scholarly journals Microtubules provide a viscoelastic resistance to myocyte motion

2018 ◽  
Author(s):  
M. A. Caporizzo ◽  
C. Y. Chen ◽  
A. K. Salomon ◽  
K. Bedi ◽  
K. B. Margulies ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Shock Absorber ◽  
Elastic Behavior ◽  
Axial Stretch ◽  
Cell Shortening ◽  
Myocyte Function ◽  
Cross Links ◽  
Length Changes ◽  
Tubulin Tyrosine Ligase

ABSTRACTBackgroundMicrotubules (MT) buckle and bear load during myocyte contraction, a behavior enhanced by post-translational detyrosination. This buckling suggests a spring-like resistance against myocyte shortening, which could store energy and aid myocyte relaxation. Despite this visual suggesting of elastic behavior, the precise mechanical contribution of the cardiac MT network remains to be defined.MethodsHere we experimentally and computationally probe the mechanical contribution of stable microtubules and their influence on myocyte function. We use multiple approaches to interrogate viscoelasticity and cell shortening in primary murine myocytes where either MTs are depolymerized or detyrosination is suppressed, and use the results to inform a mathematical model of myocyte viscoelasticity.ResultsMT ablation by colchicine concurrently enhances both the degree of shortening and speed of relaxation, a finding inconsistent with simple spring-like microtubule behavior, and suggestive of a viscoelastic mechanism. Axial stretch and transverse indentation confirm that microtubules increase myocyte viscoelasticity. Specifically, increasing the rate of strain amplifies the MT contribution to myocyte stiffness. Suppressing MT detyrosination with parthenolide or via overexpression of tubulin tyrosine ligase (TTL) has mechanical consequences that closely resemble colchicine, suggesting that the mechanical impact of MTs relies on a detyrosination-dependent linkage with the myocyte cytoskeleton. Mathematical modeling affirms that alterations in cell shortening conferred by either MT destabilization or tyrosination can be attributed to internal changes in myocyte viscoelasticity.ConclusionsThe results suggest that the cardiac MT network regulates contractile amplitudes and kinetics by acting as a cytoskeletal shock-absorber, whereby MTs provide breakable cross-links between the sarcomeric and non-sarcomeric cytoskeleton that resist rapid length changes during both shortening and stretch.

Application of the method of mathematical modeling for forecasting channel deformations at the underwater crossing of the main pipeline

2020 ◽  
Vol 10 (6) ◽  
pp. 599-609
Author(s):  
Valery А. Gruzdev ◽  
◽  
Georgy V. Mosolov ◽  
Ekaterina A. Sabayda ◽  
◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Roughness Coefficient ◽  
Computational Domain ◽  
Channel Deformations ◽  
Geological Surveys ◽  
Kuban River ◽  
The Stability ◽  
Protective Structures

In order to determine the possibility of using the method of mathematical modeling for making long-term forecasts of channel deformations of trunk line underwater crossing (TLUC) through water obstacles, a methodology for performing and analyzing the results of mathematical modeling of channel deformations in the TLUC zone across the Kuban River is considered. Within the framework of the work, the following tasks were solved: 1) the format and composition of the initial data necessary for mathematical modeling were determined; 2) the procedure for assigning the boundaries of the computational domain of the model was considered, the computational domain was broken down into the computational grid, the zoning of the computational domain was performed by the value of the roughness coefficient; 3) the analysis of the results of modeling the water flow was carried out without taking the bottom deformations into account, as well as modeling the bottom deformations, the specifics of the verification and calibration calculations were determined to build a reliable mathematical model; 4) considered the possibility of using the method of mathematical modeling to check the stability of the bottom in the area of TLUC in the presence of man-made dumping or protective structure. It has been established that modeling the flow hydraulics and structure of currents, making short-term forecasts of local high-altitude reshaping of the bottom, determining the tendencies of erosion and accumulation of sediments upstream and downstream of protective structures are applicable for predicting channel deformations in the zone of the TLUC. In all these cases, it is mandatory to have materials from engineering-hydro-meteorological and engineering-geological surveys in an amount sufficient to compile a reliable mathematical model.

Mathematical modeling of elastoplastic deformation of tubular energy-absorbing elements under static and impact loading

2020 ◽  
pp. 78-82
Author(s):  
A.Р. Evdokimov ◽  
A.N. Gromyiko ◽  
A.A. Mironov
Keyword(s):  
Mathematical Modeling ◽  
Impact Loading ◽  
Elastoplastic Deformation ◽  
Shock Absorber ◽  
Analytical Models ◽  
Dynamic Impact ◽  
Shock Absorbers ◽  
Energy Absorbing ◽  
Absorbing Elements

Analytical models of static and dynamic impact elastoplastic deformation of tubular energy-absorbing elements constituting a tubular plastic shock absorber are proposed. The developed models can be used for the calculation and design of these shock absorbers. Keywords static and dynamic elastoplastic deformation, mathematical modeling, tubular energy-absorbing element, tubular plastic shock absorber, impact loading. [email protected]

On the displacements of the contours of the optic-electronic space images. Mathematical modeling of displacement

2017 ◽  
Vol 992 (4) ◽  
pp. 32-38 ◽  
Author(s):  
E.G. Voronin
Keyword(s):  
Mathematical Modeling ◽  
Remote Sensing ◽  
Mathematical Model ◽  
Point Of View ◽  
Design Features ◽  
Space Images ◽  
Electronic Imaging ◽  
Measuring Accuracy ◽  
Physical Laws

The article opens a cycle of three consecutive publications dedicated to the phenomenon of the displacement of the same points in overlapping scans obtained adjacent CCD matrices with opto-electronic imagery. This phenomenon was noticed by other authors, but the proposed explanation for the origin of displacements and the resulting estimates are insufficient, and developed their solutions seem controversial from the point of view of recovery of the measuring accuracy of opticalelectronic space images, determined by the physical laws of their formation. In the first article the mathematical modeling of the expected displacements based on the design features of a scanning opto-electronic imaging equipment. It is shown that actual bias cannot be forecast, because they include additional terms, which may be gross, systematic and random values. The proposed algorithm for computing the most probable values of the additional displacement and ways to address some of the systematic components of these displacements in a mathematical model of optical-electronic remote sensing.

Mathematical modeling of fluid movement inside the eyeball during intravitreal injection

2021 ◽  
pp. 106-109
Author(s):  
D.V. Lipatov ◽  
◽  
S.A. Skladchikov ◽  
N.P. Savenkova ◽  
V.V. Novoderezkin ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Residence Time ◽  
Complex Structure ◽  
Posterior Vitreous Detachment ◽  
Vitreous Body ◽  
Complete Removal ◽  
Intravitreal Injections ◽  
The World

Background. The avalanche-like growth of intravitreal injections in the world has significantly increased interest in the hemodynamics of the processes that occur in the eye when a drug is injected into the vitreous cavity. Every year, the number of intravitreally used drugs and promising areas in which they can be used is growing. This also applies to the creation of new combined medicines and the development of drugs with a long-term therapeutic effect. Aims. Create mathematical model of eyeball to evaluate the movement of the drug substance in it; to estimate the time of the drug's presence in the eye cavity before its complete removal, to characterize the ways of its removal from the eye cavity; to assess the significance of posterior vitreous detachment during the time when the drug is present in the eye cavity; to evaluate the effect on the hydrodynamics of the depth of drug administration. Results. When the drug is administered closer to the center of the eyeball, its residence time increases in comparison with the parietal administration. With a complete posterior detachment of the vitreous body, the time of finding the drug in the eye is prolonged compared to its absence. The obtained results of mathematical modeling of the movement of the drug administered intravitreally cannot be mechanically transferred to the human eye, due to the more complex structure of the latter. Key words: intravitreal injections, vitreous body, mathematic computing.

MATHEMATICAL MODELING OF CONCRETE STRUCTURE CORROSION IN BIOLOGICALLY AGGRESSIVE ENVIRONMENTS

2021 ◽  
Vol 3 (102) ◽  
pp. 55-67
Author(s):  
VARVARA E. RUMYANTSEVA ◽  
SVETLANA A. LOGINOVA ◽  
NATALIA E. KARTSEVA
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Mass Transfer ◽  
Parabolic Type ◽  
Cement Concrete ◽  
Mass Conductivity ◽  
Kinetics And Dynamics ◽  
Biological Corrosion ◽  
First Time ◽  
Fourth Kind

In the aquatic environment, biocorrosion is an important factor affecting the reliability and durability of concrete structures. The destruction of cement concretes during biological corrosion is determined by the processes of mass transfer. The article presents the development of a calculated mathematical model of liquid corrosion in cement concrete, taking into account the biogenic factor. For the first time, a model of mass transfer in an unbounded two-layer plate is considered in the form of differential equations of parabolic type in partial derivatives with boundary conditions of the second kind at the interface between concrete and liquid and of the fourth kind at the interface between concrete and biofilm. The results of a numerical experiment are presented to study the influence of the coefficients of mass conductivity and mass transfer on the kinetics and dynamics of the process.

Methods of Mathematical Modeling of the Leaching Process of Cobalt-Containing Solutions

2021 ◽  
Vol 316 ◽  
pp. 661-666
Author(s):  
Nataliya V. Mokrova
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Chemical Kinetics ◽  
Group Method ◽  
Data Handling ◽  
Multistage Processes ◽  
Leaching Process ◽  
Proposed Model ◽  
Simulation Results ◽  
The Mathematical Model

Current cobalt processing practices are described. This article discusses the advantages of the group argument accounting method for mathematical modeling of the leaching process of cobalt solutions. Identification of the mathematical model of the cascade of reactors of cobalt-producing is presented. Group method of data handling is allowing: to eliminate the need to calculate quantities of chemical kinetics; to get the opportunity to take into account the results of mixed experiments; to exclude the influence of random interference on the simulation results. The proposed model confirms the capabilities of the group method of data handling for describing multistage processes.

A prey–predator model and control of a nematodes pest using control in banana: Mathematical modeling and qualitative analysis

2021 ◽  
pp. 2150089
Author(s):  
Sudhakar Yadav ◽  
Vivek Kumar
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Local Stability ◽  
Detection Method ◽  
Initial Release ◽  
Pest Detection ◽  
Predator Model ◽  
And Control ◽  
The Mathematical Model ◽  
Theoretical Results

This study develops a mathematical model for describing the dynamics of the banana-nematodes and its pest detection method to help banana farmers. Two criteria: the mathematical model and the type of nematodes pest control system are discussed. The sensitivity analysis, local stability, global stability, and the dynamic behavior of the mathematical model are performed. Further, we also develop and discuss the optimal control mathematical model. This mathematical model represents various modes of management, including the initial release of infected predators as well as the destroying of nematodes. The theoretical results are shown and verified by numerical simulations.

scholarly journals Peak Vertical Ground Reaction Force during Two-Leg Landing: A Systematic Review and Mathematical Modeling

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Wenxin Niu ◽  
Tienan Feng ◽  
Chenghua Jiang ◽  
Ming Zhang
Keyword(s):  
Mathematical Modeling ◽  
Systematic Review ◽  
Mathematical Model ◽  
Ground Reaction Force ◽  
Reaction Force ◽  
Influence Factors ◽  
Vertical Ground Reaction Force ◽  
Surface Stiffness ◽  
Drop Landing ◽  
Vertical Ground

Objectives. (1) To systematically review peak vertical ground reaction force (PvGRF) during two-leg drop landing from specific drop height (DH), (2) to construct a mathematical model describing correlations between PvGRF and DH, and (3) to analyze the effects of some factors on the pooled PvGRF regardless of DH.Methods. A computerized bibliographical search was conducted to extract PvGRF data on a single foot when participants landed with both feet from various DHs. An innovative mathematical model was constructed to analyze effects of gender, landing type, shoes, ankle stabilizers, surface stiffness and sample frequency on PvGRF based on the pooled data.Results. Pooled PvGRF and DH data of 26 articles showed that the square root function fits their relationship well. An experimental validation was also done on the regression equation for the medicum frequency. The PvGRF was not significantly affected by surface stiffness, but was significantly higher in men than women, the platform than suspended landing, the barefoot than shod condition, and ankle stabilizer than control condition, and higher than lower frequencies.Conclusions. The PvGRF and root DH showed a linear relationship. The mathematical modeling method with systematic review is helpful to analyze the influence factors during landing movement without considering DH.

scholarly journals Model of the dynamics of a wheeled vehicle for a complex of full-scale-mathematical modeling

2020 ◽  
Vol 1 (4) ◽  
pp. 46-60
Author(s):  
B.B. Kositsyn ◽  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Real Time ◽  
Block Diagram ◽  
Plane Motion ◽  
Full Scale ◽  
Practical Significance ◽  
Modes Of Operation ◽  
Wheeled Vehicle ◽  
Full Scale Tests

Introduction. The use of the method of full-scale-mathematical modeling in “real time” opens up wide opportunities associated with the analysis of the modes of operation of the “man – vehicle – environment” system, as well as the study of the loading of units and assemblies of vehicles. The existing research complexes of full-scale mathematical modeling are suitable for obtaining most of the indicators usually determined by full-scale tests. The difference lies in the ability to fully control the course of virtual testing, recording any parameters of the vehicle movement, taking into account the “human factor”, as well as complete safety of the experiment. Purpose of research. The purpose of this work is to create a mathematical model of the dynam-ics of a wheeled vehicle, suitable for use in such a complex of full-scale mathematical modeling and assessment of the load of transmission units in conditions close to real operation. Methodology and methods. The proposed model is based on the existing model of the dynamics of a wheeled vehicle developed at Bauman Moscow State Technical University. Within the framework of the model, the dynamics of a vehicle is described as a plane motion of a rigid body in a horizontal plane. The principle of possible displacements is applied to determine the normal reac-tions of the bearing surface. The interaction of the wheel with the ground in the plane of the support base is described using an approach based on the “friction ellipse” concept. To enable the driver and operator of the full-scale mathematical modeling complex to drive a virtual vehicle in “real time” mode, the mathematical model is supplemented with a control system that communicates between the control parameter set by the driver by pressing the accelerator and brake pedals and the control actions of the vehicle's transmission units, such as: an electric machine, an internal combustion en-gine, a hydrodynamic retarder and a brake system. The article presents a block diagram of the de-veloped control algorithm, as well as approbation of the system's operation in a complex of full-scale mathematical modeling. Results and scientific novelty. A mathematical model of the dynamics of a wheeled vehicle was developed. It opens up wide possibilities for studying the modes of operation of the “driver-vehicle-environment” system in “real time”, using a complex of full-scale mathematical modeling. Practical significance. A mathematical model of the dynamics of a wheeled vehicle was devel-oped. It is supplemented with an algorithm for the distribution of traction / braking torques between the transmission units, which provide a connection between the driver's pressing on the accelerator / brake pedal and the control parameters of each of the units.

scholarly journals Applications of Non-Standard analysis in Topoi to Mathematical Neurosciences and Artificial Intelligence: Infons, Energons, Receptons (I)

Mathematics ◽  
2021 ◽  
Vol 9 (17) ◽  
pp. 2048
Author(s):  
Ileana Ruxandra Badea ◽  
Carmen Elena Mocanu ◽  
Florin F. Nichita ◽  
Ovidiu Păsărescu
Keyword(s):  
Mathematical Modeling ◽  
Artificial Intelligence ◽  
Mathematical Model ◽  
Set Theory ◽  
Standard Analysis ◽  
New Methods ◽  
Internal Set ◽  
Human Thinking ◽  
Global Brain ◽  
Non Standard Analysis

The purpose of this paper is to promote new methods in mathematical modeling inspired by neuroscience—that is consciousness and subconsciousness—with an eye toward artificial intelligence as parts of the global brain. As a mathematical model, we propose topoi and their non-standard enlargements as models, due to the fact that their logic corresponds well to human thinking. For this reason, we built non-standard analysis in a special class of topoi; before now, this existed only in the topos of sets (A. Robinson). Then, we arrive at the pseudo-particles from the title and to a new axiomatics denoted by Intuitionistic Internal Set Theory (IIST); a class of models for it is provided, namely, non-standard enlargements of the previous topoi. We also consider the genetic–epigenetic interplay with a mathematical introduction consisting of a study of the Yang–Baxter equations with new mathematical results.

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