scholarly journals Eosinopenia Phenotype in Patients with Coronavirus Disease 2019: A Multi-center Retrospective Study from Anhui, China

2020 ◽  
Author(s):  
Yusheng Cheng ◽  
Yun Zhou ◽  
Mengde Zhu ◽  
Lei Zha ◽  
Zhiwei Lu ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Clinical Characteristics ◽  
Research Question ◽  
Gastrointestinal Symptoms ◽  
Public Health Emergency ◽  
Laboratory Findings ◽  
Tertiary Hospitals ◽  
Male Patients ◽  
Design And Methods ◽  
Severe Type

AbstractBackgroundCoronavirus disease 19 (COVID-19) has become a global unprecedented pandemic infecting more than one millon people, which is declared by WHO as a international public health emergency. Eosinopenia may predict a poor prognosis of COVID-19. However, to date, there is no detailed analysis of the clinical characteristics of COVID-19 patients with eosinopenia.Research questionThe aim of this study was to describe clinical characteristics of COVID-19 patients with eosinopenia.Study Design and MethodsThis was a multi-center retrospective study conducted in three tertiary hospitals. A total of 59 patients with COVID-19 were reviewed from January 23, 2020 to March 10, 2020. We described clincial characteristics of patients with COIVD-19 and eosinopenia phenotype.ResultsThe median age of patients with COVID-19 was 39 years old, and 32 (54,2%) were male. Patients with severe type had higher proportions of dyspnea (50%) and gastrointestinal symptoms (50%) compared with mild or moderate patients. Laboratory findings indicated that lower counts of lymphocyte and eosnophils were observed in patients with severe type. Cough, sputum, and fatigue were more common symptoms in eosinopenia patients compared with non-eosinopenia patients. High proportion of comorbidities was observed in eosinopenia patients. Laboratory findings indicated that lymphocyte counts (median: 101 cells/μl) in eosinopenia patients were significantly less than those of non-eosinopenia patients (median: 167 cells/μl, p<0.001). The use of corticosteroids therapy in COVID-19 patients with eosinopenia were notably higher than those in patients with non-eosinopenia (50% vs 13.8%, respectively, p=0.005). Compared with parameters in non-eosinopenia patients, eosinopenia patients were more inclined to have less lymphocyte counts (OR value 6.566, 95%CI[1.101-39.173], p=0.039).InterpretationEosinopenia are very common in COVID-19 patient, particularly in severe patients. Common symptoms included fever, cough, sputum, and fatigue are frequent in eosinopenia patients. Eosinopenia may represent a novel phenotype in COVID-19, which needs further investigation.

scholarly journals Clinical characteristics of patients with chronic cough in Guangdong, China: a multicenter descriptive study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kefang Lai ◽  
Lianrong Huang ◽  
Haijin Zhao ◽  
Feng Wu ◽  
Guocui Zhen ◽  
...  
Keyword(s):  
Educational Level ◽  
Chronic Cough ◽  
Respiratory Symptoms ◽  
Clinical Characteristics ◽  
Descriptive Study ◽  
Single Center ◽  
Cross Sectional ◽  
Tertiary Hospitals ◽  
Male Patients ◽  
Nocturnal Cough

Abstract Background The clinical characteristics of patients with chronic cough are reported only in single-center survey in China, being significantly different from that in western countries. Here, we performed a multicenter study to describe the clinical characteristics of chronic cough patients. Methods A cross-sectional observational survey was conducted in thirteen tertiary hospitals of Guangdong, South China. Relevant data were recorded using a standardized questionnaire and analyzed, including demographics, educational attainment, cough features, and concomitant symptoms. Results Of 933 patients in this study, the median age was 40.0 (IQR 31.0–52.0) years with a peaked age of 30–39 years. The proportion of females (487, 52.2 %) was comparable to that of males (446, 47.8 %). Up to 81.9 % of the patients were non-smokers. More than two-thirds of the subjects with chronic cough had a low educational level. The median cough duration was 6.0 (IQR 3.0–24.0) months, and 73.0 % of chronic cough patients presented with dry cough. Laryngeal paresthesia was the most common concomitant symptom (704, 75.5 %), followed by rhinitis/sinusitis-related (350, 37.5 %) and respiratory symptoms (322, 34.5 %). Rhinitis/sinusitis-related symptoms more frequently occurred in patients with productive cough than in those with dry cough (49.0 % vs. 33.0 %, P < 0.001). Moreover, female patients displayed an older age and a higher prevalence of nocturnal cough compared to male patients (both P < 0.05). Conclusions Our results show an equal gender, young profile and laryngeal paresthesia in patients with chronic cough, and different clinical features between females and males.

scholarly journals A Retrospective Study of Continuous Renal Therapy and Anticoagulation in Patients with Hemorrhagic Fever with Renal Syndrome

2014 ◽  
Vol 3 (2) ◽  
pp. 71-76
Author(s):  
Hong Du ◽  
Jing Li ◽  
Hai-tao Yu ◽  
Wei Jiang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Renal Replacement Therapy ◽  
Clinical Characteristics ◽  
Blood Clotting ◽  
Hemorrhagic Fever ◽  
Critical Group ◽  
Heparin Anticoagulation ◽  
Severe Group ◽  
Severe Type ◽  
Critical Type

Abstract Objective To observe the application of continuous renal replacement therapy (CRRT) and heparin anticoagulation in patients with HFRS, and to explore a more suitable anticoagulant strategy. Methods Eighty-five severe-type patients (severe group) and 71 critical-type patients (critical group) were enrolled in this study. The frequency of CRRT was compared between the two groups; the frequency of CRRT treated with and without heparin anticoagulation and the frequency of hemorrhage and channel blood clotting induced by the two anticoagulant strategies were observed. Results The frequency of CRRT in the critical group was higher than that in the severe group (P ＜ 0.001). The frequency of CRRT initiated during the overlapping phases in the critical group was significantly higher than that of the severe group (P = 0.032). The total times of CRRT was 103, and 70 of them were treated with heparin anticoagulation. The frequencies of hemorrhage induced by heparin anticoagulation and no heparinization were 16 and 0, respectively, and the frequencies of channel blood clotting were 2 and 4, respectively. Conclusions CRRT has been used extensively in the critical-type patients with HFRS. The heparin anticoagulation and no anticoagulant strategies should be used more rationally in patients treated with CRRT, according to the clinical characteristics of the disease.

scholarly journals Testicular Adrenal Rest Tumors in Patients with Congenital Adrenal Hyperplasia: A Case Series

2020 ◽  
Author(s):  
Didem Yıldırımçakar ◽  
Selda Ayça Altıncık ◽  
Murat Öcal ◽  
Bayram Özhan
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Tumor Progression ◽  
Precocious Puberty ◽  
Clinical Characteristics ◽  
Adrenal Hyperplasia ◽  
Laboratory Findings ◽  
Testicular Adrenal Rest Tumors ◽  
Male Patients ◽  
Adrenal Rest ◽  
Testicular Adrenal Rest

INTRODUCTION: Testicular adrenal rest tumors (TARTs) are the main etiology of infertility in congenital adrenal hyperplasia (CAH). The aim of this study is to determine the patients diagnosed with TART and to evaluate the risk factors associated with the development of the disease. METHODS: Clinical characteristics of 31 patients with CAH including 19 male, and 12 female patients who were followed up in our clinic were retrospectively reviewed regarding the presence of TART. Differences between clinical and laboratory findings of patients with and without TART were examined. Six male patients with TART were included in the study. Clinical characteristics such as pubertal stage, treatment doses, laboratory findings were evaluated. Changes in size of TARTs were examined with ultrasound follow-ups at six month- intervals. RESULTS: The prevalence of TARTs was 31.5 % (6/19 male). Precocious puberty was higher in patients with TART than without TART. The mean age of the patients was 9.1±2.4 (range: 5.2-12.4) years at the time of diagnosis with TART. Five patients with TART were inadequately controlled. Four patients had a history of precocious puberty. Tumor progression was detected in 4 of 6 patients. In three patients with tumor progression, serum 17-hydroxy progesterone (17-OHP) values increased during follow-up, probably due to non-compliance with treatment. DISCUSSION AND CONCLUSION: Scrotal ultrasound monitoring should be performed in all male patients with CAH in early childhood irrespective of disease control.

scholarly journals Clinical characteristics of COVID-19 in children at the Institute for Pulmonary Diseases in Children-Skopje

2020 ◽  
Vol 12 ◽  
Author(s):  
Таtjana Jakovska Mareti ◽  
Angelcho Andonovski ◽  
Eli Stojanova ◽  
Biljana Kakaraskoska-Boceska
Keyword(s):  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Gastrointestinal Symptoms ◽  
Pulmonary Diseases ◽  
Nasopharyngeal Swab ◽  
Rt Pcr ◽  
Laboratory Findings ◽  
Number Of Children ◽  
Study Results ◽  
Polymerase Chain

The aim of the paper was to evaluate clinical characteristics of COVID-19 in children and the success of the treatment. Material and methods: The study included 218 pediatric patients suspected for COVID-19 hospitalized at the Institute for Pulmonary Diseases in Children-Skopje, during the period from 16th of March to 19th of June 2020. All patients were tested for presence of SARS-CoV-2 virus in nasopharyngeal swab with real-time reverse transcription polymerase chain reaction (RT-PCR) in the Institute of Public Health of Republic of North Macedonia. Clinical symptoms, X-ray and laboratory findings were included in the study. Results: From 218 hospitalized patients, only 9 (4.13%) were positive for COVID-19 and 59% of them were males. Infants, with moderate pulmonary disease were 44.4% of the patients. Fever and gastrointestinal symptoms were present in 66.6% and 22.2% of the children, respectively. Macrolides were therapy of choice in 88% of the treated patients, 77% received intravenous therapy, 33% were on inhaled bronchodilator. Conclusions: A small number of children had COVID-19. All infected children were with mild to moderate pulmonary symptoms and reacted satisfactory to the treatment. However, the importance of transmitting the virus and influence over children’s health remains uncertain.

The application of WeChat App with “group function” in emergency management and treatment of COVID-19 (Preprint)

2020 ◽  
Author(s):  
Jing Liu ◽  
Hong Shan ◽  
Changli Tu ◽  
Meizhu Chen ◽  
Xiujuan Qu ◽  
...  
Keyword(s):  
Public Health ◽  
Group Communication ◽  
Public Health Emergency ◽  
Diagnosis And Treatment ◽  
Labor Costs ◽  
Wuhan City ◽  
Group Function ◽  
The Public ◽  
Communication Method ◽  
Tertiary Hospitals

UNSTRUCTURED Background: Since December 2019, Coronavirus Disease 2019 (COVID-19) emerged in Wuhan city and rapidly spread throughout China. Facing this kind of public health emergency, an efficient, fast and group communication method is needed. Method: As a director of the department Pulmonary and Critical Care Medicine in a tertiary hospitals, which is the only designated one for diagnosis and treatment of COVID-19 in a medium-sized city, I analyzed and summarized the “group function” of WeChat (Weixin, micro-message) App in working about COVID-19. Results: By February 16, 2020, we have completed 1,526 citywide consultations and treatment of 322 inpatients, including 97 patients diagnosed with COVID-19, with the help of 12 WeChat groups by handy. The advantages of WeChat group are as follows: 1. Work efficiency can be improved greatly, saving labor costs. 2. Accurate and intuitive information can be gotten fast and timely, avoiding close contacting with COVID-19 patients. 3. Data and message in WeChat groups can be saved, arranged and reviewed at any time. Conclusions: The “group function” in WeChat App plays a greater role in the public health emergent work about management, diagnosis and treatment of COVID-19.

scholarly journals Parasitic infections in Swiss children: Are we overtesting?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Corinne Légeret ◽  
Céline Rüttimann ◽  
Hans Fankhauser ◽  
Henrik Köhler
Keyword(s):  
Retrospective Study ◽  
Positive Result ◽  
Pediatric Patients ◽  
Intestinal Parasites ◽  
Gastrointestinal Symptoms ◽  
International Travel ◽  
Parasitic Infections ◽  
Stool Samples ◽  
Stool Specimens

Abstract Background A wide variation of causes can lead to gastrointestinal symptoms in children- an infection with parasites is one of them. The expansion of international travel might lead to an increase in testing children for a correspondent infection. Currently there are no guidelines available, which patients should be tested for a possible parasitical infection. The aim of the study was to characterize Swiss children suffering from intestinal parasites, in order to provide more knowledge for the clinician who should be tested. Methods This is a retrospective study of Swiss pediatric patients, whose stools have been tested for parasites and helminths. Results A total of 1855 stool samples, belonging to 572 different children with an average age of 7.9 years, were tested within a 10-year period. The prevalence of a positive result was 4.2%, of which all were positive for Blastocystis, and 12.5% had a co-infection with Endolimax nana. Conclusion Immigrants, immune compromised children with diarrhea and pediatric patients with bloody or protracted diarrhea should have 2 different stool specimens examined for a possible parasitical infection.

scholarly journals 369. Clinical Characteristics of the First 177 Patients Admitted with COVID-19 at a Bronx Community Hospital

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S254-S254
Author(s):  
Victoria Bengualid ◽  
Maria Martinez ◽  
Zhenisa Hysenaj ◽  
Debra M Willner ◽  
Judith Berger
Keyword(s):  
Oxygen Saturation ◽  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Retrospective Chart Review ◽  
Patient Characteristics ◽  
Altered Mental Status ◽  
Channel Blockers ◽  
First Case ◽  
Overall Mortality

Abstract Background The first case of COVID-19 was admitted on March 15th 2020 to our community based hospital in the Bronx, NY. The aim of this study is to describe the clinical characteristics and outcome of these first COVID-19 patients. Patient Characteristics and Outcome Methods IRB approved retrospective chart review study of all COVID-19 patients admitted during March 2020 focusing on patient characteristics, co-morbidities, clinical manifestations and outcome. Results A total of 177 patients were admitted during March 2020: 57% African American 23.1% Hispanic and 16.9% White. 44.9% female, average age 60 years, and 90% had at least one comorbidity. Outcome was available on all patients except for one who was transferred to another institution for ECMO. Overall mortality was 33%. Clinical presentation: 69.4% presented with cough or shortness of breath, 15.8% with diarrhea, nausea, vomiting or abdominal pain, and 14.6% with myalgia, dizziness or altered mental status. 6.2% presented only with fever. However 59.8% of patients presented with fever and respiratory or gastrointestinal symptoms. Mortality The table compares patients who died vs discharged (either home or to a short term facility). Those that were 65 years or older, hypertensive or presented to the ER with an oxygen saturation of 94% or lower, were more likely to die. Ventilated patients: 31.6% of patients were intubated with a mortality rate of 77%. 22% of these patients were intubated in the first 24 hours. Compared to non-intubated patients, there was no difference in BMI, diabetes, hypertension, COPD/Asthma, use of statins, aspirin or calcium channel blockers. Intubated patients older than 64 years had significantly higher mortality rates (p=0.0001). Conclusion This cohort of COVID-19 patients is unique as almost all received Hydroxychloroquine and Azithromycin. Only 9% received steroids and even fewer received an interleukin-6 inhibitor, convalescent plasma or Remdesivir. African Americans and Hispanics accounted for 80% of patients. Greater than 90% received Medicaid. Overall mortality was 33%. The most common presentation was respiratory followed by gastrointestinal symptoms. The overall mortality was 33% but increased to 77% in intubated patients. Age, hypertension, and ER oxygen saturation correlated with mortality. Disclosures All Authors: No reported disclosures

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