scholarly journals High Temporal Sub-millisecond Time Resolution Stimulation Increases Performances of Retina Prosthetic Vision

2018 ◽  
Author(s):  
S. Kime ◽  
C. Simon-Shane ◽  
Q. Sabatier ◽  
F. Galluppi ◽  
R. Benosman
Keyword(s):  
Temporal Resolution ◽  
Time Resolution ◽  
Clinical Studies ◽  
Vision Loss ◽  
Discrimination Performance ◽  
Performance Improvements ◽  
Fundamental Limitations ◽  
Retinal Stimulation ◽  
Retinal Implants ◽  
Using Data

AbstractVision loss has an enormous impact on affected individuals, and increasing social and economics costs for the whole of society. Important approaches have been introduced, aimed at restoring visual functionality in the case of vision degradation and loss. Currently the most promising technology is represented by retinal implants, with companies producing devices approved for commercialization. The first clinical studies encouragingly reported perception elicited by both devices. Some patients retrieve autonomy, but only a few could reach satisfactory perception levels, allowing more complex tasks such as reading. Fundamental limitations however still exist in both spatial and temporal resolution, and these limitations call for improvements of the technology and of the stimulation strategies used therein. This study focuses on the importance of temporal resolution for retinal stimulation, and how it can be used to improve restored perception for implanted patients. We show a quantification of the improvement of discrimination performance when stimulating with high frame rates compared to conventional 30-60Hz frame rates. Such effect is evaluated using data collected from implanted patients, and deriving from it a realistic phosphene model. This study allowed to accurately replicate the perceptual effects of the studied technologies, and to evaluate the hypotheses regarding performance improvements using higher temporal resolutions for stimulation strategies in visual restoration devices.

scholarly journals Prevalence of Multiple Sensory Deficits in Older Adults in BLSA and ARIC Studies

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 804-805
Author(s):  
Nicole Armstrong ◽  
Jennifer Deal ◽  
Hang Wang ◽  
Jennifer Schrack ◽  
Qu Tian ◽  
...  
Keyword(s):  
Older Adults ◽  
Vision Loss ◽  
Age Groups ◽  
Adverse Outcomes ◽  
Atherosclerosis Risk In Communities ◽  
Sensory Deficits ◽  
Olfactory Loss ◽  
Atherosclerosis Risk ◽  
Baltimore Longitudinal Study ◽  
Using Data

Abstract Individual sensory deficits have been associated with adverse outcomes, including dementia, in older adults. Using data from the Baltimore Longitudinal Study of Aging (BLSA) (N=259) and Atherosclerosis Risk in Communities Study (ARIC) (N=962), we examined the prevalence of one, two, or three sensory deficits (hearing, vision, and olfaction) among older adults ≥70 years. Any hearing loss was the most prevalent sensory deficit (70-79 year-olds: 41.3% [BLSA] and 51.2% [ARIC]; ≥80 year-olds: 82.6% [BLSA] and 74.2% [ARIC]), followed by vision loss and olfactory loss. Hearing and vision impairments were more prevalent than hearing and olfactory losses as well as vision and olfactory losses in both age groups and studies There were few people with deficits in all three senses (70-79 year-olds: 3.3% [BLSA] and 2.0% [ARIC]; ≥80 year-olds: 5.8% [BLSA] and 7.4% [ARIC]). Further research should investigate the potential impact of multisensory impairments on older adults.

scholarly journals Functional optical coherence tomography of retinal photoreceptors

2018 ◽  
Vol 243 (17-18) ◽  
pp. 1256-1264 ◽  
Author(s):  
Xincheng Yao ◽  
Taeyoon Son ◽  
Tae-Hoon Kim ◽  
Yiming Lu
Keyword(s):  
Vision Loss ◽  
Objective Assessment ◽  
Age Related Macular Degeneration ◽  
Retinal Stimulation ◽  
Age Related ◽  
Retinal Photoreceptors ◽  
Severe Vision Loss ◽  
Further Development

Age-related macular degeneration (AMD) is the leading cause of severe vision loss and legal blindness. It is known that retinal photoreceptors are the primary target of AMD. Therefore, a reliable method for objective assessment of photoreceptor function is needed for early detection and reliable treatment evaluation of AMD and other eye diseases such as retinitis pigmentosa that are known to cause photoreceptor dysfunctions. Stimulus-evoked intrinsic optical signal (IOS) changes promise a unique opportunity for objective assessment of physiological function of retinal photoreceptor and inner neurons. Instead of a comprehensive review, this mini-review is to provide a brief summary of our recent in vitro and in vivo optical coherence tomography (OCT) studies of stimulus-evoked IOS changes in animal retinas. By providing excellent axial resolution to differentiate individual retinal layers, depth-resolved OCT revealed rapid IOS response at the photoreceptor outer segment. The fast photoreceptor-IOS occurred almost right away (∼ 2 ms) after the onset of retinal stimulation, differentiating itself from slow IOS changes correlated with inner neural and hemodynamic changes. Further development of the functional IOS instruments and retinal stimulation protocols may provide a feasible solution to pursue clinical application of functional IOS imaging for objective assessment of human photoreceptors. Impact statement Retinal photoreceptors are the primary target of age-related macular degeneration (AMD) which is the leading cause of severe vision loss and legal blindness. An objective method for functional assessment of photoreceptor physiology can benefit early detection and better treatment evaluation of AMD and other eye diseases that are known to cause photoreceptor dysfunctions. This article summarizes in vitro study of IOS mechanisms and in vivo demonstration of IOS imaging of intact animals. Further development of the functional IOS imaging may provide a revolutionary solution to achieve objective assessment of human photoreceptors.

A STUDY ON THE INTRINSIC TIME RESOLUTION OF THE MRPC USED IN THE STAR-TOF

2007 ◽  
Vol 16 (07n08) ◽  
pp. 2476-2483 ◽  
Author(s):  
◽  
MING SHAO ◽  
LIANG LI
Keyword(s):  
Time Resolution ◽  
Incident Angle ◽  
Signal Amplitude ◽  
Test Results ◽  
Beam Test ◽  
Intrinsic Time ◽  
200 Gev ◽  
Star Experiment ◽  
Calibration Study ◽  
Using Data

Time-Of-Flight (TOF) based on Multi-gap Resistive Plate Chamber (MRPC) detectors have been successfully operating at the STAR experiment since 2003.2,3 The MRPC time resolution is however found to be significantly worse2 (80-90 ps) than that previously obtained in beam test (60 ps).4 In order to fully understand MRPC working principles and operating requirements, an extensive calibration study is performed using data collected by STAR in 200 GeV Au + Au collisions in 2004. The relation between MRPC timing, signal amplitude, incident angle and momentum are discussed. Contributions from tracking properties of STAR-TPC are also studied by simulation. The intrinsic time resolution of the MRPCs used in STAR-TOF, after taking all factors into consideration, is found to be in good agreement with beam test results.

scholarly journals Tropical Andes Radar Precipitation Estimates Need High Temporal and Moderate Spatial Resolution

Water ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1038 ◽  
Author(s):  
Mario Guallpa ◽  
Johanna Orellana-Alvear ◽  
Jörg Bendix
Keyword(s):  
Spatial Resolution ◽  
Temporal Resolution ◽  
Time Resolution ◽  
Weather Radar ◽  
Radar Data ◽  
Rain Gauge ◽  
Tropical Andes ◽  
The Andes ◽  
Significant Difference ◽  
The Impact

Weather radar networks are an excellent tool for quantitative precipitation estimation (QPE), due to their high resolution in space and time, particularly in remote mountain areas such as the Tropical Andes. Nevertheless, reduction of the temporal and spatial resolution might severely reduce the quality of QPE. Thus, the main objective of this study was to analyze the impact of spatial and temporal resolutions of radar data on the cumulative QPE. For this, data from the world’s highest X-band weather radar (4450 m a.s.l.), located in the Andes of Ecuador (Paute River basin), and from a rain gauge network were used. Different time resolutions (1, 5, 10, 15, 20, 30, and 60 min) and spatial resolutions (0.5, 0.25, and 0.1 km) were evaluated. An optical flow method was validated for 11 rainfall events (with different features) and applied to enhance the temporal resolution of radar data to 1-min intervals. The results show that 1-min temporal resolution images are able to capture rain event features in detail. The radar–rain gauge correlation decreases considerably when the time resolution increases (r from 0.69 to 0.31, time resolution from 1 to 60 min). No significant difference was found in the rain total volume (3%) calculated with the three spatial resolution data. A spatial resolution of 0.5 km on radar imagery is suitable to quantify rainfall in the Andes Mountains. This study improves knowledge on rainfall spatial distribution in the Ecuadorian Andes, and it will be the basis for future hydrometeorological studies.

scholarly journals Sensitivity to Interaural Phase in Older Hearing-Impaired Listeners Correlates With Nonauditory Trail Making Scores and With a Spatial Auditory Task of Unrelated Peripheral Origin

2019 ◽  
Vol 23 ◽  
pp. 233121651986449 ◽  
Author(s):  
Olaf Strelcyk ◽  
Pavel Zahorik ◽  
James Shehorn ◽  
Chhayakanta Patro ◽  
Ralph Peter Derleth
Keyword(s):  
Auditory Processing ◽  
Discrimination Performance ◽  
Hearing Impaired ◽  
Auditory Task ◽  
Cognitive Test ◽  
Interaural Level Difference ◽  
Strong Correlations ◽  
Performance Improvements ◽  
Interaural Phase ◽  
Trail Making

Interaural phase difference (IPD) discrimination upper frequency limits and just-noticeable differences (JNDs), interaural level difference (ILD) JNDs, and diotic intensity JNDs were measured for 20 older hearing-impaired listeners with matched moderate sloping to severe sensorineural hearing losses. The JNDs were measured using tone stimuli at 500 Hz. In addition to these auditory tests, the participants completed a cognitive test (Trail Making Test). Significant performance improvements in IPD discrimination were observed across test sessions. Strong correlations were found between IPD and ILD discrimination performance. Very strong correlations were observed between IPD discrimination and Trail Making performance as well as strong correlations between ILD discrimination and Trail Making performance. These relationships indicate that interindividual variability in IPD discrimination performance did not exclusively reflect deficits specific to any auditory processing, including early auditory processing of temporal information. The observed relationships between spatial audition and cognition may instead be attributable to a modality-general spatial processing deficit and/or individual differences in global processing speed.

Image Structure at the Center of Gaze during Free Viewing

2006 ◽  
Vol 18 (5) ◽  
pp. 737-748 ◽  
Author(s):  
Valentin Dragoi ◽  
Mriganka Sur
Keyword(s):  
Eye Movements ◽  
Rhesus Monkeys ◽  
Discrimination Performance ◽  
Natural Scenes ◽  
Image Patch ◽  
Image Scanning ◽  
Retinal Stimulation ◽  
Free Viewing ◽  
Precise Knowledge ◽  
Orientation Structure

It is generally believed that the visual system is adapted to the statistics of the visual world. Measuring and understanding these statistics require precise knowledge of the structure of the signals reaching fovea during image scanning. However, despite the fact that eye movements cause retinal stimulation to change several times in a second, it is implicitly assumed that images are sampled uniformly during natural viewing. By analyzing the eye movements of three rhesus monkeys freely viewing natural scenes, we report here significant anisotropy in stimulus statistics at the center of gaze. We find that fixation on an image patch is more likely to be followed by a saccade to a nearby patch of similar orientation structure or by a saccade to a more distant patch of largely dissimilar orientation structure. Furthermore, we show that orientation-selective neurons in the primary visual cortex (V1) can take advantage of eye movement statistics to selectively improve their discrimination performance.

scholarly journals Real-Time Data Assimilation for Operational Ensemble Streamflow Forecasting

2006 ◽  
Vol 7 (3) ◽  
pp. 548-565 ◽  
Author(s):  
Jasper A. Vrugt ◽  
Hoshin V. Gupta ◽  
BreanndánÓ Nualláin ◽  
Willem Bouten
Keyword(s):  
Data Assimilation ◽  
Simultaneous Optimization ◽  
Parameter Estimates ◽  
Model Parameters ◽  
Optimization Approach ◽  
Streamflow Forecasting ◽  
Time Data ◽  
Forecast Performance ◽  
Performance Improvements ◽  
Using Data

Abstract Operational flood forecasting requires that accurate estimates of the uncertainty associated with model-generated streamflow forecasts be provided along with the probable flow levels. This paper demonstrates a stochastic ensemble implementation of the Sacramento model used routinely by the National Weather Service for deterministic streamflow forecasting. The approach, the simultaneous optimization and data assimilation method (SODA), uses an ensemble Kalman filter (EnKF) for recursive state estimation allowing for treatment of streamflow data error, model structural error, and parameter uncertainty, while enabling implementation of the Sacramento model without major modification to its current structural form. Model parameters are estimated in batch using the shuffled complex evolution metropolis stochastic-ensemble optimization approach (SCEM-UA). The SODA approach was implemented using parallel computing to handle the increased computational requirements. Studies using data from the Leaf River, Mississippi, indicate that forecast performance improvements on the order of 30% to 50% can be realized even with a suboptimal implementation of the filter. Further, the SODA parameter estimates appear to be less biased, which may increase the prospects for finding useful regionalization relationships.

scholarly journals High temporal resolution estimates of columnar aerosol microphysical parameters from spectrum of aerosol optical depth by linear estimation: application to long-term AERONET and star-photometry measurements

2015 ◽  
Vol 8 (8) ◽  
pp. 3117-3133 ◽  
Author(s):  
D. Pérez-Ramírez ◽  
I. Veselovskii ◽  
D. N. Whiteman ◽  
A. Suvorina ◽  
M. Korenskiy ◽  
...  
Keyword(s):  
Aerosol Optical Depth ◽  
Optical Depth ◽  
Temporal Resolution ◽  
High Temporal Resolution ◽  
Linear Estimation ◽  
Night Time ◽  
Microphysical Properties ◽  
Fine Mode ◽  
Using Data ◽  
Aerosol Types

Abstract. This work deals with the applicability of the linear estimation technique (LE) to invert spectral measurements of aerosol optical depth (AOD) provided by AERONET CIMEL sun photometers. The inversion of particle properties using only direct-sun AODs allows the evaluation of parameters such as effective radius (reff) and columnar volume aerosol content (V) with significantly better temporal resolution than the operational AERONET algorithm which requires both direct sun and sky radiance measurements. Sensitivity studies performed demonstrate that the constraints on the range of the inversion are very important to minimize the uncertainties, and therefore estimates of reff can be obtained with uncertainties less than 30 % and of V with uncertainties below 40 %. The LE technique is applied to data acquired at five AERONET sites influenced by different aerosol types and the retrievals are compared with the results of the operational AERONET code. Good agreement between the two techniques is obtained when the fine mode predominates, while for coarse mode cases the LE results systematically underestimate both reff and V. The highest differences are found for cases where no mode predominates. To minimize these biases, correction functions are developed using the multi-year database of observations at selected sites, where the AERONET retrieval is used as the reference. The derived corrections are tested using data from 18 other AERONET stations offering a range of aerosol types. After correction, the LE retrievals provide better agreement with AERONET for all the sites considered. Finally, the LE approach developed here is applied to AERONET and star-photometry measurements in the city of Granada (Spain) to obtain day-to-night time evolution of columnar aerosol microphysical properties.

scholarly journals Stand-alone single-frequency GPS ice velocity observations on Nordenskiöldbreen, Svalbard

2010 ◽  
Vol 4 (4) ◽  
pp. 593-604 ◽  
Author(s):  
M. A. G. den Ouden ◽  
C. H. Reijmer ◽  
V. Pohjola ◽  
R. S. W. van de Wal ◽  
J. Oerlemans ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Temporal Resolution ◽  
Flow Line ◽  
Reference Station ◽  
Single Frequency ◽  
Maximum Speed ◽  
Gps Receivers ◽  
Ice Velocity ◽  
Using Data ◽  
Flow Velocities

Abstract. Precise measurements of ice-flow velocities are necessary for a proper understanding of the dynamics of glaciers and their response to climate change. We use stand-alone single-frequency GPS receivers for this purpose. They are designed to operate unattended for 1–3 years, allowing uninterrupted measurements for long periods with hourly temporal resolution. We present the system and illustrate its functioning using data from 9 GPS receivers deployed on Nordenskiöldbreen, Svalbard, for the period 2006–2009. The accuracy of the receivers is 1.62 m based on the standard deviation in the average location of a stationary reference station (NBRef). Both the location of NBRef and the observed flow velocities agree within one standard deviation with DGPS measurements. Periodicity (6, 8, 12, 24 h) in the NBRef data is largely explained by the atmospheric, mainly ionospheric, influence on the GPS signal. A (weighed) running-average on the observed locations significantly reduces the standard deviation and removes high frequency periodicities, but also reduces the temporal resolution. Results show annual average velocities varying between 40 and 55 m yr−1 at stations on the central flow-line. On weekly to monthly time-scales we observe a peak in the flow velocities (from 60 to 90 m yr−1) at the beginning of July related to increased melt-rates. No significant lag is observed between the timing of the maximum speed between different stations. This is likely due to the limited temporal resolution after averaging in combination with the relatively small distance (max. ±13 km) between the stations.

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