly infectious causative agent of this disease is transmitted through droplets, contact routes and aerosols. Even the most developed nations are having trouble limiting its spread and the disease is still spreading at an alarming rate. For filling the gaps and lacunas in the healthcare system this is high time to integrate different healthcare systems available to meet the ever-emerging health challenges. Despite worldwide efforts to contain it, the pandemic is continuing to spread for want of a clinically proven prophylaxis and therapeutic strategy. Even though no system of medicine has any evi- dence-based treatment for COVID-19 yet, clinical interventions are required to be put in place. Ayurveda has documented the first reference of epidemics as Janapadodhwamsa (“Jana” means “people” whereas the word “Pada” means “place of habitation” of Jana, any disease or conditions like natural calamities or disasters affected a Janpad, it was called Janpandodhwansa) and has given a scientific insight into its causes, effect, and prevention along with management strategies. The clinical profile of COVID-19 matches with Vata-Kapha dominant Sannipataja Jwara (Fever caused by Tridoshas) for which detailed treatment guidelines and an array of pharma- ceutical preparations are described in Ayurvedic literature which is being practised by qualified Ayurvedic physi- cians effectively for a long. This paper highlights the Ayurvedic perspective of the COVID-19 along with its aeti- ology, prevention, prophylaxis, and management strategies through Ayurveda. Keywords: COVID-19, SARS CoV-2, Ayurveda, Vata-Kaphaja Jwar,Janapadodhwamsa.

scholarly journals Coronavirus Disease 2019 Myocarditis: Insights into Pathophysiology and Management

2020 ◽  
Vol 15 ◽  
Author(s):  
Mahmoud Abdelnabi ◽  
Nouran Eshak ◽  
Yehia Saleh ◽  
Abdallah Almaghraby
Keyword(s):  
Respiratory Symptoms ◽  
Clinical Manifestations ◽  
Healthcare Systems ◽  
Current Understanding ◽  
Global Pandemic ◽  
The World ◽  
Respiratory Coronavirus

The world is dealing with a global pandemic of severe acute respiratory coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19), which is the illness caused by SARS-CoV-2, is overwhelming healthcare systems around the world. Although the main clinical manifestations of COVID-19 are respiratory symptoms, several reports have noted myocarditis, cardiomyopathy, arrhythmias and cardiac arrests as COVID-19 complications. Here, the authors highlight the current understanding of the pathophysiology of myocarditis related to COVID-19 and its management.

scholarly journals Coronaviruses – a new old menace

2021 ◽  
Author(s):  
Anna Golke ◽  
Karolina Piekarska ◽  
Tomasz Dzieciątkowski
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Healthcare Systems ◽  
Middle East Respiratory Syndrome ◽  
Control Measures ◽  
The Novel ◽  
Global Impact ◽  
Infection Control Measures ◽  
The World ◽  
Novel Coronavirus

current pandemic caused by novel coronavirus SARS-CoV-2 pandemic has been described as a global health emergency. The outbreak of this virus has raised a number of questions: what exactly is SARS-CoV-2? How transmissible the novel coronavirus is? How severely affected are patients infected with SARS-CoV-2? What are the risk factors for COVID-19? What are the differences between this novel coronavirus and other coronaviruses? To answer these questions, a comparative study of three pathogenic coronaviruses that primarily invade the human respiratory system and may cause death, namely, severe acute respiratory syndrome (SARS-CoV-1), Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Middle East respiratory syndrome coronavirus (MERS-CoV). This review describes the source of origin, transmission, and pathogenicity of these viruses. Prevention of SARS-CoV-2 spreading entails home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions. The novel coronavirus spreads faster than its two predecessors – the SARS-CoV-1 and MERS-CoV – but has lower fatality rate. The global impact of this new pandemic is still uncertain, but it is a challenge to healthcare systems around the world.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

Plasma therapy a possible hope to fight against COVID-19

2020 ◽  
Author(s):  
Ravikant Piyush ◽  
Aroni Chatterjee ◽  
Shashikant Ray
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Disease ◽  
Plasma Therapy ◽  
Therapeutic Drugs ◽  
Wild Fire ◽  
The World ◽  
Short Span ◽  
Game Changer

The world is currently going through a disastrous event and a catastrophic upheaval caused by the coronavirus disease 2019 (COVID-19). The pandemic has resulted in loss of more than 150000 deaths across the globe. Originating from China and spreading across all continents within a short span of time, it has become a matter of international emergency. Different agencies are adopting diverse approaches to stop and spread of this viral disease but still now nothing confirmatory has come up. Due to lack of vaccines and proper therapeutic drugs, the disease is still spreading like wild fire without control. An Old but very promising method- the convalescent plasma therapy could be the key therapy to stop this pandemic. This method has already proven its mettle on several occasions previously and has been found to be effective in curing the pandemics induced by Ebola, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the same group of β-Coronavirus that has resulted in the above diseases. Therefore, the role of plasma therapy is being explored for treatment of this disease. In this review, we have mainly focused on the role of convalescent plasma therapy and why its use should be promoted in fight against COVID-19, as it could turn out to be a game changer.

Sign in / Sign up

Export Citation Format

Share Document